124 VC firms investing in enterprise software and healthcare & digital health at the Series B stage.
F4 Fund tracks 124 VC firms that actively invest in enterprise software + healthcare & digital health at the Series B stage, with check sizes ranging from $10K – $100000M (median: $8.5M – $8.5M). As of June 2026, and 94% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Frist Cressey Ventures Healthcare innovation that transforms care delivery, improves patient outcomes, and creates sustainable economic value for the healthcare system. FCV partners with founder-operators who combine clinical/healthcare expertise with operational excellence to build national-scale solutions addressing critical healthcare inefficiencies and access gaps. Nashville | $1M – $60M | 43 | Leads | Active | ~1 mo | Open |
| 2 | ▶ FCA Health Innovations Healthcare technology companies that improve patient care, reduce costs, streamline operations, and reshape healthcare delivery will define the future of healthcare. We partner with experienced founding teams to build thriving businesses across providers, payers, pharma, and innovative care delivery models. Nashville | $2M – $8M | 40 | Leads | Active | ~2 mo | Open |
| 3 | ▶ 25M Health Invest in founders building transformative healthcare solutions with AI and tech. Combine venture capital with operational expertise and direct access to $50B+ health system (LifePoint Health) for pilot deployment, real-world validation, and market expansion opportunities. Focus on category-defining startups that improve healthcare operations, patient outcomes, and access to care. New York | $500K – $1M | 31 | Both | Active | ~1 wk | Open |
| 4 | ▶ Jazz Venture Partners Breakthroughs at the convergence of technology, science, and humanity improve how we live, work, and experience the world. We invest in transformative technologies for human performance and wellbeing. San Francisco | $100K – $5M | 36 | Both | Active | ~2 wks | Req'd |
| 5 | ▶ Index Ventures We invest in who you are, not just what you do. We back visionaries and game-changers with character and global ambition. We partner long-term with founders, providing capital, operational support, and deep conviction in their vision. San Francisco | $500K – $50M | 370 | Leads | Active | — | Req'd |
| 6 | ▶ Meridian Street Capital We help turn the best ideas in healthcare into category-defining companies. The best healthcare companies emerge from disciplined partnerships with visionary founders combining technical expertise with healthcare domain knowledge. New York | $100K – $5M | 30 | Leads | Active | ~1 mo | Req'd |
| 7 | ▶ Council Capital Achieve strong investment returns by investing in EBITDA-positive, founder-led healthcare companies that improve healthcare delivery. Apply the CEO Council Model — 34 senior healthcare operators who have personally invested $140M+ — to unlock growth through relationships, strategic insights, and hands-on value creation. Nashville | $10M – $50M | 25 | Leads | Active | ~2 mo | Open |
| 8 | ▶ StartX Stanford's best entrepreneurs deserve equity-free, community-first support. We provide founders with world-class mentorship from 80+ tenured professors, access to a 3,000+ founder network, and long-term community support without dilution. Mountain View | $10K – $1M | 25 | — | Active | ~2 wks | Open |
| 9 | ▶ Acrew Capital Long-term venture partnerships built on depth of thought, conviction, and dimensional thinking. We back founders with diverse lived experiences who are building transformative companies. We operate as a team sport—you don't work with individual partners, you work with Acrew. We invest in emotional intelligence, operational support, and the long arc of building meaningful companies. San Francisco | $250K – $15M | 102 | Leads | Active | ~2 wks | Open |
| 10 | ▶ Digitalis Ventures Complex health problems require multidisciplinary teams combining deep technical, financial, and domain expertise. We invest in breakthrough science and technology-enabled solutions across human and animal health. New York | $250K – $50M | 54 | Leads | Active | ~2 mo | Req'd |
| 11 | ▶ Canvas Ventures Intentional, thesis-driven early-stage investing in fintech, digital health, and AI. Focus on category-defining companies solving real customer problems with founders who understand their domain deeply. Emphasis on go-to-market strategy and execution discipline. Menlo Park | $5M – $15M | 45 | Leads | Active | ~2 wks | Req'd |
| 12 | ▶ M13 Visionary founders building disruptive software businesses deserve capital and operational support from partners who understand building category-defining companies. We provide both. Santa Monica | $500K – $5M | 70 | Leads | Active | ~1 mo | Open |
