44 VC firms investing in marketing & adtech and healthcare & digital health at the Series A stage.
F4 Fund tracks 44 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Series A stage, with check sizes ranging from $6K – $100M (median: $3.1M – $3.1M). As of August 2026, and 95% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,644+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Flagship Pioneering Create first-in-category bioplatform companies through scientific innovation and systematic entrepreneurship. Combine institutional scale with pioneer creativity to build breakthrough life sciences companies. Cambridge | $500K – $15M | 22 | Leads | Active | ~1 mo | Req'd |
| 2 | ▶ Square Peg Founders from Australia/NZ, Israel, and Southeast Asia will shape the future of global technology. We prioritize people above all else, backing entrepreneurs with compelling visions who assemble talented, mission-driven teams to tackle large, important problems, and back them repeatedly over time. Sydney | $250K – $30M | 81 | Leads | Active | 3+ mo | Open |
| 3 | ▶ The General Partnership TheGP deploys experienced builders alongside capital to help founders achieve product-market fit faster. The firm's 25+ full-time builders—engineers, recruiters, designers, sales leaders—embed in portfolio companies for an average of nine months, earning equity grants tied to milestone delivery. This 'sweat equity' model creates deeper alignment than capital-only VC and is applied across Formation ($1-5M) and Breakout ($5-15M+) stages. San Francisco | $1M – $15M | 72 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Moneta Ventures Software++ — mission-critical enterprise technology companies with differentiated tech and multi-layered monetization strategies beyond standard SaaS licensing. Seeks proprietary data, network effects, and workflow lock-in. Sacramento | $1M – $5M | 44 | Leads | Active | ~1 mo | Req'd |
| 5 | ▶ Mischief Diverse industry experience enables superior pattern recognition about which founders can succeed. Operational support from founders-turned-investors is more valuable than just capital. Markets have seasons - breakthrough companies can emerge from unexpected places. San Francisco | $500K – $5M | 25 | Leads | Active | ~2 wks | Open |
| 6 | ▶ BASS Ventures Back 'crazy dreamers' — founders with exceptional tenacity, ambition, and vision who are building transformative companies. BASS serves as the 'bassist' providing foundational support: capital, operational resources, global cloud credits, and talent. Focus on AI software, physical AI, and fashion & beauty in 2025. Seoul | $250K – $6M | 48 | Leads | Active | N/A | N/A |
| 7 | ▶ Mosaic General Partnership Partners with exceptional founders building game-changing companies at the intersection of technology, industry, and culture. Focus on sectors where deep network and experience can bend the risk curve. San Francisco | $3M – $6M | 18 | Leads | Active | ~2 wks | Req'd |
| 8 | ▶ Acurio Ventures Partner with visionary European founders at seed and Series A, leveraging the team's own operator experience and a network of 150+ international co-investors. Sector agnostic (excluding life sciences and crypto) with ~50 companies per fund. Strong focus on capital efficiency, unit economics, and realistic paths to profitability. Co-investor by default; will lead when it adds value. Bilbao, Spain | $100K – $3M | 95 | Both | Active | N/A | Open |
| 9 | ▶ f7 Ventures We identify exceptional operators with proven track records at scale (ex-Facebook, Google, Stripe) and catalyze their transition into founders. Periods of rapid societal behavior change spur dramatic innovation. We invest in the future of work and consumer utility, providing not just capital but operational expertise, network access, and proven playbooks from building at Facebook/Meta scale. San Francisco | $500K – $5M | 46 | Leads | Active | ~1 wk | Open |
| 10 | ▶ ACME Capital Backs deep-tech founders who pair technical ambition with decisive execution. Invests in frontier technologies before they become mainstream across aerospace/defense, healthcare, biotech, enterprise AI, and deep hardware. Active partner model — regulatory introductions, customer connections, and strategic guidance through all company phases. San Francisco | $500K – $15M | 33 | Leads | Active | ~1 mo | Req'd |
| 11 | ▶ AltaIR Capital Back focused founders solving real problems in markets they understand deeply, with clarity, discipline, and drive. Seek companies with motivated teams, strong product vision, scalable business models, and large addressable markets. San Francisco | $1M – $25M | 43 | Leads | Active | ~1 mo | Open |
| 12 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 13 | ▶ Fuel Ventures Backs ambitious tech founders from pre-seed to Series A through EIS/SEIS tax-efficient fund structures in the UK. Focus on Vertical AI, AI-enabled software, and FinTech 2.0. Founded by serial entrepreneur Mark Pearson, the firm brings operational expertise as entrepreneurs who have built and exited companies. London | $150K – $3M | 48 | Both | Active | N/A | Open |
