Best Series A Security & Cybersecurity + Biotech & Life Sciences Investors 2026

Essential infrastructure software used by engineering, security, and data teams. Founded by technical entrepreneurs who deeply understand infrastructure challenges. Partners commit early with conviction and provide hands-on support.

Backing transformative founders building exceptional companies across all sectors

The best companies will be built by technical founders - engineers, researchers, and scientists who have experienced a problem viscerally and are compelled to solve it. We invest in tools, platforms, and infrastructure for technical builders, and we partner with founders to help them evolve into leaders of generational companies.

Back dual-use technologies serving both commercial and government markets. Founded as investment community response to 9/11, we bring unmatched expertise from NSA, CIA, DARPA. We seek founders building innovative cyber, AI safety, and advanced technologies with meaningful impact on national security and commercial markets.

Back founder-operators with prior venture-scale exits solving hard technical problems in non-obvious, regulated deep-technical verticals including AI infrastructure, blockchain, biotech, and communications infrastructure. Co-invest alongside quality partners to maintain flexibility and focus on deep operational support and strategic value-add.

Disruptive innovation in work and education fuels human achievement. We partner with exceptional entrepreneurs who are business builders, deep domain experts, and capital efficient thinkers. We believe in long-term relationships over transactional investing, often partnering with founders across multiple ventures.

Early-stage innovation from founders backed by seasoned operators. We invest in disruptive technologies solving real problems at the intersection of scientific breakthroughs and practical execution. Our founders get patient capital, hands-on mentorship from 100+ years of combined experience, and access to our network for strategic growth.

Make no little plans. Support revolutionary (not evolutionary) ideas that transform industries and benefit society. We partner with entrepreneurs solving massively multi-disciplinary problems at the intersection of AI, data, biotech, and deep tech. Our style of in-the-trenches venture capital doesn't scale—we make fewer than 10 investments per year so we have time to roll up our sleeves with every team we back.

Madrona invests in people and ideas for the long run — backing visionary founders building transformational technology companies, with deep focus on applied AI across domain-specific applications, AI infrastructure, developer tools, enterprise software, and AI-enabled biotech. The firm serves as an active, full-stack partner providing capital plus recruiting, business development, and customer introductions.

Apply AI and data science to identify and invest in N-of-1 companies with 10-100x potential. Back founders who expand individual freedom and decentralize power. Invest in companies that embody principles from the Bill of Rights (voice, fair process, proportionality, user power) and Bitcoin whitepaper (trust-minimized, verifiable, aligned incentives, open access).

EPIC Ventures backs early-stage technology companies building in the information economy, with a focus on enterprise SaaS, healthcare technology, cybersecurity, and future of work. The firm believes the best way to build lasting companies is through genuine partnership with founders — providing capital, strategic guidance, operational expertise, and deep network access. Founded in 1994, EPIC helped build the Utah tech ecosystem and continues to be the foundational VC of the Mountain West.

We back bold, ambitious, and resilient founders driving breakthrough innovations in HealthTech, CleanTech, and AgriFoodTech. Female-led and gender-mixed teams deliver superior returns and drive meaningful impact. Over five decades of combined experience navigating financial cycles enables us to partner authentically with founders, providing not just capital but strategic guidance and operational support.

Backs bold founders in technology and healthcare building companies that will define the future of their industries. Two practice areas: Enterprise/AI (AI infrastructure, frontier systems, cybersecurity, defense, fintech, developer tools) and Healthcare/Life Sciences (digital health, therapeutics, genomics, health system modernization). Deep partnership model, long-term patient capital approach across market cycles since 1969.

The AI-first transformation of business will be as big as digital, mobile, and cloud combined. We invest in companies building the AI-first technology stack: data foundations, AI tools, autonomous applications, and product-led growth companies that accelerate adoption. Founders building at any layer of this stack can reach goals and uncover opportunities previously unattainable.

Technology will define geopolitics. We invest in the Freedom Stack—foundational technologies critical to American national security and technological leadership. We partner with mission-driven founders building capabilities essential to American prosperity and strategic advantage.

We invest in technically sophisticated founding teams solving breakthrough problems in deep-tech. We believe the next generation of transformational companies will be built by scientists and engineers with deep domain expertise tackling problems at the frontier of AI, cybersecurity, quantum, robotics, space, synthetic biology, and bioengineering. We provide patient capital and technical partnership to help these teams achieve escape velocity.

Invest in only two kinds of technologies: those that move humanity toward utopia, and those that hold the line against oblivion. Back n-of-1 visions for an era of Black Swans—unconventional companies solving civilization-scale problems that others dismiss as too early, too risky, or too misunderstood.

Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support.

Women-led fund focused on healthcare infrastructure—middleware, payments, clinical trials, and data architecture—thesis-driven, GTM-heavy partner offering hands-on commercialization support for technical founders scaling into payer and provider markets.

Back founders with deep, first-hand domain expertise in specific industry verticals — those who have 'lived' the problem they are solving. Vertical-first software delivers faster time-to-value and stronger retention versus horizontal tools requiring heavy customization.

Mayfield invests in founders building iconic companies through AI-first innovation and human-AI collaboration. The firm believes the next wave of category-defining enterprises will leverage collaborative intelligence, where AI teammates augment and amplify human capability. Mayfield seeks deep tech founders with defensible innovation, clear market advantage, and the ability to scale globally.

Partner with spiky founders building category-defining companies using novel technological approaches. Focus on AI-driven innovation across alternative architectures, custom software, research assistants, TechBio, infrastructure, and enterprise applications. Provide capital, operational support, strategic guidance, and network access for founders with unique insights and deep technical expertise.

Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital.

We invest in early-stage information technology and biotechnology companies in Colorado and the Mid-Atlantic. Our philosophy is rooted in mountain guide principles: careful pattern recognition under uncertainty, patience in waiting for proper conditions, and a commitment to realized returns over paper valuations. We provide hands-on operational partnership, board-level involvement, and access to deep regional networks built over decades.

GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI.

We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders.

Back mission-driven founders addressing significant global challenges through leading-edge technology. Provide flexible and patient capital, leveraging our time, resources, and networks to support portfolio company success. Focus on founders with authentic social and environmental missions alongside commercial viability.

Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit.

K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships.

Exceptional founders living in the future deserve operators who provide more than capital. We partner with founders on go-to-market, brand, storytelling, and team building.

Back technical teams working on breakthrough products. We invest in seed stage companies that demonstrate technical differentiation - meaning technical or product-level superiority is a major reason for future success. We pursue investments from application layer (AI/ML) through software infrastructure to hardware layers (semiconductors, photonics).

Back passionate, emerging talent solving deep technology challenges. Support founders from napkin-stage through IPO with patient, flexible evergreen capital. Focus on biotechnology, frontier software, food innovation, longevity, and AI that maximize impact and potential.

Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly.

As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection.

AI-first venture capital firm investing in AI transformation and digital infrastructure across GenAI Infrastructure (AI chips, quantum, autonomous robotics), Deep Domains (fintech, healthcare, enterprise), and GenAI Agents (autonomous AI for real-world consumer and enterprise use).

We are professional fixers for complex situations. An extension of your team. Fierce defenders when you need us most. Partners who roll up their sleeves. We invest in early-stage companies helping them avoid traditional roadblocks on their path to hypergrowth. We specialize in navigating hostile situations, IP protection, and crisis management.

Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise.

Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check.

Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support.

Battery Ventures operates as a stage-agnostic firm backing technology-driven category leaders across all growth stages from seed to buyout. The firm believes the best tech investments span the entire founder journey, and they practice collaborative, research-focused investing with embedded operational support through their Portfolio Services platform. They seek technical founders with deep domain expertise and experienced operators building in four core sectors: Application Software, Infrastructure Software, Consumer, and Industrial Tech + Life Science Tools.

Sierra believes enterprise software is being fundamentally transformed by cloud computing and AI. They invest in technical founders building the next generation of enterprise solutions that deliver superior ROI through better efficiency, automation, and capability. The firm particularly focuses on infrastructure, security, healthcare innovation, and emerging deep tech.

Corporate-advantage seed investing. We identify promising AI and deep tech startups early, then leverage our hundreds of relationships with corporate venture capital arms to de-risk investments, accelerate time to exit, and create curated dealflow where both founders and corporates benefit from strategic alignment.

Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture.

Greenoaks backs generation-defining technology companies with exceptional long-term growth potential. We make concentrated, large initial bets and maintain positions through multiple rounds and public markets, believing that exceptional founders and products deserve exceptional partnership.

Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support.

HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines.

Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem.

Back ambitious teams with strong learning and execution capacities across all sectors, stages, and geographies. Technology-enabled businesses preferred. Volume-based, founder-centric investment philosophy.

We build category-defining companies through a combination of design, product, operations, and capital. We identify market gaps, pair brilliant founders with Expa's studio resources, and help them build companies that reshape entire industries.

Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures.

Elevate Ventures partners with innovation-driven founders to provide strategic capital, mentorship, and ecosystem access. Founded by a former founder (Governor Mitch Daniels), the firm believes the best founders exhibit grit, creativity, and coachability. They invest across all sectors and geographies but maintain primary focus on Indiana and Great Lakes Region entrepreneurs building cross-sector innovations.

Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions.

Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups.

Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics.

Invest in the most promising Southern European (primarily Italian) deep-technology companies across Advanced Manufacturing, Life Science, and Energy & Environment, and actively support their expansion into Asian markets (China, South Korea, Japan, South-East Asia). The fund uses a proprietary evaluation framework and a 'pull model' — companies must demonstrate genuine Asian market interest before investment.