F4 Champions · Season 1
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F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
59 VC firms investing in biotech & life sciences and climate & clean energy at the Series B stage.
F4 Fund tracks 59 VC firms that actively invest in biotech & life sciences + climate & clean energy at the Series B stage, with check sizes ranging from $100K – $5000M (median: $7.8M – $7.8M). As of July 2026, and 95% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,544+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Leaps by Bayer Leaps by Bayer invests in teams pursuing fundamental breakthroughs in life science targeting ten huge challenges across health and agriculture — from curing genetic diseases and cancer to transforming sustainable farming. They seek paradigm-shifting biotechnologies that move medicine from treating symptoms to curing or preventing diseases, and transform agriculture to nourish a growing population while restoring the planet. Berlin | $5M – $100M | 58 | Both | Active | N/A | Open |
| 2 | ▶ RA Capital Management Evidence-based, multi-stage investing in healthcare, life sciences, and planetary health. RA Capital pairs deep scientific diligence (via proprietary TechAtlas platform) with flexible multi-stage capital—from NewCo incubation through public markets—to support breakthrough companies from inception through commercialization. The firm's core belief is that rigorous landscape research and scientific depth consistently identify winners before the market recognizes them. Boston | $500K – $200M | 38 | Both | Active | ~1 mo | Open |
| 3 | ▶ Cultivian Sandbox Ventures Building next-generation food and agriculture technology companies that commercialize solutions for sustainable production, equitable distribution, and healthy consumption. Partners with strategic investors to drive systemic impact in food systems. Chicago | $1M – $10M | 21 | Both | Active | ~2 mo | Open |
| 4 | ▶ Baruch Future Ventures (BFV) Climate restoration through identification and scaling of 'n of 1' technology opportunities combining innovative tech, viable business models, and visionary leadership. Focus on achieving $1B+ valuations in <10 years with 'scale and speed' mentality. Menlo Park | $250K – $10M | 36 | Leads | Active | ~2 mo | Open |
| 5 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Acre Venture Partners Driving positive, lasting change in food and agriculture creates exceptional financial outcomes. Impact and return aren't trade-offs—they're intertwined. Both are essential. We invest in technologies and companies addressing human health, planetary well-being, responsible production, and climate solutions. Santa Monica | $500K – $5M | 29 | Leads | Active | ~1 mo | Req'd |
| 7 | ▶ DBL Partners Top-tier venture capital returns alongside meaningful social, environmental, and economic impact — the Double Bottom Line — with no tradeoff. DBL invests in mission-driven founders across clean energy, agriculture, nature-based solutions, health, economic opportunity, mobility, and the space/Earth nexus. San Francisco | $2M – $50M | 46 | Leads | Active | ~2 mo | N/A |
| 8 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 9 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 34 | Both | Active | ~1 mo | Open |
| 10 | ▶ Playground Global Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us. Palo Alto | $1M – $20M | 32 | Both | Active | 3+ mo | Req'd |
| 11 | ▶ Refactor Capital The most enduring companies are created by founders willing to commercialize real science and scale real systems. We focus on hard tech at the intersection of computation and physical sciences—aerospace, biotech, energy, materials—where technical execution is the moat. Burlingame, CA | $1M – $2M | 48 | Leads | Active | ~1 wk | Open |
| 12 | ▶ B Capital Group Back extraordinary entrepreneurs throughout the company-building lifecycle from seed to IPO. Combine venture capital expertise with BCG management consulting to accelerate value creation. Support founders with capital, strategic guidance, and access to global networks. San Francisco | $250K – $50M | 34 | Leads | Active | ~2 wks | Req'd |
| 13 | ▶ TELUS Pollinator Fund for Good We refuse to compromise between doing good and delivering strong financial and commercial returns. Portfolio companies gain access to TELUS's commercial networks, data-rich platforms, and deep expertise across agriculture, health, and connectivity giving them a unique edge as they scale. Vancouver | $1M – $20M | 12 | Both | Active | ~1 mo | Open |
| 14 | ▶ LG Technology Ventures LGV backs early-stage and growth-stage innovators with the strategic strength of LG Group's global resources. The fund invests in companies that stand to gain exceptional value from partnerships with LG's manufacturing, display, chemical, and energy business units, with a strong focus on AI, biotech, cleantech, and advanced materials. Silicon Valley | $1M – $30M | 73 | Both | Active | ~2 mo | Open |