| 14 | ▶ Pathlight Ventures Low volume, high conviction early-stage investing in 10 thematic areas where vertical AI is reshaping regulated, complex industries: healthcare, fintech, capital markets, industrial operations, security, and government. Back strongly opinionated founders building category-defining companies with direct operator support from a team with deep fintech and growth scaling experience. New York City | $250K – $3M | 41 | Leads | Active | ~1 mo | Open |
| 15 | ▶ PeakSpan Capital PeakSpan invests exclusively in Applied AI B2B software scale-ups at $3M–$50M+ ARR, providing growth equity combined with hands-on operational platform support (500+ expert community, proprietary technology tools, proven playbooks) to help founders scale with discipline and achieve optimal risk-adjusted exits. New York | $10M – $50M | 57 | Leads | Active | ~1 mo | N/A |
| 16 | ▶ Mercury Fund Mercury backs disruptive AI and Blockchain-enabled startups outside Silicon Valley, with a focus on capital-efficient founders in the Central US reimagining core industries including fintech, enterprise software, healthcare, energy, manufacturing, and logistics through their five investment themes: Work, Build, Journeys, Data, and Power. Houston | $100K – $5M | 53 | Leads | Active | ~2 mo | Open |
| 17 | ▶ Point Nine Invest in the future of software built on AI. We partner with technical founders to provide capital, unfair shortcuts, and operational support to accelerate their learning and help them reach their potential. We position ourselves as the first institutional investor for v0.9 stage founders. Berlin | $1M – $10M | 37 | Leads | Active | ~1 wk | Req'd |
| 18 | ▶ Story Ventures Story invests in the building blocks of automated systems across three interconnected layers: sensory systems (data capture), data processing (organization and structure), and machine intelligence (applications and decision-making). We believe the most impactful problems require the most innovative solutions, and we partner with founders pursuing audacious, challenging businesses because that's what it takes to create lasting impact. New York | $500K – $5M | 44 | Both | Active | ~1 mo | Req'd |
| 19 | ▶ First Round Capital Beginnings matter. We work with founders exclusively at the earliest stages of company building, often when all they have is an 'imagine if.' We look for compelling and contrarian insights into how the world works—what do you understand about a market that others miss? Our role is to accelerate the path from idea to product-market fit through embedded partnership. San Francisco | $750K – $4M | 28 | Leads | Active | ~2 wks | Req'd |
| 20 | ▶ Eudemian Ventures Make human and technological potential actual. Eudemian invests in early-stage US software startups with demonstrated product-market fit and breakout traction, backed by mission-driven founders who tackle large markets solving vexing pain points. Rooted in the Greek philosophy of Eudaimonia, the firm believes in actualizing potential through long-term founder partnerships. San Francisco | $100K – $1.5M | 25 | Follows | Active | N/A | Open |
| 21 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 22 | ▶ Sierra Ventures Sierra believes enterprise software is being fundamentally transformed by cloud computing and AI. They invest in technical founders building the next generation of enterprise solutions that deliver superior ROI through better efficiency, automation, and capability. The firm particularly focuses on infrastructure, security, healthcare innovation, and emerging deep tech. San Mateo, California | $500K – $15M | 28 | Both | Active | ~2 wks | Req'd |
| 23 | ▶ Entrepreneurs Roundtable Accelerator (ERA) NYC has tremendous entrepreneurial talent but lacked a structured environment for early-stage founders. ERA provides capital, intense mentorship, and network access to help founders build market-leading companies. Every sector deserves innovation. New York | $150K – $150K | 39 | Leads | Active | ~2 mo | Open |
| 24 | ▶ FirstMark We back disruptive founders building category-defining companies. Our approach is founder-first, long-term, and deeply operational. We take the longest view in the room, operate with excellence and integrity, stay curious at the bleeding edge, and invest heavily in building community. New York | $250K – $10M | 32 | Leads | Active | ~2 wks | Req'd |
| 25 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 26 | ▶ Bling Capital The hardest thing in seed is finding product-market fit. We help you find it. If you already have product-market fit, we will help you scale. We partner with exceptionally ambitious founders for the long run and provide capital combined with operational expertise through our 100+ member Product Council. San Francisco | $500K – $3M | 36 | Leads | Active | ~2 mo | Open |
| 27 | ▶ Plymouth Growth Exceptional founder-led B2B technology businesses exist outside traditional coastal venture and PE systems. We back gritty founders who think differently and approach sustainable, balanced growth without venture-style moonshot pressure or traditional PE playbooks. Detroit | $5M – $25M | 19 | Leads | Active | ~1 mo | Open |
| 28 | ▶ Sigma Prime Ventures Early-stage technology companies solving hard business problems with SaaS, cloud, mobile, and disruptive technologies. We back technical founders with domain expertise and market understanding across diverse sectors. Boston | $500K – $10M | 10 | Both | Active | ~2 wks | Req'd |
