42 VC firms investing in food & beverage and biotech & life sciences at the Pre-Seed stage.
F4 Fund tracks 42 VC firms that actively invest in food & beverage + biotech & life sciences at the Pre-Seed stage, with check sizes ranging from $1K – $100M (median: $1.6M – $1.6M). As of August 2026, and 93% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,644+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Big Idea Ventures Solving the world's biggest challenges by supporting the world's best entrepreneurs in food and agriculture. Focus on sustainable, scalable solutions to global food security through innovation in alternative proteins, ingredients, and food technology. New York | $125K – $2M | 38 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Digitalis Ventures Complex health problems require multidisciplinary teams combining deep technical, financial, and domain expertise. We invest in breakthrough science and technology-enabled solutions across human and animal health. New York | $250K – $50M | 54 | Leads | Active | ~2 mo | Req'd |
| 3 | ▶ FoodLabs Revolutionize the food system and improve both planetary and human health by backing audacious entrepreneurs working at the intersection of food, agriculture, climate, and health. Berlin | $100K – $2M | 50 | Both | Active | N/A | N/A |
| 4 | ▶ Humboldt Fund Apply revolutionary biotechnology to replace industrial inputs with biology-based alternatives, transforming how the world manufactures chemicals, materials, foods, and medicines. Synthetic biology is a $25T opportunity spanning industrial inputs, food & agriculture, pharmaceuticals, and specialized applications. New York | $500K – $2M | 19 | Both | Active | ~1 mo | Req'd |
| 5 | ▶ Astanor The agrifood value chain has reached a tipping point where incremental change is not enough; systemic disruption and regeneration of the food and agriculture system is required to restore human, planetary, and economic health. Brussels, Belgium | $1M – $25M | 52 | Leads | Active | N/A | N/A |
| 6 | ▶ Acre Venture Partners Driving positive, lasting change in food and agriculture creates exceptional financial outcomes. Impact and return aren't trade-offs—they're intertwined. Both are essential. We invest in technologies and companies addressing human health, planetary well-being, responsible production, and climate solutions. Santa Monica | $500K – $5M | 29 | Leads | Active | ~1 mo | Req'd |
| 7 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 41 | Both | Active | ~1 mo | Open |
| 8 | ▶ Bluestein Ventures We invest in the future of food — backing game-changing early-stage ventures (Pre-Seed to Series A) that redefine how consumers achieve health and wellness across the entire food value chain: high-growth consumer brands, proprietary foodtech, next-gen commerce, and value-add digital technology. Fund III ($45M, 2024) emphasizes nutrition, sustainability, and digitization, with a thematic focus on food-as-medicine. Chicago | $250K – $5M | 37 | Leads | Active | N/A | N/A |
| 9 | ▶ Babel Ventures Biology is the next frontier of technology. BABEL believes early-stage consumer biotech can solve macro problems (food security, climate, health) while delivering outsized returns. The best outcomes come from diverse, science-credentialed founder teams with deep domain expertise and commitment to sustainability and impact. San Francisco | $100K – $3M | 20 | Leads | Active | ~2 wks | Req'd |
| 10 | ▶ Better Ventures Mission-driven companies solve big problems at scale while building durable competitive advantages. We back founders leveraging science & technology to build the Better Economy where people and planet thrive. Oakland | $500K – $1M | 43 | Leads | Active | ~1 mo | Open |
| 11 | ▶ LvlUp Ventures LvlUp backs founders across every stage, geography, and industry, using a large distributed network of associates and scouts to source and support a very high volume of small checks, paired with accelerator and mentorship infrastructure. New York | $1K – $1M | 37 | N/A | Active | N/A | Open |
| 12 | ▶ Supply Change Capital Supply Change Capital invests at the intersection of food, climate, and culture. We back early-stage technology transforming the food supply chain's foundational infrastructure - from supply chain resilience and logistics to health/nutrition innovation and labor automation. We believe the global food system ($10T industry) is least modernized sector globally, requiring urgent technological transformation to address climate impact (1/3 of GHG emissions), health crises (50%+ with diet-related chronic disease), and labor equity. We invest with dual lenses: climate impact (emissions reduction, soil health, biodiversity) and culture (supporting diverse founders who deliver 30% higher returns despite underinvestment). As former operators, we partner with founders not just with capital but operational expertise, impact metrics frameworks, and access to extensive advisor network of industry veterans. Chicago | $250K – $1M | 24 | Leads | Active | ~1 mo | Req'd |
| 13 | ▶ Anterra Capital Anterra backs companies that make the food system safer, more sustainable, and more resilient by combining biotechnology and digital solutions across the full value chain. Amsterdam | $1M – $10M | 12 | Both | Active | ~2 mo | Req'd |
