F4 Champions · Season 1
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F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
12 VC firms investing in insurance and biotech & life sciences at the Pre-Seed stage.
F4 Fund tracks 12 VC firms that actively invest in insurance + biotech & life sciences at the Pre-Seed stage, with check sizes ranging from $25K – $500M (median: $2.8M – $2.8M). As of July 2026, and 92% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,539+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Oak HC/FT Oak HC/FT partners with founders driving structural change in healthcare and financial services. They believe the most durable companies in the AI era will combine AI velocity with genuine understanding of how these industries work — including their regulatory, distribution, and trust dynamics. Interested in horizontal platforms that can penetrate and win in these complex, regulated sectors. Stamford | $1M – $100M | 34 | Leads | Active | ~1 mo | Open |
| 2 | ▶ Abstract Ventures Backing transformative founders building exceptional companies across all sectors San Francisco | $100K – $1M | 275 | Both | Active | N/A | N/A |
| 3 | ▶ Spark Capital Spark Capital backs transformative products built by creators with genuine vision and technical depth. We believe that the best way to evaluate a founding team is not through credentials or market analysis, but by experiencing their product firsthand. Product comes first, and everything else follows. | $500K – $60M | 65 | Both | Active | ~2 wks | Open |
| 4 | ▶ AV8 Ventures Partner with visionary founders to build category-defining companies in healthcare, enterprise software, fintech/insurtech, and deep technology. Provide deep operational support, board participation, and access to domain expert network. Focus on companies solving problems in regulated or data-rich industries. Leverage Allianz's unique vantage point on risk, data, and regulation to identify opportunities at intersection of innovation and regulatory necessity. Palo Alto | $500K – $10M | 22 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Plug N Play Ventures Connect innovative startups to 550+ corporate partners who have real business problems to solve. Our platform creates a flywheel of pilots, enterprise customers, and follow-on capital for founders who value long-term partnership and have credible paths to $100M+ ARR. Sunnyvale | $25K – $3M | 51 | Both | Active | ~1 wk | Open |
| 6 | ▶ Montage Ventures Montage Ventures aims to support radical thinkers who are bringing new ideas and platforms to foster change within the financial services, commerce and health sectors, leveraging AI as a key transformative agent. | $250K – $1M | 51 | N/A | 1mo | N/A | N/A |
| 7 | ▶ AIX Ventures AI-native companies where artificial intelligence is the core product and competitive moat, not just a feature. Three investment baskets: (1) AI infrastructure (vector databases, model serving, optimization), (2) vertical applications with 20%+ performance advantages, and (3) frontier research with clear commercialization paths. Palo Alto | $750K – $3M | 25 | Leads | Active | ~1 wk | Open |
| 8 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 9 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 10 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 11 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 12 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 12 VC firms that actively invest in insurance + biotech & life sciences at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed insurance + biotech & life sciences investors is $2.8M – $2.8M, with a full range from $25K – $500M. The distribution breaks down as: 1 firms in the <$500K range, 2 firms in the $500K-$1M range, 2 firms in the $1M-$2M range, 2 firms in the $2M-$5M range, 1 firms in the $5M-$10M range, 4 firms in the $10M+ range.
Among the 12 firms tracked, 92% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed insurance + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 30% prefer warm introductions, and the average firm has 59 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.