Best Series A Healthcare & Digital Health + Legal & Regtech Investors 2026

Shifted from traditional VC to equity-for-services model. Rather than raising funds from LPs, Tusk now partners with founders by accepting equity in exchange for regulatory, legislative, and political consulting expertise to navigate highly regulated industries.

Backing builders of the future of interactive entertainment. We invest across games, content, platforms, and ecosystem technologies with conviction that visionary founders are driving transformation in how we play, watch, create, and live.

Data, cloud, and hardware advances will create unprecedented opportunities for great companies to be built. We invest in founders with big ideas and deep tech who are building infrastructure and value chains around data. Great people are the key to company success. We provide operational expertise, strategic guidance, and access to networks of mentors and international partners, particularly in China and Asia-Pacific.

Bringing applied AI to legacy, historically under-digitized industries — healthcare operations, supply chain, insurance, and compliance — by combining venture capital with in-house product, engineering, and AI build-out (studio model), early-stage checks (Ventures), and control-stake modernization buyouts (Propel).

Independent global investment platform backing capital-efficient, high-growth technology companies across Europe and North America. Multi-stage, multi-strategy approach from venture to pre-IPO. Transatlantic local teams provide unique advantage in bridging European and US growth.

Seed capital is the foundational layer in building enduring companies. We back bold, gritty founders applying AI and machine intelligence to solve the world's toughest challenges in enterprise and industrial sectors. By end of decade, software + hardware + AI will drive ubiquitous automation in every industry. We partner with visionary founders tackling hard technical problems in regulated, complex domains.

Emergence invests in early-stage B2B software companies that will define the next era of enterprise technology. Founded in 2003 as the original cloud/SaaS-focused VC firm, they have pioneered investing through technology transitions: horizontal SaaS (Salesforce, Zoom), vertical SaaS (Veeva, Doximity), and now AI-native services — companies that sell outcomes rather than software, powered by AI that compounds competitive advantage over time.

We invest in proven operators reshaping essential industries. Our focus is on operator-founders who have deep scaling experience at companies like Uber, Flexport, and Northrop Grumman. We back First Builders—specialists and generalists who understand how to build and scale organizations.

We invest in top founders everywhere building the next generation of technology companies. We provide capital, operational expertise, and a truly global platform to scale with hands-on support through specialized teams.

The future of cities will be shaped by entrepreneurs who can navigate complex regulatory environments. We provide seed capital and regulatory/policy expertise to startups enhancing the livability, sustainability, and economic vitality of cities.

Brings private equity rigor to early-stage venture with a Capital + Talent + Growth model. Invests in Vertical SaaS, AI, Cybersecurity, and Health Tech from Pre-Seed to Series A, combining capital with in-house executive search (Roo Search, 23,000+ candidates, 600+ placements) and operational playbooks (Roo Growth). Targets companies bridging MVP to scale.

High-touch early-stage investing in technology founders building durable software and tech-enabled category leaders, with particular strength in SaaS and the Utah/Silicon Slopes ecosystem.

Exceptional founders create disproportionate outcomes. We identify entrepreneurs pulling the future forward through fundamental innovation and exceptional execution. Rather than chasing sector trends, we partner with high-signal founders solving enduring problems across any category.

Back exceptional outlier founders with conviction and unwavering support. Kevin Hartz identified that over 20% of Fund II is invested in teenage founders—not as social experiment but as genuine thesis that exceptional outliers often emerge young. The firm provides operator-heavy partnership with deep expertise in founder psychology, financial operations, and growth scaling. They position themselves as guiding outliers from idea to IPO.

We invest in founders transforming how money and goods flow across the economy. We focus on tech for traditional sectors - modernizing underserved industries through vertical AI and software solutions. We partner with operators who deeply understand industry pain points.

Ambitious founders solving fundamental problems across major industries. The next generation of transformational companies will be built on modern AI, secure infrastructure, and efficient commerce. We partner with technical founders with operator experience and compelling narratives.

Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building.

Depth-first venture investing through mastery in specific domains. We partner with bold builders challenging industry conventions, backing founders with technical depth and conviction to build enduring $1B+ companies. Complete immersion creates enduring companies.

Low volume, high conviction early-stage investing in 10 thematic areas where vertical AI is reshaping regulated, complex industries: healthcare, fintech, capital markets, industrial operations, security, and government. Back strongly opinionated founders building category-defining companies with direct operator support from a team with deep fintech and growth scaling experience.

