10 VC firms investing in agetech & longevity at the Seed stage.
F4 Fund tracks 10 VC firms that actively invest in agetech & longevity at the Seed stage, with check sizes ranging from $100K – $50M (median: $1.6M – $1.6M). As of April 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,092+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Primetime Partners The longevity economy is a massive addressable market. Companies transforming quality of life for aging adults will be highly profitable and impactful. Experienced founders over 50 solve aging problems better because they understand them firsthand. New York | $250K – $1M | 12 | Leads | Active | ~1 mo | Open |
| 2 | ▶ The Longevity Fund Longevity is a completely new industry within biotech requiring founders who can think differently. Mission-oriented, founder-led companies with unconventional backgrounds will prove most effective at bringing the first longevity drugs to market and extending human healthy lifespan. The field is at a critical inflection point where we will either breakthrough to mainstream or get silo'd in a funding winter. San Francisco | $250K – $3M | 21 | Leads | Active | ~2 wks | Open |
| 3 | ▶ AGE1 Funding the next generation of contrarian founders building breakthrough longevity biotech companies. We invest in the transition from sickcare to healthcare by extending healthy lifespan and preventing age-related disease. | $500K – $4M | 19 | Leads | Active | — | — |
| 4 | ▶ Hiro Capital Europe can lead the next phase of human evolution enabled by technology. We invest in AI, Spatial Computing, Autonomy, Robotics, Longevity, Games, and Space/Defence. We are founders backing founder leaders with hands-on engagement. | $5M – $50M | 40 | Leads | Active | — | Req'd |
| 5 | ▶ Selva Ventures Health and wellness is one of the most important pillars of the global economy. The $61 trillion global consumer economy is undergoing a seismic shift toward trusted, high-quality products with proven efficacy. We partner with entrepreneurs to advance healthier living through capital, strategic resources, and enduring support grounded in continuous learning in nutrition, biology, and psychology. San Francisco | $100K – $5M | 16 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Third Sphere We fundamentally reshape broken global systems by supporting founders who turn theory into action to build better world. Hardware-enabled solutions (80% portfolio) with software components solve transformative climate challenges in energy, infrastructure, transportation, water, and adaptation. We run toward hardware because less competition and less noise. Climate is about more than carbon—it's adaptation, resilience, and systems change. San Francisco | $250K – $3M | 22 | Leads | Active | ~2 mo | Open |
| 7 | ▶ AENU Rewriting the VC rulebook to deliver high returns with high impact. We invest in founders building climate and social impact technologies with intentional, measurable, net-positive outcomes at meaningful scale. | $1M – $4M | 12 | Leads | Active | — | — |
| 8 | ▶ Cake Ventures We invest in founders with global ambitions creating products that meet tomorrow's internet users' needs through demographic change. Focus on aging & longevity, spending power of women, and the new majority (majority-minority shift). San Francisco | $200K – $750K | 18 | Both | Active | ~2 wks | Open |
| 9 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 24 | Leads | Active | — | — |
| 10 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 32 | Both | Active | ~2 wks | Req'd |
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F4 Fund tracks 10 VC firms that actively invest in agetech & longevity at the Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for seed agetech & longevity investors is $1.6M – $1.6M, with a full range from $100K – $50M. The distribution breaks down as: 2 firms in the <$500K range, 2 firms in the $500K-$1M range, 2 firms in the $1M-$2M range, 3 firms in the $2M-$5M range, 1 firms in the $10M+ range.
Among the 10 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best seed agetech & longevity investors combine domain expertise with an active portfolio in the space. Among these firms, 29% prefer warm introductions, and the average firm has 22 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.