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MPower Partners

mpower-partners.com · Tokyo, Japan

“MPower Partners is a Japan-based, ESG-integrated venture capital fund that empowers visionary gamechangers, backing tech-enabled solutions to societal challenges plus, under Fund II's 'Japan Dynamism' theme, startups that bolster Japan's long-term resilience and growth. It goes beyond capital, applying a proprietary ESG framework and deep public/private-sector networks to help startups scale in Japan and internationally.”

Leads & Follows
Lead Tendency
01Investment Thesis

MPower Partners is a Japan-based, ESG-integrated venture capital fund that empowers visionary gamechangers, backing tech-enabled solutions to societal challenges plus, under Fund II's 'Japan Dynamism' theme, startups that bolster Japan's long-term resilience and growth. It goes beyond capital, applying a proprietary ESG framework and deep public/private-sector networks to help startups scale in Japan and internationally.

02Investment Team
KM
Kathy Matsui
General Partner
MS
Miwa Seki
General Partner
YM
Yumiko Murakami
General Partner
MF
Masatoshi Fukasawa
Partner
YX
Ye Xia
Principal
KT
Kirara Tsutsui
Vice President
KH
Kazuhiro Hosaka
Vice President
CI
Chio Ishikawa
Associate
YT
Yukiko Takahashi
Head of Operations
YU
Yuuki Umeda
IR / Fund Operation
CG
Chi Guillemette
Legal & Compliance
CW
Chika Watanabe
Office Manager
LS
Lisa Shalett
Operating Partner
KD
Katherine Davidson
Operating Partner
03F4 Research Brief

MPower Partners Research

Investment Thesis

MPower Partners is a Japan-based venture capital fund whose mission is to "empower visionary gamechangers and unlock transformative growth." Founded in 2021 by three veteran finance executives - Kathy Matsui (former Goldman Sachs Japan Vice Chair), Yumiko Murakami (former OECD Tokyo Centre Director), and Miwa Seki (former Morgan Stanley / Clay Finlay) - MPower was launched as Japan's first ESG-integrated global venture capital fund. The firm applies a proprietary ESG framework to every portfolio company and positions itself as a bridge-builder between Japan's startup ecosystem and global capital, talent, and markets. It backs "tech-enabled solutions to societal challenges," and with Fund II (launched March 2025) added a second explicit theme, "Japan Dynamism": startups that bolster Japan's national resilience and long-term growth potential (deep tech, energy security, defense-adjacent and supply-chain resilience areas).

Stage Focus

MPower operates two vehicles with different stage mandates. MPower Partners Fund II (successor to Fund I) targets middle-to-later-stage growth startups, aiming to help Japanese companies reach unicorn scale. The dedicated WPower Fund, focused on women-founded and women-empowerment businesses, invests at the early stage. Across the platform, the firm covers seed through growth/late-stage rounds, with an emphasis on being able to support a company from early traction through international scale-up.

Check Size

MPower does not publish a specific check-size range. Third-party trackers describe it as flexible across stages; visible deal sizes range from smaller WPower early-stage checks (e.g., a JPY 250M / ~$1.7M Pre-Series A for NaLaLys, co-invested alongside Delight Ventures and DNX Ventures) up to growth-stage rounds in later-stage companies like Phoenix Tailings and HistoSonics.

Lead Tendency

Evidence points to a mixed lead/follow pattern. Several announced deals (e.g., NaLaLys) show MPower as one of multiple co-investors alongside firms such as DNX Ventures and Delight Ventures, while other press releases describe MPower directly as "investing in" a company without explicit lead language. The firm should be treated as a frequent syndicate participant that also leads selectively, particularly in Japan-based deals.

Recent Activity

MPower has been highly active through 2025-2026, announcing at least nine new investments in roughly 16 months: Ex-Fusion (Jun 2025, laser nuclear fusion), Nihon Cyber Defence (Nov 2025, cybersecurity), Transcelestial (Nov 2025, laser communication infrastructure), Sakana AI (Nov 2025, frontier AI), MiRESSO (Feb 2026, beryllium for nuclear fusion), EdgeCortix (Apr 2026, energy-efficient AI semiconductors), LQUOM (Apr 2026, quantum communication), HistoSonics (Jul 2026, non-invasive cancer therapy), and Teal Health (Sep 2026, at-home cervical cancer screening). Fund II (launched March 2025) added the Japan Investment Corporation (JIC) as a new LP, with a JPY 3 billion commitment. Fund I launched in 2021 with a $150M target; Fund II's target has been reported at roughly $200M, though final close amounts for both funds are undisclosed.

Portfolio Highlights

The portfolio spans roughly 40 companies, about 80% based in Japan with the remainder in the US and Southeast Asia. Notable names include Sakana AI (frontier AI), Phoenix Tailings (critical minerals/rare earths, MIT spinout), Heralbony (art agency for artists with intellectual disabilities), Teamshares (US employee-ownership fintech), Jupiter Intelligence (climate risk analytics), HistoSonics and Teal Health (US healthtech), and JEPLAN (circular-economy chemical recycling). Deep-tech and hard-tech names (Ex-Fusion, MiRESSO, LQUOM, EdgeCortix) reflect the newer "Japan Dynamism" thesis.

