30 VC firms investing in marketing & adtech and healthcare & digital health at the Pre-Seed stage.
F4 Fund tracks 30 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Pre-Seed stage, with check sizes ranging from $25K – $25M (median: $1.6M – $1.6M). As of June 2026, and 83% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Flagship Pioneering Create first-in-category bioplatform companies through scientific innovation and systematic entrepreneurship. Combine institutional scale with pioneer creativity to build breakthrough life sciences companies. Cambridge | $500K – $15M | 22 | Leads | Active | ~1 mo | Req'd |
| 2 | ▶ Ascend Ascend backs the most active pre-seed founders in the Pacific Northwest building SaaS 3.0 (vertical AI agents), Gen AI 2.0 (fast-follower infrastructure), and Frontier AI (AI applied to the physical world). Seattle has one in four of the U.S.'s AI engineers — Ascend captures that alpha as the first institutional check. Seattle | $250K – $750K | 60 | Leads | Active | ~1 mo | Req'd |
| 3 | ▶ FoundersEdge UX is the new defensibility. As AI commoditizes the cost of building software, the competitive moat shifts to user experience and human-AI interaction design. FoundersEdge backs experienced, multi-time founders building AI-native software for legacy industries. Boston | $150K – $200K | 12 | Leads | Active | — | Open |
| 4 | ▶ AltaIR Capital Back focused founders solving real problems in markets they understand deeply, with clarity, discipline, and drive. Seek companies with motivated teams, strong product vision, scalable business models, and large addressable markets. San Francisco | $1M – $25M | 40 | Leads | Active | ~1 mo | Open |
| 5 | ▶ Mosaic General Partnership Partners with exceptional founders building game-changing companies at the intersection of technology, industry, and culture. Focus on sectors where deep network and experience can bend the risk curve. San Francisco | $3M – $6M | 18 | Leads | Active | ~2 wks | Req'd |
| 6 | ▶ f7 Ventures We identify exceptional operators with proven track records at scale (ex-Facebook, Google, Stripe) and catalyze their transition into founders. Periods of rapid societal behavior change spur dramatic innovation. We invest in the future of work and consumer utility, providing not just capital but operational expertise, network access, and proven playbooks from building at Facebook/Meta scale. San Francisco | $500K – $5M | 46 | Leads | Active | ~1 wk | Open |
| 7 | ▶ Hustle Fund Hilariously early pre-seed/seed investing. We back hustlers at concept stage—fast, scrappy, first-principles founders who act before market consensus. San Francisco | $25K – $500K | 25 | Leads | Active | ~1 wk | Open |
| 8 | ▶ 8-Bit Capital Network-powered startups connecting people and businesses through software tools and platforms | $250K – $3M | 55 | Both | Active | — | — |
| 9 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 10 | ▶ Pathlight Ventures Low volume, high conviction early-stage investing in 10 thematic areas where vertical AI is reshaping regulated, complex industries: healthcare, fintech, capital markets, industrial operations, security, and government. Back strongly opinionated founders building category-defining companies with direct operator support from a team with deep fintech and growth scaling experience. New York City | $250K – $3M | 39 | Leads | Active | ~1 mo | Open |
| 11 | ▶ Point Nine Invest in the future of software built on AI. We partner with technical founders to provide capital, unfair shortcuts, and operational support to accelerate their learning and help them reach their potential. We position ourselves as the first institutional investor for v0.9 stage founders. Berlin | $1M – $10M | 36 | Leads | Active | ~1 wk | Req'd |
| 12 | ▶ Bling Capital The hardest thing in seed is finding product-market fit. We help you find it. If you already have product-market fit, we will help you scale. We partner with exceptionally ambitious founders for the long run and provide capital combined with operational expertise through our 100+ member Product Council. San Francisco | $500K – $3M | 33 | Leads | Active | ~2 mo | Open |
| 13 | ▶ Bowery Capital Backs early-stage B2B founders building vertical AI solutions that automate administrative and operational workflows in underserved industries. Focuses on seed-stage companies with strong founder-market fit and clear unit economics. New York | $250K – $5M | 20 | Leads | Active | ~2 wks | Req'd |
| 14 | ▶ F4 Fund We back the relentless - founders with exceptional drive, clear vision, and proven execution ability building ambitious category-defining companies. | $100K – $500K | 32 | Leads | Active | ~1 wk | Req'd |
