Top Biotech & Life Sciences + Semiconductors & Hardware Investors 2026

The breakthrough is the beginning. Partner with founders commercializing scientific and technological breakthroughs in biological platforms and applied robotics, helping them solve operational challenges to build durable, generational companies.

Climate restoration through identification and scaling of 'n of 1' technology opportunities combining innovative tech, viable business models, and visionary leadership. Focus on achieving $1B+ valuations in <10 years with 'scale and speed' mentality.

Backing transformative founders building exceptional companies across all sectors

Back dual-use technologies serving both commercial and government markets. Founded as investment community response to 9/11, we bring unmatched expertise from NSA, CIA, DARPA. We seek founders building innovative cyber, AI safety, and advanced technologies with meaningful impact on national security and commercial markets.

The most enduring companies are created by founders willing to commercialize real science and scale real systems. We focus on hard tech at the intersection of computation and physical sciences—aerospace, biotech, energy, materials—where technical execution is the moat.

Material science and deep tech innovations drive outsized returns while solving urgent human problems. We back inception-stage founders turning lab breakthroughs into commercial products that make the world cleaner, more productive, and healthier.

Investing in breakthrough deep technologies that address humanity's greatest challenges. We allocate ~80% to climate solutions (carbon-negative materials, renewable energy, climate adaptation) and ~20% to frontier tech (aerospace, robotics, advanced materials, biotech). We operate as a venture-and-philanthropy platform backed by the Fukutake family, blending profit-seeking with impact objectives.

Back revolutionary technologies and visionary founders who think in first principles. We invest across all stages when conviction exists, providing patient capital and board-level partnership to founders building consequential companies that reshape industries.

Unearth, invest and grow startups into global leaders. iGlobe targets game-changing innovations at the frontier of deep tech — semiconductors, AI, quantum computing, and biotech — with a global orientation and a Singapore hub. Founded by Soo Boon Koh, Singapore's first female VC, the firm brings 25+ years of cross-border investing expertise and a top-quartile performance record.

Backs deep-tech founders who pair technical ambition with decisive execution. Invests in frontier technologies before they become mainstream across aerospace/defense, healthcare, biotech, enterprise AI, and deep hardware. Active partner model — regulatory introductions, customer connections, and strategic guidance through all company phases.

Backing dynamically developing enterprises with global aspirations at seed and early stage across Internet/SaaS, IoT/Hardware, Renewable Energy Sources, and Life Science (MedTech/BioTech). 4-14 year investment horizon with a patient capital approach through multiple fund vehicles.

Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us.

The space economy represents the next frontier for transformative economic opportunity and meaningful impact. We back pioneering founders building the technologies and services that enable humanity's expansion into space while creating value on Earth. We apply financial discipline (Wall Street cash-flow and intrinsic-value approach) to identify sustainable, scalable space businesses.

Early-stage deep tech entrepreneurs developing novel, patented solutions to the world's biggest problems in robotics, quantum computing, energy, climate, and healthcare. We back visionary founders with deep domain expertise and engage as thought partners through technology validation and commercialization.

Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access).

We back 'sub-0.1% of the population' type exceptional founders building fundamental, infrastructure-level technologies in critical sectors (computing, defence, energy) reshaping our world. Community-driven approach provides proprietary deal flow and deep technical credibility. Focus on first cheques in pre-seed/seed with hands-on mentorship and network access.

We back MIT founders building deep-tech companies with defensible science or engineering advantages. We support the transition from researcher to founder, providing both capital ($500K-$5M) and operational support through the MIT ecosystem.

AI Eats Software. Over the next decade, virtually every bit of software will be replaced by artificial intelligence. We invest in founders and entrepreneurs who understand the transformational power of AI and are building solutions that reshape how we live, work, and play.

Impact and profit are inseparable. We back visionary founders solving humanity's toughest problems in healthcare, AI, robotics, defense, and automation. We measure success in lives saved as well as returns.

Intelligence is coming into the physical world through AI and robotics applied to atoms rather than bits. We back capex-heavy, long-horizon bets in hard-to-abate decarbonization sectors and hardware-heavy industrial systems that many traditional early-stage funds avoid.

Deep tech startups at the edge of what is possible solve critical human and planetary health problems. SOSV backs founders combining scientific rigor with entrepreneurial grit, providing not just capital but access to specialized labs, manufacturing, and global expertise networks.

Technology will define geopolitics. We invest in the Freedom Stack—foundational technologies critical to American national security and technological leadership. We partner with mission-driven founders building capabilities essential to American prosperity and strategic advantage.

Back outlier founders with unconventional ambition and deep-rooted urgency operating outside conventional wisdom. We believe the best companies are built by rare entrepreneurs who can filter out 95% of typical VC advice and construct exceptional talent and culture.

Invest in only two kinds of technologies: those that move humanity toward utopia, and those that hold the line against oblivion. Back n-of-1 visions for an era of Black Swans—unconventional companies solving civilization-scale problems that others dismiss as too early, too risky, or too misunderstood.

