24 VC firms investing in healthcare & digital health and edtech at the Series B stage.
F4 Fund tracks 24 VC firms that actively invest in healthcare & digital health + edtech at the Series B stage, with check sizes ranging from $25K – $700M (median: $10.1M – $10.1M). As of June 2026, and 100% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ ECMC Education Impact Fund Impact capital can address structural problems in America's $1 trillion education and workforce system. With 6 in 10 Americans holding less than bachelor's degrees and 40% of recent grads underemployed, we partner with founders removing barriers across the learner journey - from equitable access through career success. Minneapolis | $1M – $10M | 27 | Both | Active | 3+ mo | Open |
| 2 | ▶ AirTree Ventures Big things start small. We invest at seed stage and see potential where others don't. We believe in your vision for your company's future, not as it exists today. We think in decades, not days, committing to walk the entire journey with founders to build iconic companies. We share Antipodean ingenuity with the world. Sydney | $250K – $20M | 64 | Leads | Active | ~2 wks | Req'd |
| 3 | ▶ Techstars Help founders succeed by combining capital ($120K-$250K), intensive mentorship (3-month program), and access to a powerful global network of 1,500+ mentors. We invest in founders at the earliest stage with conviction and vision, regardless of sector or geography. Our #GiveFirst philosophy drives us to help without expecting immediate return. | $120K – $250K | 20 | Leads | Active | ~2 wks | Open |
| 4 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 55 | Leads | Active | ~1 mo | Open |
| 5 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 6 | ▶ Homebrew Help founders build companies of which they can be proud. We invest in mission-driven founders solving large, urgent problems using technology to create substantive change. Capital is necessary but not sufficient—sweat, reputation, and accountability are our core commitments. San Francisco | $100K – $500K | 26 | Both | Active | ~1 wk | Req'd |
| 7 | ▶ Drive Capital World-class technology companies can be built anywhere. Greatness is in our backyard. We invest in market-defining companies across the Driveway region (Hudson River to Rocky Mountains), partnering with founders from idea to IPO. Build where your talent is. Build where your customers are. Build where you're strongest. Columbus | $500K – $150M | 33 | Leads | Active | ~2 mo | Open |
| 8 | ▶ Golden Gate Empower audacious founders who challenge norms and leverage technology to transform industries. We believe in first-time founders with scrappy outsider mentality and narrow niche focus. Silicon Valley expertise combined with deep emerging market knowledge across three continents. Singapore | $25K – $10M | 33 | Leads | Active | ~2 wks | Req'd |
| 9 | ▶ Impact America Fund Tech-enabled businesses built for and by people in marginalized communities create new frameworks of ownership and opportunity. Traditional VCs miss billion-dollar markets in overlooked communities. Oakland | $250K – $3M | 32 | Leads | Active | ~1 mo | Req'd |
| 10 | ▶ WndrCo WndrCo positions itself as 'the founders behind the founders,' combining strategic capital with deep operational involvement. Unlike traditional VCs, partners take formal operating roles (interim CEO, CFO, CPO) within portfolio companies. This approach leverages the co-founders' proven track record: Sujay Jaswa scaled Dropbox from $18M to $10B as Business Founder/CFO, and Jeffrey Katzenberg transformed Disney Studios and built DreamWorks. The firm invests across all stages through three strategies: Build (acquiring underappreciated tech companies), Venture (leading post-PMF rounds), and Seed (very early checks). Focus areas are Future of Work, Cybersecurity, Developer Infrastructure, and Consumer Technology, with increasing emphasis on AI applications. Beverly Hills, California | $100K – $10M | 32 | Leads | Active | ~2 wks | Req'd |
| 11 | ▶ Valor Capital Group Greatest opportunities come from serving unmet needs of the middle class in emerging markets. We bridge US and Latin American markets, providing institutional capital, intellectual capital flow, and geo arbitrage exit opportunities. New York | $500K – $10M | 24 | Leads | Active | ~2 wks | Open |
| 12 | ▶ Streamlined Ventures Visionary founders are the true catalysts of transformation and progress. We partner with exceptional founders at the seed stage to help them build extraordinary companies through intensive operational support, structured tools, and candid guidance. Palo Alto | $250K – $10M | 23 | Leads | Active | ~2 wks | Open |
