14 VC firms investing in biotech & life sciences and real estate & proptech at the Series B stage.
F4 Fund tracks 14 VC firms that actively invest in biotech & life sciences + real estate & proptech at the Series B stage, with check sizes ranging from $1K – $5000M (median: $7.8M – $7.8M). As of August 2026, and 71% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,644+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Balderton Capital Balderton Capital backs European-founded technology companies with visionary founders building transformative businesses. The firm combines patient capital, operational expertise, and founder support to enable European entrepreneurs to build world-class companies. | $500K – $15M | 200 | Leads | Active | ~2 wks | Open |
| 2 | ▶ LvlUp Ventures LvlUp backs founders across every stage, geography, and industry, using a large distributed network of associates and scouts to source and support a very high volume of small checks, paired with accelerator and mentorship infrastructure. New York | $1K – $1M | 37 | N/A | Active | N/A | Open |
| 3 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 52 | Both | Active | ~2 mo | Open |
| 4 | ▶ Moderne Ventures Generalist investors with vertical expertise. We invest in bold, broad, multi-vertical technology companies applicable to multi-trillion dollar industries (real estate, finance, insurance, sustainability). Our distinctive Moderne Passport program creates value by connecting 1,500+ corporate executives with portfolio companies, generating customers, strategic partnerships, and operational guidance. Chicago | $2M – $25M | 27 | Leads | Active | ~2 wks | Req'd |
| 5 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 6 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 32 | Leads | Active | ~1 mo | Req'd |
| 7 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 46 | Both | Active | ~2 mo | Req'd |
| 8 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 9 | ▶ Trust Ventures Backs founders building generational companies in markets where public policy and regulation, not technology, are the primary barrier to progress -- energy, housing, healthcare, insurance, and advanced manufacturing. Pairs capital with in-house legal and policy strategy to help portfolio companies navigate and reshape regulatory environments. Austin | $250K – $30M | 19 | Follows | Active | N/A | N/A |
| 10 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 61 | Leads | Active | ~1 mo | Open |
| 11 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 12 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 13 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 14 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 17 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 14 VC firms that actively invest in biotech & life sciences + real estate & proptech at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b biotech & life sciences + real estate & proptech investors is $7.8M – $7.8M, with a full range from $1K – $5000M. The distribution breaks down as: 1 firms in the <$500K range, 3 firms in the $500K-$1M range, 2 firms in the $2M-$5M range, 2 firms in the $5M-$10M range, 6 firms in the $10M+ range.
Among the 14 firms tracked, 71% lead or co-lead rounds, and 21% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b biotech & life sciences + real estate & proptech investors combine domain expertise with an active portfolio in the space. Among these firms, 31% prefer warm introductions, and the average firm has 47 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.