48 VC firms investing in consumer apps & social and biotech & life sciences at the Series A stage.
F4 Fund tracks 48 VC firms that actively invest in consumer apps & social + biotech & life sciences at the Series A stage, with check sizes ranging from $30K – $500M (median: $2.6M – $2.6M). As of June 2026, and 85% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Able Partners Systematically back clinically rigorous, behaviorally grounded wellbeing startups tackling stigmatized areas—alcohol use disorder, menopause, mental health—using stigma as an investing edge and insisting on consumer-grade UX. Solve the Wellness Gap: the quantifiable delta that has grown as GDP per capita increased while physical and mental health stagnated. New York | $500K – $3M | 65 | Both | Active | ~1 wk | Open |
| 2 | ▶ Spark Capital Spark Capital backs transformative products built by creators with genuine vision and technical depth. We believe that the best way to evaluate a founding team is not through credentials or market analysis, but by experiencing their product firsthand. Product comes first, and everything else follows. | $500K – $60M | 60 | Both | Active | ~2 wks | Open |
| 3 | ▶ Atinum Investment Atinum Investment identifies and invests in companies solving fundamental problems through technology innovation and market disruption. The firm specializes in growth-stage startups and paradigm-shifting companies across diverse sectors. | $500K – $10M | 56 | Leads | Active | ~2 wks | Open |
| 4 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 5 | ▶ Shrug Capital Identifying culturally resonant, consumer-focused companies with differentiated products and founder teams that will capture global attention. We invest across technology, consumer behavior, entertainment, and culture—seeking to spot emerging trends before they reach mainstream awareness. We operate as a partnership combining rigorous deal selection with exceptional founder support, creative marketing, and deep understanding of consumer psychology. San Francisco | $500K – $2M | 114 | Both | Active | ~2 wks | Open |
| 6 | ▶ DBL Partners Top-tier venture capital returns alongside meaningful social, environmental, and economic impact — the Double Bottom Line — with no tradeoff. DBL invests in mission-driven founders across clean energy, agriculture, nature-based solutions, health, economic opportunity, mobility, and the space/Earth nexus. San Francisco | $2M – $50M | 46 | Leads | Active | ~2 mo | — |
| 7 | ▶ Madrona Venture Group Madrona invests in people and ideas for the long run — backing visionary founders building transformational technology companies, with deep focus on applied AI across domain-specific applications, AI infrastructure, developer tools, enterprise software, and AI-enabled biotech. The firm serves as an active, full-stack partner providing capital plus recruiting, business development, and customer introductions. Seattle | $500K – $50M | 45 | Leads | Active | ~1 mo | Open |
| 8 | ▶ Golden Seeds Gender-diverse teams produce superior returns on equity. We fund exceptional women-led startups where women hold meaningful operating C-suite roles and own substantial equity. Research shows companies with diverse female leadership are 39% more likely to be above-average profitable, 30% more likely to outperform, and 20% more likely to improve business outcomes. New York | $250K – $2M | 34 | Both | Active | ~1 mo | Open |
| 9 | ▶ Maple VC Canadians have built over $1 trillion in enterprise value globally, yet were initially backed by US VC not Canadian investors. We back founders with Canadian roots—regardless of where they build—because exceptional talent from Canada represents a sustainable, quantifiable selection edge. San Francisco | $500K – $1.5M | 46 | Follows | Active | ~2 wks | Open |
| 10 | ▶ Upfront Ventures Early investors and long-term partners. We back exceptional founders solving real problems across sectors. When you hit a bump in the road, we're there solving problems alongside you with operational expertise and network leverage. | $1M – $15M | 46 | Leads | Active | ~2 wks | Req'd |
| 11 | ▶ Yes VC We invest in category-defining companies at Pre-Seed and Seed stages founded by entrepreneurs with authentic passion. Focus on founders working in climate, food, healthcare, AI automation, and frontier technologies. Philosophy: when the world says No, go toward the Yes as hard as you can. | $30K – $1.5M | 46 | Both | Active | ~2 wks | Open |
