F4 Champions · Season 1
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F4 Champions · Season 1
You're researching investors. We want to see what you're building.
Join the open accelerator where your standing changes with what you ship. Enrollment closes August 2.
42 VC firms investing in biotech & life sciences and semiconductors & hardware at the Series B stage.
F4 Fund tracks 42 VC firms that actively invest in biotech & life sciences + semiconductors & hardware at the Series B stage, with check sizes ranging from $100K – $100000M (median: $8.8M – $8.8M). As of July 2026, and 93% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,544+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Baruch Future Ventures (BFV) Climate restoration through identification and scaling of 'n of 1' technology opportunities combining innovative tech, viable business models, and visionary leadership. Focus on achieving $1B+ valuations in <10 years with 'scale and speed' mentality. Menlo Park | $250K – $10M | 36 | Leads | Active | ~2 mo | Open |
| 2 | ▶ Founders Fund Back revolutionary technologies and visionary founders who think in first principles. We invest across all stages when conviction exists, providing patient capital and board-level partnership to founders building consequential companies that reshape industries. San Francisco | $500K – $50M | 33 | Leads | Active | ~2 wks | Req'd |
| 3 | ▶ iGlobe Partners Unearth, invest and grow startups into global leaders. iGlobe targets game-changing innovations at the frontier of deep tech — semiconductors, AI, quantum computing, and biotech — with a global orientation and a Singapore hub. Founded by Soo Boon Koh, Singapore's first female VC, the firm brings 25+ years of cross-border investing expertise and a top-quartile performance record. Singapore | $1M – $15M | 49 | Both | Active | ~2 mo | Open |
| 4 | ▶ Playground Global Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us. Palo Alto | $1M – $20M | 32 | Both | Active | 3+ mo | Req'd |
| 5 | ▶ Refactor Capital The most enduring companies are created by founders willing to commercialize real science and scale real systems. We focus on hard tech at the intersection of computation and physical sciences—aerospace, biotech, energy, materials—where technical execution is the moat. Burlingame, CA | $1M – $2M | 48 | Leads | Active | ~1 wk | Open |
| 6 | ▶ Tribe Capital Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access). Menlo Park | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 7 | ▶ DSC Investment DSC invests in paradigm-leading innovative entrepreneurs. The firm is strongest at early stage but open to all stages for teams with exceptional capability. Known for pioneering deep tech investments (AI, semiconductors, biotech) before they became mainstream, and for identifying unicorns years before public market recognition. Seoul | $1M – $30M | 22 | Both | Active | ~1 mo | N/A |
| 8 | ▶ LG Technology Ventures LGV backs early-stage and growth-stage innovators with the strategic strength of LG Group's global resources. The fund invests in companies that stand to gain exceptional value from partnerships with LG's manufacturing, display, chemical, and energy business units, with a strong focus on AI, biotech, cleantech, and advanced materials. Silicon Valley | $1M – $30M | 73 | Both | Active | ~2 mo | Open |
| 9 | ▶ Acequia Capital (AceCap) Acequia Capital partners with technical founders and product teams building the next wave of global businesses. They provide more than capital—experienced operators offer strategic guidance on product roadmap, technology strategy, business model, and GTM execution. The firm is a center of a global innovation ecosystem with unique capability to detect earliest signal in emerging technology trends. Seattle | $1M – $25M | 31 | Leads | Active | ~1 mo | Open |
| 10 | ▶ Tesi Tesi (Finnish Industry Investment Ltd) is a state-owned investment company that helps Finland's most promising companies grow bigger. Tesi invests on market terms as a minority co-investor alongside private capital in Finnish startups, scale-ups, and industrial projects, as well as in VC and PE funds. Its mandate is both financial returns and economic impact — driving growth, jobs, and renewal in the Finnish economy. Helsinki | $1M – $30M | 31 | Follows | Active | 3+ mo | Open |
| 11 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 12 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 54 | Leads | Active | ~2 mo | Open |
| 13 | ▶ Entrepreneur First It matters not only which companies get started, but who starts them. EF identifies exceptional individual talent before a company, co-founder, or idea exists, and builds the company from Day Zero through cohort-based co-founder matching, an equity-free grant phase, and up to $250K in formation capital (via SAFE) once a team passes its Investment Committee. London | $250K – $5M | 78 | Leads | Active | N/A | Open |
| 14 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 52 | Both | Active | ~2 mo | Open |
| 15 | ▶ NATO Innovation Fund NIF invests in cutting-edge science and engineering startups that strengthen the defence, security, and resilience of NATO Allied nations. Backed by 24 sovereign governments, NIF provides deep tech founders with unprecedented access to government procurement markets across 24 countries, connectivity to ~90 NATO-affiliated test centres, and 6,000+ Allied scientists. NIF leads initial investments with up to €15M and maintains substantial follow-on reserves. Amsterdam | $1M – $16.5M | 26 | Leads | Active | 3+ mo | Open |