| 15 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 16 | ▶ Tesi Tesi (Finnish Industry Investment Ltd) is a state-owned investment company that helps Finland's most promising companies grow bigger. Tesi invests on market terms as a minority co-investor alongside private capital in Finnish startups, scale-ups, and industrial projects, as well as in VC and PE funds. Its mandate is both financial returns and economic impact — driving growth, jobs, and renewal in the Finnish economy. Helsinki | $1M – $30M | 31 | Follows | Active | 3+ mo | Open |
| 17 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 18 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 54 | Leads | Active | ~2 mo | Open |
| 19 | ▶ Seventure Partners Seventure Partners identifies and backs innovative European companies in Life Sciences and Digital Technologies at all stages from seed to pre-IPO, serving as the lead investor and active board-level partner. The firm is a global pioneer in microbiome investing and has built a 25+ year track record of 150+ exits and 30 IPOs. Institutional backing from Natixis Investment Managers/Groupe BPCE provides unique co-investment and network access. Paris | $500K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 20 | ▶ Entrepreneur First It matters not only which companies get started, but who starts them. EF identifies exceptional individual talent before a company, co-founder, or idea exists, and builds the company from Day Zero through cohort-based co-founder matching, an equity-free grant phase, and up to $250K in formation capital (via SAFE) once a team passes its Investment Committee. London | $250K – $5M | 78 | Leads | Active | N/A | Open |
| 21 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 52 | Both | Active | ~2 mo | Open |
| 22 | ▶ Innovating Capital Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support. New York | $250K – $5M | 38 | Leads | Active | ~1 mo | Open |
| 23 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 24 | ▶ F-Prime Capital Partner with visionary founders to turn bold ambitions into world-changing breakthroughs in life sciences, technology, healthtech, and crypto. Distinctive 'technical-risk-yes, regulatory-risk-no' filter ensures clear pathways to success. Cambridge | $250K – $15M | 26 | Leads | Active | ~1 wk | Open |
| 25 | ▶ NATO Innovation Fund NIF invests in cutting-edge science and engineering startups that strengthen the defence, security, and resilience of NATO Allied nations. Backed by 24 sovereign governments, NIF provides deep tech founders with unprecedented access to government procurement markets across 24 countries, connectivity to ~90 NATO-affiliated test centres, and 6,000+ Allied scientists. NIF leads initial investments with up to €15M and maintains substantial follow-on reserves. Amsterdam | $1M – $16.5M | 26 | Leads | Active | 3+ mo | Open |
| 26 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 27 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 28 | ▶ BGF BGF provides patient, minority growth capital to ambitious SMEs and deep tech/life sciences startups across the UK and Ireland. Founded to address the SME funding gap, BGF never takes controlling stakes, provides long-term support without fixed exit deadlines, and offers portfolio access to its talent network, operating specialists, and community platform. London | $3.8M – $38M | 22 | Both | Active | ~2 mo | Open |
| 29 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 30 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 31 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 32 | ▶ SBI Investment One of Japan's most active VC firms and the venture capital arm of SBI Holdings, managing JPY 841.4 billion in cumulative fund commitments. Focused on concentrated investments in growth sectors including AI/blockchain, fintech, biotech/life sciences, and clean energy globally. Mission to cultivate key industries for the 21st century, serving as Japan's bridge to global technology ecosystems. Tokyo | $1M – $30M | 20 | Both | Active | ~2 mo | Req'd |
| 33 | ▶ Eurazeo Eurazeo backs high-potential companies across the full lifecycle — from venture and growth equity to buyout — with a focus on building European champions with global ambitions. The firm invests at the intersection of technology, healthcare, and sustainability, with a distinct impact mandate spanning 8 dedicated impact funds. Paris | $5M – $600M | 18 | Leads | Active | 3+ mo | Open |
| 34 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 46 | Both | Active | ~2 mo | Req'd |
| 35 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 36 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | N/A |
| 37 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 38 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | N/A | Open |
