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Third Rock Ventures

A closer look at the companies associated with this firm. Verified team members can update the portfolio after signing in.

Portfolio

Third Rock Ventures portfolio

This is the portfolio currently shown on the public firm page.

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Tango TherapeuticsListed
tangotx.combiotech_life_sciences

Tango Therapeutics is leveraging the principle of synthetic lethality to develop genetically targeted therapies for specific tumors, focusing on genetically defined subsets of can…

Maze TherapeuticsListed
mazetx.combiotech_life_sciences

Maze Therapeutics is a clinical-stage biopharmaceutical company focused on developing breakthrough precision medicines for common diseases, particularly chronic kidney disease, le…

Rapport TherapeuticsListed
rapportrx.combiotech_life_sciences

Rapport Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of precision small molecule medicines for central nervous system (CNS)…

SepternaListed
septerna.combiotech_life_sciences

Septerna is a biotechnology company focused on pioneering GPCR drug discovery through its proprietary Native Complex Platform™, aiming to develop oral small molecule therapies tar…

Global Blood TherapeuticsDetails pending
gbtx.com

Details are not available yet. The company remains listed.

Sage TherapeuticsListed
sagerx.combiotech_life_sciences

Sage Therapeutics is an award-winning biopharmaceutical company with over 30 years of experience in developing and commercializing products that treat central nervous system (CNS)…

Blueprint MedicinesListed
blueprintmedicines.combiotech_life_sciences

Blueprint Medicines is focused on developing innovative therapies for patients with mast cell disorders and solid tumors, utilizing a proven drug discovery platform and robust cli…

Syremis TherapeuticsListed
syremis.combiotech_life_sciences

Syremis Therapeutics is a clinical-stage biopharmaceutical company developing novel medicines to make a profound impact on the treatment of mental health disorders. The company’s…

Azalea TherapeuticsListed
azaleatx.combiotech_life_sciences

Azalea Therapeutics is enabling precision genome engineering directly inside the body, with an initial focus on creating cancer immunotherapies in vivo. The company uses precision…

InsitroListed
insitro.combiotech_life_sciences

Insitro is a drug discovery company that leverages machine learning and large-scale data to develop new medicines more efficiently. They focus on understanding complex biological…

Candid TherapeuticsListed
candidtx.combiotech_life_sciences

Candid Therapeutics is a biotech company focused on developing treatments for fungal infections.

Marea TherapeuticsListed
mareatx.combiotech_life_sciences

Marea Therapeutics is focused on developing next-generation medicines for cardioendocrine diseases by leveraging large-scale human genetic data and advancements in biology.

Seaport TherapeuticsListed
seaporttx.combiotech_life_sciences

Advancing novel antidepressants and anxiolytics based on clinically validated mechanisms powered by our Glyph™ platform.

Agios PharmaceuticalsListed
agios.combiotech_life_sciences

Agios Pharmaceuticals is focused on discovering and developing innovative medicines for patients with rare diseases, particularly those related to metabolic disorders.

Editas MedicineListed
editasmedicine.combiotech_life_sciences

Editas Medicine is a pioneering gene editing company focused on developing transformative medicines using CRISPR technology to treat serious diseases.

Fulcrum TherapeuticsListed
fulcrumtx.combiotech_life_sciences

Fulcrum Therapeutics focuses on developing small molecules to improve the lives of patients with genetically defined rare diseases, particularly in areas of high unmet medical nee…

Element ScienceListed
elementscience.combiotech_life_sciences

Element Science is a San Francisco-based medical device and digital health company focused on developing solutions to address the needs of high-risk cardiovascular patients, inclu…

Terremoto BiosciencesListed
terremotobio.combiotech_life_sciences

Terremoto Biosciences is a clinical-stage company breaking new ground in the targeted therapy landscape in oncology and genetic disease, focusing on developing groundbreaking, bes…

ARTBIOListed
artbio.combiotech_life_sciences

ARTBIO is redefining cancer care by developing a new class of alpha radioligand therapies (ART) and building the ecosystem that maximizes their potential.

