151 VC firms investing in biotech & life sciences and climate & clean energy, ranked by portfolio depth and activity.
F4 Fund tracks 151 VC firms that actively invest in biotech & life sciences + climate & clean energy, with check sizes ranging from $5K – $5000M (median: $1.9M – $1.9M). As of June 2026, and 91% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Cultivian Sandbox Ventures Building next-generation food and agriculture technology companies that commercialize solutions for sustainable production, equitable distribution, and healthy consumption. Partners with strategic investors to drive systemic impact in food systems. Chicago | $1M – $10M | 21 | Both | Active | ~2 mo | Open |
| 2 | ▶ Baruch Future Ventures (BFV) Climate restoration through identification and scaling of 'n of 1' technology opportunities combining innovative tech, viable business models, and visionary leadership. Focus on achieving $1B+ valuations in <10 years with 'scale and speed' mentality. Menlo Park | $250K – $10M | 36 | Leads | Active | ~2 mo | Open |
| 3 | ▶ IndieBio Synthetic biology and life sciences are engineering disciplines. The world's greatest challenges in human and planetary health will be solved by scientists and engineers using biology as a tool. We fund the earliest-stage founders with breakthrough ideas and provide wet lab infrastructure, capital, and long-term partnership. San Francisco | $500K – $525K | 33 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Shrug Capital Identifying culturally resonant, consumer-focused companies with differentiated products and founder teams that will capture global attention. We invest across technology, consumer behavior, entertainment, and culture—seeking to spot emerging trends before they reach mainstream awareness. We operate as a partnership combining rigorous deal selection with exceptional founder support, creative marketing, and deep understanding of consumer psychology. San Francisco | $500K – $2M | 114 | Both | Active | ~2 wks | Open |
| 6 | ▶ Acre Venture Partners Driving positive, lasting change in food and agriculture creates exceptional financial outcomes. Impact and return aren't trade-offs—they're intertwined. Both are essential. We invest in technologies and companies addressing human health, planetary well-being, responsible production, and climate solutions. Santa Monica | $500K – $5M | 29 | Leads | Active | ~1 mo | Req'd |
| 7 | ▶ 7thirty Capital Cannabis is fundamentally a technology and compliance problem. We back companies building essential infrastructure—software, hardware, data, and supply chain systems—that enable the regulated cannabis industry to operate efficiently and scale. Denver | $500K – $3M | 12 | Leads | Active | ~2 wks | Open |
| 8 | ▶ Virta Ventures We back bold, growth-oriented founders transforming how the world is moved, powered, and built through AI and physical infrastructure innovation. We invest in early-stage companies making physical industries more profitable, efficient, and resilient through capital-efficient business models combining software, hardware, and structured finance. | $100K – $750K | 28 | Both | Active | ~1 mo | Open |
| 9 | ▶ Refactor Capital The most enduring companies are created by founders willing to commercialize real science and scale real systems. We focus on hard tech at the intersection of computation and physical sciences—aerospace, biotech, energy, materials—where technical execution is the moat. Burlingame, CA | $1M – $2M | 47 | Leads | Active | ~1 wk | Open |
| 10 | ▶ SNØCAP VC SNØCAP backs companies building the materials, molecules, and machines that power modern industry. We love businesses that create efficiency gains, reduce costs, reduce emissions, own IP, have scientific roots, show corporate interest, need engineering support, leverage ecosystems, and are raising their first institutional round. Seattle | $250K – $2M | 11 | Leads | Active | ~2 wks | Open |
| 11 | ▶ DBL Partners Top-tier venture capital returns alongside meaningful social, environmental, and economic impact — the Double Bottom Line — with no tradeoff. DBL invests in mission-driven founders across clean energy, agriculture, nature-based solutions, health, economic opportunity, mobility, and the space/Earth nexus. San Francisco | $2M – $50M | 46 | Leads | Active | ~2 mo | — |
| 12 | ▶ Better Ventures Mission-driven companies solve big problems at scale while building durable competitive advantages. We back founders leveraging science & technology to build the Better Economy where people and planet thrive. Oakland | $500K – $1M | 43 | Leads | Active | ~1 mo | Open |
| 13 | ▶ Endgame Capital Near-market climate technologies with proven economics, low capex, and clear paths to rapid deployment — solutions that win on cost, speed, and performance, not subsidies or green premiums. Each company must demonstrate potential to reduce 50M+ tons of CO₂e annually by 2050. Brussels, Belgium | $250K – $750K | 10 | Leads | Active | — | Open |
| 14 | ▶ First Star Ventures Invest with conviction in visionary, technical founders inventing the future with frontier computing technology. Focus on computing×real-world startups (techbio, climate, robotics, industrial infrastructure). Enforce strict rebuildability bar—won't invest if 3-5 Google engineers could recreate product in 3-12 months. Position against SaaS/consumer playbook; future venture outliers will be very different. Boston | $100K – $1M | 42 | Follows | Active | ~2 wks | Req'd |
| 15 | ▶ Humba Ventures We invest in hard tech and hard sectors—companies building solutions to difficult, underexplored problems that others won't. Unlocking society's potential depends on founders willing to build what others won't. We're hyper curious, drawn to difficult and underexplored areas. San Francisco | $250K – $1M | 38 | Leads | Active | ~2 wks | Open |
