28 VC firms investing in e-commerce & marketplaces and biotech & life sciences at the Pre-Seed stage.
F4 Fund tracks 28 VC firms that actively invest in e-commerce & marketplaces + biotech & life sciences at the Pre-Seed stage, with check sizes ranging from $20K – $200M (median: $1.3M – $1.3M). As of June 2026, and 82% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,356+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Abstract Ventures Backing transformative founders building exceptional companies across all sectors San Francisco | $100K – $1M | 275 | Both | Active | — | — |
| 2 | ▶ Bluestein Ventures We invest in the future of food — backing game-changing early-stage ventures (Pre-Seed to Series A) that redefine how consumers achieve health and wellness across the entire food value chain: high-growth consumer brands, proprietary foodtech, next-gen commerce, and value-add digital technology. Fund III ($45M, 2024) emphasizes nutrition, sustainability, and digitization, with a thematic focus on food-as-medicine. Chicago | $250K – $5M | 37 | Leads | Active | — | — |
| 3 | ▶ Montage Ventures Montage Ventures aims to support radical thinkers who are bringing new ideas and platforms to foster change within the financial services, commerce and health sectors, leveraging AI as a key transformative agent. | $250K – $1M | 51 | — | 2mo | — | — |
| 4 | ▶ Yes VC We invest in category-defining companies at Pre-Seed and Seed stages founded by entrepreneurs with authentic passion. Focus on founders working in climate, food, healthcare, AI automation, and frontier technologies. Philosophy: when the world says No, go toward the Yes as hard as you can. | $30K – $1.5M | 46 | Both | Active | ~2 wks | Open |
| 5 | ▶ NFX Network effects are the #1 way to create defensibility in digital businesses. We invest in visionary founders building defensible businesses with network effects embedded in their core product. San Francisco | $1M – $5M | 25 | Leads | Active | — | — |
| 6 | ▶ Hummingbird VC We back outliers of the outliers - founders with unreasonable ambition who can filter out 95% of conventional VC advice. We seek category-defining companies aiming for $10B+ outcomes, not incremental improvements. Our conviction is deep, selective, and global. We don't meddle - we provide brutal honesty, talent upgrades, and capital for survival through near-death moments. London | $500K – $50M | 34 | Both | Active | ~2 wks | Open |
| 7 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 8 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 9 | ▶ UpHonest Capital We invest in the most promising entrepreneurs building the fastest-growing early-stage startups. We provide cross-border access by connecting founders to resources and networks across the world's most valuable and influential VC markets. Palo Alto | $50K – $1M | 26 | Follows | Active | ~1 mo | Open |
| 10 | ▶ Pear VC Exceptional founders backed at pre-seed and seed with both capital and hands-on operational support—talent, GTM, fundraising—build the most enduring companies. Pear is founder-first: founders-and-operators turned investors who have been in founders' shoes. Menlo Park | $250K – $6M | 43 | Leads | Active | ~1 mo | Open |
| 11 | ▶ Brickyard Extraordinary founders execute faster when isolated from distractions and provided intensive on-site support. We seek junkyard dogs with high agency, non-obvious vision, delusional optimism, and execution discipline. Category matters far less than founder quality. Chattanooga, TN | $100K – $500K | 52 | Both | Active | ~2 wks | Open |
| 12 | ▶ Antler Backing exceptional people at the very start of their journey. We support founders from inception to scale through our global residency programs, providing capital, mentorship, and access to a network of 1,500+ companies across six continents. | $125K – $500K | 28 | Leads | Active | ~2 wks | Open |
| 13 | ▶ Boro Capital Invest in scalable, capital-efficient tech and tech-enabled startups at the Seed stage led by exceptional founders. We identify companies showing early traction that can achieve significant scale with disciplined capital deployment. New York | $100K – $500K | 32 | Leads | Active | ~2 wks | Open |
| 14 | ▶ Supernode Ventures We invest in the technologies that are transforming our lives, now and into the future. Founded by a successful entrepreneur and former tech journalist, Supernode backs exceptional founders building innovative technology companies across all sectors, from pre-seed through Series A and beyond. San Francisco | $250K – $3M | 20 | Both | Active | 3+ mo | Open |
| 15 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 16 | ▶ Vast Ventures We invest in companies organized around five concrete objectives: improving worldwide health and happiness, promoting resource sustainability, increasing human potential and productivity, increasing knowledge/empathy/connectedness, and disrupting industries that resist these goals. We operate as both investors and company-builders, providing operational expertise and hands-on support far beyond capital. New York | $250K – $3M | 26 | Leads | Active | ~2 wks | Req'd |
| 17 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 18 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 28 | Leads | Active | — | — |
| 19 | ▶ Staircase Ventures Lead pre-seed and seed rounds in Canadian B2B software and AI-enabled vertical workflow companies with an initial product in market, early product-market-fit signals, and ambition to scale across North America or globally. Toronto | $1M – $2.5M | 14 | Leads | Active | — | — |
| 20 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 21 | ▶ Rule30 Rule30 uses a fully algorithmic decision engine to identify outlier founders at pre-seed and seed stages across Europe and North America. The fund removes human bias by analyzing founder experience, educational background, network evolution, and career trajectory — excluding names and photos. The algorithm ranks founders into top 10%, 3%, and 0.1% tiers. An index-style strategy of 75-85 bets targets ≥3x minimum returns with 97.5% confidence. London | $100K – $300K | 21 | Follows | Active | ~1 wk | Open |
| 22 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 23 | ▶ Montis VC Backs European pre-seed and seed founders building technologies for Energy, Industry, and Resilience, especially energy transition, industrial automation, practical AI for infrastructure, manufacturing, logistics, energy grids, and critical systems. Warsaw | $500K – $2M | 11 | Both | Active | — | Open |
| 24 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 25 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 26 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 27 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
| 28 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
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Firms that frequently co-invest with investors on this page
F4 Fund tracks 28 VC firms that actively invest in e-commerce & marketplaces + biotech & life sciences at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed e-commerce & marketplaces + biotech & life sciences investors is $1.3M – $1.3M, with a full range from $20K – $200M. The distribution breaks down as: 7 firms in the <$500K range, 6 firms in the $500K-$1M range, 5 firms in the $1M-$2M range, 6 firms in the $2M-$5M range, 4 firms in the $10M+ range.
Among the 28 firms tracked, 82% lead or co-lead rounds, and 14% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed e-commerce & marketplaces + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 23% prefer warm introductions, and the average firm has 41 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.