Best Series B Security & Cybersecurity + Healthcare & Digital Health Investors 2026

We invest in who you are, not just what you do. We back visionaries and game-changers with character and global ambition. We partner long-term with founders, providing capital, operational support, and deep conviction in their vision.

Long-term venture partnerships built on depth of thought, conviction, and dimensional thinking. We back founders with diverse lived experiences who are building transformative companies. We operate as a team sport—you don't work with individual partners, you work with Acrew. We invest in emotional intelligence, operational support, and the long arc of building meaningful companies.

Point72 Ventures backs ambitious founders building for big outcomes across critical domains. Going deep, not wide—the firm focuses on specialized investment theses in AI, Consumer, and Defense Tech, bringing deep sector insights, partnership, and hands-on support from seed to pre-IPO.

Patient Capital. True Resources. Big Impacts. S3 backs visionary founders building in Business Software and Healthcare Technology. Unique single-LP structure (a multi-billion dollar philanthropic family office) enables patient, flexible investing unconstrained by traditional VC fundraising cycles. Founded in Texas in 2005 — the largest and longest-serving VC native to Texas.

Blumberg Capital backs visionary teams as early and growth stage investors, active board members, and hands-on advisors. They invest in transformative technology companies across enterprise software, cybersecurity, fintech, healthcare tech, and AI with particular strength in the US-Israel technology corridor.

Partner with exceptional founders building technology companies with long-term growth potential capable of fundamentally shifting markets for the common good. Provide capital, operational expertise, board participation, and network access to support founder vision and company building.

Independent global investment platform backing capital-efficient, high-growth technology companies across Europe and North America. Multi-stage, multi-strategy approach from venture to pre-IPO. Transatlantic local teams provide unique advantage in bridging European and US growth.

Cota Capital invests in 'net new' technologies — visionary ideas that either were never before possible or solve problems that didn't exist before. Knowledge is the true capital. The firm backs early-stage enterprise technology companies where deep operational expertise, competitive intelligence, and network access can provide compounding advantage beyond the check.

Category-defining entrepreneurs building fundamental shifts that upend entire industries. Focus on disruptive business models in energy transition, healthcare, AI, and consumer. Thesis values human relationships and founder-centric partnerships over financial metrics alone.

Radian Capital partners with software-driven B2B companies at scale, providing capital and hands-on operational support. They concentrate on select companies and go deep with each, emphasizing sustainable growth over growth at all costs.

We partner with bold builders of category-defining companies from Seed to Series F and beyond. Depth of commitment, depth of relationships, and depth of belief distinguish us. Complete immersion, authentic partnership, and unwavering conviction through market cycles.

The next decade will be defined by the addition of machine intelligence to software. Scale backs 'Cognitive Apps' — AI-powered applications that augment manual work and enable data-driven predictions — partnering with founders who can transition from founder-led to scalable go-to-market, accompanying them from Series A through IPO.

NTTVC backs founders with vision and energy to build transformative technology companies, particularly in enterprise technology, digital health, and AI/ML. The firm's unique structural advantage is its partnership with NTT — a Fortune 100 global IT services provider with 120,000 enterprise customers, $5B+ in annual tech resales, and a $22B systems integration business — giving portfolio companies extraordinary enterprise distribution and market validation channels.

BGV backs hands-on, cross-border enterprise AI startups operating under the Enterprise 5.0 framework — companies that combine intelligent machines with human ingenuity to drive leapfrog productivity improvements. They focus on vertical AI (industry-specific, proprietary data) and horizontal agentic platforms (cross-functional automation), with a strong preference for immigrant founders pursuing US go-to-market strategies from France, Israel, and India.

Madrona invests in people and ideas for the long run — backing visionary founders building transformational technology companies, with deep focus on applied AI across domain-specific applications, AI infrastructure, developer tools, enterprise software, and AI-enabled biotech. The firm serves as an active, full-stack partner providing capital plus recruiting, business development, and customer introductions.

Phoenix Court partners with exceptional founders from pre-seed through public markets and beyond. The firm operates as a multi-stage, multi-fund group — LocalGlobe (seed), Latitude (growth), Solar (late-stage), and Basecamp (emerging managers) — built on the conviction that the best companies grow big not just in private markets but across their full lifecycle. Founded on purpose: 10% of profits and 2% of carry go to Phoenix Court Works, which is transitioning to the single largest shareholder in the firm.

Georgian invests in market-leading B2B software companies across the AI technology stack—from infrastructure and developer tools to enterprise applications and cybersecurity. They pair growth-stage capital with an in-house AI Lab of 20+ ML engineers who embed with portfolio companies post-investment.

Community-driven VC led by active operators who simultaneously build and invest. Best support for founders comes from operators understanding current market challenges firsthand, not just history. Invest in category-defining technology companies.

Overlooked markets where distribution advantage compounds. Founders with deep domain empathy build durable moats. B2B software rebuilding industries through core workflows, data connectivity, and embedded intelligence.

We back founders venturing beyond to build transformational companies that create positive, enduring change. Applied AI and global resilience are fundamental forces reshaping industries.

The world's most successful B2B software companies require presence and success in both North America and Europe. Frontline specializes in facilitating frictionless transatlantic expansion, supporting founders with global ambition through a dual-fund strategy optimized for international growth.

Big things start small. We invest at seed stage and see potential where others don't. We believe in your vision for your company's future, not as it exists today. We think in decades, not days, committing to walk the entire journey with founders to build iconic companies. We share Antipodean ingenuity with the world.