| 16 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 17 | ▶ Babel Ventures Biology is the next frontier of technology. BABEL believes early-stage consumer biotech can solve macro problems (food security, climate, health) while delivering outsized returns. The best outcomes come from diverse, science-credentialed founder teams with deep domain expertise and commitment to sustainability and impact. San Francisco | $100K – $3M | 19 | Leads | Active | ~2 wks | Req'd |
| 18 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 34 | Both | Active | ~1 mo | Open |
| 19 | ▶ Material Impact Fund Material science and deep tech innovations drive outsized returns while solving urgent human problems. We back inception-stage founders turning lab breakthroughs into commercial products that make the world cleaner, more productive, and healthier. Boston | $100K – $10M | 34 | Leads | Active | ~1 mo | Open |
| 20 | ▶ Aera VC Investing in breakthrough deep technologies that address humanity's greatest challenges. We allocate ~80% to climate solutions (carbon-negative materials, renewable energy, climate adaptation) and ~20% to frontier tech (aerospace, robotics, advanced materials, biotech). We operate as a venture-and-philanthropy platform backed by the Fukutake family, blending profit-seeking with impact objectives. Singapore | $500K – $20M | 33 | Leads | Active | ~1 mo | Open |
| 21 | ▶ Ecliptic Capital Early-stage innovation from founders backed by seasoned operators. We invest in disruptive technologies solving real problems at the intersection of scientific breakthroughs and practical execution. Our founders get patient capital, hands-on mentorship from 100+ years of combined experience, and access to our network for strategic growth. Austin | $250K – $15M | 18 | Both | Active | ~1 mo | Req'd |
| 22 | ▶ BRAVE Venture Capital Backing dynamically developing enterprises with global aspirations at seed and early stage across Internet/SaaS, IoT/Hardware, Renewable Energy Sources, and Life Science (MedTech/BioTech). 4-14 year investment horizon with a patient capital approach through multiple fund vehicles. Wrocław, Poland | $25K – $500K | 32 | Leads | Active | — | Open |
| 23 | ▶ Playground Global Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us. Palo Alto | $1M – $20M | 31 | Both | Active | 3+ mo | Req'd |
| 24 | ▶ Conscience VC Invest in science-led consumer companies using a rigorous '12+ months to replicate' defensibility test. We back founders creating genuine technological moats by applying rigorous science to solve real consumer problems, with special focus on underrepresented founders (80% of portfolio). Miami | $100K – $3M | 7 | Leads | Active | ~2 wks | Open |
| 25 | ▶ Presight Capital We invest in transformative frontier science and technology that most VCs avoid. Our focus is on biotech, deep tech, psychedelics, brain-computer interfaces, life extension, and infrastructure bets in undercapitalized global markets. We believe the biggest winners in biotech are companies producing quality-adjusted life years (QALYs). Los Angeles | $500K – $100M | 17 | Both | Active | ~1 wk | Open |
| 26 | ▶ E2MC Ventures The space economy represents the next frontier for transformative economic opportunity and meaningful impact. We back pioneering founders building the technologies and services that enable humanity's expansion into space while creating value on Earth. We apply financial discipline (Wall Street cash-flow and intrinsic-value approach) to identify sustainable, scalable space businesses. Miami | $1M – $5M | 30 | Leads | Active | ~1 mo | Req'd |
| 27 | ▶ Winklevoss Capital We back determined builders working on hard problems in critical domains. Real innovation is non-obvious at first and often misunderstood. We support contrarian founders during frontier exploration when they need it most. New York | $100K – $5M | 29 | Both | Active | ~2 wks | Open |
| 28 | ▶ MFV Partners Early-stage deep tech entrepreneurs developing novel, patented solutions to the world's biggest problems in robotics, quantum computing, energy, climate, and healthcare. We back visionary founders with deep domain expertise and engage as thought partners through technology validation and commercialization. Palo Alto | $1M – $5M | 16 | Leads | Active | ~2 wks | Open |
| 29 | ▶ Divergent Capital We back deeply technical founders solving hard problems with innovative technologies. Combining capital with go-to-market expertise and structured fellowships, we partner with founders who have authentic personal connections to their problems and bring novel technological approaches to market. New York | $250K – $1M | 44 | Leads | Active | ~2 wks | Req'd |
| 30 | ▶ At One Ventures Invest in early-stage companies using disruptive deep tech to upend unit economics of established industries while delivering climate-positive outcomes. Focus on undercapitalized climate verticals (water, agriculture, robotics, materials, energy) where deep tech can achieve 2.5-3x unit economics improvement paired with environmental benefits. Menlo Park | $500K – $5M | 15 | Leads | Active | ~2 wks | Open |
| 31 | ▶ Starlight Ventures We invest in teams and solutions that address multi-decade problems that humanity has no choice but to solve. Our focus is breakthrough science and technology applied to energy transition, life sciences, space, and next-generation computing. Miami | $250K – $2.5M | 15 | Leads | Active | ~2 wks | Open |
| 32 | ▶ Silicon Roundabout We back 'sub-0.1% of the population' type exceptional founders building fundamental, infrastructure-level technologies in critical sectors (computing, defence, energy) reshaping our world. Community-driven approach provides proprietary deal flow and deep technical credibility. Focus on first cheques in pre-seed/seed with hands-on mentorship and network access. | $150K – $8.7M | 27 | Leads | Active | ~2 wks | Open |
