11 VC firms investing in travel & hospitality and healthcare & digital health at the Pre-Seed stage.
F4 Fund tracks 11 VC firms that actively invest in travel & hospitality + healthcare & digital health at the Pre-Seed stage, with check sizes ranging from $25K – $50M (median: $2.8M – $2.8M). As of June 2026, and 82% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ JAM Fund Back underestimated founders with something to prove who are disrupting large markets. Emphasizes geographic arbitrage in emerging markets (Africa, LATAM, Asia) where founder quality is exceptional but capital access is limited. Los Angeles | $500K – $20M | 58 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Unpopular Ventures Invest in the smartest people, regardless of what they're building, especially if the idea sounds bad in the beginning. Focus on exceptional founders in overlooked markets and non-consensus businesses. Optimize for founder quality over sector fit. San Francisco | $25K – $1M | 41 | Leads | Active | ~1 wk | Open |
| 3 | ▶ New Enterprise Associates (NEA) NEA partners with ambitious founders at every stage of company building, from pre-seed through IPO. They invest at the intersection of technology and healthcare, believing the most transformational innovation occurs where deep domain expertise meets world-class technical founders. NEA serves as both capital provider and active operator. Menlo Park | $1M – $50M | 21 | Both | Active | ~2 mo | Open |
| 4 | ▶ Antler Backing exceptional people at the very start of their journey. We support founders from inception to scale through our global residency programs, providing capital, mentorship, and access to a network of 1,500+ companies across six continents. | $125K – $500K | 28 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Eniac Ventures Partner with exceptional founders building from 0 to 1, with focus on AI applications, developer tools, SaaS, and healthcare. Believe in founders who have succeeded once or have deep domain expertise. | $500K – $5M | 26 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Backstage Capital Underestimated founders are systematically mispriced assets that create alpha rather than requiring concessionary returns. We invest in the very best founders who identify as women, people of color, or LGBTQ, treating capital allocation as activism. Los Angeles | $50K – $500K | 30 | Follows | Active | ~2 wks | Open |
| 7 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 8 | ▶ Goodwater Capital Consumer technology has the power to measurably improve billions of lives across the globe. We invest in exceptional entrepreneurs building digital utilities that provide better access to housing, healthcare, food, financial services, transportation, education, and entertainment globally. Burlingame, California | $5M – $50M | 29 | Leads | Active | ~1 mo | Req'd |
| 9 | ▶ Fireroad Ventures Back founders solving existential problems for small and medium-sized businesses in contracting, healthcare, hospitality, and other local industries. Focus on applied AI for service sectors and SMBs, backing founders with deep operational knowledge of the markets they serve. Cincinnati | $25K – $250K | 11 | Follows | Active | — | — |
| 10 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 11 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
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F4 Fund tracks 11 VC firms that actively invest in travel & hospitality + healthcare & digital health at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed travel & hospitality + healthcare & digital health investors is $2.8M – $2.8M, with a full range from $25K – $50M. The distribution breaks down as: 4 firms in the <$500K range, 1 firms in the $500K-$1M range, 3 firms in the $2M-$5M range, 3 firms in the $10M+ range.
Among the 11 firms tracked, 82% lead or co-lead rounds, and 18% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed travel & hospitality + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 20% prefer warm introductions, and the average firm has 34 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.