| 13 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 14 | ▶ OpenAI Startup Fund New and powerful AI systems will give rise to transformative startups. We back exceptional engineers, designers, researchers, and product builders using AI to solve critical problems in healthcare, law, education, energy, sciences, and enterprise. We provide capital, operational support, talent expertise, and conviction follow-on investing. San Francisco | $1M – $5M | 15 | Both | Active | ~2 wks | Open |
| 15 | ▶ Left Lane Capital Invest in hyper-growth consumer and technology businesses with enduring customer relationships. Back founders challenging the status quo through digital transformation. Focus on companies with strong unit economics, loyal customer bases, and defensible competitive advantages in complex, regulation-heavy markets. Brooklyn | $5M – $50M | 42 | Both | Active | ~2 wks | Open |
| 16 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 17 | ▶ Emerson Collective Emerson Collective invests in entrepreneurs and innovators driven by purpose, seeking consequential companies that deliver both generational impact and venture-scale returns. The firm targets sectors where biggest market opportunities meet meaningful impact levers: energy & environment, digital health, fintech, education, work, and media. Palo Alto | $10M – $700M | 16 | Both | Active | ~1 mo | Req'd |
| 18 | ▶ White Star Capital Technology companies are becoming intertwined with the global economy more so than ever before. The most compelling founders build businesses through a broader world view. White Star Capital backs globally ambitious entrepreneurs at Series A, B, and Seed stages across North America, Europe, and Asia, helping them scale internationally through deep local presence on three continents. London | $1M – $25M | 41 | Leads | Active | ~1 mo | Open |
| 19 | ▶ Lightbox Early-growth brands that India will obsess over tomorrow — technology-led consumer businesses where product is the champion and tech a catalyst. Lightbox takes concentrated bets in select entrepreneurs and partners beyond capital through deep operational involvement. Mumbai | $5M – $30M | 20 | Leads | Slowing | ~2 mo | Open |
| 20 | ▶ Goodwater Capital Consumer technology has the power to measurably improve billions of lives across the globe. We invest in exceptional entrepreneurs building digital utilities that provide better access to housing, healthcare, food, financial services, transportation, education, and entertainment globally. Burlingame, California | $5M – $50M | 29 | Leads | Active | ~1 mo | Req'd |
| 21 | ▶ Tribeca Venture Partners We partner with gritty and determined entrepreneurs leveraging emerging technologies to create or disrupt huge markets. We invest in people first, second, and third—founders with passion, obsession, and vision. Only partners with founders when we believe their company alone can return our entire fund or more. New York | $1M – $10M | 16 | Leads | Active | ~2 mo | Req'd |
| 22 | ▶ Insight Partners Software founders need more than capital to scale successfully. Insight Partners combines investment capital with hands-on operational expertise, embedded teams, and network access to accelerate company growth across all stages. New York | $10M – $350M | 28 | Leads | Active | ~1 mo | Open |
| 23 | ▶ Peak XV Partners Outlier founders and ideas shape the future of humanity. We back ambitious founders building category-defining companies that create significant impact while generating returns that support non-profit and educational causes. Bangalore | $500K – $100M | 18 | Leads | Active | ~2 wks | Open |
| 24 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
F4 Fund tracks 24 VC firms that actively invest in healthcare & digital health + edtech at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b healthcare & digital health + edtech investors is $10.1M – $10.1M, with a full range from $25K – $700M. The distribution breaks down as: 2 firms in the <$500K range, 1 firms in the $1M-$2M range, 2 firms in the $2M-$5M range, 7 firms in the $5M-$10M range, 12 firms in the $10M+ range.
Among the 24 firms tracked, 100% lead or co-lead rounds. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b healthcare & digital health + edtech investors combine domain expertise with an active portfolio in the space. Among these firms, 35% prefer warm introductions, and the average firm has 30 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.