9 VC firms investing in healthcare & digital health and legal & regtech at the Series B stage.
F4 Fund tracks 9 VC firms that actively invest in healthcare & digital health + legal & regtech at the Series B stage, with check sizes ranging from $100K – $60M (median: $26M – $26M). As of July 2026, and 89% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,518+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Makers Fund Backing builders of the future of interactive entertainment. We invest across games, content, platforms, and ecosystem technologies with conviction that visionary founders are driving transformation in how we play, watch, create, and live. | $500K – $5M | 158 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Activant Capital Partner with relentless founders through their most defining stages of growth, using an in-house Research team to underwrite and support commerce-infrastructure and AI-native technology companies. Greenwich, CT | $15M – $60M | 118 | Both | Active | — | — |
| 3 | ▶ Emergence Capital Emergence invests in early-stage B2B software companies that will define the next era of enterprise technology. Founded in 2003 as the original cloud/SaaS-focused VC firm, they have pioneered investing through technology transitions: horizontal SaaS (Salesforce, Zoom), vertical SaaS (Veeva, Doximity), and now AI-native services — companies that sell outcomes rather than software, powered by AI that compounds competitive advantage over time. San Francisco | $5M – $50M | 55 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Headline We invest in top founders everywhere building the next generation of technology companies. We provide capital, operational expertise, and a truly global platform to scale with hands-on support through specialized teams. | $2M – $50M | 51 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Redpoint Depth-first venture investing through mastery in specific domains. We partner with bold builders challenging industry conventions, backing founders with technical depth and conviction to build enduring $1B+ companies. Complete immersion creates enduring companies. Menlo Park | $500K – $50M | 18 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Left Lane Capital Invest in hyper-growth consumer and technology businesses with enduring customer relationships. Back founders challenging the status quo through digital transformation. Focus on companies with strong unit economics, loyal customer bases, and defensible competitive advantages in complex, regulation-heavy markets. Brooklyn | $5M – $50M | 42 | Both | Active | ~2 wks | Open |
| 7 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 8 | ▶ DCM Unconventional ideas shape progress. DCM looks for potential in the overlooked, applying first-principles thinking and concentrating deeply on a small cohort of companies each year rather than spreading capital thin, with a global (US/Asia-Pacific) perspective and local execution. Menlo Park | $2M – $25M | 19 | Leads | Active | — | Req'd |
| 9 | ▶ Hearst Ventures Strategic investments at the intersection of media, information, and technology, prioritizing businesses that benefit from Hearst operating expertise, distribution, and permanent capital. New York | $2M – $50M | 16 | Follows | Active | — | — |
What other stages do these firms also invest in?
Investors on this page also frequently invest in these sectors
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 9 VC firms that actively invest in healthcare & digital health + legal & regtech at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b healthcare & digital health + legal & regtech investors is $26M – $26M, with a full range from $100K – $60M. The distribution breaks down as: 1 firms in the $2M-$5M range, 1 firms in the $5M-$10M range, 7 firms in the $10M+ range.
Among the 9 firms tracked, 89% lead or co-lead rounds, and 11% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b healthcare & digital health + legal & regtech investors combine domain expertise with an active portfolio in the space. Among these firms, 14% prefer warm introductions, and the average firm has 58 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.