| 13 | ▶ Red Swan Ventures Thematic-driven investor backing ambitious founders building for big outcomes across critical domains. Core conviction: defensible businesses create competitive advantages by transforming data challenges and market opportunities into sustainable value. We Go Deep, Not Wide. Focus on AI (defensible AI turns data challenges into advantages), Consumer (vision and strategy to break through attention economy), and Defense Tech (modern solutions for global stability). Active operational partnership beyond capital provision. | $250K – $100M | 65 | Leads | Active | ~2 wks | Open |
| 14 | ▶ Point72 Ventures Point72 Ventures backs ambitious founders building for big outcomes across critical domains. Going deep, not wide—the firm focuses on specialized investment theses in AI, Consumer, and Defense Tech, bringing deep sector insights, partnership, and hands-on support from seed to pre-IPO. New York | $250K – $50M | 203 | Both | Active | ~2 wks | Req'd |
| 15 | ▶ Atinum Investment Atinum Investment identifies and invests in companies solving fundamental problems through technology innovation and market disruption. The firm specializes in growth-stage startups and paradigm-shifting companies across diverse sectors. | $500K – $10M | 56 | Leads | Active | ~2 wks | Open |
| 16 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 17 | ▶ S3 Ventures Patient Capital. True Resources. Big Impacts. S3 backs visionary founders building in Business Software and Healthcare Technology. Unique single-LP structure (a multi-billion dollar philanthropic family office) enables patient, flexible investing unconstrained by traditional VC fundraising cycles. Founded in Texas in 2005 — the largest and longest-serving VC native to Texas. Austin | $500K – $15M | 52 | Leads | Active | ~2 mo | — |
| 18 | ▶ Blumberg Capital Blumberg Capital backs visionary teams as early and growth stage investors, active board members, and hands-on advisors. They invest in transformative technology companies across enterprise software, cybersecurity, fintech, healthcare tech, and AI with particular strength in the US-Israel technology corridor. Miami | $500K – $50M | 51 | Leads | Active | ~1 mo | Open |
| 19 | ▶ ECMC Education Impact Fund Impact capital can address structural problems in America's $1 trillion education and workforce system. With 6 in 10 Americans holding less than bachelor's degrees and 40% of recent grads underemployed, we partner with founders removing barriers across the learner journey - from equitable access through career success. Minneapolis | $1M – $10M | 27 | Both | Active | 3+ mo | Open |
| 20 | ▶ Makers Fund Backing builders of the future of interactive entertainment. We invest across games, content, platforms, and ecosystem technologies with conviction that visionary founders are driving transformation in how we play, watch, create, and live. | $500K – $5M | 158 | Leads | Active | ~2 wks | Open |
| 21 | ▶ AME Cloud Ventures Data, cloud, and hardware advances will create unprecedented opportunities for great companies to be built. We invest in founders with big ideas and deep tech who are building infrastructure and value chains around data. Great people are the key to company success. We provide operational expertise, strategic guidance, and access to networks of mentors and international partners, particularly in China and Asia-Pacific. Palo Alto | $5M – $50M | 26 | Leads | Active | ~2 wks | Open |
| 22 | ▶ Unilever Ventures We support forward-thinking founders crafting brands for the modern consumer. We invest across beauty & wellness, commerce technology, and B2B/enterprise, leveraging Unilever's global distribution, brand-building capabilities, and consumer insights. London | $500K – $15M | 45 | Both | Active | ~2 mo | Open |
| 23 | ▶ Interplay Ventures Application-layer AI and B2B marketplace businesses at Series A, focused on industries undergoing digitization and specialization. Conviction co-investors who do independent underwriting but never lead. New York | $500K – $2M | 43 | Follows | Active | ~2 wks | Open |
| 24 | ▶ Toba Capital Partner with exceptional founders building technology companies with long-term growth potential capable of fundamentally shifting markets for the common good. Provide capital, operational expertise, board participation, and network access to support founder vision and company building. Los Angeles & Newport Beach, CA | $500K – $10M | 42 | Leads | Active | ~1 mo | Open |