| 14 | ▶ Pale Blue Dot Early-stage climate tech companies building the sustainable future. We invest in both software and hardware solutions addressing climate change through optimization, adaptation, and pioneering innovations. The next billion-dollar companies will be built with climate in mind. Sweden | $500K – $2M | 46 | Leads | Active | ~2 mo | Req'd |
| 15 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 16 | ▶ Ataraxia VC Fund companies that help people live longer and live better through science and technology. We support exceptional technical founders solving real health and happiness problems with scientific rigor and consumer appeal. Our data-driven methodology and proprietary ML platform identify outsize return potential in complex early-stage companies. San Francisco | $500K – $5M | 11 | Both | Active | ~2 wks | Open |
| 17 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 52 | Both | Active | ~2 mo | Open |
| 18 | ▶ ToSeed & Partners Support innovative, research-originated solutions for a better agrifood system, combining capital with hands-on venture-building and technical incubation for Italian university spinouts and deep-tech agrifood founders. Siena, Italy | $100K – $700K | 10 | Both | Active | N/A | N/A |
| 19 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 20 | ▶ SoGal Ventures First women-led VC investing in underrepresented founders solving underserved problems in undercapitalized geographies. We capitalize on three biggest arbitrage opportunities: diversity of founders, geographic expansion beyond Silicon Valley, and problems with meaningful social impact. We back exceptional teams in consumer tech, digital health, and future of work sectors. New York | $250K – $2M | 17 | Leads | Active | ~2 wks | Open |
| 21 | ▶ EPIC Ventures EPIC Ventures backs early-stage technology companies building in the information economy, with a focus on enterprise SaaS, healthcare technology, cybersecurity, and future of work. The firm believes the best way to build lasting companies is through genuine partnership with founders — providing capital, strategic guidance, operational expertise, and deep network access. Founded in 1994, EPIC helped build the Utah tech ecosystem and continues to be the foundational VC of the Mountain West. Salt Lake City, UT | $500K – $5M | 71 | Leads | Active | ~1 mo | Open |
| 22 | ▶ Privilège Ventures We back bold, ambitious, and resilient founders driving breakthrough innovations in HealthTech, CleanTech, and AgriFoodTech. Female-led and gender-mixed teams deliver superior returns and drive meaningful impact. Over five decades of combined experience navigating financial cycles enables us to partner authentically with founders, providing not just capital but strategic guidance and operational support. Switzerland | $100K – $1M | 25 | Both | Active | N/A | N/A |
| 23 | ▶ FTW Ventures The $12 trillion food and agriculture industries still rely on centuries-old methods. We back disruptive science and technology to modernize the food system—from biotech and sensors to automation and software—to feed 10 billion people by 2050 while preserving nature and nurturing humankind. San Francisco | $500K – $5M | 24 | Leads | Active | ~2 mo | Req'd |
| 24 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 55 | Both | Active | ~1 mo | Open |
| 25 | ▶ Adverb Ventures The adverbs matter just as much as the verbs — how you build is as important as what you build. Exceptional people and character transform ideas into industry-shaping companies. We back extraordinary founders at pre-seed and seed who have unique insight into their market and the operational excellence to build in the right way. San Francisco | $500K – $5M | 33 | Leads | Active | ~1 mo | N/A |
| 26 | ▶ Positron Ventures Positron assists scientists in turning outstanding research into successful companies, providing first-check capital to scientist-entrepreneurs across the natural sciences tackling major global challenges. Amsterdam | $250K – $3M | 11 | Both | Active | N/A | N/A |
| 27 | ▶ BoxOne Ventures Back passionate, emerging talent solving deep technology challenges. Support founders from napkin-stage through IPO with patient, flexible evergreen capital. Focus on biotechnology, frontier software, food innovation, longevity, and AI that maximize impact and potential. Montreal | $100K – $5M | 17 | Both | Active | ~2 mo | Open |
| 28 | ▶ SMOK Ventures CEE founders (Polish, Ukrainian, Romanian, etc.) are building the next generation of global software companies. We partner with experienced operators who combine deep industry expertise with serial entrepreneurship. Geographic arbitrage: exceptional technical talent in CEE with lower burn rates, global ambition. We provide early capital plus connections to Silicon Valley for follow-on funding (80% of portfolio follow-ons from SV/Europe/Asia). Goal: $500M+ exits in 8-10 years. | $100K – $1M | 38 | Leads | Active | ~1 wk | Open |
| 29 | ▶ SOSV Deep tech startups at the edge of what is possible solve critical human and planetary health problems. SOSV backs founders combining scientific rigor with entrepreneurial grit, providing not just capital but access to specialized labs, manufacturing, and global expertise networks. San Francisco | $250K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 30 | ▶ The Helm Women receive only 2% of venture capital despite female-founded startups delivering 2x return per dollar vs. all-male teams. The Helm invests in game-changing, undervalued companies at seed stage founded by women, providing not just capital but operational support and ecosystem access. New York | $250K – $1.5M | 27 | Leads | Active | ~2 wks | Open |
| 31 | ▶ Redalpine Redalpine backs companies at the convergence of software and science — where rigorous engineering meets scientific breakthroughs. Half the team are scientists, half are operators, enabling them to engage deeply with highly technical founders and support them hands-on from day one through to exit. Primary focus areas: frontier science and biotech, digital health, AI and automation, fintech, synthetic biology, and climate tech. Zug | $500K – $5M | 40 | Leads | Active | N/A | N/A |
| 32 | ▶ Brickyard Extraordinary founders execute faster when isolated from distractions and provided intensive on-site support. We seek junkyard dogs with high agency, non-obvious vision, delusional optimism, and execution discipline. Category matters far less than founder quality. Chattanooga, TN | $100K – $500K | 52 | Both | Active | ~2 wks | Open |
| 33 | ▶ SVG Ventures We back bold founders and AI-enabled, game-changing innovations that improve planetary and population health. We target capital-efficient, highly scalable startups reimagining sectors like agri-food, climate, fintech, life sciences and nutrition through deep tech and proprietary IP. We engineer outcomes through operational support, strategic partnerships, and sector expertise. Los Gatos, California | $500K – $100M | 17 | Both | Active | ~2 mo | Req'd |
| 34 | ▶ SeaX Ventures Backs early-stage companies building groundbreaking exponential technologies that can transform societies and help countries achieve higher levels of economic progress, bridging US deep-tech deal flow with a large Southeast Asian corporate and family-office LP network. Millbrae, CA | $500K – $5M | 29 | Both | Active | N/A | N/A |
| 35 | ▶ Debut Capital Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks. New York | $500K – $5M | 48 | Leads | Active | ~2 wks | Req'd |
| 36 | ▶ Vast Ventures We invest in companies organized around five concrete objectives: improving worldwide health and happiness, promoting resource sustainability, increasing human potential and productivity, increasing knowledge/empathy/connectedness, and disrupting industries that resist these goals. We operate as both investors and company-builders, providing operational expertise and hands-on support far beyond capital. New York | $250K – $3M | 27 | Leads | Active | ~2 wks | Req'd |
| 37 | ▶ Antler Backing exceptional people at the very start of their journey. We support founders from inception to scale through our global residency programs, providing capital, mentorship, and access to a network of 1,500+ companies across six continents. | $125K – $500K | 31 | Leads | Active | ~2 wks | Open |
| 38 | ▶ LDV Capital A majority of the data our brains analyze is visual. Therefore, the majority of the data AI will analyze will also be visual, spanning the light and electromagnetic spectrums across all sectors. We thrive on collaborating with deep technical teams who leverage computer vision, machine learning and artificial intelligence to analyze visual data. New York | $500K – $1.5M | 28 | Leads | Active | ~2 wks | Req'd |
| 39 | ▶ Noon Ventures We invest in proven, transformative technologies that have the potential to be industry-defining while driving meaningful impact on the climate and environment. We partner with founders as active co-developers, not passive investors. Copenhagen | $500K – $10M | 5 | Leads | Active | ~1 mo | Open |
| 40 | ▶ Elevate Ventures Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations. Indianapolis | $20K – $2M | 28 | Leads | Active | ~1 mo | Open |
| 41 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | N/A | 3mo | ~2 wks | Open |
| 42 | ▶ Avinya Ventures Avinya backs India-based founders with strong founder-market fit: deep problem understanding, relevant domain expertise, and demonstrated execution capability, across a sector-agnostic mandate spanning deep tech, healthcare, fintech, and consumer. Mumbai | $250K – $5M | 11 | Follows | Active | ~1 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 42 VC firms that actively invest in food & beverage + biotech & life sciences at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed food & beverage + biotech & life sciences investors is $1.6M – $1.6M, with a full range from $1K – $100M. The distribution breaks down as: 4 firms in the <$500K range, 7 firms in the $500K-$1M range, 11 firms in the $1M-$2M range, 14 firms in the $2M-$5M range, 3 firms in the $5M-$10M range, 3 firms in the $10M+ range.
Among the 42 firms tracked, 93% lead or co-lead rounds, and 2% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed food & beverage + biotech & life sciences investors combine domain expertise with an active portfolio in the space. Among these firms, 36% prefer warm introductions, and the average firm has 33 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.