| 33 | ▶ SV Latam Capital Early-stage Latin American entrepreneurs solving critical healthcare, environmental, and societal challenges using science and technology. We provide capital, Silicon Valley networks, and operational expertise to build transformational companies. San Francisco | $50K – $2M | 14 | Leads | Active | ~2 mo | Open |
| 34 | ▶ EPIC Ventures EPIC Ventures backs early-stage technology companies building in the information economy, with a focus on enterprise SaaS, healthcare technology, cybersecurity, and future of work. The firm believes the best way to build lasting companies is through genuine partnership with founders — providing capital, strategic guidance, operational expertise, and deep network access. Founded in 1994, EPIC helped build the Utah tech ecosystem and continues to be the foundational VC of the Mountain West. Salt Lake City, UT | $500K – $5M | 70 | Leads | Active | ~1 mo | Open |
| 35 | ▶ Privilège Ventures We back bold, ambitious, and resilient founders driving breakthrough innovations in HealthTech, CleanTech, and AgriFoodTech. Female-led and gender-mixed teams deliver superior returns and drive meaningful impact. Over five decades of combined experience navigating financial cycles enables us to partner authentically with founders, providing not just capital but strategic guidance and operational support. Switzerland | $100K – $1M | 25 | Both | Active | — | — |
| 36 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 53 | Leads | Active | ~2 mo | Open |
| 37 | ▶ Montage Ventures Montage Ventures aims to support radical thinkers who are bringing new ideas and platforms to foster change within the financial services, commerce and health sectors, leveraging AI as a key transformative agent. | $250K – $1M | 51 | — | 2mo | — | — |
| 38 | ▶ The E14 Fund We back MIT founders building deep-tech companies with defensible science or engineering advantages. We support the transition from researcher to founder, providing both capital ($500K-$5M) and operational support through the MIT ecosystem. Cambridge | $500K – $5M | 51 | Leads | Active | ~1 mo | Open |
| 39 | ▶ Spacecadet Ventures Founders building the possibly impossible deserve capital plus marketing support. Great technology combined with exceptional storytelling and narrative development creates world-changing moonshots. We provide both the capital and the story-telling expertise to help founders achieve escape velocity. New York | $250K – $1M | 99 | Leads | Active | ~2 wks | Open |
| 40 | ▶ Radical Ventures AI Eats Software. Over the next decade, virtually every bit of software will be replaced by artificial intelligence. We invest in founders and entrepreneurs who understand the transformational power of AI and are building solutions that reshape how we live, work, and play. Toronto | $1M – $25M | 50 | Leads | Active | ~2 mo | Req'd |
| 41 | ▶ R7 Partners Intelligence is coming into the physical world through AI and robotics applied to atoms rather than bits. We back capex-heavy, long-horizon bets in hard-to-abate decarbonization sectors and hardware-heavy industrial systems that many traditional early-stage funds avoid. Chicago | $100K – $5M | 35 | Leads | Active | ~2 mo | Req'd |
| 42 | ▶ B Capital Group Back extraordinary entrepreneurs throughout the company-building lifecycle from seed to IPO. Combine venture capital expertise with BCG management consulting to accelerate value creation. Support founders with capital, strategic guidance, and access to global networks. San Francisco | $250K – $50M | 34 | Leads | Active | ~2 wks | Req'd |
| 43 | ▶ Golden Seeds Gender-diverse teams produce superior returns on equity. We fund exceptional women-led startups where women hold meaningful operating C-suite roles and own substantial equity. Research shows companies with diverse female leadership are 39% more likely to be above-average profitable, 30% more likely to outperform, and 20% more likely to improve business outcomes. New York | $250K – $2M | 34 | Both | Active | ~1 mo | Open |
| 44 | ▶ KdT Ventures We believe the greatest advancements of our lifetime will be the result of reprogramming chemistry and biology using creative technology platforms. We invest at the frontier of science, supporting founders re-architecting the world at a molecular level. Austin | $500K – $5M | 22 | Leads | Active | ~2 wks | Open |
| 45 | ▶ SOSV Deep tech startups at the edge of what is possible solve critical human and planetary health problems. SOSV backs founders combining scientific rigor with entrepreneurial grit, providing not just capital but access to specialized labs, manufacturing, and global expertise networks. San Francisco | $250K – $5M | 22 | Leads | Active | ~1 wk | Open |
| 46 | ▶ TELUS Pollinator Fund for Good We refuse to compromise between doing good and delivering strong financial and commercial returns. Portfolio companies gain access to TELUS's commercial networks, data-rich platforms, and deep expertise across agriculture, health, and connectivity giving them a unique edge as they scale. Vancouver | $1M – $20M | 12 | Both | Active | ~1 mo | Open |
| 47 | ▶ Harpoon Ventures Technology will define geopolitics. We invest in the Freedom Stack—foundational technologies critical to American national security and technological leadership. We partner with mission-driven founders building capabilities essential to American prosperity and strategic advantage. San Diego | $500K – $5M | 46 | Leads | Active | ~2 wks | Req'd |
| 48 | ▶ Maple VC Canadians have built over $1 trillion in enterprise value globally, yet were initially backed by US VC not Canadian investors. We back founders with Canadian roots—regardless of where they build—because exceptional talent from Canada represents a sustainable, quantifiable selection edge. San Francisco | $500K – $1.5M | 46 | Follows | Active | ~2 wks | Open |