Team

  • Kathy Matsui, General Partner - former Vice Chair and Chief Japan Equity Strategist, Goldman Sachs Japan
  • Miwa Seki, General Partner - former Morgan Stanley investment banking and Clay Finlay Tokyo branch head; founded and sold a childcare company
  • Yumiko Murakami, General Partner - co-founder
  • Masatoshi Fukasawa, Partner
  • Ye Xia, Principal - focuses on AI/ML healthcare and decarbonization/climate innovation
  • Kirara Tsutsui and Kazuhiro Hosaka, Vice Presidents
  • Chio Ishikawa, Associate - WPower Fund capitalist focused on eldercare, childcare, healthcare, fintech
  • Yukiko Takahashi (Head of Operations), Yuuki Umeda (IR/Fund Operation), Chi Guillemette (Legal & Compliance), Chika Watanabe (Office Manager)
  • Lisa Shalett and Katherine Davidson, Operating Partners
  • A bench of Industry Experts (e.g., Mihoko Manabe, Simeon Bochev, Paul N. Matsui, Kanoko Oishi) and External Advisors including Tadashi Yanai (Fast Retailing), Mark Schwartz (former Goldman Sachs Vice Chairman), and Yoky Matsuoka (Panasonic, ex-Nest CTO) supplement the core team.

Decision Process

Three General Partners co-lead the firm (partnership model), supported by a Partner, Principal, and VP/Associate-level investment team plus dedicated Operating Partners and Industry Experts for diligence and portfolio support.

Founder Preferences

MPower explicitly prioritizes diversity: roughly 55% of portfolio companies are led by women or other diverse founders. The WPower Fund exclusively backs female founders and women-empowerment businesses across women's wellbeing, childcare/eldercare, women's economic independence, and broader social diversity. Outside WPower, MPower backs technical founders tackling large societal or structural problems (healthcare access, climate, energy security, cybersecurity, deep tech).

Geographic Focus

Primarily Japan (about 80% of the portfolio), with the remainder in the US and Southeast Asia. MPower positions itself explicitly as a bridge between Japan and global capital markets, supporting portfolio companies' expansion both into and out of Japan.

04Selected Portfolio
Biotech & Life Sciences
Cyto-Facto·Teal Health·HistoSonics
Climate & Sustainability
JEPLAN·Aclima·Miresso·Jupiter Intelligence
E-commerce & Marketplaces
Unifa
Energy & Power
EX-Fusion
Enterprise Software
ClipLine·FastLabel·Teamshares·NaLaLys·bgrass·LQUOM·Sakana AI·Transcelestial·Wovn Technologies·Sukedachi
Fintech & Payments
RABO
Food & Beverage
newmo·Uniam
Healthcare & Digital Health
TXP Medical·Ichirou·mamawell·Boost Health·Magic Shields
Legal & Regtech
Lisse
Manufacturing & Industrial
Phoenix Tailings
Marketing & Adtech
Knowns
Media & Entertainment
SHE·Heralbony·Mantra
Mobility & Transportation
HQ
Real Estate & PropTech
Rukita
Security & Cybersecurity
Nihon Cyber Defence
Semiconductors & Hardware
EdgeCortix
Travel & Hospitality
TAZ·Ikura
Other
MeetsMore
Open the full portfolio→
05Recent Updates

Fresh signals from public announcements, essays, and portfolio activity.

See full activity (13) →
Invested in Teal Health, a San Francisco-based startup modernizing cervical cancer screening with its FDA-authorized Teal Wand self-collection device.
INVESTMENT·mpower-partners.com
SEP 24, 2026
Invested in HistoSonics, a US-based pioneer in non-invasive focused-ultrasound cancer therapy.
INVESTMENT·mpower-partners.com
JUL 1, 2026
Invested in LQUOM to advance quantum communication infrastructure.
INVESTMENT·mpower-partners.com
APR 21, 2026
Invested in EdgeCortix, a pioneer in energy-efficient AI semiconductor technology.
INVESTMENT·mpower-partners.com
APR 15, 2026
Invested in MiRESSO, a Japan-based beryllium innovator for nuclear fusion.
INVESTMENT·mpower-partners.com
FEB 27, 2026
06Frequent co-investors
DV
Delight Ventures
Both backed 2 of the same companies
NaLaLys, EX-Fusion
GC
Geodesic Capital
Both backed 2 of the same companies
Phoenix Tailings, Sakana AI
GB
Global Brain
Both backed 2 of the same companies
SHE, newmo
I(
In-Q-Tel (IQT)
Both backed 2 of the same companies
Sakana AI, EdgeCortix
PA
Plum Alley Investments
Both backed 2 of the same companies
Phoenix Tailings, Aclima
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Quick Reference
Stages
Seed · Series A · Growth
Decision
Partnership
Location
Tokyo, Japan
Sector Focus
Fintech & PaymentsReal Estate & PropTechSemiconductors & HardwareRobotics & AutomationMobility & TransportationClimate & SustainabilityAgeTech & LongevityEnterprise SoftwareDeveloper Tools & InfrastructureSecurity & CybersecurityEnergy & PowerHealthcare & Digital Health
Models
B2B SaaSFemTechAgeTechClimate TechDeep Tech
Technology
AI/MLSemiconductors/HardwareRobotics
See all Fintech & Payments investors →See all Real Estate & PropTech investors →See all Semiconductors & Hardware investors →
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Focus Areas
Fintech & PaymentsReal Estate & PropTechSemiconductors & HardwareRobotics & AutomationMobility & TransportationClimate & SustainabilityAgeTech & LongevityEnterprise SoftwareDeveloper Tools & InfrastructureSecurity & CybersecurityEnergy & PowerHealthcare & Digital Health

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F4 Intelligence Report · Last Researched September 25, 2026F4 Research Engine