Merida BiosciencesListed
meridabio.combiotech_life_sciences

Merida Biosciences is focused on developing precision therapies for autoimmune-driven diseases, targeting the pathogenic drivers of antibody-driven diseases with high specificity.

Corvia MedicalListed
corviamedical.combiotech_life_sciences

Corvia Medical is focused on transforming the standard of care for heart failure treatment with its innovative Corvia Atrial Shunt System, aimed at improving quality of life for p…

Flare TherapeuticsListed
flaretx.combiotech_life_sciences

Flare Therapeutics is focused on developing small molecule medicines that target transcription factors to treat diseases, particularly in precision oncology. Their pipeline includ…

InflectionListed
No domain yetenterprise_software

Inflection AI develops human-centered, emotionally intelligent AI, including Pi, a personal AI companion, and foundation models and APIs for developers, agents, and enterprises. I…

Trace NeuroscienceListed
No domain yetbiotech_life_sciences

Biopharmaceutical company developing genomic medicines for neurodegenerative diseases, initially targeting ALS. Its lead antisense oligonucleotide program aims to correct UNC13A m…

Clasp TherapeuticsListed
No domain yetbiotech_life_sciences

Clasp Therapeutics aims to bring absolute precision to immuno-oncology by developing next-generation T cell engagers (TCEs) that target tumor-specific oncogenic driver mutations a…

Synnovation TherapeuticsListed
synnovation.combiotech_life_sciences

Synnovation Therapeutics is a precision medicine company developing small molecule therapies optimized to achieve best-in-class pharmacology against highly validated disease targe…

Abata TherapeuticsListed
No domain yetbiotech_life_sciences

Clinical-stage biotechnology company developing engineered regulatory T-cell (Treg) therapies for severe autoimmune and inflammatory diseases. Its tissue-specific cell therapy pip…

AblexisListed
No domain yetbiotech_life_sciences

Develops and licenses the AlivaMab transgenic mouse platform for discovering human therapeutic antibodies and antibody-derived drug candidates. The platform is used by pharmaceuti…

Afferent PharmaceuticalsListed
No domain yetbiotech_life_sciences

Clinical-stage biopharmaceutical company developing first-in-class small-molecule P2X3 receptor antagonists for chronic pain and other neurogenic disorders, including chronic coug…

Alcresta TherapeuticsListed
No domain yethealthcare_digital

Develops and commercializes enzyme-based medical devices and products for enteral nutrition, addressing fat malabsorption and nutritional challenges associated with gastrointestin…

Allena PharmaceuticalsListed
No domain yetbiotech_life_sciences

Biotechnology company developing and commercializing first-in-class oral enzyme therapeutics for rare and severe metabolic disorders affecting the kidneys. Its non-absorbed, stabl…

Alnara PharmaceuticalsListed
No domain yetbiotech_life_sciences

Biopharmaceutical company developing protein-based therapies for metabolic diseases, with a focus on orally delivered therapeutics that act locally in the gastrointestinal tract.…

Ambys MedicinesListed
No domain yetbiotech_life_sciences

Bi biotechnology company developing hepatocyte transplantation and engineered liver-cell therapies for severe liver disease, including diseases of acquired and genetic origin. Its…

Asher BioListed
No domain yetbiotech_life_sciences

Clinical-stage biotechnology company developing cis-targeted immunotherapies that selectively activate specific immune cell types. Its lead program, etakafusp alfa, is an IL-2 the…

bluebirdbioListed
No domain yetbiotech_life_sciences

Biotechnology company (now rebranded as Genetix Biotherapeutics) developing genetic therapies for sickle cell disease, beta-thalassemia, and cerebral adrenoleukodystrophy.

