F4 Champions · Season 1
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F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
9 VC firms investing in biotech & life sciences and legal & regtech, ranked by portfolio depth and activity.
F4 Fund tracks 9 VC firms that actively invest in biotech & life sciences + legal & regtech, with check sizes ranging from $100K – $15M (median: $2.8M – $2.8M). As of July 2026, and 89% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,539+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ 42CAP Backing seed-stage, tech- and data-driven B2B software companies across Europe with global ambition. Focus on Agility Drivers (verticalized, consumerized, XaaS solutions) and Seductive Solutions with genuine product-market fit. Invest in AI-first and AI-enabled businesses as well as frontier tech (BioIT, Space, DLT, Quantum Computing). Munich | $500K – $3M | 56 | Leads | Active | N/A | N/A |
| 2 | ▶ Moxxie Ventures Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building. San Francisco | $500K – $2M | 60 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Valhalla Ventures We partner with visionaries building enduring moats in deeptech and gaming. We invest up to $12M from inception to Seed. We restore the original essence of venture capital - working directly with bold entrepreneurs to tackle the world's toughest challenges through breakthrough physical technologies and novel gaming experiences. | $500K – $12M | 14 | Leads | Active | ~2 wks | Req'd |
| 4 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 5 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 6 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 23 | Leads | Active | ~2 wks | Req'd |
| 7 | ▶ Rule30 Rule30 uses a fully algorithmic decision engine to identify outlier founders at pre-seed and seed stages across Europe and North America. The fund removes human bias by analyzing founder experience, educational background, network evolution, and career trajectory — excluding names and photos. The algorithm ranks founders into top 10%, 3%, and 0.1% tiers. An index-style strategy of 75-85 bets targets ≥3x minimum returns with 97.5% confidence. London | $100K – $300K | 35 | Follows | Active | ~1 wk | Open |
| 8 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 9 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 9 VC firms that actively invest in biotech & life sciences + legal & regtech. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for biotech & life sciences + legal & regtech investors is $2.8M – $2.8M, with a full range from $100K – $15M. The distribution breaks down as: 2 firms in the <$500K range, 2 firms in the $1M-$2M range, 2 firms in the $2M-$5M range, 3 firms in the $5M-$10M range.
Among the 9 firms tracked, 89% lead or co-lead rounds, and 11% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best biotech & life sciences + legal & regtech investors combine domain expertise with an active portfolio in the space. Among these firms, 50% prefer warm introductions, and the average firm has 42 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.