47 VC firms investing in fintech & payments and biotech & life sciences at the Series B stage.
F4 Fund tracks 47 VC firms that actively invest in fintech & payments + biotech & life sciences at the Series B stage, with check sizes ranging from $100K – $5000M (median: $7.8M – $7.8M). As of June 2026, and 94% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Balderton Capital Balderton Capital backs European-founded technology companies with visionary founders building transformative businesses. The firm combines patient capital, operational expertise, and founder support to enable European entrepreneurs to build world-class companies. | $500K – $15M | 197 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Spark Capital Spark Capital backs transformative products built by creators with genuine vision and technical depth. We believe that the best way to evaluate a founding team is not through credentials or market analysis, but by experiencing their product firsthand. Product comes first, and everything else follows. | $500K – $60M | 60 | Both | Active | ~2 wks | Open |
| 3 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 4 | ▶ Founders Fund Back revolutionary technologies and visionary founders who think in first principles. We invest across all stages when conviction exists, providing patient capital and board-level partnership to founders building consequential companies that reshape industries. San Francisco | $500K – $50M | 33 | Leads | Active | ~2 wks | Req'd |
| 5 | ▶ iGlobe Partners Unearth, invest and grow startups into global leaders. iGlobe targets game-changing innovations at the frontier of deep tech — semiconductors, AI, quantum computing, and biotech — with a global orientation and a Singapore hub. Founded by Soo Boon Koh, Singapore's first female VC, the firm brings 25+ years of cross-border investing expertise and a top-quartile performance record. Singapore | $1M – $15M | 49 | Both | Active | ~2 mo | Open |
| 6 | ▶ Tribe Capital Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access). Menlo Park | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 7 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 53 | Leads | Active | ~2 mo | Open |
| 8 | ▶ Wing Venture Capital The AI-first transformation of business will be as big as digital, mobile, and cloud combined. We invest in companies building the AI-first technology stack: data foundations, AI tools, autonomous applications, and product-led growth companies that accelerate adoption. Founders building at any layer of this stack can reach goals and uncover opportunities previously unattainable. Palo Alto | $200K – $20M | 36 | Leads | Active | ~2 wks | Open |
| 9 | ▶ B Capital Group Back extraordinary entrepreneurs throughout the company-building lifecycle from seed to IPO. Combine venture capital expertise with BCG management consulting to accelerate value creation. Support founders with capital, strategic guidance, and access to global networks. San Francisco | $250K – $50M | 34 | Leads | Active | ~2 wks | Req'd |
| 10 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 11 | ▶ Innovating Capital Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support. New York | $250K – $5M | 38 | Leads | Active | ~1 mo | Open |
| 12 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 13 | ▶ F-Prime Capital Partner with visionary founders to turn bold ambitions into world-changing breakthroughs in life sciences, technology, healthtech, and crypto. Distinctive 'technical-risk-yes, regulatory-risk-no' filter ensures clear pathways to success. Cambridge | $250K – $15M | 26 | Leads | Active | ~1 wk | Open |
| 14 | ▶ Binance Labs Support visionary founders building transformative technologies across blockchain, AI, and biotechnology. Provide capital, technical resources, and access to Binance's 300M+ user base and infrastructure. Partner for long-term value creation with founder-centric approach. Cayman Islands | $100K – $5M | 24 | Both | Active | ~2 wks | Open |
| 15 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 16 | ▶ GV (Google Ventures) GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI. San Francisco | $500K – $50M | 30 | Both | Active | ~1 mo | Open |
| 17 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 18 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 19 | ▶ Moderne Ventures Generalist investors with vertical expertise. We invest in bold, broad, multi-vertical technology companies applicable to multi-trillion dollar industries (real estate, finance, insurance, sustainability). Our distinctive Moderne Passport program creates value by connecting 1,500+ corporate executives with portfolio companies, generating customers, strategic partnerships, and operational guidance. Chicago | $2M – $25M | 21 | Leads | Active | ~2 wks | Req'd |
| 20 | ▶ Anthem Venture Partners Identify exceptional founders and unique talent combinations building contrarian, under-the-radar technology solutions. Provide hands-on support, operational guidance, and board-level involvement to early-stage Series A and B companies, primarily in Southern California. We fight for our founders and expect all investments to succeed. Santa Monica | $1M – $5M | 12 | Leads | Active | ~2 wks | Open |