| 39 | ▶ Mitsubishi UFJ Capital Support the realization of start-ups' dreams by sharing the aspirations of entrepreneurs, establishing trust as a capital partner, and assisting throughout all growth stages — from seed to IPO. MUCAP invests across all industry types and stages with particular depth in life sciences (dedicated department) and new industrial fields requiring patient capital. Tokyo | $500K – $50M | 21 | Both | Active | ~2 mo | Open |
| 40 | ▶ Interlagos The biggest venture returns of the next decade will come from applied science and advanced manufacturing companies in space, defense, robotics, energy, and biotech, businesses that are hard to build without rare operational and engineering know-how. El Segundo, CA | $5M – $50M | 9 | Leads | Active | N/A | Req'd |
| 41 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 42 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | N/A | N/A |
| 43 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 18 | Leads | Active | ~2 wks | Req'd |
| 44 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 45 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 46 | ▶ Yu Galaxy Conviction-driven venture capital backing visionary founders solving humanity's toughest problems. Focus on impact measurement: profitability and positive societal impact are inseparable. Invests from seed through Series B with follow-on capacity through exit. | $500K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 47 | ▶ Redalpine Redalpine backs companies at the convergence of software and science — where rigorous engineering meets scientific breakthroughs. Half the team are scientists, half are operators, enabling them to engage deeply with highly technical founders and support them hands-on from day one through to exit. Primary focus areas: frontier science and biotech, digital health, AI and automation, fintech, synthetic biology, and climate tech. Zug | $500K – $5M | 40 | Leads | Active | N/A | N/A |
| 48 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 49 | ▶ Sawari Ventures North Africa and Africa possess tremendous entrepreneurial talent. Strategic capital combined with operational expertise can unlock transformative solutions that reshape industries. We invest in founders solving region-critical problems. Cairo | $200K – $2M | 20 | Leads | Active | ~1 mo | Open |
| 50 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 25 | Leads | Active | ~2 mo | Open |
| 51 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 52 | ▶ Sutter Hill Ventures Build or back enduring technology companies solving hard technical problems in massive markets. SHV's origination model has them serve as Founding CEO of incubated companies — recruiting experts, handling operations, and letting technical founders focus purely on building. Identify large macro tech shifts (cloud, AI infrastructure, power for AI), recruit domain experts, build small focused teams until product-market fit, then scale rapidly with the full support of SHV's centralized operations team. Palo Alto | $500K – $50M | 19 | Leads | Active | ~2 mo | Req'd |
| 53 | ▶ Not Boring Capital Invest in companies with compelling stories to tell. We couple capital deployment with media storytelling through the Not Boring newsletter, creating a unique flywheel that amplifies both company and fund narrative. New York | $100K – $2M | 10 | Both | Active | ~2 wks | Req'd |
| 54 | ▶ IDG Capital Backing founders and teams building lasting companies across TMT, healthcare, consumer & entertainment, and advanced manufacturing/clean tech, with a multi-decade time horizon and a bridge role between China and global capital markets. Hong Kong | $1M – $100M | 23 | Both | Active | ~2 mo | Req'd |
| 55 | ▶ Main Sequence Main Sequence backs deep tech founders solving humanity-scale problems, especially companies connected to publicly funded research and spinouts that can turn breakthrough science into global businesses. Eveleigh, NSW, Australia | $250K – $500K | 14 | Leads | Active | ~1 mo | N/A |
| 56 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 57 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 58 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 59 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 17 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 59 VC firms that actively invest in biotech & life sciences + climate & clean energy at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b biotech & life sciences + climate & clean energy investors is $7.8M – $7.8M, with a full range from $100K – $5000M. The distribution breaks down as: 2 firms in the <$500K range, 2 firms in the $500K-$1M range, 6 firms in the $1M-$2M range, 11 firms in the $2M-$5M range, 11 firms in the $5M-$10M range, 27 firms in the $10M+ range.
Among the 59 firms tracked, 95% lead or co-lead rounds, and 5% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b biotech & life sciences + climate & clean energy investors combine domain expertise with an active portfolio in the space. Among these firms, 26% prefer warm introductions, and the average firm has 36 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.