| 16 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 17 | ▶ Baidu Ventures Back deep tech companies enabling AI at the infrastructure layer (chips, hardware, algorithms) and AI-powered applications previously impossible without AI — with a current focus on GenAI, embodied intelligence, autonomous driving, and healthcare AI. Leverage Baidu's unique resources: engineering talent, data annotation infrastructure, and ecosystem customer relationships. Beijing | $500K – $10M | 23 | Both | Active | N/A | N/A |
| 18 | ▶ Third Point Ventures Identifies technology transitions creating market opportunities, particularly AI/ML-powered automation transforming enterprise infrastructure. Current focus on AI security (Zenity, DataGrail, Grip Security), AI durability (Diagrid), and AI observability (Kentik) — the three pillars needed to bring AI from experimentation to production at scale. Menlo Park | $1M – $50M | 39 | Leads | Active | N/A | N/A |
| 19 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 20 | ▶ NVIDIA Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology. | $20M – $100000M | 37 | Both | Active | ~2 wks | Open |
| 21 | ▶ Korea Investment Partners Korea Investment Partners backs global winners across early to growth stages, combining capital with operating support and cross-border expansion help. Seoul | $2M – $3M | 19 | Both | Active | ~2 mo | Req'd |
| 22 | ▶ Anthem Venture Partners Identify exceptional founders and unique talent combinations building contrarian, under-the-radar technology solutions. Provide hands-on support, operational guidance, and board-level involvement to early-stage Series A and B companies, primarily in Southern California. We fight for our founders and expect all investments to succeed. Santa Monica | $1M – $5M | 12 | Leads | Active | ~2 wks | Open |
| 23 | ▶ Korea Investment Management Co. Back the global winners of tomorrow through disciplined venture capital and growth equity investing. We are a trustworthy partner providing capital, operational expertise, and access to pan-Asian networks. Fund-oriented professional VC with fundamental philosophy of quality, responsibility, and stability. | $500K – $100M | 25 | Leads | Active | ~1 mo | Open |
| 24 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 46 | Both | Active | ~2 mo | Req'd |
| 25 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 26 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 27 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 28 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 29 | ▶ Human Capital Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise. San Francisco | $250K – $200M | 25 | Both | Active | ~1 wk | Open |
| 30 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 18 | Leads | Active | ~2 wks | Req'd |
| 31 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 32 | ▶ Yu Galaxy Conviction-driven venture capital backing visionary founders solving humanity's toughest problems. Focus on impact measurement: profitability and positive societal impact are inseparable. Invests from seed through Series B with follow-on capacity through exit. | $500K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 33 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 25 | Leads | Active | ~2 mo | Open |
| 34 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 35 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 36 | ▶ Sutter Hill Ventures Build or back enduring technology companies solving hard technical problems in massive markets. SHV's origination model has them serve as Founding CEO of incubated companies — recruiting experts, handling operations, and letting technical founders focus purely on building. Identify large macro tech shifts (cloud, AI infrastructure, power for AI), recruit domain experts, build small focused teams until product-market fit, then scale rapidly with the full support of SHV's centralized operations team. Palo Alto | $500K – $50M | 19 | Leads | Active | ~2 mo | Req'd |
| 37 | ▶ Not Boring Capital Invest in companies with compelling stories to tell. We couple capital deployment with media storytelling through the Not Boring newsletter, creating a unique flywheel that amplifies both company and fund narrative. New York | $100K – $2M | 10 | Both | Active | ~2 wks | Req'd |
| 38 | ▶ Main Sequence Main Sequence backs deep tech founders solving humanity-scale problems, especially companies connected to publicly funded research and spinouts that can turn breakthrough science into global businesses. Eveleigh, NSW, Australia | $250K – $500K | 14 | Leads | Active | ~1 mo | N/A |
| 39 | ▶ HongShan Back transformative entrepreneurs building category-defining companies across technology, healthcare, and consumer sectors, from seed to buyout. Partner with founders throughout the full company lifecycle with capital, operational support, and the network built over 20 years of China and global investing. Hong Kong | $500K – $2000M | 20 | Leads | Active | ~1 mo | Req'd |
| 40 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 41 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 42 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 17 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 42 VC firms that actively invest in biotech & life sciences + semiconductors & hardware at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b biotech & life sciences + semiconductors & hardware investors is $8.8M – $8.8M, with a full range from $100K – $100000M. The distribution breaks down as: 1 firms in the <$500K range, 1 firms in the $500K-$1M range, 4 firms in the $1M-$2M range, 8 firms in the $2M-$5M range, 8 firms in the $5M-$10M range, 20 firms in the $10M+ range.
Among the 42 firms tracked, 93% lead or co-lead rounds, and 7% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b biotech & life sciences + semiconductors & hardware investors combine domain expertise with an active portfolio in the space. Among these firms, 26% prefer warm introductions, and the average firm has 34 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.