| 21 | ▶ K5 Global K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships. Los Angeles | $1M – $3M | 34 | Leads | Active | ~1 mo | Open |
| 22 | ▶ Korea Investment Management Co. Back the global winners of tomorrow through disciplined venture capital and growth equity investing. We are a trustworthy partner providing capital, operational expertise, and access to pan-Asian networks. Fund-oriented professional VC with fundamental philosophy of quality, responsibility, and stability. | $500K – $100M | 25 | Leads | Active | ~1 mo | Open |
| 23 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 30 | Leads | Active | ~1 mo | Req'd |
| 24 | ▶ Valia Ventures We back technically ambitious founders building tomorrow's most iconic companies in frontier sectors like AI, hardtech, robotics, healthcare, and fintech. We believe great companies come from founders willing to tackle complex problems that generalist funds avoid. New York | $250K – $1.5M | 16 | Leads | Active | ~2 wks | Req'd |
| 25 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 26 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 27 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 28 | ▶ New Enterprise Associates (NEA) NEA partners with ambitious founders at every stage of company building, from pre-seed through IPO. They invest at the intersection of technology and healthcare, believing the most transformational innovation occurs where deep domain expertise meets world-class technical founders. NEA serves as both capital provider and active operator. Menlo Park | $1M – $50M | 21 | Both | Active | ~2 mo | Open |
| 29 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 41 | Both | Active | ~2 mo | Req'd |
| 30 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 31 | ▶ Sawari Ventures North Africa and Africa possess tremendous entrepreneurial talent. Strategic capital combined with operational expertise can unlock transformative solutions that reshape industries. We invest in founders solving region-critical problems. Cairo | $200K – $2M | 20 | Leads | Active | ~1 mo | Open |
| 32 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 33 | ▶ Human Capital Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise. San Francisco | $250K – $200M | 25 | Both | Active | ~1 wk | Open |
| 34 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 35 | ▶ Battery Ventures Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools. Boston | $1M – $500M | 23 | Both | Active | ~2 wks | Open |
| 36 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 37 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 38 | ▶ Argonautic Ventures AI is a milestone in data maturity progression, not a product category. Argonautic invests in founders building data-centric solutions across infrastructure (horizontal) and vertical markets. Multi-fund structure allows pre-seed to Series B deployment with unified thesis: recognizing verticals at different data adoption stages and deploying capital to those crossing inflection points into AI operationalization. | $250K – $1M | 7 | Both | Active | ~2 wks | Open |
| 39 | ▶ Greenoaks Greenoaks backs generation-defining technology companies with exceptional long-term growth potential. We make concentrated, large initial bets and maintain positions through multiple rounds and public markets, believing that exceptional founders and products deserve exceptional partnership. San Francisco | $25M – $75M | 20 | Both | Active | ~2 mo | Req'd |
| 40 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 41 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 42 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 43 | ▶ Not Boring Capital Invest in companies with compelling stories to tell. We couple capital deployment with media storytelling through the Not Boring newsletter, creating a unique flywheel that amplifies both company and fund narrative. New York | $100K – $2M | 9 | Both | Active | ~2 wks | Req'd |
| 44 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 45 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 46 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 47 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 47 VC firms that actively invest in fintech & payments + biotech & life sciences at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b fintech & payments + biotech & life sciences investors is $7.8M – $7.8M, with a full range from $100K – $5000M. The distribution breaks down as: 1 firms in the <$500K range, 5 firms in the $500K-$1M range, 2 firms in the $1M-$2M range, 9 firms in the $2M-$5M range, 8 firms in the $5M-$10M range, 22 firms in the $10M+ range.
Among the 47 firms tracked, 94% lead or co-lead rounds, and 6% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b fintech & payments + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 28% prefer warm introductions, and the average firm has 35 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.