72 VC firms investing in biotech & life sciences and aerospace & defense at the Pre-Seed stage.
F4 Fund tracks 72 VC firms that actively invest in biotech & life sciences + aerospace & defense at the Pre-Seed stage, with check sizes ranging from $5K – $500M (median: $2M – $2M). As of June 2026, and 85% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,356+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 2 | ▶ Shrug Capital Identifying culturally resonant, consumer-focused companies with differentiated products and founder teams that will capture global attention. We invest across technology, consumer behavior, entertainment, and culture—seeking to spot emerging trends before they reach mainstream awareness. We operate as a partnership combining rigorous deal selection with exceptional founder support, creative marketing, and deep understanding of consumer psychology. San Francisco | $500K – $2M | 114 | Both | Active | ~2 wks | Open |
| 3 | ▶ Refactor Capital The most enduring companies are created by founders willing to commercialize real science and scale real systems. We focus on hard tech at the intersection of computation and physical sciences—aerospace, biotech, energy, materials—where technical execution is the moat. Burlingame, CA | $1M – $2M | 47 | Leads | Active | ~1 wk | Open |
| 4 | ▶ ZAKA VC Founders backed by entrepreneurs. ZAKA bridges North American and CEE startup ecosystems, investing pre-seed to seed in Health & Biotech and Industrial Tech. The firm deploys institutional capital while leveraging operator networks to help European founders scale globally. Prague | $100K – $500K | 67 | Follows | Active | ~1 mo | Open |
| 5 | ▶ Humba Ventures We invest in hard tech and hard sectors—companies building solutions to difficult, underexplored problems that others won't. Unlocking society's potential depends on founders willing to build what others won't. We're hyper curious, drawn to difficult and underexplored areas. San Francisco | $250K – $1M | 38 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Olive Tree Capital Olive Tree Capital invests in groundbreaking technology and life sciences companies guided by the Golden Rule philosophy. As an evergreen vehicle without asset class limitations or holding period constraints, OTC can be a long-term partner to founders across any stage and geography. Boston | $250K – $5M | 35 | Both | Slowing | — | Open |
| 7 | ▶ Manta Ray Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability. London | $250K – $3M | 52 | Both | Active | ~1 mo | Open |
| 8 | ▶ Aera VC Investing in breakthrough deep technologies that address humanity's greatest challenges. We allocate ~80% to climate solutions (carbon-negative materials, renewable energy, climate adaptation) and ~20% to frontier tech (aerospace, robotics, advanced materials, biotech). We operate as a venture-and-philanthropy platform backed by the Fukutake family, blending profit-seeking with impact objectives. Singapore | $500K – $20M | 33 | Leads | Active | ~1 mo | Open |
| 9 | ▶ E2MC Ventures The space economy represents the next frontier for transformative economic opportunity and meaningful impact. We back pioneering founders building the technologies and services that enable humanity's expansion into space while creating value on Earth. We apply financial discipline (Wall Street cash-flow and intrinsic-value approach) to identify sustainable, scalable space businesses. Miami | $1M – $5M | 30 | Leads | Active | ~1 mo | Req'd |
| 10 | ▶ Winklevoss Capital We back determined builders working on hard problems in critical domains. Real innovation is non-obvious at first and often misunderstood. We support contrarian founders during frontier exploration when they need it most. New York | $100K – $5M | 29 | Both | Active | ~2 wks | Open |
| 11 | ▶ Divergent Capital We back deeply technical founders solving hard problems with innovative technologies. Combining capital with go-to-market expertise and structured fellowships, we partner with founders who have authentic personal connections to their problems and bring novel technological approaches to market. New York | $250K – $1M | 44 | Leads | Active | ~2 wks | Req'd |
| 12 | ▶ Tribe Capital Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access). Menlo Park | $500K – $5M | 60 | Leads | Active | ~1 wk | Open |
| 13 | ▶ Starlight Ventures We invest in teams and solutions that address multi-decade problems that humanity has no choice but to solve. Our focus is breakthrough science and technology applied to energy transition, life sciences, space, and next-generation computing. Miami | $250K – $2.5M | 15 | Leads | Active | ~2 wks | Open |
| 14 | ▶ Silicon Roundabout We back 'sub-0.1% of the population' type exceptional founders building fundamental, infrastructure-level technologies in critical sectors (computing, defence, energy) reshaping our world. Community-driven approach provides proprietary deal flow and deep technical credibility. Focus on first cheques in pre-seed/seed with hands-on mentorship and network access. | $150K – $8.7M | 27 | Leads | Active | ~2 wks | Open |
| 15 | ▶ Air Street Capital We invest exclusively in AI-first companies where advances in artificial intelligence are the primary driver of product capability, competitive advantage, and long-term value creation. We are deeply coupled to the frontier of AI research and industry, enabling us to identify emerging technical inflection points and structural shifts early. London | $1M – $300M | 26 | Leads | Active | ~1 mo | Open |
| 16 | ▶ Spacecadet Ventures Founders building the possibly impossible deserve capital plus marketing support. Great technology combined with exceptional storytelling and narrative development creates world-changing moonshots. We provide both the capital and the story-telling expertise to help founders achieve escape velocity. New York | $250K – $1M | 99 | Leads | Active | ~2 wks | Open |
| 17 | ▶ R7 Partners Intelligence is coming into the physical world through AI and robotics applied to atoms rather than bits. We back capex-heavy, long-horizon bets in hard-to-abate decarbonization sectors and hardware-heavy industrial systems that many traditional early-stage funds avoid. Chicago | $100K – $5M | 35 | Leads | Active | ~2 mo | Req'd |
| 18 | ▶ Harpoon Ventures Technology will define geopolitics. We invest in the Freedom Stack—foundational technologies critical to American national security and technological leadership. We partner with mission-driven founders building capabilities essential to American prosperity and strategic advantage. San Diego | $500K – $5M | 46 | Leads | Active | ~2 wks | Req'd |
| 19 | ▶ Upfront Ventures Early investors and long-term partners. We back exceptional founders solving real problems across sectors. When you hit a bump in the road, we're there solving problems alongside you with operational expertise and network leverage. | $1M – $15M | 46 | Leads | Active | ~2 wks | Req'd |
| 20 | ▶ 11.2 Capital We invest in technically sophisticated founding teams solving breakthrough problems in deep-tech. We believe the next generation of transformational companies will be built by scientists and engineers with deep domain expertise tackling problems at the frontier of AI, cybersecurity, quantum, robotics, space, synthetic biology, and bioengineering. We provide patient capital and technical partnership to help these teams achieve escape velocity. San Francisco | $500K – $3M | 21 | Leads | Active | ~2 wks | Open |
| 21 | ▶ BlueYard Capital Invest in only two kinds of technologies: those that move humanity toward utopia, and those that hold the line against oblivion. Back n-of-1 visions for an era of Black Swans—unconventional companies solving civilization-scale problems that others dismiss as too early, too risky, or too misunderstood. Berlin | $500K – $5M | 58 | Leads | Active | ~2 mo | Open |
| 22 | ▶ Level Ventures Level Ventures is the capital partner to outlier managers and entrepreneurs. The firm uses data-driven algorithms to identify top-quartile emerging VC managers (<$150M) and co-invests directly into their most promising portfolio companies. Core sectors: AI in life sciences, defense tech/aerospace, enterprise software, and developer infrastructure. New York | $500K – $10M | 11 | Follows | Active | ~1 mo | Open |
| 23 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 24 | ▶ The Venture Collective (TVC) Permanent balance-sheet investor backing highly defensible, category-defining, mission-driven companies solving the world's biggest problems. Focus on founders transforming legacy industries with emphasis on diversity, equity, and inclusion. New York | $100K – $2M | 53 | Leads | Active | ~2 wks | Open |
| 25 | ▶ Pale Blue Dot Early-stage climate tech companies building the sustainable future. We invest in both software and hardware solutions addressing climate change through optimization, adaptation, and pioneering innovations. The next billion-dollar companies will be built with climate in mind. Sweden | $500K – $2M | 40 | Leads | Active | ~2 mo | Req'd |
| 26 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 51 | Both | Active | ~2 mo | Open |
| 27 | ▶ Elementum Ventures Seed-stage deep technology with IP defensibility, deployed by multi-exit founder-operators willing to be hands-on operational partners. Focus on frontier sectors—defense, climate, space, biotech, fusion—where bold technical founders are building mission-critical capabilities. Menlo Park | $250K – $1.5M | 26 | Leads | Active | ~1 mo | Req'd |
| 28 | ▶ Fifty Years We back founders using technology to solve the world's biggest problems. We believe capitalism can be a force for good when companies are built to be both massively profitable AND create positive impact. The best entrepreneurs are determined, passionate, smart, creative, and can inspire thousands of talented people. San Francisco | $250K – $2M | 25 | Leads | Active | ~2 wks | Open |
| 29 | ▶ NFX Network effects are the #1 way to create defensibility in digital businesses. We invest in visionary founders building defensible businesses with network effects embedded in their core product. San Francisco | $1M – $5M | 25 | Leads | Active | — | — |
| 30 | ▶ Contrary Identify and invest in the world's top talent before they start a company. Build lifelong relationships through a proprietary university scout network at Stanford, MIT, Harvard, and other elite universities. Back exceptional founders within 1-3 years of graduation before they are widely recognized. San Francisco | $100K – $15M | 55 | Both | Active | ~2 wks | Req'd |
| 31 | ▶ Ten VC Invest in brilliant founders building breakthrough technologies that can scale into transformational platforms. Focus on breakthrough applications of deep science, industrial new normal, and new infrastructure & tools across deeptech, biotech, advanced manufacturing, and critical infrastructure. Menlo Park | $250K – $1.5M | 15 | Leads | Active | ~2 wks | Open |
| 32 | ▶ Cantos We invest in people who will transform the physical world. Near frontier technology solving climate change, disease, armed conflict, poverty, and existential risks. Technical founders building capital-intensive, long-horizon companies. San Francisco | $400K – $1.5M | 42 | Leads | Active | ~1 mo | Req'd |
| 33 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 34 | ▶ Asymmetry Ventures Backing transformative startups with exceptional defensibility and civilization-level impact potential. Focus on technical complexity, defensible innovation, and companies solving large-scale problems. Quality over volume approach with selective, thesis-driven investing. San Francisco | $100K – $500K | 23 | Follows | Active | ~2 mo | Req'd |
| 35 | ▶ 8VC Partner with elite founders building transformational technologies that create lasting economic and societal value. Focus on Smart Enterprise across five sectors: Logistics, Life Sciences, Healthcare, IT Infrastructure, and Government/Defense. Invest in platforms that enable human experts to solve non-linear problems through data integration and network effects. Austin | $500K – $50M | 30 | Leads | Active | ~2 wks | Open |
| 36 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 37 | ▶ Angular Ventures Backs inception-stage technical founders across Europe and Israel building solutions for hard markets including AI infrastructure, space/aerospace, advanced manufacturing, energy, biology, and other deep-tech verticals. London | $500K – $5M | 46 | Leads | Active | ~2 wks | Open |
| 38 | ▶ DCVC We back entrepreneurs using computational approaches (AI, simulation) to solve trillion-dollar problems in climate, health, industrial transformation, and national security. Deep tech requires patient capital and scientific rigor. San Francisco | $5M – $25M | 31 | Leads | Active | ~2 mo | Req'd |
| 39 | ▶ K5 Global K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships. Los Angeles | $1M – $3M | 31 | Leads | Active | ~1 mo | Open |
| 40 | ▶ Batshit Crazy Ventures Support unconventional, bold founder-led companies solving real problems at the earliest stages. We provide capital, operational mentorship, and resources to pre-revenue and pre-seed startups that traditional investors overlook. Boulder, Colorado | $100K – $1M | 23 | Both | Between | ~2 wks | Req'd |
| 41 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 42 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 43 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 44 | ▶ Baobab Ventures Operator-led capital for global pre-seed and seed technical founders building AI, robotics, defense, developer tools, AI-native applications, and adjacent deep-tech companies where rapid execution and distribution matter. London | $300K – $350K | 15 | Both | Active | — | Open |
| 45 | ▶ Black Flag Be the first check in for founders building America's next era of critical technologies. Invest in audacious founders across Defense, Aerospace, Energy, AI, Manufacturing, Cybersecurity, and Health+Bio solving problems critical to national security and American technological leadership. Provide capital ($250K-$1M), unmatched government access, mentor network, and go-to-market acceleration. San Diego | $250K – $1M | 21 | Leads | Active | ~1 mo | Open |
| 46 | ▶ UpHonest Capital We invest in the most promising entrepreneurs building the fastest-growing early-stage startups. We provide cross-border access by connecting founders to resources and networks across the world's most valuable and influential VC markets. Palo Alto | $50K – $1M | 26 | Follows | Active | ~1 mo | Open |
| 47 | ▶ Human Capital Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise. San Francisco | $250K – $200M | 25 | Both | Active | ~1 wk | Open |
| 48 | ▶ Celesta (fka WRVI) Celesta invests in brilliance at the forefront of science and engineering, targeting companies that enable mass adoption of emerging tech, radically improve health outcomes, and transform large industries. Focus on platforms enabling emerging tech adoption, bioconvergence innovations (high-tech + biotech), and technologies disrupting legacy industries with deep tech. San Francisco | $250K – $20M | 19 | Leads | Active | ~2 mo | Open |
| 49 | ▶ Julian Capital First check for deeptech founders building across all deeptech sectors (chips, energy, robotics, medtech, materials science, aerospace). We provide more than capital—we become your growth team, design your website, and offer hands-on go-to-market support backed by deep expertise in startup scaling and commercialization. San Francisco | $750K – $1M | 13 | Leads | Active | ~2 wks | Open |
| 50 | ▶ Boost VC Back the quirky underdog pursuing seemingly impossible ideas. Frontier tech (aerospace, biotech, climate, robotics, crypto, AI, VR/AR) will create the next generation of legendary companies. Technical founders with deep domain expertise can solve the hardest problems in physics, chemistry, and computing. San Mateo, California | $500K – $3M | 30 | Leads | Active | ~1 wk | Open |