| 49 | ▶ Yes VC We invest in category-defining companies at Pre-Seed and Seed stages founded by entrepreneurs with authentic passion. Focus on founders working in climate, food, healthcare, AI automation, and frontier technologies. Philosophy: when the world says No, go toward the Yes as hard as you can. | $30K – $1.5M | 46 | Both | Active | ~2 wks | Open |
| 50 | ▶ Wireframe Ventures Extraordinary companies are built by driven founders whose mission to improve the health of people and planet is inseparable from their product. We partner with technical founders building technology solutions to the world's most important challenges across climate, health, biotech, and enabling technologies. San Francisco | $500K – $2M | 33 | Leads | Active | ~2 wks | Open |
| 51 | ▶ Social Impact Capital Social impact companies are undervalued at the earliest stages when metrics are unclear. We invest very early in mission-driven founders tackling the world's hardest problems, supporting them until they're attractive to top-tier VCs. 12-15 exceptional entrepreneurs can solve the largest global challenges. New York | $250K – $5M | 21 | Leads | Active | ~2 wks | Req'd |
| 52 | ▶ BlueYard Capital Invest in only two kinds of technologies: those that move humanity toward utopia, and those that hold the line against oblivion. Back n-of-1 visions for an era of Black Swans—unconventional companies solving civilization-scale problems that others dismiss as too early, too risky, or too misunderstood. Berlin | $500K – $5M | 58 | Leads | Active | ~2 mo | Open |
| 53 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 54 | ▶ Blue Bear Ventures We invest in co-founding teams from research labs solving the most pressing challenges in science and technology. The most important aspect of deep tech companies is the founding team—we invest in technical founders with entrepreneurial spirit, not just ideas. We provide patient capital, deep technical mentorship, and access to UC Berkeley's innovation ecosystem and corporate networks. San Francisco | $100K – $400K | 20 | Leads | Active | ~2 mo | Open |
| 55 | ▶ Empirical Ventures Backing 'Venture Scientists' — PhD-trained technical founders applying rigorous scientific methodology to build transformative companies from fundamental research. Focus on deep tech and life sciences areas that address climate change, resource scarcity, and healthcare accessibility. Targets university spinouts and science-led startups in areas that are difficult to diligence for generalist investors. Bristol, United Kingdom | $100K – $750K | 20 | Leads | Active | ~2 mo | Open |
| 56 | ▶ Obvious Ventures The most valuable companies of our time will be the ones solving humanity's biggest problems across planetary health, human health, and economic health. We back exceptional founders building breakthrough solutions that create both financial returns and positive impact. San Francisco | $5M – $12M | 20 | Leads | Active | ~2 wks | Open |
| 57 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 58 | ▶ The Venture Collective (TVC) Permanent balance-sheet investor backing highly defensible, category-defining, mission-driven companies solving the world's biggest problems. Focus on founders transforming legacy industries with emphasis on diversity, equity, and inclusion. New York | $100K – $2M | 53 | Leads | Active | ~2 wks | Open |
| 59 | ▶ Pale Blue Dot Early-stage climate tech companies building the sustainable future. We invest in both software and hardware solutions addressing climate change through optimization, adaptation, and pioneering innovations. The next billion-dollar companies will be built with climate in mind. Sweden | $500K – $2M | 40 | Leads | Active | ~2 mo | Req'd |
| 60 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 51 | Both | Active | ~2 mo | Open |
| 61 | ▶ Future Ventures Support passionate founders forging the future. Invest in seed and early-stage companies with unique ideas that have potential to reinvent entire industries. Focus on frontier technologies that make the world better and don't prey on human frailty. San Francisco | $500K – $10M | 28 | Leads | Active | ~1 mo | Open |
| 62 | ▶ Innovating Capital Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support. New York | $250K – $5M | 38 | Leads | Active | ~1 mo | Open |
| 63 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 64 | ▶ Necessary Ventures Invest in companies addressing fundamental societal needs. Provide Talent/Capital/Attention platform via in-house content and advisory network. Mission-driven investments with specialized expertise in healthcare, climate, robotics, and deep tech. San Francisco | $1M – $2M | 37 | Leads | Active | ~2 wks | Open |
| 65 | ▶ Elementum Ventures Seed-stage deep technology with IP defensibility, deployed by multi-exit founder-operators willing to be hands-on operational partners. Focus on frontier sectors—defense, climate, space, biotech, fusion—where bold technical founders are building mission-critical capabilities. Menlo Park | $250K – $1.5M | 26 | Leads | Active | ~1 mo | Req'd |
| 66 | ▶ F-Prime Capital Partner with visionary founders to turn bold ambitions into world-changing breakthroughs in life sciences, technology, healthtech, and crypto. Distinctive 'technical-risk-yes, regulatory-risk-no' filter ensures clear pathways to success. Cambridge | $250K – $15M | 26 | Leads | Active | ~1 wk | Open |
| 67 | ▶ Fifty Years We back founders using technology to solve the world's biggest problems. We believe capitalism can be a force for good when companies are built to be both massively profitable AND create positive impact. The best entrepreneurs are determined, passionate, smart, creative, and can inspire thousands of talented people. San Francisco | $250K – $2M | 25 | Leads | Active | ~2 wks | Open |