CARGO Therapeutics, Inc.Listed
cargotx.combiotech_life_sciences

CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO’s programs…

CASMA TherapeuticsListed
No domain yetbiotech_life_sciences

Biotechnology company developing targeted cellular degradation therapeutics by reprogramming the autophagy pathway. Its PHLYT™ platform directs disease-causing cellular targets—in…

Cedilla TherapeuticsListed
No domain yetbiotech_life_sciences

Biotechnology company developing small-molecule conditional inhibitors that modulate proteins in their functional state to selectively target oncogenic drivers. Its precision onco…

CelsiusListed
celsius.comfood_beverage

Celsius offers a range of energy drinks that are clinically proven to boost metabolism and enhance physical performance. Their products are made with natural ingredients and are d…

CibiemListed
No domain yethealthcare_digital

Medical device company developing minimally invasive, catheter-based therapeutics for diseases mediated by the sympathetic nervous system, including hypertension, heart failure, d…

Constellation PharmaceuticalsListed
No domain yetbiotech_life_sciences

Constellation Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel therapeutics that selectively modulate gene expression to address serious unmet medica…

Cytomx TherapeuticsListed
No domain yetbiotech_life_sciences

Clinical-stage, oncology-focused biopharmaceutical company developing antibody-based cancer therapeutics using its Probody platform. The platform conditionally activates antibody-…

Decibel TherapeuticsListed
decibeltx.combiotech_life_sciences

Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of…

edimerListed
No domain yetbiotech_life_sciences

Privately held biotechnology company developing EDI200, a recombinant ectodysplasin-A1 replacement protein intended to treat X-linked hypohidrotic ectodermal dysplasia (XLHED), a…

Ember TherapeuticsListed
No domain yetbiotech_life_sciences

A product-focused biotechnology company developing peripherally acting treatments for metabolic disease, based on research into brown fat biology and selective insulin sensitivity…

Faze MedicinesListed
No domain yetbiotech_life_sciences

Faze Medicines was a Cambridge, Massachusetts biotechnology company founded in 2020 that harnessed biomolecular condensates to develop medical breakthroughs. It raised $81 million…

Foundation MedicineListed
No domain yetbiotech_life_sciences

A precision medicine and clinical diagnostics company providing comprehensive genomic profiling tests for cancer and other diseases. It uses next-generation sequencing and AI-enab…

Goldfinch BioListed
No domain yetbiotech_life_sciences

Clinical-stage biotechnology company developing precision medicines for kidney diseases. Its genomics-based approach and proprietary Kidney Genome Atlas platform support target di…

Igenica BiotherapeuticsListed
No domain yetbiotech_life_sciences

Biotherapeutics company focused on discovering and developing antibodies and antibody-drug conjugates (ADCs) for cancer treatment. Its integrated platform supports target and func…

Jounce TherapeuticsListed
No domain yetbiotech_life_sciences

Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to atta…

Kala BioListed
kalarx.combiotech_life_sciences

KALA BIO is a biopharmaceutical company focused on optimizing clinical trial data for enhanced outcomes in clinical research, particularly in the field of mesenchymal stem cell se…

Kibur MedicalListed
No domain yetbiotech_life_sciences

Kibur Medical develops an implantable, drug-eluting microdevice platform for in situ profiling of tumor responses to multiple oncology drugs or combinations. Its NanoNail™ enables…

Lotus Tissue RepairListed
No domain yetbiotech_life_sciences

Biotechnology company developing recombinant human collagen type VII (rC7), a protein replacement therapy for dystrophic epidermolysis bullosa (DEB), a rare genetic skin disorder.…

Magenta TherapeuticsListed
No domain yetbiotech_life_sciences

Clinical-stage biotechnology company developing medicines to make the curative potential of stem cell transplantation available to more patients with blood cancers, genetic diseas…

MOMA TherapeuticsListed
No domain yetbiotech_life_sciences

MOMA Therapeutics is a clinical-stage, next-generation precision medicine company dedicated to targeting highly dynamic proteins that underlie human disease via a small molecule a…