| 12 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 13 | ▶ Acequia Capital (AceCap) Acequia Capital partners with technical founders and product teams building the next wave of global businesses. They provide more than capital—experienced operators offer strategic guidance on product roadmap, technology strategy, business model, and GTM execution. The firm is a center of a global innovation ecosystem with unique capability to detect earliest signal in emerging technology trends. Seattle | $1M – $25M | 31 | Leads | Active | ~1 mo | Open |
| 14 | ▶ Ataraxia VC Fund companies that help people live longer and live better through science and technology. We support exceptional technical founders solving real health and happiness problems with scientific rigor and consumer appeal. Our data-driven methodology and proprietary ML platform identify outsize return potential in complex early-stage companies. San Francisco | $500K – $5M | 11 | Both | Active | ~2 wks | Open |
| 15 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 16 | ▶ SoGal Ventures First women-led VC investing in underrepresented founders solving underserved problems in undercapitalized geographies. We capitalize on three biggest arbitrage opportunities: diversity of founders, geographic expansion beyond Silicon Valley, and problems with meaningful social impact. We back exceptional teams in consumer tech, digital health, and future of work sectors. New York | $250K – $2M | 16 | Leads | Active | ~2 wks | Open |
| 17 | ▶ Contrary Identify and invest in the world's top talent before they start a company. Build lifelong relationships through a proprietary university scout network at Stanford, MIT, Harvard, and other elite universities. Back exceptional founders within 1-3 years of graduation before they are widely recognized. San Francisco | $100K – $15M | 55 | Both | Active | ~2 wks | Req'd |
| 18 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 19 | ▶ GV (Google Ventures) GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI. San Francisco | $500K – $50M | 30 | Both | Active | ~1 mo | Open |
| 20 | ▶ Okapi Venture Capital Southern California's original seed-stage venture capital fund, focused on capital-efficient technology startups with differentiated competitive advantages targeting large, addressable and growing markets outside the Bay Area. Active, hands-on management with emphasis on venture fundamentals and disciplined investment strategy. Newport Beach | $750K – $3M | 30 | Leads | Active | ~2 wks | Open |
| 21 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 22 | ▶ K5 Global K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships. Los Angeles | $1M – $3M | 34 | Leads | Active | ~1 mo | Open |
| 23 | ▶ Moxxie Ventures Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building. San Francisco | $500K – $2M | 50 | Leads | Active | ~2 wks | Open |
| 24 | ▶ Korea Investment Management Co. Back the global winners of tomorrow through disciplined venture capital and growth equity investing. We are a trustworthy partner providing capital, operational expertise, and access to pan-Asian networks. Fund-oriented professional VC with fundamental philosophy of quality, responsibility, and stability. | $500K – $100M | 25 | Leads | Active | ~1 mo | Open |
| 25 | ▶ Correlation Ventures We combine world-class AI analytics with industry-leading networks to identify exceptional companies and make rapid investment decisions. Great companies, regardless of sector or geography. San Diego | $100K – $4M | 32 | Follows | Active | ~1 wk | Open |
| 26 | ▶ Better Capital Day 0 venture capital applied by a deep operator. Better Capital invests at the earliest stage where ambiguity is highest and operator judgment adds the most value. Solo GP model keeps conviction high and enables deep engagement with 20-25 companies at critical inflection points. Pune | $300K – $1M | 47 | Leads | Active | ~1 wk | Req'd |
| 27 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 28 | ▶ New Enterprise Associates (NEA) NEA partners with ambitious founders at every stage of company building, from pre-seed through IPO. They invest at the intersection of technology and healthcare, believing the most transformational innovation occurs where deep domain expertise meets world-class technical founders. NEA serves as both capital provider and active operator. Menlo Park | $1M – $50M | 21 | Both | Active | ~2 mo | Open |
| 29 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 30 | ▶ Pareto Holdings Back exceptional founders early, globally. Self-funded model enables founder-first alignment, rapid deployment, and direct support. We believe the best companies come from the best founders, regardless of background or current stage. Miami | $100K – $25M | 20 | Leads | Active | ~1 wk | Open |
| 31 | ▶ The Helm Women receive only 2% of venture capital despite female-founded startups delivering 2x return per dollar vs. all-male teams. The Helm invests in game-changing, undervalued companies at seed stage founded by women, providing not just capital but operational support and ecosystem access. New York | $250K – $1.5M | 26 | Leads | Active | ~2 wks | Open |