Build category-defining technology businesses that deliver strong investment returns while addressing pressing business challenges. Leverage Fortune 500 parent (MassMutual) assets including real estate portfolios, renewable energy assets, and capital networks.

Exceptional technology companies can be built anywhere—US, Israel, or Europe. We partner with experienced founders to provide capital, US market expertise, and global networks to help them scale internationally.

Ambitious founders solving fundamental problems across major industries. The next generation of transformational companies will be built on modern AI, secure infrastructure, and efficient commerce. We partner with technical founders with operator experience and compelling narratives.

Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support.

Depth-first venture investing through mastery in specific domains. We partner with bold builders challenging industry conventions, backing founders with technical depth and conviction to build enduring $1B+ companies. Complete immersion creates enduring companies.

Back notable founders with global ambitions using technology to transform industries. We partner with exceptional teams to scale from seed through IPO, providing capital, operational expertise, and network access.

Menlo invests in transformative technology companies at multiple stages of early growth. We provide capital, operational expertise, and hands-on support to help founders build scalable businesses that change how we live and work.

Back technical founders building critical infrastructure for foundational industries. Pair growth-stage capital with deep regulatory expertise and government/industry connectivity to create defensible advantages in overlooked, essential sectors.

We support ambitious founders solving large problems through technology across all stages. Independent thinkers who challenge conventional wisdom are our ideal partners. We provide not just capital but operational expertise, global networks, and hands-on support from day one through scale.

GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI.

We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders.

Exceptional founders with clear technical solutions to enterprise market pain points, focused on SaaS, cybersecurity, infrastructure, data intelligence, and computer vision. We provide capital plus operational excellence through Shasta Elevate playbooks.

Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit.

Partner with exceptional founders building transformative technology companies from inception to IPO and beyond. Our moral compass is serving humanity with technology and capital. We provide not just capital but operational support, network access, and board participation to maximize the potential of founders' ideas and make history.

K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships.

Help founders build companies of which they can be proud. We invest in mission-driven founders solving large, urgent problems using technology to create substantive change. Capital is necessary but not sufficient—sweat, reputation, and accountability are our core commitments.

World-class technology companies can be built anywhere. Greatness is in our backyard. We invest in market-defining companies across the Driveway region (Hudson River to Rocky Mountains), partnering with founders from idea to IPO. Build where your talent is. Build where your customers are. Build where you're strongest.

WndrCo positions itself as 'the founders behind the founders,' combining strategic capital with deep operational involvement. Unlike traditional VCs, partners take formal operating roles (interim CEO, CFO, CPO) within portfolio companies. This approach leverages the co-founders' proven track record: Sujay Jaswa scaled Dropbox from $18M to $10B as Business Founder/CFO, and Jeffrey Katzenberg transformed Disney Studios and built DreamWorks. The firm invests across all stages through three strategies: Build (acquiring underappreciated tech companies), Venture (leading post-PMF rounds), and Seed (very early checks). Focus areas are Future of Work, Cybersecurity, Developer Infrastructure, and Consumer Technology, with increasing emphasis on AI applications.

As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection.

New and powerful AI systems will give rise to transformative startups. We back exceptional engineers, designers, researchers, and product builders using AI to solve critical problems in healthcare, law, education, energy, sciences, and enterprise. We provide capital, operational support, talent expertise, and conviction follow-on investing.

We back founders who combine emotional intelligence with business acumen and are on a mission to solve problems they deeply care about. We're often the first institutional check and provide mentorship, community, and long-term partnership support.

We invest in startups and venture funds, creating a symbiotic network that propels innovation. Our approach is characterized by long-term thinking and a 'give first' philosophy.

Mangusta backs founders building mission-critical capabilities at the intersection of vertical AI and consumer disruption. Three investment filters: Domain Depth (vertical-specific expertise), Defensibility (proprietary data + systems integration), and Distribution (embedded GTM). The firm believes vertical AI co-pilots that augment domain experts — rather than generic AI — represent the most durable and defensible category.

Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise.

We supercharge growth in breakout companies, converting momentum into market dominance. We invest exclusively at Series B and beyond in companies that have achieved product-market fit and are ready to scale from millions to hundreds of millions in revenue.

Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check.

Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support.

We seek to create positive economic impact and long-term value by providing lifetime support to companies from seed through late-stage equity and credit. We differentiate through deep Wall Street expertise, strategic LP networks, and innovative financing vehicles.

Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture.

Real estate has been stagnant for 50 years despite massive innovation in other industries. Shifting demographics, transportation changes, and evolving preferences are forcing modernization. We back visionary entrepreneurs building solutions across construction, property management, residential finance, and retail that will improve quality of life, work, and community.

Technology companies are becoming intertwined with the global economy more so than ever before. The most compelling founders build businesses through a broader world view. White Star Capital backs globally ambitious entrepreneurs at Series A, B, and Seed stages across North America, Europe, and Asia, helping them scale internationally through deep local presence on three continents.

HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines.

Leading global companies that leverage technological innovation across public and private markets. Proven founders (especially ex-Googlers, AWS, Stripe) with large TAMs (billions+), product-led growth, and global ambitions. Conviction-based investing post-2022 correction emphasizing quality over quantity.

Software founders need more than capital to scale successfully. Insight Partners combines investment capital with hands-on operational expertise, embedded teams, and network access to accelerate company growth across all stages.

Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups.

Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics.