11 VC firms investing in gaming and biotech & life sciences at the Series B stage.
F4 Fund tracks 11 VC firms that actively invest in gaming + biotech & life sciences at the Series B stage, with check sizes ranging from $200K – $200M (median: $7.8M – $7.8M). As of August 2026, and 91% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,581+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Balderton Capital Balderton Capital backs European-founded technology companies with visionary founders building transformative businesses. The firm combines patient capital, operational expertise, and founder support to enable European entrepreneurs to build world-class companies. | $500K – $15M | 200 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Atinum Investment Atinum Investment identifies and invests in companies solving fundamental problems through technology innovation and market disruption. The firm specializes in growth-stage startups and paradigm-shifting companies across diverse sectors. | $500K – $10M | 56 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Acequia Capital (AceCap) Acequia Capital partners with technical founders and product teams building the next wave of global businesses. They provide more than capital—experienced operators offer strategic guidance on product roadmap, technology strategy, business model, and GTM execution. The firm is a center of a global innovation ecosystem with unique capability to detect earliest signal in emerging technology trends. Seattle | $1M – $25M | 32 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Third Point Ventures Identifies technology transitions creating market opportunities, particularly AI/ML-powered automation transforming enterprise infrastructure. Current focus on AI security (Zenity, DataGrail, Grip Security), AI durability (Diagrid), and AI observability (Kentik) — the three pillars needed to bring AI from experimentation to production at scale. Menlo Park | $1M – $50M | 39 | Leads | Active | N/A | N/A |
| 5 | ▶ Anthem Venture Partners Identify exceptional founders and unique talent combinations building contrarian, under-the-radar technology solutions. Provide hands-on support, operational guidance, and board-level involvement to early-stage Series A and B companies, primarily in Southern California. We fight for our founders and expect all investments to succeed. Santa Monica | $1M – $5M | 12 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Korea Investment Management Co. Back the global winners of tomorrow through disciplined venture capital and growth equity investing. We are a trustworthy partner providing capital, operational expertise, and access to pan-Asian networks. Fund-oriented professional VC with fundamental philosophy of quality, responsibility, and stability. | $500K – $100M | 25 | Leads | Active | ~1 mo | Open |
| 7 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 53 | Both | Active | ~2 wks | Open |
| 8 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 9 | ▶ Argonautic Ventures AI is a milestone in data maturity progression, not a product category. Argonautic invests in founders building data-centric solutions across infrastructure (horizontal) and vertical markets. Multi-fund structure allows pre-seed to Series B deployment with unified thesis: recognizing verticals at different data adoption stages and deploying capital to those crossing inflection points into AI operationalization. | $250K – $1M | 12 | Both | Active | ~2 wks | Open |
| 10 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 11 | ▶ Atomico Founder-centric, largely sector-agnostic investing across Europe, backing technically strong founders building globally ambitious companies, including capital-intensive deep tech and moonshot bets alongside traditional software and consumer businesses. London | $5M – $50M | 13 | Leads | Active | N/A | Req'd |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 11 VC firms that actively invest in gaming + biotech & life sciences at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b gaming + biotech & life sciences investors is $7.8M – $7.8M, with a full range from $200K – $200M. The distribution breaks down as: 1 firms in the <$500K range, 1 firms in the $500K-$1M range, 1 firms in the $2M-$5M range, 3 firms in the $5M-$10M range, 5 firms in the $10M+ range.
Among the 11 firms tracked, 91% lead or co-lead rounds, and 9% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b gaming + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 20% prefer warm introductions, and the average firm has 45 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.