| 68 | ▶ Plum Alley Investments Frontier technologies and medical breakthroughs offer the best opportunities to address fundamental human and environmental challenges. Diversity of founder backgrounds drives innovation and superior returns. Founders with domain expertise, technical credentials, and distinctive visions solve the world's biggest problems. New York | $750K – $3M | 25 | Both | Active | ~1 mo | Req'd |
| 69 | ▶ Contrary Identify and invest in the world's top talent before they start a company. Build lifelong relationships through a proprietary university scout network at Stanford, MIT, Harvard, and other elite universities. Back exceptional founders within 1-3 years of graduation before they are widely recognized. San Francisco | $100K – $15M | 55 | Both | Active | ~2 wks | Req'd |
| 70 | ▶ Atento Capital Great entrepreneurship exists everywhere—not just in traditional tech hubs. We invest in high-potential early-stage founders with a focus on underrepresented geographies (Midwest, Latin America) and demographics (women, minorities, immigrants). Beyond capital, we provide strategic guidance, ecosystem connections, and relocation support through our Tulsa-based infrastructure. Tulsa, Oklahoma | $500K – $2M | 24 | Leads | Active | ~2 wks | Req'd |
| 71 | ▶ FTW Ventures The $12 trillion food and agriculture industries still rely on centuries-old methods. We back disruptive science and technology to modernize the food system—from biotech and sensors to automation and software—to feed 10 billion people by 2050 while preserving nature and nurturing humankind. San Francisco | $500K – $5M | 24 | Leads | Active | ~2 mo | Req'd |
| 72 | ▶ Cantos We invest in people who will transform the physical world. Near frontier technology solving climate change, disease, armed conflict, poverty, and existential risks. Technical founders building capital-intensive, long-horizon companies. San Francisco | $400K – $1.5M | 42 | Leads | Active | ~1 mo | Req'd |
| 73 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 74 | ▶ Asymmetry Ventures Backing transformative startups with exceptional defensibility and civilization-level impact potential. Focus on technical complexity, defensible innovation, and companies solving large-scale problems. Quality over volume approach with selective, thesis-driven investing. San Francisco | $100K – $500K | 23 | Follows | Active | ~2 mo | Req'd |
| 75 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 76 | ▶ Cartography Capital Breakthrough technologies and materials that power every AI chip, quantum computer, robot, battery, solar panel, biotech solution, and space exploration tool. Back founders who move beyond conventional industry boundaries to build bedrock economic infrastructure. Oakland | $250K – $3M | 14 | Both | Active | ~1 mo | Open |
| 77 | ▶ E2JDJ Entrepreneurship × Exponential Growth. We back visionary founders solving systemic inefficiencies across the food and agriculture value chain. Our co-founders combine operational expertise (Providence growth equity, White House service, corporate law) with deep commitment to founder success. San Francisco | $100K – $3M | 14 | Leads | Active | ~2 wks | Req'd |
| 78 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 79 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 80 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 55 | Both | Active | ~1 mo | Open |
| 81 | ▶ Creative Ventures Humanizing deep tech by bringing advanced breakthrough technologies to where the people are and maximizing the value they generate for solving humanity's most critical crises. We invest in companies addressing climate, manufacturing labor shortages, healthcare costs, sustainable food production, and computing infrastructure. Oakland | $1M – $3M | 28 | Both | Active | ~1 mo | Req'd |
| 82 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 83 | ▶ Moxxie Ventures Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building. San Francisco | $500K – $2M | 50 | Leads | Active | ~2 wks | Open |
| 84 | ▶ Prime Movers Lab Prime Movers Lab partners with serial entrepreneurs building breakthrough scientific companies that tackle the world's biggest problems. We believe the best venture partners provide operational excellence, technical expertise, and hands-on support—not just capital. We invest in companies reinventing energy, transportation, infrastructure, manufacturing, human augmentation, and agriculture. Jackson, Wyoming | $2M – $30M | 18 | Leads | Active | ~1 mo | Req'd |
| 85 | ▶ Scribble Ventures AI companies are built differently. We back the world's best AI native founders and help them reshape our world for the better. We go wide on product and deep on GTM. San Francisco | $300K – $1.5M | 18 | Leads | Active | ~1 wk | Open |
| 86 | ▶ Innovation Endeavors We invest in the Super Evolution—the convergence of ubiquitous sensors, advanced machine learning, cloud systems, robotics, 3D printing, and CRISPR. We partner with technical founders solving hard engineering and science problems to rethink large industries and tackle humanity's most pressing challenges. Palo Alto | $1M – $15M | 25 | Leads | Active | ~2 mo | Open |
| 87 | ▶ 1955 Capital Invest in advanced technologies solving the world's greatest challenges in energy, environment, food safety, sustainable manufacturing, healthcare, and education. Back contrarian founders building capital-intensive, deep-tech ventures that address survival-driven global needs. Bridge breakthrough technologies from developed markets into emerging economies and vice versa. Create high-return, high-impact outcomes through hard technology. Los Altos, California | $5M – $10M | 11 | Leads | Active | ~2 mo | Req'd |
