F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
31 VC firms investing in security & cybersecurity and biotech & life sciences at the Series B stage.
F4 Fund tracks 31 VC firms that actively invest in security & cybersecurity + biotech & life sciences at the Series B stage, with check sizes ranging from $100K – $100000M (median: $8M – $8M). As of July 2026, and 90% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,544+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Elaia A full stack investor for a complex world, backing tech disruptors with performance, values and care. Elaia partners with ambitious, technical founders from inception to leadership across two dedicated strategies: Digital Venture (B2B SaaS, AI, fintech, adtech, e-commerce) and DeepTech Seed (energy, aerospace, robotics, biotech, semiconductors), sourcing heavily from research institutions and lab spinouts. Paris | $1M – $16M | 95 | Both | Active | ~1 mo | Req'd |
| 2 | ▶ Amplify Partners The best companies will be built by technical founders - engineers, researchers, and scientists who have experienced a problem viscerally and are compelled to solve it. We invest in tools, platforms, and infrastructure for technical builders, and we partner with founders to help them evolve into leaders of generational companies. Menlo Park | $1.5M – $10M | 28 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Madrona Venture Group Madrona invests in people and ideas for the long run — backing visionary founders building transformational technology companies, with deep focus on applied AI across domain-specific applications, AI infrastructure, developer tools, enterprise software, and AI-enabled biotech. The firm serves as an active, full-stack partner providing capital plus recruiting, business development, and customer introductions. Seattle | $500K – $50M | 45 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Wing Venture Capital The AI-first transformation of business will be as big as digital, mobile, and cloud combined. We invest in companies building the AI-first technology stack: data foundations, AI tools, autonomous applications, and product-led growth companies that accelerate adoption. Founders building at any layer of this stack can reach goals and uncover opportunities previously unattainable. Palo Alto | $200K – $20M | 44 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Tribe Capital Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access). Menlo Park | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 6 | ▶ LG Technology Ventures LGV backs early-stage and growth-stage innovators with the strategic strength of LG Group's global resources. The fund invests in companies that stand to gain exceptional value from partnerships with LG's manufacturing, display, chemical, and energy business units, with a strong focus on AI, biotech, cleantech, and advanced materials. Silicon Valley | $1M – $30M | 73 | Both | Active | ~2 mo | Open |
| 7 | ▶ Seventure Partners Seventure Partners identifies and backs innovative European companies in Life Sciences and Digital Technologies at all stages from seed to pre-IPO, serving as the lead investor and active board-level partner. The firm is a global pioneer in microbiome investing and has built a 25+ year track record of 150+ exits and 30 IPOs. Institutional backing from Natixis Investment Managers/Groupe BPCE provides unique co-investment and network access. Paris | $500K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 8 | ▶ Sands Capital Long-term, concentrated investment in high-quality innovative growth businesses across public equity, venture capital, and growth equity. Applies six investment criteria universally: sustainable above-average earnings growth, leadership in a promising business space, significant competitive advantages, clear mission, financial strength, and rational valuation. Integrates public and private market insights for superior sourcing and diligence. Arlington, VA | $10M – $150M | 40 | Leads | Active | ~2 mo | Req'd |
| 9 | ▶ Entrepreneur First It matters not only which companies get started, but who starts them. EF identifies exceptional individual talent before a company, co-founder, or idea exists, and builds the company from Day Zero through cohort-based co-founder matching, an equity-free grant phase, and up to $250K in formation capital (via SAFE) once a team passes its Investment Committee. London | $250K – $5M | 78 | Leads | Active | N/A | Open |
| 10 | ▶ Innovating Capital Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support. New York | $250K – $5M | 38 | Leads | Active | ~1 mo | Open |
| 11 | ▶ NATO Innovation Fund NIF invests in cutting-edge science and engineering startups that strengthen the defence, security, and resilience of NATO Allied nations. Backed by 24 sovereign governments, NIF provides deep tech founders with unprecedented access to government procurement markets across 24 countries, connectivity to ~90 NATO-affiliated test centres, and 6,000+ Allied scientists. NIF leads initial investments with up to €15M and maintains substantial follow-on reserves. Amsterdam | $1M – $16.5M | 26 | Leads | Active | 3+ mo | Open |
| 12 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 13 | ▶ GV (Google Ventures) GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI. San Francisco | $500K – $50M | 30 | Both | Active | ~1 mo | Open |
| 14 | ▶ Third Point Ventures Identifies technology transitions creating market opportunities, particularly AI/ML-powered automation transforming enterprise infrastructure. Current focus on AI security (Zenity, DataGrail, Grip Security), AI durability (Diagrid), and AI observability (Kentik) — the three pillars needed to bring AI from experimentation to production at scale. Menlo Park | $1M – $50M | 39 | Leads | Active | N/A | N/A |
| 15 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 16 | ▶ NVIDIA Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology. | $20M – $100000M | 37 | Both | Active | ~2 wks | Open |
| 17 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 18 | ▶ K5 Global K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships. Los Angeles | $1M – $3M | 34 | Leads | Active | ~1 mo | Open |
| 19 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 32 | Leads | Active | ~1 mo | Req'd |
| 20 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 21 | ▶ Human Capital Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise. San Francisco | $250K – $200M | 25 | Both | Active | ~1 wk | Open |
| 22 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 23 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 24 | ▶ Battery Ventures Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools. Boston | $1M – $500M | 23 | Both | Active | ~2 wks | Open |
| 25 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 26 | ▶ Greenoaks Greenoaks backs generation-defining technology companies with exceptional long-term growth potential. We make concentrated, large initial bets and maintain positions through multiple rounds and public markets, believing that exceptional founders and products deserve exceptional partnership. San Francisco | $25M – $75M | 20 | Both | Active | ~2 mo | Req'd |
| 27 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 28 | ▶ Sutter Hill Ventures Build or back enduring technology companies solving hard technical problems in massive markets. SHV's origination model has them serve as Founding CEO of incubated companies — recruiting experts, handling operations, and letting technical founders focus purely on building. Identify large macro tech shifts (cloud, AI infrastructure, power for AI), recruit domain experts, build small focused teams until product-market fit, then scale rapidly with the full support of SHV's centralized operations team. Palo Alto | $500K – $50M | 19 | Leads | Active | ~2 mo | Req'd |
| 29 | ▶ Main Sequence Main Sequence backs deep tech founders solving humanity-scale problems, especially companies connected to publicly funded research and spinouts that can turn breakthrough science into global businesses. Eveleigh, NSW, Australia | $250K – $500K | 14 | Leads | Active | ~1 mo | N/A |
| 30 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 31 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 31 VC firms that actively invest in security & cybersecurity + biotech & life sciences at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b security & cybersecurity + biotech & life sciences investors is $8M – $8M, with a full range from $100K – $100000M. The distribution breaks down as: 2 firms in the <$500K range, 1 firms in the $500K-$1M range, 1 firms in the $1M-$2M range, 6 firms in the $2M-$5M range, 8 firms in the $5M-$10M range, 13 firms in the $10M+ range.
Among the 31 firms tracked, 90% lead or co-lead rounds, and 10% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b security & cybersecurity + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 28% prefer warm introductions, and the average firm has 37 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.