| 51 | ▶ 1517 Fund We back dropouts, renegade students, and deep-tech scientists working on ideas that would appear in science fiction. We exist to prove that great founders don't need university degrees and are found in the oddest places. We invest at inception stage (R&D through Seed), providing capital, mentorship, community access, and operational support. People-first approach: it's more about the who than the what. Telluride, Colorado | $50K – $1M | 18 | Leads | Active | ~1 wk | Open |
| 52 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 53 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 54 | ▶ Battery Ventures Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools. Boston | $1M – $500M | 23 | Both | Active | ~2 wks | Open |
| 55 | ▶ Brickyard Extraordinary founders execute faster when isolated from distractions and provided intensive on-site support. We seek junkyard dogs with high agency, non-obvious vision, delusional optimism, and execution discipline. Category matters far less than founder quality. Chattanooga, TN | $100K – $500K | 52 | Both | Active | ~2 wks | Open |
| 56 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 17 | Leads | Active | ~2 wks | Req'd |
| 57 | ▶ Deep Checks Deep Checks matches deeptech founders worldwide with venture capital investors who specialize in their specific technology niches. We operate as a specialized deal-flow curation platform connecting founders with 50+ deeptech VCs, angels, and founder-investors. Our mission is to democratize access to expert capital for scientific and hardware founders who are otherwise hard to reach. San Francisco | $500K – $5M | 12 | — | 1mo | ~2 wks | Open |
| 58 | ▶ Impact Venture Capital Corporate-advantage seed investing. We identify promising AI and deep tech startups early, then leverage our hundreds of relationships with corporate venture capital arms to de-risk investments, accelerate time to exit, and create curated dealflow where both founders and corporates benefit from strategic alignment. El Dorado Hills, CA | $250K – $1M | 22 | Leads | Active | ~2 wks | Req'd |
| 59 | ▶ FAST — by GETTYLAB Breakthrough innovations emerge from engineers tackling frontier problems. We provide fast capital, domain expertise across AI/robotics/space/biotech, and deeptech credibility to pre-seed teams. San Francisco | $5K – $100K | 11 | Follows | Active | ~1 wk | Open |
| 60 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 61 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 62 | ▶ KittyHawk Ventures Backing exceptional, mission-driven entrepreneurs creating companies with Massively Transformative Purpose (MTP) that impact billions of people. We invest across the full innovation lifecycle, from early-stage frontier technology through scale to liquidity. We love companies and individuals that are different, fishing where others aren't, seeking opportunities where exceptional visionary entrepreneurs see novel paths to greatness. Los Angeles | $500K – $5M | 10 | Leads | Active | ~2 mo | Req'd |
| 63 | ▶ Draper Associates Invest in bold, visionary founders building transformational businesses long before the world believes in them. We back founders solving impossible-seeming problems across frontier sectors: AI/robotics, crypto, biotech, aerospace, and unconventional ideas. San Mateo, CA | $500K – $30M | 23 | Leads | Active | ~1 wk | Open |
| 64 | ▶ OVNI Capital Back European technical founders building globally ambitious deeptech and critical technology companies at pre-seed and seed, with concentrated first-check conviction and Paris/San Francisco/Berlin support. Paris | $250K – $2M | 18 | Both | Active | — | Open |
| 65 | ▶ Sand Hill Angels Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem. Mountain View | $50K – $2M | 30 | Follows | Active | — | Open |
| 66 | ▶ Hard2beat We invest in early-stage Polish deep tech startups with a clear technological edge—solving hard problems through software-driven or hardware-enabled solutions. Defensible technology, early validation, and resilient founders are non-negotiables. A deeptech project without real customers becomes a research project. Wrocław, Poland | $100K – $750K | 7 | Both | Active | ~1 wk | Open |
| 67 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | — | 1mo | ~2 wks | Open |
| 68 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 69 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 70 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 71 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
| 72 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 72 VC firms that actively invest in biotech & life sciences + aerospace & defense at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed biotech & life sciences + aerospace & defense investors is $2M – $2M, with a full range from $5K – $500M. The distribution breaks down as: 9 firms in the <$500K range, 13 firms in the $500K-$1M range, 14 firms in the $1M-$2M range, 16 firms in the $2M-$5M range, 7 firms in the $5M-$10M range, 13 firms in the $10M+ range.
Among the 72 firms tracked, 85% lead or co-lead rounds, and 13% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed biotech & life sciences + aerospace & defense investors combine domain expertise with an active portfolio in the space. Among these firms, 25% prefer warm introductions, and the average firm has 35 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.