| 88 | ▶ Better Capital Day 0 venture capital applied by a deep operator. Better Capital invests at the earliest stage where ambiguity is highest and operator judgment adds the most value. Solo GP model keeps conviction high and enables deep engagement with 20-25 companies at critical inflection points. Pune | $300K – $1M | 47 | Leads | Active | ~1 wk | Req'd |
| 89 | ▶ BoxOne Ventures Back passionate, emerging talent solving deep technology challenges. Support founders from napkin-stage through IPO with patient, flexible evergreen capital. Focus on biotechnology, frontier software, food innovation, longevity, and AI that maximize impact and potential. Montreal | $100K – $5M | 17 | Both | Active | ~2 mo | Open |
| 90 | ▶ Julian Capital First check for deeptech founders building across all deeptech sectors (chips, energy, robotics, medtech, materials science, aerospace). We provide more than capital—we become your growth team, design your website, and offer hands-on go-to-market support backed by deep expertise in startup scaling and commercialization. San Francisco | $750K – $1M | 17 | Leads | Active | ~2 wks | Open |
| 91 | ▶ DCVC We back entrepreneurs using computational approaches (AI, simulation) to solve trillion-dollar problems in climate, health, industrial transformation, and national security. Deep tech requires patient capital and scientific rigor. San Francisco | $5M – $25M | 31 | Leads | Active | ~2 mo | Req'd |
| 92 | ▶ Batshit Crazy Ventures Support unconventional, bold founder-led companies solving real problems at the earliest stages. We provide capital, operational mentorship, and resources to pre-revenue and pre-seed startups that traditional investors overlook. Boulder, Colorado | $100K – $1M | 23 | Both | Between | ~2 wks | Req'd |
| 93 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 94 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 95 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 96 | ▶ Swift Ventures Founders backing founders. Swift invests in B2B AI and automation companies led by bold operators with a high Do:Say ratio, offering garage-to-IPO operating expertise from former company-builders. San Francisco | $2M – $8M | 35 | Both | Active | — | Open |
| 97 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 98 | ▶ Black Flag Be the first check in for founders building America's next era of critical technologies. Invest in audacious founders across Defense, Aerospace, Energy, AI, Manufacturing, Cybersecurity, and Health+Bio solving problems critical to national security and American technological leadership. Provide capital ($250K-$1M), unmatched government access, mentor network, and go-to-market acceleration. San Diego | $250K – $1M | 21 | Leads | Active | ~1 mo | Open |
| 99 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 41 | Both | Active | ~2 mo | Req'd |
| 100 | ▶ The Helm Women receive only 2% of venture capital despite female-founded startups delivering 2x return per dollar vs. all-male teams. The Helm invests in game-changing, undervalued companies at seed stage founded by women, providing not just capital but operational support and ecosystem access. New York | $250K – $1.5M | 26 | Leads | Active | ~2 wks | Open |
| 101 | ▶ AENU Rewriting the VC rulebook to deliver high returns with high impact. We invest in founders building climate and social impact technologies with intentional, measurable, net-positive outcomes at meaningful scale. | $1M – $4M | 14 | Leads | Active | — | — |
| 102 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 103 | ▶ AIX Ventures AI-native companies where artificial intelligence is the core product and competitive moat, not just a feature. Three investment baskets: (1) AI infrastructure (vector databases, model serving, optimization), (2) vertical applications with 20%+ performance advantages, and (3) frontier research with clear commercialization paths. Palo Alto | $750K – $3M | 25 | Leads | Active | ~1 wk | Open |
| 104 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | — | — |
| 105 | ▶ Celesta (fka WRVI) Celesta invests in brilliance at the forefront of science and engineering, targeting companies that enable mass adoption of emerging tech, radically improve health outcomes, and transform large industries. Focus on platforms enabling emerging tech adoption, bioconvergence innovations (high-tech + biotech), and technologies disrupting legacy industries with deep tech. San Francisco | $250K – $20M | 19 | Leads | Active | ~2 mo | Open |
| 106 | ▶ Pear VC Exceptional founders backed at pre-seed and seed with both capital and hands-on operational support—talent, GTM, fundraising—build the most enduring companies. Pear is founder-first: founders-and-operators turned investors who have been in founders' shoes. Menlo Park | $250K – $6M | 43 | Leads | Active | ~1 mo | Open |
| 107 | ▶ Boost VC Back the quirky underdog pursuing seemingly impossible ideas. Frontier tech (aerospace, biotech, climate, robotics, crypto, AI, VR/AR) will create the next generation of legendary companies. Technical founders with deep domain expertise can solve the hardest problems in physics, chemistry, and computing. San Mateo, California | $500K – $3M | 30 | Leads | Active | ~1 wk | Open |
| 108 | ▶ No Label Ventures Backing immigrant entrepreneurs building companies in Europe. Immigrants account for ~50% of US and ~40% of UK unicorns. NLV spots and supports this talent before the market catches up, investing unconditionally as the first check before lead VCs are in place. London | $150K – $250K | 24 | Follows | Active | ~2 wks | Open |
| 109 | ▶ 1517 Fund We back dropouts, renegade students, and deep-tech scientists working on ideas that would appear in science fiction. We exist to prove that great founders don't need university degrees and are found in the oddest places. We invest at inception stage (R&D through Seed), providing capital, mentorship, community access, and operational support. People-first approach: it's more about the who than the what. Telluride, Colorado | $50K – $1M | 18 | Leads | Active | ~1 wk | Open |
| 110 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 18 | Leads | Active | ~2 wks | Req'd |
| 111 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 112 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 113 | ▶ Brickyard Extraordinary founders execute faster when isolated from distractions and provided intensive on-site support. We seek junkyard dogs with high agency, non-obvious vision, delusional optimism, and execution discipline. Category matters far less than founder quality. Chattanooga, TN | $100K – $500K | 52 | Both | Active | ~2 wks | Open |
| 114 | ▶ Deep Checks Deep Checks matches deeptech founders worldwide with venture capital investors who specialize in their specific technology niches. We operate as a specialized deal-flow curation platform connecting founders with 50+ deeptech VCs, angels, and founder-investors. Our mission is to democratize access to expert capital for scientific and hardware founders who are otherwise hard to reach. San Francisco | $500K – $5M | 12 | — | 1mo | ~2 wks | Open |
| 115 | ▶ Day One Ventures We help mission-driven pioneers win by harnessing the power of storytelling, art and culture. We back early-stage companies with customer obsession in their DNA and accelerate the mass adoption of technologies they create. Founders need more than capital—they need strategic support in building their narrative and leveraging media to accelerate adoption. San Francisco | $300K – $5M | 27 | Leads | Active | ~1 wk | Open |
| 116 | ▶ Boro Capital Invest in scalable, capital-efficient tech and tech-enabled startups at the Seed stage led by exceptional founders. We identify companies showing early traction that can achieve significant scale with disciplined capital deployment. New York | $100K – $500K | 32 | Leads | Active | ~2 wks | Open |
| 117 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 118 | ▶ SVG Ventures We back bold founders and AI-enabled, game-changing innovations that improve planetary and population health. We target capital-efficient, highly scalable startups reimagining sectors like agri-food, climate, fintech, life sciences and nutrition through deep tech and proprietary IP. We engineer outcomes through operational support, strategic partnerships, and sector expertise. Los Gatos, California | $500K – $100M | 16 | Both | Active | ~2 mo | Req'd |
| 119 | ▶ FAST — by GETTYLAB Breakthrough innovations emerge from engineers tackling frontier problems. We provide fast capital, domain expertise across AI/robotics/space/biotech, and deeptech credibility to pre-seed teams. San Francisco | $5K – $100K | 11 | Follows | Active | ~1 wk | Open |
| 120 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 20 | Leads | Active | ~2 wks | Req'd |
| 121 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 122 | ▶ Bitspiration The only early-stage deep tech VC in CEE focusing on resilient technologies. We invest in founders building breakthrough technologies with proprietary IP in deep tech, MedTech, cleantech, autonomous vehicles/robotics, industrial, and resilient-tech. Technology must be genuinely unique and address real problems. Kraków, Poland | $50K – $1M | 10 | Both | Active | — | — |
| 123 | ▶ KittyHawk Ventures Backing exceptional, mission-driven entrepreneurs creating companies with Massively Transformative Purpose (MTP) that impact billions of people. We invest across the full innovation lifecycle, from early-stage frontier technology through scale to liquidity. We love companies and individuals that are different, fishing where others aren't, seeking opportunities where exceptional visionary entrepreneurs see novel paths to greatness. Los Angeles | $500K – $5M | 10 | Leads | Active | ~2 mo | Req'd |
| 124 | ▶ Draper Associates Invest in bold, visionary founders building transformational businesses long before the world believes in them. We back founders solving impossible-seeming problems across frontier sectors: AI/robotics, crypto, biotech, aerospace, and unconventional ideas. San Mateo, CA | $500K – $30M | 23 | Leads | Active | ~1 wk | Open |
| 125 | ▶ OVNI Capital Back European technical founders building globally ambitious deeptech and critical technology companies at pre-seed and seed, with concentrated first-check conviction and Paris/San Francisco/Berlin support. Paris | $250K – $2M | 18 | Both | Active | — | Open |
| 126 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 127 | ▶ Vast Ventures We invest in companies organized around five concrete objectives: improving worldwide health and happiness, promoting resource sustainability, increasing human potential and productivity, increasing knowledge/empathy/connectedness, and disrupting industries that resist these goals. We operate as both investors and company-builders, providing operational expertise and hands-on support far beyond capital. New York | $250K – $3M | 26 | Leads | Active | ~2 wks | Req'd |
| 128 | ▶ Not Boring Capital Invest in companies with compelling stories to tell. We couple capital deployment with media storytelling through the Not Boring newsletter, creating a unique flywheel that amplifies both company and fund narrative. New York | $100K – $2M | 9 | Both | Active | ~2 wks | Req'd |
| 129 | ▶ Sand Hill Angels Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem. Mountain View | $50K – $2M | 30 | Follows | Active | — | Open |
| 130 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 131 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 28 | Leads | Active | — | — |