| 29 | ▶ ZhenFund Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support. Beijing | $250K – $3M | 27 | Leads | Active | ~2 wks | Open |
| 30 | ▶ SignalFire Data and technology combined with sector expertise and operational support unlock unfair advantages for early-stage startups. We build venture capital like a tech company. San Francisco | $250K – $100M | 17 | Leads | Active | ~2 wks | Open |
| 31 | ▶ Tribeca Venture Partners We partner with gritty and determined entrepreneurs leveraging emerging technologies to create or disrupt huge markets. We invest in people first, second, and third—founders with passion, obsession, and vision. Only partners with founders when we believe their company alone can return our entire fund or more. New York | $1M – $10M | 17 | Leads | Active | ~2 mo | Req'd |
| 32 | ▶ Tonic Fund Member-driven regional angel investment fund focused on building the Northwest Arkansas entrepreneurial ecosystem. Tonic provides democratized access to early-stage deals for its members while co-investing with established VCs to support the most promising Arkansas-based startups. Fayetteville, AR | $50K – $500K | 9 | Follows | Between | ~1 mo | Open |
| 33 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 61 | Leads | Active | ~1 mo | Open |
| 34 | ▶ Kima Ventures Back ambitious teams with strong learning and execution capacities across all sectors, stages, and geographies. Technology-enabled businesses preferred. Volume-based, founder-centric investment philosophy. Paris | $100K – $200K | 25 | Leads | Active | ~2 wks | Open |
| 35 | ▶ Rainfall Ventures We invest in world-class founders solving significant problems. We prioritize founder quality, founder-problem fit, and values-aligned partnerships. We help exceptional founders become category leaders early, before they become obvious trends. Los Angeles | $500K – $5M | 41 | Leads | Active | ~2 wks | Req'd |
| 36 | ▶ Array Ventures Array Ventures leads $250K-$2.5M first institutional checks for technical founders building enterprise data, AI infrastructure, security, and developer tools, partnering from Day 0 (concept) through Series A. Solo GP Shruti Gandhi, an AI engineer and Columbia University CS professor, has been the first investor in 100+ companies with 15 realized exits. Kolkata | $6K – $60K | 19 | Both | Active | ~2 mo | Open |
| 37 | ▶ Freesearch Ventures Back experienced IT and Fintech founders with early PMF signals and global ambition targeting TAMs >$1B. Emphasize cross-border scalability across EU, US, MENA, and Southeast Asia. Singapore | $300K – $1.5M | 14 | Both | Active | ~1 mo | Open |
| 38 | ▶ 3VC Entrepreneurs by heart, investors by choice: 3VC partners with regional talent across DACH, CEE, the Baltics, and Southern Europe showing early signs of product-market fit and customer love, and helps them become global category leaders. Vienna | $2M – $10M | 24 | Both | Active | N/A | Open |
| 39 | ▶ Purpose Ventures Backs founders who are chasing after their life cause and building companies with global ambition, screening on Character, Competency, and Chemistry rather than a fixed sector thesis. Commits at least 70% of the fund to WA-founded or WA-operated companies. Perth | $250K – $3M | 13 | Both | Active | ~2 mo | Open |
| 40 | ▶ SEEDRA Ventures SEEDRA backs bold, technology-driven founders redefining traditional industries across Saudi Arabia and MENA, providing hands-on operational support alongside capital, in alignment with Saudi Vision 2030. Riyadh | $250K – $15M | 13 | Both | Active | N/A | Req'd |
| 41 | ▶ Streamlined Ventures Visionary founders are the true catalysts of transformation and progress. We partner with exceptional founders at the seed stage to help them build extraordinary companies through intensive operational support, structured tools, and candid guidance. Palo Alto | $250K – $10M | 26 | Leads | Active | ~2 wks | Open |
| 42 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 43 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 44 | ▶ Praetura Ventures Praetura backs ambitious northern founders building software, health, life sciences, fintech, cybersecurity, robotics, and other high-growth businesses where operator support and regional conviction matter. The firm positions itself as a more-than-money investor and emphasizes practical support from experienced operators, not just capital. Manchester, United Kingdom | $200K – $8M | 16 | Both | Active | N/A | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 44 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a marketing & adtech + healthcare & digital health investors is $3.1M – $3.1M, with a full range from $6K – $100M. The distribution breaks down as: 5 firms in the <$500K range, 3 firms in the $500K-$1M range, 6 firms in the $1M-$2M range, 12 firms in the $2M-$5M range, 12 firms in the $5M-$10M range, 6 firms in the $10M+ range.
Among the 44 firms tracked, 95% lead or co-lead rounds, and 5% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a marketing & adtech + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 33% prefer warm introductions, and the average firm has 34 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.