40 VC firms investing in e-commerce & marketplaces and healthcare & digital health at the Series B stage.
F4 Fund tracks 40 VC firms that actively invest in e-commerce & marketplaces + healthcare & digital health at the Series B stage, with check sizes ranging from $25K – $350M (median: $10.5M – $10.5M). As of June 2026, and 93% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ M13 Visionary founders building disruptive software businesses deserve capital and operational support from partners who understand building category-defining companies. We provide both. Santa Monica | $500K – $5M | 70 | Leads | Active | ~1 mo | Open |
| 2 | ▶ Makers Fund Backing builders of the future of interactive entertainment. We invest across games, content, platforms, and ecosystem technologies with conviction that visionary founders are driving transformation in how we play, watch, create, and live. | $500K – $5M | 158 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Unilever Ventures We support forward-thinking founders crafting brands for the modern consumer. We invest across beauty & wellness, commerce technology, and B2B/enterprise, leveraging Unilever's global distribution, brand-building capabilities, and consumer insights. London | $500K – $15M | 45 | Both | Active | ~2 mo | Open |
| 4 | ▶ Interplay Ventures Application-layer AI and B2B marketplace businesses at Series A, focused on industries undergoing digitization and specialization. Conviction co-investors who do independent underwriting but never lead. New York | $500K – $2M | 43 | Follows | Active | ~2 wks | Open |
| 5 | ▶ Rocana Venture Partners Democratizing health and wellness through disruptive consumer brands that combine purpose with profitability. Rocana backs authentic founders solving real wellness problems with products that deliver genuine health benefits while operating sustainably. Los Angeles | $500K – $30M | 20 | Leads | Active | ~1 mo | Open |
| 6 | ▶ Bond We identify and scale proven product-market-fit technology companies for global expansion and IPO readiness. Our partnership combines world-class macro research analysis with hands-on operational expertise from experienced technology leaders who have built and scaled billion-dollar companies. San Francisco | $1M – $50M | 42 | Leads | Active | ~2 mo | Open |
| 7 | ▶ Crew Capital Community-driven VC led by active operators who simultaneously build and invest. Best support for founders comes from operators understanding current market challenges firsthand, not just history. Invest in category-defining technology companies. New York | $500K – $2M | 39 | Leads | Active | ~2 wks | Open |
| 8 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 55 | Leads | Active | ~1 mo | Open |
| 9 | ▶ Headline We invest in top founders everywhere building the next generation of technology companies. We provide capital, operational expertise, and a truly global platform to scale with hands-on support through specialized teams. | $2M – $50M | 51 | Leads | Active | ~2 wks | Open |
| 10 | ▶ Bain Capital Ventures Ambitious founders solving fundamental problems across major industries. The next generation of transformational companies will be built on modern AI, secure infrastructure, and efficient commerce. We partner with technical founders with operator experience and compelling narratives. San Francisco | $1M – $20M | 28 | Leads | Active | ~2 wks | Open |
| 11 | ▶ Coefficient Capital Consumer investing requires a fundamentally new playbook built for an omni-channel world where technology, data, and brand storytelling are deeply intertwined. Coefficient identifies growth-stage consumer businesses in established categories undergoing structural change, using proprietary data and an annual Consumer Trends Report to find category-defining brands early. Strategy centers on backing brands positioned for strategic exits to major CPG acquirers. New York | $2M – $40M | 17 | Leads | Active | ~1 mo | Open |
| 12 | ▶ GGV Capital Back notable founders with global ambitions using technology to transform industries. We partner with exceptional teams to scale from seed through IPO, providing capital, operational expertise, and network access. Menlo Park | $1M – $15M | 35 | Both | Active | ~2 wks | Open |
| 13 | ▶ Partech Partners We support ambitious founders solving large problems through technology across all stages. Independent thinkers who challenge conventional wisdom are our ideal partners. We provide not just capital but operational expertise, global networks, and hands-on support from day one through scale. Paris | $300K – $100M | 24 | Both | Active | ~1 mo | Open |
| 14 | ▶ Gobi Partners Bespoke Capital for Enduring Impact. Gobi invests where capital alone is insufficient — requiring deep local relationships, sustained engagement, and informed judgment across Asia's diverse and complex markets. They focus on technology companies solving structural inefficiencies across underserved Asian markets, from fintech to deep tech to sustainable infrastructure. Kuala Lumpur | $1M – $50M | 37 | Leads | Active | — | — |
| 15 | ▶ REMUS Capital Building, not betting, with rebels transforming massive traditional industries through applied AI. Hands-on operational partnership combining capital with customer acquisition, team building, and strategic guidance. Boston | $1M – $20M | 27 | Leads | Active | ~2 wks | Req'd |
| 16 | ▶ Golden Gate Empower audacious founders who challenge norms and leverage technology to transform industries. We believe in first-time founders with scrappy outsider mentality and narrow niche focus. Silicon Valley expertise combined with deep emerging market knowledge across three continents. Singapore | $25K – $10M | 33 | Leads | Active | ~2 wks | Req'd |
| 17 | ▶ Valor Capital Group Greatest opportunities come from serving unmet needs of the middle class in emerging markets. We bridge US and Latin American markets, providing institutional capital, intellectual capital flow, and geo arbitrage exit opportunities. New York | $500K – $10M | 24 | Leads | Active | ~2 wks | Open |
| 18 | ▶ Riverpark Ventures Disruptive businesses that eliminate intermediaries and compress value chains. We invest in entrepreneurs backed by entrepreneurs who understand the unique challenges of building. We look for innovative thinkers with proven track records and tremendous dedication, in large markets addressing significant customer needs. New York | $500K – $25M | 23 | Leads | Active | ~2 wks | Req'd |
| 19 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 20 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 21 | ▶ Resolute Ventures We back founders who combine emotional intelligence with business acumen and are on a mission to solve problems they deeply care about. We're often the first institutional check and provide mentorship, community, and long-term partnership support. San Francisco | $50K – $1.5M | 21 | Leads | Active | ~2 wks | Req'd |
| 22 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 23 | ▶ Bling Capital The hardest thing in seed is finding product-market fit. We help you find it. If you already have product-market fit, we will help you scale. We partner with exceptionally ambitious founders for the long run and provide capital combined with operational expertise through our 100+ member Product Council. San Francisco | $500K – $3M | 33 | Leads | Active | ~2 mo | Open |
| 24 | ▶ Sawari Ventures North Africa and Africa possess tremendous entrepreneurial talent. Strategic capital combined with operational expertise can unlock transformative solutions that reshape industries. We invest in founders solving region-critical problems. Cairo | $200K – $2M | 20 | Leads | Active | ~1 mo | Open |
| 25 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | — | — |
| 26 | ▶ Left Lane Capital Invest in hyper-growth consumer and technology businesses with enduring customer relationships. Back founders challenging the status quo through digital transformation. Focus on companies with strong unit economics, loyal customer bases, and defensible competitive advantages in complex, regulation-heavy markets. Brooklyn | $5M – $50M | 42 | Both | Active | ~2 wks | Open |
| 27 | ▶ Cherryrock Capital Cherryrock Capital backs underinvested entrepreneurs — specifically Black and Latine founders — building transformative software companies. They invest in the possible, seeking founders with domain expertise, compelling right-to-win stories, and products that generate measurable customer outcomes in structurally underserved markets. San Francisco | $2M – $15M | 4 | Leads | Active | ~1 mo | Open |
| 28 | ▶ Rosecliff Ventures We seek to create positive economic impact and long-term value by providing lifetime support to companies from seed through late-stage equity and credit. We differentiate through deep Wall Street expertise, strategic LP networks, and innovative financing vehicles. New York | $500K – $10M | 22 | Both | Active | ~2 mo | Open |
| 29 | ▶ White Star Capital Technology companies are becoming intertwined with the global economy more so than ever before. The most compelling founders build businesses through a broader world view. White Star Capital backs globally ambitious entrepreneurs at Series A, B, and Seed stages across North America, Europe, and Asia, helping them scale internationally through deep local presence on three continents. London | $1M – $25M | 41 | Leads | Active | ~1 mo | Open |
| 30 | ▶ Lightbox Early-growth brands that India will obsess over tomorrow — technology-led consumer businesses where product is the champion and tech a catalyst. Lightbox takes concentrated bets in select entrepreneurs and partners beyond capital through deep operational involvement. Mumbai | $5M – $30M | 20 | Leads | Slowing | ~2 mo | Open |
| 31 | ▶ Coatue The best investment opportunities emerge at the intersection of innovation and scale. We invest across the full lifecycle from seed to public markets, focusing on technology companies that will transform sectors globally with particular conviction in AI-enabled platforms and infrastructure. New York | $1M – $100M | 30 | Both | Active | ~2 wks | Open |
| 32 | ▶ Goodwater Capital Consumer technology has the power to measurably improve billions of lives across the globe. We invest in exceptional entrepreneurs building digital utilities that provide better access to housing, healthcare, food, financial services, transportation, education, and entertainment globally. Burlingame, California | $5M – $50M | 29 | Leads | Active | ~1 mo | Req'd |
| 33 | ▶ Tiger Global Management Leading global companies that leverage technological innovation across public and private markets. Proven founders (especially ex-Googlers, AWS, Stripe) with large TAMs (billions+), product-led growth, and global ambitions. Conviction-based investing post-2022 correction emphasizing quality over quantity. New York | $1M – $100M | 21 | Leads | Active | ~1 wk | Req'd |
| 34 | ▶ Insight Partners Software founders need more than capital to scale successfully. Insight Partners combines investment capital with hands-on operational expertise, embedded teams, and network access to accelerate company growth across all stages. New York | $10M – $350M | 28 | Leads | Active | ~1 mo | Open |
| 35 | ▶ Peak XV Partners Outlier founders and ideas shape the future of humanity. We back ambitious founders building category-defining companies that create significant impact while generating returns that support non-profit and educational causes. Bangalore | $500K – $100M | 18 | Leads | Active | ~2 wks | Open |
| 36 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 37 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 38 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 39 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 40 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
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What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 40 VC firms that actively invest in e-commerce & marketplaces + healthcare & digital health at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b e-commerce & marketplaces + healthcare & digital health investors is $10.5M – $10.5M, with a full range from $25K – $350M. The distribution breaks down as: 1 firms in the <$500K range, 2 firms in the $500K-$1M range, 4 firms in the $1M-$2M range, 6 firms in the $2M-$5M range, 6 firms in the $5M-$10M range, 21 firms in the $10M+ range.
Among the 40 firms tracked, 93% lead or co-lead rounds, and 8% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b e-commerce & marketplaces + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 22% prefer warm introductions, and the average firm has 34 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.