11 VC firms investing in healthcare & digital health and manufacturing & industrial at the Series B stage.
F4 Fund tracks 11 VC firms that actively invest in healthcare & digital health + manufacturing & industrial at the Series B stage, with check sizes ranging from $100K – $500M (median: $5.3M – $5.3M). As of June 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 2 | ▶ REMUS Capital Building, not betting, with rebels transforming massive traditional industries through applied AI. Hands-on operational partnership combining capital with customer acquisition, team building, and strategic guidance. Boston | $1M – $20M | 27 | Leads | Active | ~2 wks | Req'd |
| 3 | ▶ Impact America Fund Tech-enabled businesses built for and by people in marginalized communities create new frameworks of ownership and opportunity. Traditional VCs miss billion-dollar markets in overlooked communities. Oakland | $250K – $3M | 32 | Leads | Active | ~1 mo | Req'd |
| 4 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 5 | ▶ Foundry Group We invest in startups and venture funds, creating a symbiotic network that propels innovation. Our approach is characterized by long-term thinking and a 'give first' philosophy. Boulder, Colorado | $500K – $10M | 26 | Leads | Active | ~1 mo | Req'd |
| 6 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 7 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | — | — |
| 8 | ▶ Argonautic Ventures AI is a milestone in data maturity progression, not a product category. Argonautic invests in founders building data-centric solutions across infrastructure (horizontal) and vertical markets. Multi-fund structure allows pre-seed to Series B deployment with unified thesis: recognizing verticals at different data adoption stages and deploying capital to those crossing inflection points into AI operationalization. | $250K – $1M | 7 | Both | Active | ~2 wks | Open |
| 9 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 10 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 11 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
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Firms that frequently co-invest with investors on this page
F4 Fund tracks 11 VC firms that actively invest in healthcare & digital health + manufacturing & industrial at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b healthcare & digital health + manufacturing & industrial investors is $5.3M – $5.3M, with a full range from $100K – $500M. The distribution breaks down as: 1 firms in the $500K-$1M range, 2 firms in the $1M-$2M range, 1 firms in the $2M-$5M range, 2 firms in the $5M-$10M range, 5 firms in the $10M+ range.
Among the 11 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b healthcare & digital health + manufacturing & industrial investors combine domain expertise with an active portfolio in the space. Among these firms, 40% prefer warm introductions, and the average firm has 40 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.