19 VC firms investing in hr tech & future of work and biotech & life sciences at the Pre-Seed stage.
F4 Fund tracks 19 VC firms that actively invest in hr tech & future of work + biotech & life sciences at the Pre-Seed stage, with check sizes ranging from $20K – $8M (median: $1.1M – $1.1M). As of August 2026, and 95% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,644+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Abstract Ventures Backing transformative founders building exceptional companies across all sectors San Francisco | $100K – $1M | 277 | Both | Active | N/A | N/A |
| 2 | ▶ Delight Ventures By entrepreneurs for entrepreneurs — backing bold founders creating societal value through AI-native vertical software, momentum-driven market shifts, and Japanese founders scaling to the US. Operates both as a direct investor and as a venture builder co-creating startups from scratch. Tokyo | $67K – $670K | 50 | Leads | Active | ~2 wks | Open |
| 3 | ▶ SoGal Ventures First women-led VC investing in underrepresented founders solving underserved problems in undercapitalized geographies. We capitalize on three biggest arbitrage opportunities: diversity of founders, geographic expansion beyond Silicon Valley, and problems with meaningful social impact. We back exceptional teams in consumer tech, digital health, and future of work sectors. New York | $250K – $2M | 17 | Leads | Active | ~2 wks | Open |
| 4 | ▶ EPIC Ventures EPIC Ventures backs early-stage technology companies building in the information economy, with a focus on enterprise SaaS, healthcare technology, cybersecurity, and future of work. The firm believes the best way to build lasting companies is through genuine partnership with founders — providing capital, strategic guidance, operational expertise, and deep network access. Founded in 1994, EPIC helped build the Utah tech ecosystem and continues to be the foundational VC of the Mountain West. Salt Lake City, UT | $500K – $5M | 71 | Leads | Active | ~1 mo | Open |
| 5 | ▶ Springbank Collective We invest in mission-critical infrastructure serving women and working families. Many essential systems have been dismissed as too complex or too human to solve, but technology and AI advances make transformation possible. This is a $1 trillion opportunity and generational economic growth driver. New York | $250K – $2M | 36 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Basis Set Ventures The best way to find and support AI companies is to be one ourselves. We back independent thinkers building real systems before consensus forms, partnering as radical learning partners from day one. Menlo Park | $250K – $3M | 29 | Leads | Active | ~2 wks | Open |
| 7 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 55 | Both | Active | ~1 mo | Open |
| 8 | ▶ Frst All you need is a Unique Insight. Frst backs exceptional, ambitious founders on Day One, often before there is a product, team, or incorporated company, evaluating opportunities through Ambition, Vision, and Execution. Paris | $1M – $3M | 37 | Leads | Active | ~1 wk | N/A |
| 9 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 10 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 30 | Leads | Active | N/A | N/A |
| 11 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 12 | ▶ Firstpick VC First-check VC backing Baltic founders (Lithuania, Latvia, Estonia) at inception and pre-seed stages, with a strong focus on AI-first software. Backs founders who don't fit traditional VC criteria—no FAANG background or Ivy League degree required. Seeks undervalued talent before mainstream investor recognition. Vilnius, Lithuania | $100K – $500K | 42 | Leads | Active | ~1 wk | Open |
| 13 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 14 | ▶ Xeed Ventures Partner with exceptional founders to build rocketships, focusing on enterprise, B2B, and fintech categories, with capital, strategic insight, and network access. Bengaluru, India | $250K – $2M | 22 | Follows | Active | N/A | Req'd |
| 15 | ▶ 500 Global Global venture capital that invests where talent is abundant but capital and opportunity are not. 500 Global backs technology founders with global ambitions across underinvested, fast-growing markets using Silicon Valley expertise combined with deep local knowledge. Core belief: The best founders and innovation emerge globally, not just Silicon Valley. San Francisco | $100K – $1M | 18 | Both | Active | ~2 wks | Open |
| 16 | ▶ Picus Capital Empowering entrepreneurs to reimagine the way we live and work by investing in daring technology companies challenging the status quo with permanent capital, lifelong sparring partnership from pre-seed through IPO and beyond. Munich | $100K – $5M | 24 | Leads | Active | ~1 mo | Open |
| 17 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 18 | ▶ Praetura Ventures Praetura backs ambitious northern founders building software, health, life sciences, fintech, cybersecurity, robotics, and other high-growth businesses where operator support and regional conviction matter. The firm positions itself as a more-than-money investor and emphasizes practical support from experienced operators, not just capital. Manchester, United Kingdom | $200K – $8M | 16 | Both | Active | N/A | Open |
| 19 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
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F4 Fund tracks 19 VC firms that actively invest in hr tech & future of work + biotech & life sciences at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed hr tech & future of work + biotech & life sciences investors is $1.1M – $1.1M, with a full range from $20K – $8M. The distribution breaks down as: 4 firms in the <$500K range, 3 firms in the $500K-$1M range, 6 firms in the $1M-$2M range, 6 firms in the $2M-$5M range.
Among the 19 firms tracked, 95% lead or co-lead rounds, and 5% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed hr tech & future of work + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 19% prefer warm introductions, and the average firm has 49 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.