| 15 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 16 | ▶ Entrepreneurs Roundtable Accelerator (ERA) NYC has tremendous entrepreneurial talent but lacked a structured environment for early-stage founders. ERA provides capital, intense mentorship, and network access to help founders build market-leading companies. Every sector deserves innovation. New York | $150K – $150K | 39 | Leads | Active | ~2 mo | Open |
| 17 | ▶ Liquid 2 Champions exceptional founders to build lasting companies through experience, community, and capital. Generalist technology investor whose edge is network depth — Joe Montana's unmatched rolodex and 800+ portfolio company network enables introductions that most seed funds cannot provide. San Francisco | $250K – $5M | 27 | Follows | Active | ~2 wks | Open |
| 18 | ▶ FirstMark We back disruptive founders building category-defining companies. Our approach is founder-first, long-term, and deeply operational. We take the longest view in the room, operate with excellence and integrity, stay curious at the bleeding edge, and invest heavily in building community. New York | $250K – $10M | 32 | Leads | Active | ~2 wks | Req'd |
| 19 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 20 | ▶ Rainfall Ventures We invest in world-class founders solving significant problems. We prioritize founder quality, founder-problem fit, and values-aligned partnerships. We help exceptional founders become category leaders early, before they become obvious trends. Los Angeles | $500K – $5M | 41 | Leads | Active | ~2 wks | Req'd |
| 21 | ▶ Firsthand VC Inception-stage VC backing experienced founders building B2B autonomous agentic AI from day zero. Leverages Salesforce alumni network to provide portfolio companies with enterprise distribution and operational support. New York | $100K – $2M | 19 | Follows | Active | ~1 mo | Open |
| 22 | ▶ LOI Venture Back the brightest early-stage founders under 30. We provide capital, mentorship, and network access to accelerate ambitious young entrepreneurs who graduate from our League of Innovators program or demonstrate exceptional founder quality. Vancouver | $100K – $1M | 35 | Leads | Active | ~2 wks | Open |
| 23 | ▶ Kima Ventures Back ambitious teams with strong learning and execution capacities across all sectors, stages, and geographies. Technology-enabled businesses preferred. Volume-based, founder-centric investment philosophy. Paris | $100K – $200K | 25 | Leads | Active | ~2 wks | Open |
| 24 | ▶ Fireroad Ventures Back founders solving existential problems for small and medium-sized businesses in contracting, healthcare, hospitality, and other local industries. Focus on applied AI for service sectors and SMBs, backing founders with deep operational knowledge of the markets they serve. Cincinnati | $25K – $250K | 11 | Follows | Active | — | — |
| 25 | ▶ Laconia Serious founders building must-have technology for mission-critical industries. We focus on B2B software companies digitizing legacy industries and transforming established workflows. Specializing in seed-stage, where hands-on operational support, sales acceleration, and capital strategy matter most. New York | $250K – $1M | 20 | Leads | Active | ~1 wk | Open |
| 26 | ▶ Daring Ventures Extraordinary talent is equally distributed. Extraordinary opportunity is not. We invest in non-obvious founders building critical infrastructure for overlooked markets—solving operational friction in complex industries with real relationships, judgment, and expertise. | $250K – $1M | 4 | Follows | Active | ~1 wk | Req'd |
| 27 | ▶ Kaedan Capital Entrepreneur-centric private investment firm backing Israeli-related seed to early-stage ventures across diverse technology areas. Patient partners who allow founders to build global tech companies at their own pace. Tel Aviv | $250K – $1.5M | 21 | — | Active | ~1 mo | Open |
| 28 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 29 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 30 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
Investors on this page also frequently invest in these sectors
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Firms that frequently co-invest with investors on this page
F4 Fund tracks 30 VC firms that actively invest in marketing & adtech + healthcare & digital health at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed marketing & adtech + healthcare & digital health investors is $1.6M – $1.6M, with a full range from $25K – $25M. The distribution breaks down as: 8 firms in the <$500K range, 6 firms in the $500K-$1M range, 4 firms in the $1M-$2M range, 7 firms in the $2M-$5M range, 4 firms in the $5M-$10M range, 1 firms in the $10M+ range.
Among the 30 firms tracked, 83% lead or co-lead rounds, and 13% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed marketing & adtech + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 39% prefer warm introductions, and the average firm has 30 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.