26 VC firms investing in biotech & life sciences and manufacturing & industrial at the Series A stage.
F4 Fund tracks 26 VC firms that actively invest in biotech & life sciences + manufacturing & industrial at the Series A stage, with check sizes ranging from $25K – $500M (median: $2.8M – $2.8M). As of June 2026, and 88% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Baruch Future Ventures (BFV) Climate restoration through identification and scaling of 'n of 1' technology opportunities combining innovative tech, viable business models, and visionary leadership. Focus on achieving $1B+ valuations in <10 years with 'scale and speed' mentality. Menlo Park | $250K – $10M | 36 | Leads | Active | ~2 mo | Open |
| 2 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 3 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 34 | Both | Active | ~1 mo | Open |
| 4 | ▶ Material Impact Fund Material science and deep tech innovations drive outsized returns while solving urgent human problems. We back inception-stage founders turning lab breakthroughs into commercial products that make the world cleaner, more productive, and healthier. Boston | $100K – $10M | 34 | Leads | Active | ~1 mo | Open |
| 5 | ▶ At One Ventures Invest in early-stage companies using disruptive deep tech to upend unit economics of established industries while delivering climate-positive outcomes. Focus on undercapitalized climate verticals (water, agriculture, robotics, materials, energy) where deep tech can achieve 2.5-3x unit economics improvement paired with environmental benefits. Menlo Park | $500K – $5M | 15 | Leads | Active | ~2 wks | Open |
| 6 | ▶ R7 Partners Intelligence is coming into the physical world through AI and robotics applied to atoms rather than bits. We back capex-heavy, long-horizon bets in hard-to-abate decarbonization sectors and hardware-heavy industrial systems that many traditional early-stage funds avoid. Chicago | $100K – $5M | 35 | Leads | Active | ~2 mo | Req'd |
| 7 | ▶ KdT Ventures We believe the greatest advancements of our lifetime will be the result of reprogramming chemistry and biology using creative technology platforms. We invest at the frontier of science, supporting founders re-architecting the world at a molecular level. Austin | $500K – $5M | 22 | Leads | Active | ~2 wks | Open |
| 8 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 51 | Both | Active | ~2 mo | Open |
| 9 | ▶ Contrary Identify and invest in the world's top talent before they start a company. Build lifelong relationships through a proprietary university scout network at Stanford, MIT, Harvard, and other elite universities. Back exceptional founders within 1-3 years of graduation before they are widely recognized. San Francisco | $100K – $15M | 55 | Both | Active | ~2 wks | Req'd |
| 10 | ▶ 8VC Partner with elite founders building transformational technologies that create lasting economic and societal value. Focus on Smart Enterprise across five sectors: Logistics, Life Sciences, Healthcare, IT Infrastructure, and Government/Defense. Invest in platforms that enable human experts to solve non-linear problems through data integration and network effects. Austin | $500K – $50M | 30 | Leads | Active | ~2 wks | Open |
| 11 | ▶ Creative Ventures Humanizing deep tech by bringing advanced breakthrough technologies to where the people are and maximizing the value they generate for solving humanity's most critical crises. We invest in companies addressing climate, manufacturing labor shortages, healthcare costs, sustainable food production, and computing infrastructure. Oakland | $1M – $3M | 28 | Both | Active | ~1 mo | Req'd |
| 12 | ▶ Prime Movers Lab Prime Movers Lab partners with serial entrepreneurs building breakthrough scientific companies that tackle the world's biggest problems. We believe the best venture partners provide operational excellence, technical expertise, and hands-on support—not just capital. We invest in companies reinventing energy, transportation, infrastructure, manufacturing, human augmentation, and agriculture. Jackson, Wyoming | $2M – $30M | 18 | Leads | Active | ~1 mo | Req'd |
| 13 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 14 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | — | — |
| 15 | ▶ Battery Ventures Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools. Boston | $1M – $500M | 23 | Both | Active | ~2 wks | Open |
| 16 | ▶ Day One Ventures We help mission-driven pioneers win by harnessing the power of storytelling, art and culture. We back early-stage companies with customer obsession in their DNA and accelerate the mass adoption of technologies they create. Founders need more than capital—they need strategic support in building their narrative and leveraging media to accelerate adoption. San Francisco | $300K – $5M | 27 | Leads | Active | ~1 wk | Open |
| 17 | ▶ Argonautic Ventures AI is a milestone in data maturity progression, not a product category. Argonautic invests in founders building data-centric solutions across infrastructure (horizontal) and vertical markets. Multi-fund structure allows pre-seed to Series B deployment with unified thesis: recognizing verticals at different data adoption stages and deploying capital to those crossing inflection points into AI operationalization. | $250K – $1M | 7 | Both | Active | ~2 wks | Open |
| 18 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 20 | Leads | Active | ~2 wks | Req'd |
| 19 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 20 | ▶ Noon Ventures We invest in proven, transformative technologies that have the potential to be industry-defining while driving meaningful impact on the climate and environment. We partner with founders as active co-developers, not passive investors. Copenhagen | $500K – $10M | 5 | Leads | Active | ~1 mo | Open |
| 21 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | — | 1mo | ~2 wks | Open |
| 22 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 23 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 24 | ▶ Levante Capital Invest in the most promising Southern European (primarily Italian) deep-technology companies across Advanced Manufacturing, Life Science, and Energy & Environment, and actively support their expansion into Asian markets (China, South Korea, Japan, South-East Asia). The fund uses a proprietary evaluation framework and a 'pull model' — companies must demonstrate genuine Asian market interest before investment. Milan, Italy | $500K – $3M | 8 | — | Active | ~2 mo | Open |
| 25 | ▶ Sher Ventures Exceptional founders applying unique talents and backgrounds to produce disruptive and differentiated products and services. Minimum $500K ARR at entry. Generalist across AI, B2B SaaS, logistics, healthcare, and advanced manufacturing. Sugar Land, TX | $25K – $100K | 4 | Follows | Active | ~1 mo | Open |
| 26 | ▶ IGC - Innovative Growth Capital IGC pioneered the Reverse VC™ model — starting with corporate demand rather than capital deployment. Their ReverseVision platform identifies what Global 5000 companies want to buy, then matches emerging tech founders to those demand signals. Investment flow: Demand → Commercialization → Valuation → Capital → Exit. This approach claims higher success rates, better deal terms, and reduced downside risk by replacing intuition with engineered outcomes. San Francisco | $25K – $500K | 1 | Leads | Active | ~1 mo | Open |
Investors on this page also frequently invest in these sectors
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What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 26 VC firms that actively invest in biotech & life sciences + manufacturing & industrial at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a biotech & life sciences + manufacturing & industrial investors is $2.8M – $2.8M, with a full range from $25K – $500M. The distribution breaks down as: 3 firms in the <$500K range, 1 firms in the $500K-$1M range, 2 firms in the $1M-$2M range, 8 firms in the $2M-$5M range, 6 firms in the $5M-$10M range, 6 firms in the $10M+ range.
Among the 26 firms tracked, 88% lead or co-lead rounds, and 4% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a biotech & life sciences + manufacturing & industrial investors combine domain expertise with an active portfolio in the space. Among these firms, 24% prefer warm introductions, and the average firm has 30 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.