MotusListed
No domain yetenterprise_software

Motus provides an AI-powered enterprise platform for managing employee driving programs, including mileage capture, vehicle reimbursement, driver risk monitoring, safety, and anal…

MyoKardiaListed
No domain yetbiotech_life_sciences

Biotechnology company developing genetically targeted small-molecule therapeutics for genetic cardiovascular diseases, initially hypertrophic and dilated cardiomyopathy. Its drug…

Neon TherapeuticsListed
No domain yetbiotech_life_sciences

Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. A neoantigen-based product engine allows Ne…

Nine Point MedicalListed
No domain yethealthcare_digital

Medical technology company developing imaging and diagnostic devices. The provided search results confirm its medical-device industry association but provide little detail about i…

NurixListed
No domain yetbiotech_life_sciences

Clinical-stage biopharmaceutical company developing targeted protein degradation medicines. Its DEL-AI drug discovery engine supports a pipeline of degrader therapies and degrader…

PanopticaListed
No domain yetenterprise_software

The search results do not provide reliable information identifying the company Panoptica or describing its products. The supplied panoptica.com page appears to be an unrelated med…

Pliant TherapeuticsListed
No domain yetbiotech_life_sciences

Clinical-stage biopharmaceutical company developing integrin-based therapeutics for serious diseases, including oncology and other areas of unmet medical need. Its lead candidate,…

Relay TherapeuticsListed
relaytx.combiotech_life_sciences

Relay Therapeutics is a clinical-stage precision medicine company focused on drug discovery through the integration of computational and experimental technologies, particularly ta…

Revolution MedicinesListed
revmed.combiotech_life_sciences

Revolution Medicines is dedicated to discovering, developing, and delivering innovative, targeted medicines for patients living with RAS-addicted cancers. They focus on pioneering…

Rheos MedicinesListed
No domain yetbiotech_life_sciences

Biopharmaceutical company developing precision therapies for autoimmune and inflammatory diseases by targeting metabolic pathways in immune cells. Its preclinical work includes MA…

Rhythm PharmaceuticalsListed
No domain yetbiotech_life_sciences

Global commercial-stage biopharmaceutical company developing and commercializing precision medicines for rare neuroendocrine diseases, including MC4R pathway disorders, rare genet…

Sesen BioListed
No domain yetbiotech_life_sciences

Sesen Bio is a clinical-stage biopharmaceutical company that developed targeted fusion protein therapeutics for cancer, particularly Vicineum for non-muscle invasive bladder cance…

Taris BioListed
No domain yetbiotech_life_sciences

TARIS Biomedical is a pharmaceutical company focused on developing targeted therapies for difficult-to-treat bladder diseases and other urologic conditions. Its investigational pr…

Thrive Earlier DetectionListed
No domain yetbiotech_life_sciences

Thrive Earlier Detection is a healthcare company focused on incorporating earlier cancer detection into routine medical care to extend and save lives. Thrive is developing CancerS…

Topica PharmaceuticalsListed
No domain yetbiotech_life_sciences

Dissolved California pharmaceutical company founded in 2004 that developed topical antifungal treatments, including luliconazole solution, for dermatophyte skin and nail infection…

Voyager TherapeuticsListed
No domain yetbiotech_life_sciences

Biotechnology company developing genetic medicines for neurological and central nervous system diseases. It leverages human genetics and its TRACER AAV capsid discovery platform t…

Warp Drive BioListed
No domain yetbiotech_life_sciences

Biotechnology company that develops proprietary genomic search engines and customized search queries to identify natural products based on their distinctive genomic signatures, se…

yourbioListed
No domain yetbiotech_life_sciences

YourBio Health develops TAP® touch-activated blood collection devices that use proprietary microneedle and vacuum technology to collect virtually painless capillary whole-blood sa…

ZafgenListed
No domain yetbiotech_life_sciences

Clinical-stage biopharmaceutical company developing therapies for metabolic diseases, including Prader-Willi syndrome. Its programs draw on proprietary knowledge of MetAP2 systems…