| 25 | ▶ AVP Independent global investment platform backing capital-efficient, high-growth technology companies across Europe and North America. Multi-stage, multi-strategy approach from venture to pre-IPO. Transatlantic local teams provide unique advantage in bridging European and US growth. Paris | $1M – $150M | 63 | Leads | Active | — | Open |
| 26 | ▶ Cota Capital Cota Capital invests in 'net new' technologies — visionary ideas that either were never before possible or solve problems that didn't exist before. Knowledge is the true capital. The firm backs early-stage enterprise technology companies where deep operational expertise, competitive intelligence, and network access can provide compounding advantage beyond the check. San Francisco | $1M – $15M | 63 | Both | Active | ~1 mo | Open |
| 27 | ▶ Northzone Category-defining entrepreneurs building fundamental shifts that upend entire industries. Focus on disruptive business models in energy transition, healthcare, AI, and consumer. Thesis values human relationships and founder-centric partnerships over financial metrics alone. London | $1M – $40M | 34 | Leads | Active | ~2 wks | Req'd |
| 28 | ▶ Radian Capital Radian Capital partners with software-driven B2B companies at scale, providing capital and hands-on operational support. They concentrate on select companies and go deep with each, emphasizing sustainable growth over growth at all costs. New York | $5M – $30M | 34 | Leads | Active | ~1 mo | Req'd |
| 29 | ▶ Lightspeed Venture Partners We partner with bold builders of category-defining companies from Seed to Series F and beyond. Depth of commitment, depth of relationships, and depth of belief distinguish us. Complete immersion, authentic partnership, and unwavering conviction through market cycles. | $1M – $300M | 51 | Leads | Active | ~2 wks | Open |
| 30 | ▶ Scale Venture Partners The next decade will be defined by the addition of machine intelligence to software. Scale backs 'Cognitive Apps' — AI-powered applications that augment manual work and enable data-driven predictions — partnering with founders who can transition from founder-led to scalable go-to-market, accompanying them from Series A through IPO. Foster City, CA | $5M – $30M | 50 | Leads | Active | ~2 mo | Open |
| 31 | ▶ iGlobe Partners Unearth, invest and grow startups into global leaders. iGlobe targets game-changing innovations at the frontier of deep tech — semiconductors, AI, quantum computing, and biotech — with a global orientation and a Singapore hub. Founded by Soo Boon Koh, Singapore's first female VC, the firm brings 25+ years of cross-border investing expertise and a top-quartile performance record. Singapore | $1M – $15M | 49 | Both | Active | ~2 mo | Open |
| 32 | ▶ NTTVC NTTVC backs founders with vision and energy to build transformative technology companies, particularly in enterprise technology, digital health, and AI/ML. The firm's unique structural advantage is its partnership with NTT — a Fortune 100 global IT services provider with 120,000 enterprise customers, $5B+ in annual tech resales, and a $22B systems integration business — giving portfolio companies extraordinary enterprise distribution and market validation channels. Menlo Park | $3M – $15M | 17 | Leads | Active | ~1 mo | Open |
| 33 | ▶ Benhamou Global Ventures BGV backs hands-on, cross-border enterprise AI startups operating under the Enterprise 5.0 framework — companies that combine intelligent machines with human ingenuity to drive leapfrog productivity improvements. They focus on vertical AI (industry-specific, proprietary data) and horizontal agentic platforms (cross-functional automation), with a strong preference for immigrant founders pursuing US go-to-market strategies from France, Israel, and India. Menlo Park | $2M – $10M | 46 | Leads | Active | ~2 mo | Open |
| 34 | ▶ Madrona Venture Group Madrona invests in people and ideas for the long run — backing visionary founders building transformational technology companies, with deep focus on applied AI across domain-specific applications, AI infrastructure, developer tools, enterprise software, and AI-enabled biotech. The firm serves as an active, full-stack partner providing capital plus recruiting, business development, and customer introductions. Seattle | $500K – $50M | 45 | Leads | Active | ~1 mo | Open |
| 35 | ▶ Phoenix Court Phoenix Court partners with exceptional founders from pre-seed through public markets and beyond. The firm operates as a multi-stage, multi-fund group — LocalGlobe (seed), Latitude (growth), Solar (late-stage), and Basecamp (emerging managers) — built on the conviction that the best companies grow big not just in private markets but across their full lifecycle. Founded on purpose: 10% of profits and 2% of carry go to Phoenix Court Works, which is transitioning to the single largest shareholder in the firm. London | $500K – $20M | 28 | Leads | Active | ~1 mo | Req'd |
| 36 | ▶ Bond We identify and scale proven product-market-fit technology companies for global expansion and IPO readiness. Our partnership combines world-class macro research analysis with hands-on operational expertise from experienced technology leaders who have built and scaled billion-dollar companies. San Francisco | $1M – $50M | 42 | Leads | Active | ~2 mo | Open |
| 37 | ▶ Georgian Georgian invests in market-leading B2B software companies across the AI technology stack—from infrastructure and developer tools to enterprise applications and cybersecurity. They pair growth-stage capital with an in-house AI Lab of 20+ ML engineers who embed with portfolio companies post-investment. Toronto | $20M – $75M | 27 | Leads | Active | ~2 wks | Req'd |
| 38 | ▶ Crew Capital Community-driven VC led by active operators who simultaneously build and invest. Best support for founders comes from operators understanding current market challenges firsthand, not just history. Invest in category-defining technology companies. New York | $500K – $2M | 39 | Leads | Active | ~2 wks | Open |
| 39 | ▶ BluePointe Ventures Overlooked markets where distribution advantage compounds. Founders with deep domain empathy build durable moats. B2B software rebuilding industries through core workflows, data connectivity, and embedded intelligence. San Francisco | $250K – $1.5M | 25 | Leads | Active | ~1 wk | Req'd |
| 40 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 53 | Leads | Active | ~2 mo | Open |
| 41 | ▶ General Catalyst We back founders venturing beyond to build transformational companies that create positive, enduring change. Applied AI and global resilience are fundamental forces reshaping industries. | $2M – $50M | 38 | Leads | Active | — | — |
| 42 | ▶ Frontline Ventures The world's most successful B2B software companies require presence and success in both North America and Europe. Frontline specializes in facilitating frictionless transatlantic expansion, supporting founders with global ambition through a dual-fund strategy optimized for international growth. London | $250K – $20M | 24 | Both | Active | ~1 wk | Open |
| 43 | ▶ AirTree Ventures Big things start small. We invest at seed stage and see potential where others don't. We believe in your vision for your company's future, not as it exists today. We think in decades, not days, committing to walk the entire journey with founders to build iconic companies. We share Antipodean ingenuity with the world. Sydney | $250K – $20M | 64 | Leads | Active | ~2 wks | Req'd |
| 44 | ▶ MassMutual Ventures Build category-defining technology businesses that deliver strong investment returns while addressing pressing business challenges. Leverage Fortune 500 parent (MassMutual) assets including real estate portfolios, renewable energy assets, and capital networks. Boston | $2M – $10M | 23 | Both | Active | ~1 mo | Open |
| 45 | ▶ B Capital Group Back extraordinary entrepreneurs throughout the company-building lifecycle from seed to IPO. Combine venture capital expertise with BCG management consulting to accelerate value creation. Support founders with capital, strategic guidance, and access to global networks. San Francisco | $250K – $50M | 34 | Leads | Active | ~2 wks | Req'd |
| 46 | ▶ Thrive Capital Back great founders building category-defining companies, regardless of stage. We provide patient capital, hands-on operational support, and deep network access to enable breakout success. New York | $500K – $50M | 22 | Both | Active | ~2 wks | Req'd |
| 47 | ▶ Collab Fund Investing at the intersection of for-profit and for-good. Companies that make the world better AND deliver strong financial returns. The Villain Test ensures both impact and profit alignment. New York | $500K – $10M | 44 | Leads | Active | ~2 wks | Open |
| 48 | ▶ NVIDIA Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology. | $20M – $100000M | 31 | Both | Active | ~2 wks | Open |
| 49 | ▶ Techstars Help founders succeed by combining capital ($120K-$250K), intensive mentorship (3-month program), and access to a powerful global network of 1,500+ mentors. We invest in founders at the earliest stage with conviction and vision, regardless of sector or geography. Our #GiveFirst philosophy drives us to help without expecting immediate return. | $120K – $250K | 20 | Leads | Active | ~2 wks | Open |
