F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
48 VC firms investing in biotech & life sciences and robotics & automation at the Series B stage.
F4 Fund tracks 48 VC firms that actively invest in biotech & life sciences + robotics & automation at the Series B stage, with check sizes ranging from $100K – $100000M (median: $8M – $8M). As of July 2026, and 94% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,544+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ OYSTER BAY Venture Capital The way we nourish ourselves defines our future. We invest in rare founders disrupting the food system for better economic and ecological outcomes across the entire food value chain—from agriculture and inputs through food production, ingredients, consumer brands, and food service. We seek to partner with ambitious, resourceful founders who combine strong execution capability with deep commitment to positive impact. | $1M – $5M | 19 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Acre Venture Partners Driving positive, lasting change in food and agriculture creates exceptional financial outcomes. Impact and return aren't trade-offs—they're intertwined. Both are essential. We invest in technologies and companies addressing human health, planetary well-being, responsible production, and climate solutions. Santa Monica | $500K – $5M | 29 | Leads | Active | ~1 mo | Req'd |
| 4 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 5 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 34 | Both | Active | ~1 mo | Open |
| 6 | ▶ Playground Global Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us. Palo Alto | $1M – $20M | 32 | Both | Active | 3+ mo | Req'd |
| 7 | ▶ Air Street Capital We invest exclusively in AI-first companies where advances in artificial intelligence are the primary driver of product capability, competitive advantage, and long-term value creation. We are deeply coupled to the frontier of AI research and industry, enabling us to identify emerging technical inflection points and structural shifts early. London | $1M – $300M | 26 | Leads | Active | ~1 mo | Open |
| 8 | ▶ TELUS Pollinator Fund for Good We refuse to compromise between doing good and delivering strong financial and commercial returns. Portfolio companies gain access to TELUS's commercial networks, data-rich platforms, and deep expertise across agriculture, health, and connectivity giving them a unique edge as they scale. Vancouver | $1M – $20M | 12 | Both | Active | ~1 mo | Open |
| 9 | ▶ LG Technology Ventures LGV backs early-stage and growth-stage innovators with the strategic strength of LG Group's global resources. The fund invests in companies that stand to gain exceptional value from partnerships with LG's manufacturing, display, chemical, and energy business units, with a strong focus on AI, biotech, cleantech, and advanced materials. Silicon Valley | $1M – $30M | 73 | Both | Active | ~2 mo | Open |
| 10 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 11 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 54 | Leads | Active | ~2 mo | Open |
| 12 | ▶ Entrepreneur First It matters not only which companies get started, but who starts them. EF identifies exceptional individual talent before a company, co-founder, or idea exists, and builds the company from Day Zero through cohort-based co-founder matching, an equity-free grant phase, and up to $250K in formation capital (via SAFE) once a team passes its Investment Committee. London | $250K – $5M | 78 | Leads | Active | N/A | Open |
| 13 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 52 | Both | Active | ~2 mo | Open |
| 14 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 15 | ▶ Eight Roads Back ambitious technology and healthcare founders in Asia, Europe, and Israel, providing not just capital but access to a global ecosystem spanning 350+ portfolio companies across four continents. Fidelity backing allows more flexible and focused support than typical VC. London | $5M – $50M | 26 | Both | Active | ~2 mo | N/A |
| 16 | ▶ NATO Innovation Fund NIF invests in cutting-edge science and engineering startups that strengthen the defence, security, and resilience of NATO Allied nations. Backed by 24 sovereign governments, NIF provides deep tech founders with unprecedented access to government procurement markets across 24 countries, connectivity to ~90 NATO-affiliated test centres, and 6,000+ Allied scientists. NIF leads initial investments with up to €15M and maintains substantial follow-on reserves. Amsterdam | $1M – $16.5M | 26 | Leads | Active | 3+ mo | Open |
| 17 | ▶ Binance Labs Support visionary founders building transformative technologies across blockchain, AI, and biotechnology. Provide capital, technical resources, and access to Binance's 300M+ user base and infrastructure. Partner for long-term value creation with founder-centric approach. Cayman Islands | $100K – $5M | 24 | Both | Active | ~2 wks | Open |
| 18 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 19 | ▶ Baidu Ventures Back deep tech companies enabling AI at the infrastructure layer (chips, hardware, algorithms) and AI-powered applications previously impossible without AI — with a current focus on GenAI, embodied intelligence, autonomous driving, and healthcare AI. Leverage Baidu's unique resources: engineering talent, data annotation infrastructure, and ecosystem customer relationships. Beijing | $500K – $10M | 23 | Both | Active | N/A | N/A |
| 20 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 21 | ▶ NVIDIA Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology. | $20M – $100000M | 37 | Both | Active | ~2 wks | Open |
