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#90 · Top 100 · 2026

Gradient Ventures

gradient.ventures · San Francisco, CA

“Artificial intelligence will reshape every industry. We partner with technical founders building the next generation of AI applications, infrastructure, and tools across every layer of the AI stack.”

$750K – $25M
Check Size
Leads
Lead Tendency
$2B
AUM
~1 Month
Timeline
01Investment Thesis

Artificial intelligence will reshape every industry. We partner with technical founders building the next generation of AI applications, infrastructure, and tools across every layer of the AI stack.

Exclusion Criteria

Generic AI applications without defensible differentiation, hardware-only plays, consumer apps with unclear monetization, teams without deep technical leadership

02Investment Team
DS
Darian Shirazi
General Partner
ZB
Zach Bratun-Glennon
General Partner
AB
Andrew Brackin
Partner
03F4 Research Brief

Gradient Ventures Research

Investment Thesis

Gradient Ventures is Google's (now Alphabet's) AI-focused venture capital fund that has evolved into an independent investment entity as of October 2025. The fund's core thesis centers on backing founders building the next generation of AI applications, infrastructure, and tools. The fund believes that artificial intelligence will reshape every industry and that early-stage AI startups require not just capital but deep technical expertise and access to cutting-edge infrastructure.

Originally launched by Google in 2017 as a corporate venture vehicle, Gradient Ventures spun out from Google in October 2025 to better compete independently in the rapidly evolving early-stage AI market. The spinout reflects a strategic decision to move faster and avoid perception conflicts with founders concerned about having a major tech competitor on their cap table.

Sector and Technology Focus

Gradient Ventures invests across every layer of the AI stack, with particular emphasis on:

AI Applications & Infrastructure:

  • Generative AI applications (LLMs, writing platforms, content generation)
  • AI-powered workflow automation and business process automation
  • Machine learning platforms and tools for developers
  • AI infrastructure and GPU cloud platforms
  • Data infrastructure and databases optimized for AI workloads
  • Observability, monitoring, and governance tools for AI systems

Vertical AI Applications:

  • Healthcare and life sciences (medical imaging AI, drug discovery, clinical workflows)
  • Financial services (fintech, insurance, wealth management)
  • Legal tech and document automation
  • Sales and revenue operations automation
  • Enterprise software with AI-native architectures
  • Consumer AI applications

Developer Tools and Enablement:

  • Low-code/no-code AI application builders
  • Open-source AI frameworks and libraries
  • API platforms for AI integrations
  • AI agent infrastructure and agentic AI frameworks

The fund has demonstrated particular strength in AI infrastructure investments, with notable wins including Lambda Labs (GPU cloud), Streamlit (acquired by Snowflake), and CentML (acquired by NVIDIA).

Investment Stage and Check Sizes

Stage Focus: Seed and Series A, with selective pre-seed investments for exceptional founders

Typical Check Sizes:

  • Pre-Seed: $750K - $2.5M
  • Seed: $1M - $5M (average $5.26M based on market data)
  • Series A: $5M - $25M (participating but less frequently leading)

Overall Range: $1M - $30M per investment, with the fund maintaining flexibility to go outside these ranges for compelling opportunities.

The fund has completed approximately 250+ investments across its portfolio life, with 99 investments at seed stage and 53 at Series A stage.

Lead Tendency and Decision Process

Lead Pattern: Gradient Ventures typically leads or co-leads early-stage rounds. Analysis of their portfolio shows a strong lead tendency at seed stage, particularly for AI infrastructure and platform companies.

Decision Process: Partnership-driven with a team of general partners and operating partners who bring deep technical and domain expertise.

Decision Timeline: 3-6 weeks typical for seed-stage decisions

Warm Introduction: Not strictly required but preferred.

Recent Activity and Fund Status

Current Fund: Gradient Fund V, raising $200M (as of mid-2025)

Fund Status: Actively deploying with strong momentum. Recent investments in 2025 include Sapiom, Ditto, Mastra, Anchor, and Hostie.

Notable Exits:

  • Streamlit → Snowflake (acquisition)
  • CentML → NVIDIA (acquisition)
  • Prepared → Axon (acquisition)
  • Astro → Cloudflare (acquisition)
  • Reclaim.ai → Dropbox (acquisition)
  • And 20+ other successful exits

Last Known Activity: February 2026 (continuous active deal flow)

Team

The team consists of experienced AI investors and operators, including:

  • Darian Shirazi (General Partner) - Former Google executive
  • Zach Bratun-Glennon (General Partner) - Technical founder background
  • Seven additional partners with deep AI infrastructure and domain expertise

Notably technical team with many partners having direct engineering or founder experience.