| 50 | ▶ Emergence Capital Emergence invests in early-stage B2B software companies that will define the next era of enterprise technology. Founded in 2003 as the original cloud/SaaS-focused VC firm, they have pioneered investing through technology transitions: horizontal SaaS (Salesforce, Zoom), vertical SaaS (Veeva, Doximity), and now AI-native services — companies that sell outcomes rather than software, powered by AI that compounds competitive advantage over time. San Francisco | $5M – $50M | 55 | Leads | Active | ~1 mo | Open |
| 51 | ▶ Kaszek Partner with extraordinary founders building the next generation of iconic Latin American technology companies. Invest in any tech-enabled sector where innovation can drive significant disruption. Bring not just capital but deep operational expertise as former MercadoLibre executives and entrepreneurs. Buenos Aires | $500K – $50M | 55 | Leads | Active | ~1 mo | Open |
| 52 | ▶ Flint Capital Exceptional technology companies can be built anywhere—US, Israel, or Europe. We partner with experienced founders to provide capital, US market expertise, and global networks to help them scale internationally. Boston | $500K – $5M | 29 | Both | Active | ~1 mo | Open |
| 53 | ▶ Headline We invest in top founders everywhere building the next generation of technology companies. We provide capital, operational expertise, and a truly global platform to scale with hands-on support through specialized teams. | $2M – $50M | 51 | Leads | Active | ~2 wks | Open |
| 54 | ▶ Bain Capital Ventures Ambitious founders solving fundamental problems across major industries. The next generation of transformational companies will be built on modern AI, secure infrastructure, and efficient commerce. We partner with technical founders with operator experience and compelling narratives. San Francisco | $1M – $20M | 28 | Leads | Active | ~2 wks | Open |
| 55 | ▶ Innovating Capital Technology can have a highly disruptive impact on society. We back founders on the forefront of innovation with clear vision towards positive change, leveraging domain expertise to ensure value creation. Founder-first approach with operational support. New York | $250K – $5M | 38 | Leads | Active | ~1 mo | Open |
| 56 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 57 | ▶ Redpoint Depth-first venture investing through mastery in specific domains. We partner with bold builders challenging industry conventions, backing founders with technical depth and conviction to build enduring $1B+ companies. Complete immersion creates enduring companies. Menlo Park | $500K – $50M | 17 | Leads | Active | ~2 wks | Open |
| 58 | ▶ F-Prime Capital Partner with visionary founders to turn bold ambitions into world-changing breakthroughs in life sciences, technology, healthtech, and crypto. Distinctive 'technical-risk-yes, regulatory-risk-no' filter ensures clear pathways to success. Cambridge | $250K – $15M | 26 | Leads | Active | ~1 wk | Open |
| 59 | ▶ GGV Capital Back notable founders with global ambitions using technology to transform industries. We partner with exceptional teams to scale from seed through IPO, providing capital, operational expertise, and network access. Menlo Park | $1M – $15M | 35 | Both | Active | ~2 wks | Open |
| 60 | ▶ Menlo Ventures Menlo invests in transformative technology companies at multiple stages of early growth. We provide capital, operational expertise, and hands-on support to help founders build scalable businesses that change how we live and work. San Francisco | $500K – $20M | 16 | Leads | Active | ~2 wks | Open |
| 61 | ▶ 9Yards Capital Back technical founders building critical infrastructure for foundational industries. Pair growth-stage capital with deep regulatory expertise and government/industry connectivity to create defensible advantages in overlooked, essential sectors. San Francisco | $3M – $10M | 34 | Both | Active | ~2 wks | Open |
| 62 | ▶ Partech Partners We support ambitious founders solving large problems through technology across all stages. Independent thinkers who challenge conventional wisdom are our ideal partners. We provide not just capital but operational expertise, global networks, and hands-on support from day one through scale. Paris | $300K – $100M | 24 | Both | Active | ~1 mo | Open |
| 63 | ▶ How Women Invest Women founders represent an overlooked asset class that delivers superior returns. Women-founded companies earn 26% more for investors, yet receive only 2% of venture funding. We invest exclusively in women-founded companies, providing capital, network access, and operational support to drive transformative change. San Francisco | $250K – $5M | 31 | Leads | Active | ~1 mo | Req'd |