| 32 | ▶ UpHonest Capital We invest in the most promising entrepreneurs building the fastest-growing early-stage startups. We provide cross-border access by connecting founders to resources and networks across the world's most valuable and influential VC markets. Palo Alto | $50K – $1M | 26 | Follows | Active | ~1 mo | Open |
| 33 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 34 | ▶ Battery Ventures Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools. Boston | $1M – $500M | 23 | Both | Active | ~2 wks | Open |
| 35 | ▶ Day One Ventures We help mission-driven pioneers win by harnessing the power of storytelling, art and culture. We back early-stage companies with customer obsession in their DNA and accelerate the mass adoption of technologies they create. Founders need more than capital—they need strategic support in building their narrative and leveraging media to accelerate adoption. San Francisco | $300K – $5M | 27 | Leads | Active | ~1 wk | Open |
| 36 | ▶ Canaan Partners Canaan invests in visionaries with transformative ideas across a 60/40 technology-to-healthcare split. The firm seeks early-stage companies with authentic founder passion, clear problem-solving value, and the potential to improve lives. Canaan runs a transparent, debate-driven partnership with deep operational expertise in healthcare regulation, biotech fundraising, and enterprise scaling. Menlo Park | $1M – $20M | 20 | Both | Active | ~2 mo | Req'd |
| 37 | ▶ ZhenFund Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support. Beijing | $250K – $3M | 25 | Leads | Active | ~2 wks | Open |
| 38 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 39 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 40 | ▶ Vast Ventures We invest in companies organized around five concrete objectives: improving worldwide health and happiness, promoting resource sustainability, increasing human potential and productivity, increasing knowledge/empathy/connectedness, and disrupting industries that resist these goals. We operate as both investors and company-builders, providing operational expertise and hands-on support far beyond capital. New York | $250K – $3M | 26 | Leads | Active | ~2 wks | Req'd |
| 41 | ▶ Sand Hill Angels Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem. Mountain View | $50K – $2M | 30 | Follows | Active | — | Open |
| 42 | ▶ Kima Ventures Back ambitious teams with strong learning and execution capacities across all sectors, stages, and geographies. Technology-enabled businesses preferred. Volume-based, founder-centric investment philosophy. Paris | $100K – $200K | 25 | Leads | Active | ~2 wks | Open |
| 43 | ▶ Expa We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries. San Francisco | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 44 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 45 | ▶ MaC Venture Capital MaC backs visionary founders building category-defining companies with deep understanding of cultural shifts, technological advancements, and emerging market trends. Founders must demonstrate authentic insight into why their problem needs solving now, combined with ability to see how the world is changing. Particular focus on founders paying attention to shifts others might miss. | $500K – $2M | 19 | Leads | Active | ~2 wks | Req'd |
| 46 | ▶ Animal Capital Leverage creator economy and influencer networks to add tangible value to early-stage companies. Invest in ambitious Gen Z founders building consumer products with high influencer marketing potential. Influencer partners actively support portfolio companies with marketing, business development, and strategic partnerships. | $500K – $5M | 11 | Follows | Active | ~1 mo | Req'd |
| 47 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 48 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 48 VC firms that actively invest in consumer apps & social + biotech & life sciences at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a consumer apps & social + biotech & life sciences investors is $2.6M – $2.6M, with a full range from $30K – $500M. The distribution breaks down as: 2 firms in the <$500K range, 6 firms in the $500K-$1M range, 12 firms in the $1M-$2M range, 9 firms in the $2M-$5M range, 5 firms in the $5M-$10M range, 14 firms in the $10M+ range.
Among the 48 firms tracked, 85% lead or co-lead rounds, and 15% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a consumer apps & social + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 21% prefer warm introductions, and the average firm has 40 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.