7 VC firms investing in biotech & life sciences and legal & regtech, ranked by portfolio depth and activity.
F4 Fund tracks 7 VC firms that actively invest in biotech & life sciences + legal & regtech, with check sizes ranging from $25K – $12M (median: $2.8M – $2.8M). As of July 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,364+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Moxxie Ventures Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building. San Francisco | $500K – $2M | 60 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Valhalla Ventures We partner with visionaries building enduring moats in deeptech and gaming. We invest up to $12M from inception to Seed. We restore the original essence of venture capital - working directly with bold entrepreneurs to tackle the world's toughest challenges through breakthrough physical technologies and novel gaming experiences. | $500K – $12M | 14 | Leads | Active | ~2 wks | Req'd |
| 3 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 4 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 5 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 6 | ▶ Plug N Play Ventures We connect innovative startups with 550+ corporate partners who have real business problems to solve. Our unique position in the ecosystem creates a flywheel of pilots, proofs-of-concept, enterprise customers, and follow-on capital. We back founders solving real market problems with credible corporate validation. Sunnyvale | $25K – $3M | 19 | Leads | Active | ~1 wk | Open |
| 7 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
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Firms that frequently co-invest with investors on this page
F4 Fund tracks 7 VC firms that actively invest in biotech & life sciences + legal & regtech. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for biotech & life sciences + legal & regtech investors is $2.8M – $2.8M, with a full range from $25K – $12M. The distribution breaks down as: 1 firms in the <$500K range, 2 firms in the $1M-$2M range, 2 firms in the $2M-$5M range, 2 firms in the $5M-$10M range.
Among the 7 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best biotech & life sciences + legal & regtech investors combine domain expertise with an active portfolio in the space. Among these firms, 43% prefer warm introductions, and the average firm has 40 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.