| 64 | ▶ GV (Google Ventures) GV backs innovative founders moving the world forward, operating on long time horizons and dealing in decades, not rounds. Since 2023, GV has accelerated its focus on AI-native companies across infrastructure, applications, healthcare, and developer tools — with approximately 80% of new European investments now in AI. San Francisco | $500K – $50M | 30 | Both | Active | ~1 mo | Open |
| 65 | ▶ Horizons Ventures Invest in deep science and disruptive technology companies that solve fundamental human problems—inequality, health, climate adaptation. We back founders with vision, instinct, and drive to scale impact. Hong Kong | $1M – $25M | 39 | Leads | Active | ~1 mo | Open |
| 66 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 67 | ▶ Shasta Ventures Exceptional founders with clear technical solutions to enterprise market pain points, focused on SaaS, cybersecurity, infrastructure, data intelligence, and computer vision. We provide capital plus operational excellence through Shasta Elevate playbooks. Menlo Park | $2M – $15M | 21 | Leads | Active | ~2 mo | Open |
| 68 | ▶ TMV Back founders building startups that reimagine the future across healthcare, logistics, fintech, and sustainable innovation. Investment thesis emphasizes mission-driven founders solving meaningful problems with bold, long-term vision. New York | $250K – $10M | 21 | Leads | Active | ~1 mo | Open |
| 69 | ▶ Gobi Partners Bespoke Capital for Enduring Impact. Gobi invests where capital alone is insufficient — requiring deep local relationships, sustained engagement, and informed judgment across Asia's diverse and complex markets. They focus on technology companies solving structural inefficiencies across underserved Asian markets, from fintech to deep tech to sustainable infrastructure. Kuala Lumpur | $1M – $50M | 37 | Leads | Active | — | — |
| 70 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 71 | ▶ Kleiner Perkins Partner with exceptional founders building transformative technology companies from inception to IPO and beyond. Our moral compass is serving humanity with technology and capital. We provide not just capital but operational support, network access, and board participation to maximize the potential of founders' ideas and make history. Menlo Park | $100K – $150M | 27 | Leads | Active | ~2 wks | Open |
| 72 | ▶ REMUS Capital Building, not betting, with rebels transforming massive traditional industries through applied AI. Hands-on operational partnership combining capital with customer acquisition, team building, and strategic guidance. Boston | $1M – $20M | 27 | Leads | Active | ~2 wks | Req'd |
| 73 | ▶ K5 Global K5 Global backs category-defining companies from inception to IPO. The firm leverages exceptional networks across media, entertainment, politics, finance, and technology to provide strategic value beyond capital. We believe the best companies are built by founders who can access world-class talent, capital, and strategic relationships. Los Angeles | $1M – $3M | 34 | Leads | Active | ~1 mo | Open |
| 74 | ▶ Homebrew Help founders build companies of which they can be proud. We invest in mission-driven founders solving large, urgent problems using technology to create substantive change. Capital is necessary but not sufficient—sweat, reputation, and accountability are our core commitments. San Francisco | $100K – $500K | 26 | Both | Active | ~1 wk | Req'd |
| 75 | ▶ Drive Capital World-class technology companies can be built anywhere. Greatness is in our backyard. We invest in market-defining companies across the Driveway region (Hudson River to Rocky Mountains), partnering with founders from idea to IPO. Build where your talent is. Build where your customers are. Build where you're strongest. Columbus | $500K – $150M | 33 | Leads | Active | ~2 mo | Open |
| 76 | ▶ Golden Gate Empower audacious founders who challenge norms and leverage technology to transform industries. We believe in first-time founders with scrappy outsider mentality and narrow niche focus. Silicon Valley expertise combined with deep emerging market knowledge across three continents. Singapore | $25K – $10M | 33 | Leads | Active | ~2 wks | Req'd |
| 77 | ▶ Impact America Fund Tech-enabled businesses built for and by people in marginalized communities create new frameworks of ownership and opportunity. Traditional VCs miss billion-dollar markets in overlooked communities. Oakland | $250K – $3M | 32 | Leads | Active | ~1 mo | Req'd |