| 132 | ▶ LDV Capital A majority of the data our brains analyze is visual. Therefore, the majority of the data AI will analyze will also be visual, spanning the light and electromagnetic spectrums across all sectors. We thrive on collaborating with deep technical teams who leverage computer vision, machine learning and artificial intelligence to analyze visual data. New York | $500K – $1.5M | 28 | Leads | Active | ~2 wks | Req'd |
| 133 | ▶ Noon Ventures We invest in proven, transformative technologies that have the potential to be industry-defining while driving meaningful impact on the climate and environment. We partner with founders as active co-developers, not passive investors. Copenhagen | $500K – $10M | 5 | Leads | Active | ~1 mo | Open |
| 134 | ▶ Vibe Capital Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures. New York | $250K – $500K | 22 | Both | Active | ~2 mo | Open |
| 135 | ▶ Rockies Venture Fund High-growth early-stage companies with disruptive innovation across diversified sectors. Particular focus on underserved communities and Rocky Mountain region. Platform approach with multiple themed funds for specialized strategies. Denver | $100K – $500K | 18 | Both | Active | ~2 mo | Req'd |
| 136 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 137 | ▶ TheFounderVC Backs U.S. pre-seed and seed founders building vertical AI applications where domain expertise, workflow-native products, differentiated data, and personalized UX can create category leaders. Seattle | $100K – $250K | 7 | Both | Active | — | — |
| 138 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | — | 1mo | ~2 wks | Open |
| 139 | ▶ MiLA Capital (Make in LA) Emerging hardware founders are overlooked by traditional VC. By combining capital with hands-on manufacturing expertise, infrastructure access, and operational support, we unlock value for founders building tech you can touch. Chatsworth, CA | $1.5M – $2.5M | 15 | Leads | Slowing | ~1 mo | Open |
| 140 | ▶ Rule30 Rule30 uses a fully algorithmic decision engine to identify outlier founders at pre-seed and seed stages across Europe and North America. The fund removes human bias by analyzing founder experience, educational background, network evolution, and career trajectory — excluding names and photos. The algorithm ranks founders into top 10%, 3%, and 0.1% tiers. An index-style strategy of 75-85 bets targets ≥3x minimum returns with 97.5% confidence. London | $100K – $300K | 21 | Follows | Active | ~1 wk | Open |
| 141 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 142 | ▶ Montis VC Backs European pre-seed and seed founders building technologies for Energy, Industry, and Resilience, especially energy transition, industrial automation, practical AI for infrastructure, manufacturing, logistics, energy grids, and critical systems. Warsaw | $500K – $2M | 11 | Both | Active | — | Open |
| 143 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 144 | ▶ MaC Venture Capital MaC backs visionary founders building category-defining companies with deep understanding of cultural shifts, technological advancements, and emerging market trends. Founders must demonstrate authentic insight into why their problem needs solving now, combined with ability to see how the world is changing. Particular focus on founders paying attention to shifts others might miss. | $500K – $2M | 19 | Leads | Active | ~2 wks | Req'd |
| 145 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 146 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 147 | ▶ Levante Capital Invest in the most promising Southern European (primarily Italian) deep-technology companies across Advanced Manufacturing, Life Science, and Energy & Environment, and actively support their expansion into Asian markets (China, South Korea, Japan, South-East Asia). The fund uses a proprietary evaluation framework and a 'pull model' — companies must demonstrate genuine Asian market interest before investment. Milan, Italy | $500K – $3M | 8 | — | Active | ~2 mo | Open |
| 148 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
| 149 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
| 150 | ▶ Sher Ventures Exceptional founders applying unique talents and backgrounds to produce disruptive and differentiated products and services. Minimum $500K ARR at entry. Generalist across AI, B2B SaaS, logistics, healthcare, and advanced manufacturing. Sugar Land, TX | $25K – $100K | 4 | Follows | Active | ~1 mo | Open |
| 151 | ▶ IGC - Innovative Growth Capital IGC pioneered the Reverse VC™ model — starting with corporate demand rather than capital deployment. Their ReverseVision platform identifies what Global 5000 companies want to buy, then matches emerging tech founders to those demand signals. Investment flow: Demand → Commercialization → Valuation → Capital → Exit. This approach claims higher success rates, better deal terms, and reduced downside risk by replacing intuition with engineered outcomes. San Francisco | $25K – $500K | 1 | Leads | Active | ~1 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 151 VC firms that actively invest in biotech & life sciences + climate & clean energy. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for biotech & life sciences + climate & clean energy investors is $1.9M – $1.9M, with a full range from $5K – $5000M. The distribution breaks down as: 19 firms in the <$500K range, 23 firms in the $500K-$1M range, 35 firms in the $1M-$2M range, 31 firms in the $2M-$5M range, 19 firms in the $5M-$10M range, 24 firms in the $10M+ range.
Among the 151 firms tracked, 91% lead or co-lead rounds, and 7% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best biotech & life sciences + climate & clean energy investors combine domain expertise with an active portfolio in the space. Among these firms, 30% prefer warm introductions, and the average firm has 31 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.