7 VC firms investing in media & entertainment and biotech & life sciences at the Series B stage.
F4 Fund tracks 7 VC firms that actively invest in media & entertainment + biotech & life sciences at the Series B stage, with check sizes ranging from $100K – $2000M (median: $2.6M – $2.6M). As of July 2026, and 86% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,477+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 2 | ▶ Korea Investment Partners Korea Investment Partners backs global winners across early to growth stages, combining capital with operating support and cross-border expansion help. Seoul | $2M – $3M | 19 | Both | Active | ~2 mo | Req'd |
| 3 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 4 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 5 | ▶ HongShan Back transformative entrepreneurs building category-defining companies across technology, healthcare, and consumer sectors, from seed to buyout. Partner with founders throughout the full company lifecycle with capital, operational support, and the network built over 20 years of China and global investing. Hong Kong | $500K – $2000M | 20 | Leads | Active | ~1 mo | Req'd |
| 6 | ▶ Sky9 Capital Sky9 backs technical founders building category-defining companies across AI, consumer internet, fintech, deep tech, and biotech. The firm uses a cross-border platform and direct partner involvement to help companies scale from the earliest stages into international growth. San Francisco | $250K – $5M | 9 | Leads | Active | ~2 wks | Req'd |
| 7 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 7 VC firms that actively invest in media & entertainment + biotech & life sciences at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b media & entertainment + biotech & life sciences investors is $2.6M – $2.6M, with a full range from $100K – $2000M. The distribution breaks down as: 1 firms in the <$500K range, 1 firms in the $500K-$1M range, 2 firms in the $2M-$5M range, 3 firms in the $10M+ range.
Among the 7 firms tracked, 86% lead or co-lead rounds, and 14% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b media & entertainment + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 57% prefer warm introductions, and the average firm has 31 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.