| 78 | ▶ WndrCo WndrCo positions itself as 'the founders behind the founders,' combining strategic capital with deep operational involvement. Unlike traditional VCs, partners take formal operating roles (interim CEO, CFO, CPO) within portfolio companies. This approach leverages the co-founders' proven track record: Sujay Jaswa scaled Dropbox from $18M to $10B as Business Founder/CFO, and Jeffrey Katzenberg transformed Disney Studios and built DreamWorks. The firm invests across all stages through three strategies: Build (acquiring underappreciated tech companies), Venture (leading post-PMF rounds), and Seed (very early checks). Focus areas are Future of Work, Cybersecurity, Developer Infrastructure, and Consumer Technology, with increasing emphasis on AI applications. Beverly Hills, California | $100K – $10M | 32 | Leads | Active | ~2 wks | Req'd |
| 79 | ▶ Valor Capital Group Greatest opportunities come from serving unmet needs of the middle class in emerging markets. We bridge US and Latin American markets, providing institutional capital, intellectual capital flow, and geo arbitrage exit opportunities. New York | $500K – $10M | 24 | Leads | Active | ~2 wks | Open |
| 80 | ▶ Riverpark Ventures Disruptive businesses that eliminate intermediaries and compress value chains. We invest in entrepreneurs backed by entrepreneurs who understand the unique challenges of building. We look for innovative thinkers with proven track records and tremendous dedication, in large markets addressing significant customer needs. New York | $500K – $25M | 23 | Leads | Active | ~2 wks | Req'd |
| 81 | ▶ Streamlined Ventures Visionary founders are the true catalysts of transformation and progress. We partner with exceptional founders at the seed stage to help them build extraordinary companies through intensive operational support, structured tools, and candid guidance. Palo Alto | $250K – $10M | 23 | Leads | Active | ~2 wks | Open |
| 82 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 30 | Leads | Active | ~1 mo | Req'd |
| 83 | ▶ Valia Ventures We back technically ambitious founders building tomorrow's most iconic companies in frontier sectors like AI, hardtech, robotics, healthcare, and fintech. We believe great companies come from founders willing to tackle complex problems that generalist funds avoid. New York | $250K – $1.5M | 16 | Leads | Active | ~2 wks | Req'd |
| 84 | ▶ Dalus Capital Back purposeful entrepreneurs building scalable technology solutions for significant Latin American problems, with emphasis on inclusion, climate innovation, and business productivity while generating positive impact and strong returns. Monterrey | $500K – $5M | 29 | Both | Active | ~1 mo | — |
| 85 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 86 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 87 | ▶ OpenAI Startup Fund New and powerful AI systems will give rise to transformative startups. We back exceptional engineers, designers, researchers, and product builders using AI to solve critical problems in healthcare, law, education, energy, sciences, and enterprise. We provide capital, operational support, talent expertise, and conviction follow-on investing. San Francisco | $1M – $5M | 15 | Both | Active | ~2 wks | Open |
| 88 | ▶ Plymouth Growth Exceptional founder-led B2B technology businesses exist outside traditional coastal venture and PE systems. We back gritty founders who think differently and approach sustainable, balanced growth without venture-style moonshot pressure or traditional PE playbooks. Detroit | $5M – $25M | 15 | Leads | Active | ~1 mo | Open |
| 89 | ▶ New Enterprise Associates (NEA) NEA partners with ambitious founders at every stage of company building, from pre-seed through IPO. They invest at the intersection of technology and healthcare, believing the most transformational innovation occurs where deep domain expertise meets world-class technical founders. NEA serves as both capital provider and active operator. Menlo Park | $1M – $50M | 21 | Both | Active | ~2 mo | Open |
| 90 | ▶ Resolute Ventures We back founders who combine emotional intelligence with business acumen and are on a mission to solve problems they deeply care about. We're often the first institutional check and provide mentorship, community, and long-term partnership support. San Francisco | $50K – $1.5M | 21 | Leads | Active | ~2 wks | Req'd |
| 91 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 41 | Both | Active | ~2 mo | Req'd |
| 92 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 93 | ▶ Bling Capital The hardest thing in seed is finding product-market fit. We help you find it. If you already have product-market fit, we will help you scale. We partner with exceptionally ambitious founders for the long run and provide capital combined with operational expertise through our 100+ member Product Council. San Francisco | $500K – $3M | 33 | Leads | Active | ~2 mo | Open |