| 22 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 23 | ▶ Korea Investment Partners Korea Investment Partners backs global winners across early to growth stages, combining capital with operating support and cross-border expansion help. Seoul | $2M – $3M | 19 | Both | Active | ~2 mo | Req'd |
| 24 | ▶ Valia Ventures We back technically ambitious founders building tomorrow's most iconic companies in frontier sectors like AI, hardtech, robotics, healthcare, and fintech. We believe great companies come from founders willing to tackle complex problems that generalist funds avoid. New York | $250K – $1.5M | 19 | Leads | Active | ~2 wks | Req'd |
| 25 | ▶ Caffeinated Capital Support founders pursuing their life's work with an alternative to the hype cycle: the luxury of long-term thinking. We support founders building category-defining companies across all sectors that will last for lifetimes. San Francisco | $1M – $5M | 18 | Leads | Active | N/A | N/A |
| 26 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 32 | Leads | Active | ~1 mo | Req'd |
| 27 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 46 | Both | Active | ~2 mo | Req'd |
| 28 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 29 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 30 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | N/A | Open |
| 31 | ▶ Mitsubishi UFJ Capital Support the realization of start-ups' dreams by sharing the aspirations of entrepreneurs, establishing trust as a capital partner, and assisting throughout all growth stages — from seed to IPO. MUCAP invests across all industry types and stages with particular depth in life sciences (dedicated department) and new industrial fields requiring patient capital. Tokyo | $500K – $50M | 21 | Both | Active | ~2 mo | Open |
| 32 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 33 | ▶ Interlagos The biggest venture returns of the next decade will come from applied science and advanced manufacturing companies in space, defense, robotics, energy, and biotech, businesses that are hard to build without rare operational and engineering know-how. El Segundo, CA | $5M – $50M | 9 | Leads | Active | N/A | Req'd |
| 34 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 35 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | N/A | N/A |
| 36 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 18 | Leads | Active | ~2 wks | Req'd |
| 37 | ▶ Yu Galaxy Conviction-driven venture capital backing visionary founders solving humanity's toughest problems. Focus on impact measurement: profitability and positive societal impact are inseparable. Invests from seed through Series B with follow-on capacity through exit. | $500K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 38 | ▶ Redalpine Redalpine backs companies at the convergence of software and science — where rigorous engineering meets scientific breakthroughs. Half the team are scientists, half are operators, enabling them to engage deeply with highly technical founders and support them hands-on from day one through to exit. Primary focus areas: frontier science and biotech, digital health, AI and automation, fintech, synthetic biology, and climate tech. Zug | $500K – $5M | 40 | Leads | Active | N/A | N/A |
| 39 | ▶ Greenoaks Greenoaks backs generation-defining technology companies with exceptional long-term growth potential. We make concentrated, large initial bets and maintain positions through multiple rounds and public markets, believing that exceptional founders and products deserve exceptional partnership. San Francisco | $25M – $75M | 20 | Both | Active | ~2 mo | Req'd |
| 40 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 25 | Leads | Active | ~2 mo | Open |
| 41 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 42 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 43 | ▶ Main Sequence Main Sequence backs deep tech founders solving humanity-scale problems, especially companies connected to publicly funded research and spinouts that can turn breakthrough science into global businesses. Eveleigh, NSW, Australia | $250K – $500K | 14 | Leads | Active | ~1 mo | N/A |
| 44 | ▶ HongShan Back transformative entrepreneurs building category-defining companies across technology, healthcare, and consumer sectors, from seed to buyout. Partner with founders throughout the full company lifecycle with capital, operational support, and the network built over 20 years of China and global investing. Hong Kong | $500K – $2000M | 20 | Leads | Active | ~1 mo | Req'd |
| 45 | ▶ Bessemer Venture Partners We partner with entrepreneurs from their early days through every stage of growth, focusing on innovative solutions in technology, healthcare, and financial services. Redwood City, California | $5.8M – $34.3M | 6 | N/A | 2mo | N/A | N/A |
| 46 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 47 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 48 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 17 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 48 VC firms that actively invest in biotech & life sciences + robotics & automation at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b biotech & life sciences + robotics & automation investors is $8M – $8M, with a full range from $100K – $100000M. The distribution breaks down as: 2 firms in the <$500K range, 3 firms in the $500K-$1M range, 3 firms in the $1M-$2M range, 12 firms in the $2M-$5M range, 6 firms in the $5M-$10M range, 22 firms in the $10M+ range.
Among the 48 firms tracked, 94% lead or co-lead rounds, and 4% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b biotech & life sciences + robotics & automation investors combine domain expertise with an active portfolio in the space. Among these firms, 29% prefer warm introductions, and the average firm has 35 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.