Acequia Capital partners with technical founders and product teams building the next wave of global businesses. They provide more than capital—experienced operators offer strategic guidance on product roadmap, technology strategy, business model, and GTM execution. The firm is a center of a global innovation ecosystem with unique capability to detect earliest signal in emerging technology trends.

Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology.

Invest in century-defining technologies and companies. Focus on infrastructure-oriented, cross-vertical applied AI for physical-world and life-science problems, with deep healthcare systems expertise. Transform industries through foundational technology breakthroughs.

Backing 'Venture Scientists' — PhD-trained technical founders applying rigorous scientific methodology to build transformative companies from fundamental research. Focus on deep tech and life sciences areas that address climate change, resource scarcity, and healthcare accessibility. Targets university spinouts and science-led startups in areas that are difficult to diligence for generalist investors.

We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products.

Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't.

Support passionate founders forging the future. Invest in seed and early-stage companies with unique ideas that have potential to reinvent entire industries. Focus on frontier technologies that make the world better and don't prey on human frailty.

Seed-stage deep technology with IP defensibility, deployed by multi-exit founder-operators willing to be hands-on operational partners. Focus on frontier sectors—defense, climate, space, biotech, fusion—where bold technical founders are building mission-critical capabilities.

Mayfield invests in founders building iconic companies through AI-first innovation and human-AI collaboration. The firm believes the next wave of category-defining enterprises will leverage collaborative intelligence, where AI teammates augment and amplify human capability. Mayfield seeks deep tech founders with defensible innovation, clear market advantage, and the ability to scale globally.

Frontier technologies and medical breakthroughs offer the best opportunities to address fundamental human and environmental challenges. Diversity of founder backgrounds drives innovation and superior returns. Founders with domain expertise, technical credentials, and distinctive visions solve the world's biggest problems.

Invest in brilliant founders building breakthrough technologies that can scale into transformational platforms. Focus on breakthrough applications of deep science, industrial new normal, and new infrastructure & tools across deeptech, biotech, advanced manufacturing, and critical infrastructure.

We invest in people who will transform the physical world. Near frontier technology solving climate change, disease, armed conflict, poverty, and existential risks. Technical founders building capital-intensive, long-horizon companies.

Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital.

Backing transformative startups with exceptional defensibility and civilization-level impact potential. Focus on technical complexity, defensible innovation, and companies solving large-scale problems. Quality over volume approach with selective, thesis-driven investing.

Story invests in the building blocks of automated systems across three interconnected layers: sensory systems (data capture), data processing (organization and structure), and machine intelligence (applications and decision-making). We believe the most impactful problems require the most innovative solutions, and we partner with founders pursuing audacious, challenging businesses because that's what it takes to create lasting impact.

Breakthrough technologies and materials that power every AI chip, quantum computer, robot, battery, solar panel, biotech solution, and space exploration tool. Back founders who move beyond conventional industry boundaries to build bedrock economic infrastructure.

We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders.

The most defensible companies are built on hard technology solving real problems at scale. We partner with technical founders leveraging deep domain expertise and the Tsinghua network to identify and nurture transformative innovations in deeptech, healthtech, and the data economy.

Humanizing deep tech by bringing advanced breakthrough technologies to where the people are and maximizing the value they generate for solving humanity's most critical crises. We invest in companies addressing climate, manufacturing labor shortages, healthcare costs, sustainable food production, and computing infrastructure.

Identify exceptional founders and unique talent combinations building contrarian, under-the-radar technology solutions. Provide hands-on support, operational guidance, and board-level involvement to early-stage Series A and B companies, primarily in Southern California. We fight for our founders and expect all investments to succeed.

We back outliers of the outliers - founders with unreasonable ambition who can filter out 95% of conventional VC advice. We seek category-defining companies aiming for $10B+ outcomes, not incremental improvements. Our conviction is deep, selective, and global. We don't meddle - we provide brutal honesty, talent upgrades, and capital for survival through near-death moments.

Prime Movers Lab partners with serial entrepreneurs building breakthrough scientific companies that tackle the world's biggest problems. We believe the best venture partners provide operational excellence, technical expertise, and hands-on support—not just capital. We invest in companies reinventing energy, transportation, infrastructure, manufacturing, human augmentation, and agriculture.

Back technical teams working on breakthrough products. We invest in seed stage companies that demonstrate technical differentiation - meaning technical or product-level superiority is a major reason for future success. We pursue investments from application layer (AI/ML) through software infrastructure to hardware layers (semiconductors, photonics).

We invest in the Super Evolution—the convergence of ubiquitous sensors, advanced machine learning, cloud systems, robotics, 3D printing, and CRISPR. We partner with technical founders solving hard engineering and science problems to rethink large industries and tackle humanity's most pressing challenges.

Back the global winners of tomorrow through disciplined venture capital and growth equity investing. We are a trustworthy partner providing capital, operational expertise, and access to pan-Asian networks. Fund-oriented professional VC with fundamental philosophy of quality, responsibility, and stability.

