14 VC firms investing in hr tech & future of work and biotech & life sciences at the Seed stage.
F4 Fund tracks 14 VC firms that actively invest in hr tech & future of work + biotech & life sciences at the Seed stage, with check sizes ranging from $20K – $5M (median: $1.1M – $1.1M). As of June 2026, and 93% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Abstract Ventures Backing transformative founders building exceptional companies across all sectors San Francisco | $100K – $1M | 275 | Both | Active | — | — |
| 2 | ▶ Osage Venture Partners Disruptive innovation in work and education fuels human achievement. We partner with exceptional entrepreneurs who are business builders, deep domain experts, and capital efficient thinkers. We believe in long-term relationships over transactional investing, often partnering with founders across multiple ventures. Pittsburgh | $1M – $5M | 71 | Leads | Active | ~1 mo | Open |
| 3 | ▶ EPIC Ventures EPIC Ventures backs early-stage technology companies building in the information economy, with a focus on enterprise SaaS, healthcare technology, cybersecurity, and future of work. The firm believes the best way to build lasting companies is through genuine partnership with founders — providing capital, strategic guidance, operational expertise, and deep network access. Founded in 1994, EPIC helped build the Utah tech ecosystem and continues to be the foundational VC of the Mountain West. Salt Lake City, UT | $500K – $5M | 70 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Springbank Collective We invest in mission-critical infrastructure serving women and working families. Many essential systems have been dismissed as too complex or too human to solve, but technology and AI advances make transformation possible. This is a $1 trillion opportunity and generational economic growth driver. New York | $250K – $2M | 36 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Basis Set Ventures The best way to find and support AI companies is to be one ourselves. We back independent thinkers building real systems before consensus forms, partnering as radical learning partners from day one. Menlo Park | $250K – $3M | 27 | Leads | Active | ~2 wks | Open |
| 6 | ▶ SoGal Ventures First women-led VC investing in underrepresented founders solving underserved problems in undercapitalized geographies. We capitalize on three biggest arbitrage opportunities: diversity of founders, geographic expansion beyond Silicon Valley, and problems with meaningful social impact. We back exceptional teams in consumer tech, digital health, and future of work sectors. New York | $250K – $2M | 16 | Leads | Active | ~2 wks | Open |
| 7 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 55 | Both | Active | ~1 mo | Open |
| 8 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 9 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 10 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 28 | Leads | Active | — | — |
| 11 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 12 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 13 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
| 14 | ▶ Sher Ventures Exceptional founders applying unique talents and backgrounds to produce disruptive and differentiated products and services. Minimum $500K ARR at entry. Generalist across AI, B2B SaaS, logistics, healthcare, and advanced manufacturing. Sugar Land, TX | $25K – $100K | 4 | Follows | Active | ~1 mo | Open |
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Firms that frequently co-invest with investors on this page
F4 Fund tracks 14 VC firms that actively invest in hr tech & future of work + biotech & life sciences at the Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for seed hr tech & future of work + biotech & life sciences investors is $1.1M – $1.1M, with a full range from $20K – $5M. The distribution breaks down as: 3 firms in the <$500K range, 2 firms in the $500K-$1M range, 5 firms in the $1M-$2M range, 4 firms in the $2M-$5M range.
Among the 14 firms tracked, 93% lead or co-lead rounds, and 7% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best seed hr tech & future of work + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 17% prefer warm introductions, and the average firm has 56 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.