11 VC firms investing in biotech & life sciences and legal & regtech at the Series A stage.
F4 Fund tracks 11 VC firms that actively invest in biotech & life sciences + legal & regtech at the Series A stage, with check sizes ranging from $100K – $50M (median: $6M – $6M). As of August 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,698+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ AME Cloud Ventures Data, cloud, and hardware advances will create unprecedented opportunities for great companies to be built. We invest in founders with big ideas and deep tech who are building infrastructure and value chains around data. Great people are the key to company success. We provide operational expertise, strategic guidance, and access to networks of mentors and international partners, particularly in China and Asia-Pacific. Palo Alto | $5M – $50M | 30 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Accel Partner with exceptional teams building transformative technology companies across all stages San Francisco | $2M – $10M | 136 | Both | Active | N/A | N/A |
| 3 | ▶ Moxxie Ventures Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building. San Francisco | $500K – $2M | 60 | Leads | Active | ~2 wks | Open |
| 4 | ▶ Future Communities Capital Empowering founders to transform legacy industries: government, healthcare, finance, and real estate. Berkeley | $250K – $3.2M | 15 | Both | Active | N/A | N/A |
| 5 | ▶ Valhalla Ventures We partner with visionaries building enduring moats in deeptech and gaming. We invest up to $12M from inception to Seed. We restore the original essence of venture capital - working directly with bold entrepreneurs to tackle the world's toughest challenges through breakthrough physical technologies and novel gaming experiences. | $500K – $12M | 14 | Leads | Active | ~2 wks | Req'd |
| 6 | ▶ 8VC Partner with elite founders building transformational technologies that create lasting economic and societal value. Focus on Smart Enterprise across five sectors: Logistics, Life Sciences, Healthcare, IT Infrastructure, and Government/Defense. Invest in platforms that enable human experts to solve non-linear problems through data integration and network effects. Austin | $500K – $50M | 36 | Leads | Active | ~2 wks | Open |
| 7 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 8 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 9 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 23 | Leads | Active | ~2 wks | Req'd |
| 10 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 61 | Leads | Active | ~1 mo | Open |
| 11 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 11 VC firms that actively invest in biotech & life sciences + legal & regtech at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a biotech & life sciences + legal & regtech investors is $6M – $6M, with a full range from $100K – $50M. The distribution breaks down as: 2 firms in the $1M-$2M range, 2 firms in the $2M-$5M range, 4 firms in the $5M-$10M range, 3 firms in the $10M+ range.
Among the 11 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a biotech & life sciences + legal & regtech investors combine domain expertise with an active portfolio in the space. Among these firms, 33% prefer warm introductions, and the average firm has 48 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.