Offscript

Offscript is a Boston-based, founder-first generalist seed fund launched in 2025 by Giuseppe Stuto, who is also co-founder and managing partner of 186 Ventures (a $37M pre-seed and seed fund whose portfolio is described as fully built and now being maintained). Its first vehicle, Offscript I, LP, filed a Form D in February 2026 (a Delaware venture capital fund at 867 Boylston Street, Boston), and a third-party profile reports the first fund closed in April 2026. Fund size is not confirmed in sources I could read; one deal-tracker lists an Offscript SPV raising $7.7M, which may be a separate vehicle.

Investment Thesis

The firm's public site is a minimal, narrative-themed page (Prologue, Narrators, Write Us). Its tagline is "Backing the ones the world writes off." The prologue says the best founders are written off for refusing to stay inside the margins, that protagonists are often misunderstood and doubted before they are quoted, that chapters take time to write, and that the best stories never follow a script. LinkedIn describes it as a thoughtful investor in unconventional narratives that invests before the first draft and supports founders until they become a classic. In practice this means founders with unconventional backgrounds and high agency who challenge conventional paths, rather than a specific sector thesis.

Stage Focus and Check Size

Seed stage, with some sources saying pre-seed to seed. Directory data (Massinvestor) says initial checks typically run $100K to $200K, and LinkedIn describes $100K to $200K checks into early-stage startups. The firm has also followed on in later rounds, appearing in a $10M Series A and a $50M Series B as a participant.

Sectors

Generalist. Directories list AI/ML, healthcare and biotech, fintech, enterprise SaaS and consumer. The visible portfolio skews to digital health and AI-enabled health or biotech tooling.

Lead Tendency

No evidence of leading rounds. In both public rounds found, the firm is named as a participant behind other leads (Bessemer led Flagler Health; Will Ventures led Throne Science). Given $100K to $200K checks, it is most likely a small-check participant or a first-check investor rather than a lead. Marked unknown to stay conservative.

Recent Activity and Portfolio

Flagler Health (NYC, AI-native operating system for musculoskeletal care): $50M Series B announced August 2026, led by Bessemer Venture Partners with SignalFire, Alumni Ventures, Streamlined, 186 Ventures, Proof VC, Tribeca Venture Partners and Offscript participating. Total raised $63M.
Throne Science (Austin, TX, smart toilet sensor using computer vision and AI): $10M Series A announced July 2026, led by Will Ventures with Offscript, V1.VC and Morrison Seger. Total funding about $18M.
LiteFold (Bengaluru, AI-assisted drug discovery infrastructure): listed as having raised from Offscript VC on the 3F portfolio page; round details not confirmed.

The site itself has no portfolio page, so the portfolio list comes from external announcements and is likely incomplete for a fund that is under a year old.

Team

Giuseppe Stuto, General Partner: co-founder and managing partner of 186 Ventures (Nov 2018 to present), a DraftKings alumnus who helped lead the launch of 186 and got its first fund started in under six months; earlier a founder and CEO of Fam (acquired) and an operator who grew teams at fast-growing startups. Sophie Panarese and Sean Robins are listed as partners; the site shows only names and sketch portraits, and I did not find verified bios.

Decision Process

Not documented. The small team and generalist, founder-first framing suggest a partnership that moves quickly, with Stuto as the senior decision-maker. Treated as partnership with low confidence.

Founder Preferences

High-agency founders with non-traditional paths, who have been doubted or overlooked, and who are early enough to be "before the first draft." The Write Us page is the stated route for approaching the firm; a warm intro through Boston ecosystem contacts or through 186 Ventures portfolio founders would likely help but is not required by anything I found.

Geographic Focus

Boston-headquartered. Portfolio spans New York, Austin and Bengaluru, so geography appears open. No stated geographic restriction.

Gaps

Fund size, exact check range confirmation from the firm itself, bios for Panarese and Robins, a full portfolio list, and lead behavior are all unverified. Re-run research as the firm publishes more.