18 VC firms investing in healthcare & digital health and real estate & proptech at the Series B stage.
F4 Fund tracks 18 VC firms that actively invest in healthcare & digital health + real estate & proptech at the Series B stage, with check sizes ranging from $50K – $5000M (median: $7.8M – $7.8M). As of June 2026, and 89% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 55 | Leads | Active | ~1 mo | Open |
| 2 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 3 | ▶ 9Yards Capital Back technical founders building critical infrastructure for foundational industries. Pair growth-stage capital with deep regulatory expertise and government/industry connectivity to create defensible advantages in overlooked, essential sectors. San Francisco | $3M – $10M | 34 | Both | Active | ~2 wks | Open |
| 4 | ▶ Riverpark Ventures Disruptive businesses that eliminate intermediaries and compress value chains. We invest in entrepreneurs backed by entrepreneurs who understand the unique challenges of building. We look for innovative thinkers with proven track records and tremendous dedication, in large markets addressing significant customer needs. New York | $500K – $25M | 23 | Leads | Active | ~2 wks | Req'd |
| 5 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 30 | Leads | Active | ~1 mo | Req'd |
| 6 | ▶ Resolute Ventures We back founders who combine emotional intelligence with business acumen and are on a mission to solve problems they deeply care about. We're often the first institutional check and provide mentorship, community, and long-term partnership support. San Francisco | $50K – $1.5M | 21 | Leads | Active | ~2 wks | Req'd |
| 7 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 41 | Both | Active | ~2 mo | Req'd |
| 8 | ▶ Foundry Group We invest in startups and venture funds, creating a symbiotic network that propels innovation. Our approach is characterized by long-term thinking and a 'give first' philosophy. Boulder, Colorado | $500K – $10M | 26 | Leads | Active | ~1 mo | Req'd |
| 9 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 10 | ▶ Zigg Capital Real estate has been stagnant for 50 years despite massive innovation in other industries. Shifting demographics, transportation changes, and evolving preferences are forcing modernization. We back visionary entrepreneurs building solutions across construction, property management, residential finance, and retail that will improve quality of life, work, and community. New York | $500K – $10M | 26 | Both | Active | ~2 wks | Open |
| 11 | ▶ White Star Capital Technology companies are becoming intertwined with the global economy more so than ever before. The most compelling founders build businesses through a broader world view. White Star Capital backs globally ambitious entrepreneurs at Series A, B, and Seed stages across North America, Europe, and Asia, helping them scale internationally through deep local presence on three continents. London | $1M – $25M | 41 | Leads | Active | ~1 mo | Open |
| 12 | ▶ Goodwater Capital Consumer technology has the power to measurably improve billions of lives across the globe. We invest in exceptional entrepreneurs building digital utilities that provide better access to housing, healthcare, food, financial services, transportation, education, and entertainment globally. Burlingame, California | $5M – $50M | 29 | Leads | Active | ~1 mo | Req'd |
| 13 | ▶ Tribeca Venture Partners We partner with gritty and determined entrepreneurs leveraging emerging technologies to create or disrupt huge markets. We invest in people first, second, and third—founders with passion, obsession, and vision. Only partners with founders when we believe their company alone can return our entire fund or more. New York | $1M – $10M | 16 | Leads | Active | ~2 mo | Req'd |
| 14 | ▶ Insight Partners Software founders need more than capital to scale successfully. Insight Partners combines investment capital with hands-on operational expertise, embedded teams, and network access to accelerate company growth across all stages. New York | $10M – $350M | 28 | Leads | Active | ~1 mo | Open |
| 15 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 16 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 17 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 18 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 18 VC firms that actively invest in healthcare & digital health + real estate & proptech at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b healthcare & digital health + real estate & proptech investors is $7.8M – $7.8M, with a full range from $50K – $5000M. The distribution breaks down as: 1 firms in the <$500K range, 3 firms in the $500K-$1M range, 1 firms in the $2M-$5M range, 5 firms in the $5M-$10M range, 8 firms in the $10M+ range.
Among the 18 firms tracked, 89% lead or co-lead rounds, and 11% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b healthcare & digital health + real estate & proptech investors combine domain expertise with an active portfolio in the space. Among these firms, 44% prefer warm introductions, and the average firm has 31 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.