F4 Champions · Season 1
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F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
35 VC firms investing in marketing & adtech and healthcare & digital health at the Series A stage.
F4 Fund tracks 35 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Series A stage, with check sizes ranging from $50K – $100M (median: $2.8M – $2.8M). As of July 2026, and 94% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,544+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Flagship Pioneering Create first-in-category bioplatform companies through scientific innovation and systematic entrepreneurship. Combine institutional scale with pioneer creativity to build breakthrough life sciences companies. Cambridge | $500K – $15M | 22 | Leads | Active | ~1 mo | Req'd |
| 2 | ▶ Square Peg Founders from Australia/NZ, Israel, and Southeast Asia will shape the future of global technology. We prioritize people above all else, backing entrepreneurs with compelling visions who assemble talented, mission-driven teams to tackle large, important problems, and back them repeatedly over time. Sydney | $250K – $30M | 81 | Leads | Active | 3+ mo | Open |
| 3 | ▶ Moneta Ventures Software++ — mission-critical enterprise technology companies with differentiated tech and multi-layered monetization strategies beyond standard SaaS licensing. Seeks proprietary data, network effects, and workflow lock-in. Sacramento | $1M – $5M | 42 | Leads | Active | ~1 mo | Req'd |
| 4 | ▶ Mischief Diverse industry experience enables superior pattern recognition about which founders can succeed. Operational support from founders-turned-investors is more valuable than just capital. Markets have seasons - breakthrough companies can emerge from unexpected places. San Francisco | $500K – $5M | 25 | Leads | Active | ~2 wks | Open |
| 5 | ▶ AltaIR Capital Back focused founders solving real problems in markets they understand deeply, with clarity, discipline, and drive. Seek companies with motivated teams, strong product vision, scalable business models, and large addressable markets. San Francisco | $1M – $25M | 40 | Leads | Active | ~1 mo | Open |
| 6 | ▶ Mosaic General Partnership Partners with exceptional founders building game-changing companies at the intersection of technology, industry, and culture. Focus on sectors where deep network and experience can bend the risk curve. San Francisco | $3M – $6M | 18 | Leads | Active | ~2 wks | Req'd |
| 7 | ▶ Acurio Ventures Partner with visionary European founders at seed and Series A, leveraging the team's own operator experience and a network of 150+ international co-investors. Sector agnostic (excluding life sciences and crypto) with ~50 companies per fund. Strong focus on capital efficiency, unit economics, and realistic paths to profitability. Co-investor by default; will lead when it adds value. Bilbao, Spain | $100K – $3M | 95 | Both | Active | N/A | Open |
| 8 | ▶ f7 Ventures We identify exceptional operators with proven track records at scale (ex-Facebook, Google, Stripe) and catalyze their transition into founders. Periods of rapid societal behavior change spur dramatic innovation. We invest in the future of work and consumer utility, providing not just capital but operational expertise, network access, and proven playbooks from building at Facebook/Meta scale. San Francisco | $500K – $5M | 46 | Leads | Active | ~1 wk | Open |
| 9 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 10 | ▶ Pathlight Ventures Low volume, high conviction early-stage investing in 10 thematic areas where vertical AI is reshaping regulated, complex industries: healthcare, fintech, capital markets, industrial operations, security, and government. Back strongly opinionated founders building category-defining companies with direct operator support from a team with deep fintech and growth scaling experience. New York City | $250K – $3M | 39 | Leads | Active | ~1 mo | Open |
| 11 | ▶ Fuel Ventures Backs ambitious tech founders from pre-seed to Series A through EIS/SEIS tax-efficient fund structures in the UK. Focus on Vertical AI, AI-enabled software, and FinTech 2.0. Founded by serial entrepreneur Mark Pearson, the firm brings operational expertise as entrepreneurs who have built and exited companies. London | $150K – $3M | 48 | Both | Active | N/A | Open |
| 12 | ▶ Eudemian Ventures Make human and technological potential actual. Eudemian invests in early-stage US software startups with demonstrated product-market fit and breakout traction, backed by mission-driven founders who tackle large markets solving vexing pain points. Rooted in the Greek philosophy of Eudaimonia, the firm believes in actualizing potential through long-term founder partnerships. San Francisco | $100K – $1.5M | 21 | Follows | Active | N/A | Open |
| 13 | ▶ PeakSpan Capital PeakSpan invests exclusively in Applied AI B2B software scale-ups at $3M–$50M+ ARR, providing growth equity combined with hands-on operational platform support (500+ expert community, proprietary technology tools, proven playbooks) to help founders scale with discipline and achieve optimal risk-adjusted exits. New York | $10M – $50M | 57 | Leads | Active | ~1 mo | N/A |
| 14 | ▶ Point Nine Invest in the future of software built on AI. We partner with technical founders to provide capital, unfair shortcuts, and operational support to accelerate their learning and help them reach their potential. We position ourselves as the first institutional investor for v0.9 stage founders. Berlin | $1M – $10M | 37 | Leads | Active | ~1 wk | Req'd |
| 15 | ▶ Story Ventures Story invests in the building blocks of automated systems across three interconnected layers: sensory systems (data capture), data processing (organization and structure), and machine intelligence (applications and decision-making). We believe the most impactful problems require the most innovative solutions, and we partner with founders pursuing audacious, challenging businesses because that's what it takes to create lasting impact. New York | $500K – $5M | 44 | Both | Active | ~1 mo | Req'd |