Inertia invests in AI-native companies built to become core infrastructure for legacy industries, especially platforms operating in regulated, context-heavy, and physical-world workflows where durable data, compliance, audit trails, or embodied operations create compounding advantages.

Back exceptional entrepreneurs building enduring companies that defy expectations. Value authenticity and tenacity to turn daring ideas into lasting impact. One life-altering investment can lead to industry-wide transformation.

The future belongs to those who build. JSV convenes and connects the next generation of AI-native founders, drawing on its all-partner team of former founders and operators to back software and marketplace companies from seed through growth.

Beginnings matter. We work with founders exclusively at the earliest stages of company building, often when all they have is an 'imagine if.' We look for compelling and contrarian insights into how the world works—what do you understand about a market that others miss? Our role is to accelerate the path from idea to product-market fit through embedded partnership.

Technology is the 'new West' — Westbound invests financial and social capital into visionary, values-aligned founders to build a virtuous cycle of wealth and opportunity, with an explicit mission to close the racial wealth gap.

Partner with elite founders building transformational technologies that create lasting economic and societal value. Focus on Smart Enterprise across five sectors: Logistics, Life Sciences, Healthcare, IT Infrastructure, and Government/Defense. Invest in platforms that enable human experts to solve non-linear problems through data integration and network effects.

We back the companies of tomorrow before it's obvious. We combine early-stage European investing with a permanent San Francisco presence to help founders build category-defining global companies. We invest in ambitious technical founders who deeply understand industry transformation.

Invest in hyper-growth consumer and technology businesses with enduring customer relationships. Back founders challenging the status quo through digital transformation. Focus on companies with strong unit economics, loyal customer bases, and defensible competitive advantages in complex, regulation-heavy markets.

Founder-first early-stage investing that combines capital with founder resilience, operating support, and capital-efficient company building for durable, profitable outcomes.

Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support.

We invest in paradigm shifters—truly disruptive technologies that change our perspective of the world. We believe in missionary founders committed to their vision, and we focus on business-team-idea-timing fit, not just product-market fit. We target transformative companies across defense, climate, fintech, legal tech, and emerging domains.

NYC has tremendous entrepreneurial talent but lacked a structured environment for early-stage founders. ERA provides capital, intense mentorship, and network access to help founders build market-leading companies. Every sector deserves innovation.

We back disruptive founders building category-defining companies. Our approach is founder-first, long-term, and deeply operational. We take the longest view in the room, operate with excellence and integrity, stay curious at the bleeding edge, and invest heavily in building community.

At the earliest stages, team > market > product > idea. Great founders find their way into large markets. Focus on unit economics and value capture alongside value creation. Strong emphasis on B2B managed marketplaces and India-first consumer/enterprise plays.

Unconventional ideas shape progress. DCM looks for potential in the overlooked, applying first-principles thinking and concentrating deeply on a small cohort of companies each year rather than spreading capital thin, with a global (US/Asia-Pacific) perspective and local execution.

Early-stage venture capital for IT and Biotech companies in Colorado Front Range and Mid-Atlantic. Focus on experienced founding teams solving important problems with potential for significant financial returns. Patient capital approach with operational support and deep regional networks.

First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital.

Data and technology combined with sector expertise and operational support unlock unfair advantages for early-stage startups. We build venture capital like a tech company.

Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs.

We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries.

Accelerating digital innovation across Southeast Asia and Northeast Asia by backing category-defining founders in AI, semiconductors, med-tech, and digital infrastructure, with OCBC's ecosystem providing enterprise access, capital pathways, and exit routes.

Cherry backs ambitious, resourceful, resilient founders with a novel insight ("anomaly") and a coherent, feasible path to an underexplored shared need ("the red thread"), investing industry-curiously across Europe often before product or revenue exist.

Entrepreneurs by heart, investors by choice: 3VC partners with regional talent across DACH, CEE, the Baltics, and Southern Europe showing early signs of product-market fit and customer love, and helps them become global category leaders.

Strategic investments at the intersection of media, information, and technology, prioritizing businesses that benefit from Hearst operating expertise, distribution, and permanent capital.

Partner operators who have scaled Latin American tech companies back B2B and tech-enabled businesses that digitize offline or fragmented Brazilian SMB and enterprise industries.