Geographic Focus

Primary markets: United States (SF Bay Area, NYC, Seattle) Secondary markets: Selected international for AI-focused companies

Founder Preferences

Gradient Ventures seeks:

  • Technical founders with deep AI/ML expertise
  • Experienced founders with track record at scale
  • Clear problem definition in AI infrastructure or applications
  • Strong execution capability and shipping track record
  • Domain expertise in their target vertical

Market Position

Positioned as the premier seed and Series A investor for founders building at every layer of the AI stack. Recently spun out from Google to move independently and faster without CVC constraints. Maintains strong portfolio network of 250+ companies and successful exit history.

04Selected Portfolio
Biotech & Life Sciences
Cambrium·Cascade·Helical
Crypto & Web3
Mural·Conduit Pay
Developer Tools & Infrastructure
Streamlit·Back·Nango
E-commerce & Marketplaces
Cake
EdTech
Elsa
Enterprise Software
Writer·Lambda·CentML·Labelbox·Unit21·Stack AI·Clarify·Gigs·Airspace Intelligence·Syrup·Algorithmia·Anvil·Arrows·Astro·BackOps·Botkeeper·Cerebrium·Chili Piper·Collective·Concierge AI·CTGT·Linkup·Mastra·Fazeshift·Malachyte·Credible Data·Respan·Layers·Arga Labs
Fintech & Payments
Range·Arva
Gaming
Arrow
Healthcare & Digital Health
Rad AI·OURA·Enzo Health·Vera Health
HR Tech & Future of Work
Sona·AllyO·Benepass
Insurance
Openly
Legal & Regtech
CaseMark
Media & Entertainment
Krea·Anchor·Boxo
Security & Cybersecurity
Backline·Quantro Security
Other
Prepared·Vijil·Flashfile·Aqua·Charm·Digitail
Open the full portfolio→
05Recent Updates

Fresh signals from public announcements, essays, and portfolio activity.

See full activity (12) →
Participated in Fazeshift's $17M Series A for AI-powered accounts receivable automation.
INVESTMENT·news.crunchbase.com
MAY 7, 2026
Portfolio company Enzo Health announced $26M total funding, including a $20M Series A led by N47 and participation from Gradient.
INVESTMENT·gradient.com
MAY 4, 2026
Participated in Helical's $10M seed round for a virtual AI lab serving pharma R&D.
INVESTMENT·globenewswire.com
APR 14, 2026
Portfolio company Mastra raised a $22M Series A led by Spark Capital.
INVESTMENT·app.dealroom.co+1
APR 9, 2026
Gradient Ventures raised $200M for its fifth fund, as shown in an SEC regulatory filing.
NEW FUND·globalventuring.com
MAR 17, 2026
06Frequent co-investors
LC
Leblon Capital
Both backed 5 of the same companies
Cambrium, Arrows, Gigs, Sona,
+1 moreLinkup
SC
Script Capital
Both backed 4 of the same companies
Anvil, Unit21, Collective, Mastra
2V
2468 Ventures
Both backed 3 of the same companies
Writer, OURA, Lambda
BC
BAG Collective
Both backed 3 of the same companies
Syrup, Sona, Lambda
BC
B Capital Group
Both backed 3 of the same companies
Writer, Labelbox, Lambda
Find the investors for your round→
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Quick Reference
Check Size
$750K – $25M
Stages
Pre-Seed · Seed · Series A
AUM
$2B
Decision
Partnership · ~1 Month
Warm Intro
Not Required
Involvement
Board Seat
Location
San Francisco, CA
Sector Focus
Fintech & PaymentsBiotech & Life SciencesLogistics & Supply ChainRobotics & AutomationEnterprise SoftwareDeveloper Tools & InfrastructureSecurity & CybersecurityHealthcare & Digital Health
Models
AI ApplicationsAI InfrastructureDeveloper ToolsLLM ApplicationsVertical SaaSAI AgentsOpen Source AI Infrastructure
Technology
AI/MLLLMGenerative AIComputer VisionAI InfrastructureAgentic AISmall ModelsHybrid ComputeRobotics AIBiology AI
See all Fintech & Payments investors →See all Biotech & Life Sciences investors →See all Logistics & Supply Chain investors →
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Focus Areas
Fintech & PaymentsBiotech & Life SciencesLogistics & Supply ChainRobotics & AutomationEnterprise SoftwareDeveloper Tools & InfrastructureSecurity & CybersecurityHealthcare & Digital Health

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F4 Intelligence Report · Last Researched September 9, 2026F4 Research Engine