| 16 | ▶ First Round Capital Beginnings matter. We work with founders exclusively at the earliest stages of company building, often when all they have is an 'imagine if.' We look for compelling and contrarian insights into how the world works—what do you understand about a market that others miss? Our role is to accelerate the path from idea to product-market fit through embedded partnership. San Francisco | $750K – $4M | 28 | Leads | Active | ~2 wks | Req'd |
| 17 | ▶ Bling Capital The hardest thing in seed is finding product-market fit. We help you find it. If you already have product-market fit, we will help you scale. We partner with exceptionally ambitious founders for the long run and provide capital combined with operational expertise through our 100+ member Product Council. San Francisco | $500K – $3M | 33 | Leads | Active | ~2 mo | Open |
| 18 | ▶ Freesearch Ventures Back experienced IT and Fintech founders with early PMF signals and global ambition targeting TAMs >$1B. Emphasize cross-border scalability across EU, US, MENA, and Southeast Asia. Singapore | $300K – $1.5M | 14 | Both | Active | ~1 mo | Open |
| 19 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 20 | ▶ Sierra Ventures Sierra believes enterprise software is being fundamentally transformed by cloud computing and AI. They invest in technical founders building the next generation of enterprise solutions that deliver superior ROI through better efficiency, automation, and capability. The firm particularly focuses on infrastructure, security, healthcare innovation, and emerging deep tech. San Mateo, California | $500K – $15M | 28 | Both | Active | ~2 wks | Req'd |
| 21 | ▶ Entrepreneurs Roundtable Accelerator (ERA) NYC has tremendous entrepreneurial talent but lacked a structured environment for early-stage founders. ERA provides capital, intense mentorship, and network access to help founders build market-leading companies. Every sector deserves innovation. New York | $150K – $150K | 39 | Leads | Active | ~2 mo | Open |
| 22 | ▶ FirstMark We back disruptive founders building category-defining companies. Our approach is founder-first, long-term, and deeply operational. We take the longest view in the room, operate with excellence and integrity, stay curious at the bleeding edge, and invest heavily in building community. New York | $250K – $10M | 32 | Leads | Active | ~2 wks | Req'd |
| 23 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 24 | ▶ Plymouth Growth Exceptional founder-led B2B technology businesses exist outside traditional coastal venture and PE systems. We back gritty founders who think differently and approach sustainable, balanced growth without venture-style moonshot pressure or traditional PE playbooks. Detroit | $5M – $25M | 19 | Leads | Active | ~1 mo | Open |
| 25 | ▶ Sigma Prime Ventures Early-stage technology companies solving hard business problems with SaaS, cloud, mobile, and disruptive technologies. We back technical founders with domain expertise and market understanding across diverse sectors. Boston | $500K – $10M | 10 | Both | Active | ~2 wks | Req'd |
| 26 | ▶ ZhenFund Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support. Beijing | $250K – $3M | 27 | Leads | Active | ~2 wks | Open |
| 27 | ▶ SignalFire Data and technology combined with sector expertise and operational support unlock unfair advantages for early-stage startups. We build venture capital like a tech company. San Francisco | $250K – $100M | 17 | Leads | Active | ~2 wks | Open |
| 28 | ▶ Tribeca Venture Partners We partner with gritty and determined entrepreneurs leveraging emerging technologies to create or disrupt huge markets. We invest in people first, second, and third—founders with passion, obsession, and vision. Only partners with founders when we believe their company alone can return our entire fund or more. New York | $1M – $10M | 17 | Leads | Active | ~2 mo | Req'd |
| 29 | ▶ Tonic Fund Member-driven regional angel investment fund focused on building the Northwest Arkansas entrepreneurial ecosystem. Tonic provides democratized access to early-stage deals for its members while co-investing with established VCs to support the most promising Arkansas-based startups. Fayetteville, AR | $50K – $500K | 9 | Follows | Between | ~1 mo | Open |
| 30 | ▶ Kima Ventures Back ambitious teams with strong learning and execution capacities across all sectors, stages, and geographies. Technology-enabled businesses preferred. Volume-based, founder-centric investment philosophy. Paris | $100K – $200K | 25 | Leads | Active | ~2 wks | Open |
| 31 | ▶ Rainfall Ventures We invest in world-class founders solving significant problems. We prioritize founder quality, founder-problem fit, and values-aligned partnerships. We help exceptional founders become category leaders early, before they become obvious trends. Los Angeles | $500K – $5M | 41 | Leads | Active | ~2 wks | Req'd |
| 32 | ▶ Streamlined Ventures Visionary founders are the true catalysts of transformation and progress. We partner with exceptional founders at the seed stage to help them build extraordinary companies through intensive operational support, structured tools, and candid guidance. Palo Alto | $250K – $10M | 26 | Leads | Active | ~2 wks | Open |
| 33 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 34 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 35 | ▶ Praetura Ventures Praetura backs ambitious northern founders building software, health, life sciences, fintech, cybersecurity, robotics, and other high-growth businesses where operator support and regional conviction matter. The firm positions itself as a more-than-money investor and emphasizes practical support from experienced operators, not just capital. Manchester, United Kingdom | $200K – $8M | 16 | Both | Active | N/A | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 35 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a marketing & adtech + healthcare & digital health investors is $2.8M – $2.8M, with a full range from $50K – $100M. The distribution breaks down as: 4 firms in the <$500K range, 3 firms in the $500K-$1M range, 5 firms in the $1M-$2M range, 10 firms in the $2M-$5M range, 8 firms in the $5M-$10M range, 5 firms in the $10M+ range.
Among the 35 firms tracked, 94% lead or co-lead rounds, and 6% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a marketing & adtech + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 35% prefer warm introductions, and the average firm has 33 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.