First check for deeptech founders building across all deeptech sectors (chips, energy, robotics, medtech, materials science, aerospace). We provide more than capital—we become your growth team, design your website, and offer hands-on go-to-market support backed by deep expertise in startup scaling and commercialization.

We back entrepreneurs using computational approaches (AI, simulation) to solve trillion-dollar problems in climate, health, industrial transformation, and national security. Deep tech requires patient capital and scientific rigor.

Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly.

AI-first venture capital firm investing in AI transformation and digital infrastructure across GenAI Infrastructure (AI chips, quantum, autonomous robotics), Deep Domains (fintech, healthcare, enterprise), and GenAI Agents (autonomous AI for real-world consumer and enterprise use).

Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector.

Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification.

Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era.

We partner with visionaries building enduring moats in deeptech and gaming. We invest up to $12M from inception to Seed. We restore the original essence of venture capital - working directly with bold entrepreneurs to tackle the world's toughest challenges through breakthrough physical technologies and novel gaming experiences.

We are professional fixers for complex situations. An extension of your team. Fierce defenders when you need us most. Partners who roll up their sleeves. We invest in early-stage companies helping them avoid traditional roadblocks on their path to hypergrowth. We specialize in navigating hostile situations, IP protection, and crisis management.

Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems.

Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise.

Celesta invests in brilliance at the forefront of science and engineering, targeting companies that enable mass adoption of emerging tech, radically improve health outcomes, and transform large industries. Focus on platforms enabling emerging tech adoption, bioconvergence innovations (high-tech + biotech), and technologies disrupting legacy industries with deep tech.

Exceptional founders backed at pre-seed and seed with both capital and hands-on operational support—talent, GTM, fundraising—build the most enduring companies. Pear is founder-first: founders-and-operators turned investors who have been in founders' shoes.

We back dropouts, renegade students, and deep-tech scientists working on ideas that would appear in science fiction. We exist to prove that great founders don't need university degrees and are found in the oddest places. We invest at inception stage (R&D through Seed), providing capital, mentorship, community access, and operational support. People-first approach: it's more about the who than the what.

Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind.

Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check.

Sierra believes enterprise software is being fundamentally transformed by cloud computing and AI. They invest in technical founders building the next generation of enterprise solutions that deliver superior ROI through better efficiency, automation, and capability. The firm particularly focuses on infrastructure, security, healthcare innovation, and emerging deep tech.

Deep Checks matches deeptech founders worldwide with venture capital investors who specialize in their specific technology niches. We operate as a specialized deal-flow curation platform connecting founders with 50+ deeptech VCs, angels, and founder-investors. Our mission is to democratize access to expert capital for scientific and hardware founders who are otherwise hard to reach.

Corporate-advantage seed investing. We identify promising AI and deep tech startups early, then leverage our hundreds of relationships with corporate venture capital arms to de-risk investments, accelerate time to exit, and create curated dealflow where both founders and corporates benefit from strategic alignment.

Breakthrough innovations emerge from engineers tackling frontier problems. We provide fast capital, domain expertise across AI/robotics/space/biotech, and deeptech credibility to pre-seed teams.

Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support.

We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history.

HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines.

Invest in bold, visionary founders building transformational businesses long before the world believes in them. We back founders solving impossible-seeming problems across frontier sectors: AI/robotics, crypto, biotech, aerospace, and unconventional ideas.

Back European technical founders building globally ambitious deeptech and critical technology companies at pre-seed and seed, with concentrated first-check conviction and Paris/San Francisco/Berlin support.

We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses.

Invest in companies with compelling stories to tell. We couple capital deployment with media storytelling through the Not Boring newsletter, creating a unique flywheel that amplifies both company and fund narrative.

A majority of the data our brains analyze is visual. Therefore, the majority of the data AI will analyze will also be visual, spanning the light and electromagnetic spectrums across all sectors. We thrive on collaborating with deep technical teams who leverage computer vision, machine learning and artificial intelligence to analyze visual data.

We invest in proven, transformative technologies that have the potential to be industry-defining while driving meaningful impact on the climate and environment. We partner with founders as active co-developers, not passive investors.

Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures.

Emerging hardware founders are overlooked by traditional VC. By combining capital with hands-on manufacturing expertise, infrastructure access, and operational support, we unlock value for founders building tech you can touch.

Leverage creator economy and influencer networks to add tangible value to early-stage companies. Invest in ambitious Gen Z founders building consumer products with high influencer marketing potential. Influencer partners actively support portfolio companies with marketing, business development, and strategic partnerships.

Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies.

Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics.

Invest in the most promising Southern European (primarily Italian) deep-technology companies across Advanced Manufacturing, Life Science, and Energy & Environment, and actively support their expansion into Asian markets (China, South Korea, Japan, South-East Asia). The fund uses a proprietary evaluation framework and a 'pull model' — companies must demonstrate genuine Asian market interest before investment.

Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders.

Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing.