28 VC firms investing in biotech & life sciences and edtech at the Seed stage.
F4 Fund tracks 28 VC firms that actively invest in biotech & life sciences + edtech at the Seed stage, with check sizes ranging from $20K – $700M (median: $1.6M – $1.6M). As of June 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Better Ventures Mission-driven companies solve big problems at scale while building durable competitive advantages. We back founders leveraging science & technology to build the Better Economy where people and planet thrive. Oakland | $500K – $1M | 43 | Leads | Active | ~1 mo | Open |
| 2 | ▶ Realist Ventures We invest in groundbreaking startups with diverse founding teams building modern solutions to modern problems with capital-efficient approaches and realistic valuations. We support underrepresented entrepreneurs (women, Black, Latinx, Indigenous, LGBTQ+) who are creating products that solve real problems. Stamford | $100K – $500K | 8 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Osage Venture Partners Disruptive innovation in work and education fuels human achievement. We partner with exceptional entrepreneurs who are business builders, deep domain experts, and capital efficient thinkers. We believe in long-term relationships over transactional investing, often partnering with founders across multiple ventures. Pittsburgh | $1M – $5M | 71 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Spacecadet Ventures Founders building the possibly impossible deserve capital plus marketing support. Great technology combined with exceptional storytelling and narrative development creates world-changing moonshots. We provide both the capital and the story-telling expertise to help founders achieve escape velocity. New York | $250K – $1M | 99 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Wing Venture Capital The AI-first transformation of business will be as big as digital, mobile, and cloud combined. We invest in companies building the AI-first technology stack: data foundations, AI tools, autonomous applications, and product-led growth companies that accelerate adoption. Founders building at any layer of this stack can reach goals and uncover opportunities previously unattainable. Palo Alto | $200K – $20M | 36 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Social Impact Capital Social impact companies are undervalued at the earliest stages when metrics are unclear. We invest very early in mission-driven founders tackling the world's hardest problems, supporting them until they're attractive to top-tier VCs. 12-15 exceptional entrepreneurs can solve the largest global challenges. New York | $250K – $5M | 21 | Leads | Active | ~2 wks | Req'd |
| 7 | ▶ The Venture Collective (TVC) Permanent balance-sheet investor backing highly defensible, category-defining, mission-driven companies solving the world's biggest problems. Focus on founders transforming legacy industries with emphasis on diversity, equity, and inclusion. New York | $100K – $2M | 53 | Leads | Active | ~2 wks | Open |
| 8 | ▶ Vertical Venture Partners Back founders with deep, first-hand domain expertise in specific industry verticals — those who have 'lived' the problem they are solving. Vertical-first software delivers faster time-to-value and stronger retention versus horizontal tools requiring heavy customization. Palo Alto | $500K – $4M | 47 | Both | Active | ~1 mo | Open |
| 9 | ▶ Atento Capital Great entrepreneurship exists everywhere—not just in traditional tech hubs. We invest in high-potential early-stage founders with a focus on underrepresented geographies (Midwest, Latin America) and demographics (women, minorities, immigrants). Beyond capital, we provide strategic guidance, ecosystem connections, and relocation support through our Tulsa-based infrastructure. Tulsa, Oklahoma | $500K – $2M | 24 | Leads | Active | ~2 wks | Req'd |
| 10 | ▶ Binance Labs Support visionary founders building transformative technologies across blockchain, AI, and biotechnology. Provide capital, technical resources, and access to Binance's 300M+ user base and infrastructure. Partner for long-term value creation with founder-centric approach. Cayman Islands | $100K – $5M | 24 | Both | Active | ~2 wks | Open |
| 11 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 12 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 55 | Both | Active | ~1 mo | Open |
| 13 | ▶ Better Capital Day 0 venture capital applied by a deep operator. Better Capital invests at the earliest stage where ambiguity is highest and operator judgment adds the most value. Solo GP model keeps conviction high and enables deep engagement with 20-25 companies at critical inflection points. Pune | $300K – $1M | 47 | Leads | Active | ~1 wk | Req'd |
| 14 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 15 | ▶ The Helm Women receive only 2% of venture capital despite female-founded startups delivering 2x return per dollar vs. all-male teams. The Helm invests in game-changing, undervalued companies at seed stage founded by women, providing not just capital but operational support and ecosystem access. New York | $250K – $1.5M | 26 | Leads | Active | ~2 wks | Open |
| 16 | ▶ AENU Rewriting the VC rulebook to deliver high returns with high impact. We invest in founders building climate and social impact technologies with intentional, measurable, net-positive outcomes at meaningful scale. | $1M – $4M | 14 | Leads | Active | — | — |
| 17 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 18 | ▶ Boro Capital Invest in scalable, capital-efficient tech and tech-enabled startups at the Seed stage led by exceptional founders. We identify companies showing early traction that can achieve significant scale with disciplined capital deployment. New York | $100K – $500K | 32 | Leads | Active | ~2 wks | Open |
| 19 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 20 | ▶ Supernode Ventures We invest in the technologies that are transforming our lives, now and into the future. Founded by a successful entrepreneur and former tech journalist, Supernode backs exceptional founders building innovative technology companies across all sectors, from pre-seed through Series A and beyond. San Francisco | $250K – $3M | 20 | Both | Active | 3+ mo | Open |
| 21 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 22 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 28 | Leads | Active | — | — |
| 23 | ▶ Vibe Capital Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures. New York | $250K – $500K | 22 | Both | Active | ~2 mo | Open |
| 24 | ▶ Rockies Venture Fund High-growth early-stage companies with disruptive innovation across diversified sectors. Particular focus on underserved communities and Rocky Mountain region. Platform approach with multiple themed funds for specialized strategies. Denver | $100K – $500K | 18 | Both | Active | ~2 mo | Req'd |
| 25 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 26 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 27 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 28 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
Investors on this page also frequently invest in these sectors
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What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 28 VC firms that actively invest in biotech & life sciences + edtech at the Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for seed biotech & life sciences + edtech investors is $1.6M – $1.6M, with a full range from $20K – $700M. The distribution breaks down as: 6 firms in the <$500K range, 5 firms in the $500K-$1M range, 5 firms in the $1M-$2M range, 7 firms in the $2M-$5M range, 1 firms in the $5M-$10M range, 4 firms in the $10M+ range.
Among the 28 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best seed biotech & life sciences + edtech investors combine domain expertise with an active portfolio in the space. Among these firms, 24% prefer warm introductions, and the average firm has 35 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.