| 94 | ▶ Sawari Ventures North Africa and Africa possess tremendous entrepreneurial talent. Strategic capital combined with operational expertise can unlock transformative solutions that reshape industries. We invest in founders solving region-critical problems. Cairo | $200K – $2M | 20 | Leads | Active | ~1 mo | Open |
| 95 | ▶ Foundry Group We invest in startups and venture funds, creating a symbiotic network that propels innovation. Our approach is characterized by long-term thinking and a 'give first' philosophy. Boulder, Colorado | $500K – $10M | 26 | Leads | Active | ~1 mo | Req'd |
| 96 | ▶ Mangusta Capital Mangusta backs founders building mission-critical capabilities at the intersection of vertical AI and consumer disruption. Three investment filters: Domain Depth (vertical-specific expertise), Defensibility (proprietary data + systems integration), and Distribution (embedded GTM). The firm believes vertical AI co-pilots that augment domain experts — rather than generic AI — represent the most durable and defensible category. San Francisco | $1M – $20M | 14 | Both | Active | ~1 mo | Req'd |
| 97 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 98 | ▶ Human Capital Partner with exceptional founders to build generational companies that define the world's most critical industries. We provide not just capital but assemble teams of the highest caliber through our 5,000+ member builder community and deep operational expertise. San Francisco | $250K – $200M | 25 | Both | Active | ~1 wk | Open |
| 99 | ▶ IVP We supercharge growth in breakout companies, converting momentum into market dominance. We invest exclusively at Series B and beyond in companies that have achieved product-market fit and are ready to scale from millions to hundreds of millions in revenue. San Francisco | $1M – $25M | 31 | Leads | Active | ~2 mo | Req'd |
| 100 | ▶ Left Lane Capital Invest in hyper-growth consumer and technology businesses with enduring customer relationships. Back founders challenging the status quo through digital transformation. Focus on companies with strong unit economics, loyal customer bases, and defensible competitive advantages in complex, regulation-heavy markets. Brooklyn | $5M – $50M | 42 | Both | Active | ~2 wks | Open |
| 101 | ▶ Felicis Ventures Back founders building iconic companies that transcend boundaries. We invest directly in their growth to make them unbreakable. Founded on principle that luck isn't made, it's engineered. Founders are our customer, not LPs. We always vote shares with founders and provide 1% non-dilutive founder development capital alongside every first check. Menlo Park | $500K – $15M | 29 | Both | Active | ~1 wk | Open |
| 102 | ▶ Icehouse Ventures Back exceptional Kiwi founders building globally transformative companies, from day one to IPO. New Zealand founders represent a significantly undervalued asset class, and Icehouse provides capital plus an ecosystem of 3,000+ investors and deep operational support. Auckland | $100K – $10M | 41 | Leads | Active | ~2 mo | Open |
| 103 | ▶ Cherryrock Capital Cherryrock Capital backs underinvested entrepreneurs — specifically Black and Latine founders — building transformative software companies. They invest in the possible, seeking founders with domain expertise, compelling right-to-win stories, and products that generate measurable customer outcomes in structurally underserved markets. San Francisco | $2M – $15M | 4 | Leads | Active | ~1 mo | Open |
| 104 | ▶ Rosecliff Ventures We seek to create positive economic impact and long-term value by providing lifetime support to companies from seed through late-stage equity and credit. We differentiate through deep Wall Street expertise, strategic LP networks, and innovative financing vehicles. New York | $500K – $10M | 22 | Both | Active | ~2 mo | Open |
| 105 | ▶ Liquid 2 Champions exceptional founders to build lasting companies through experience, community, and capital. Generalist technology investor whose edge is network depth — Joe Montana's unmatched rolodex and 800+ portfolio company network enables introductions that most seed funds cannot provide. San Francisco | $250K – $5M | 27 | Follows | Active | ~2 wks | Open |
| 106 | ▶ IA Ventures Data is the defensible moat in technology. We invest in companies that build proprietary data assets, analytics capabilities, or machine learning advantages to dominate their categories. Founded on 'information arbitrage' thesis - applying hedge fund quantitative discipline to early-stage venture. New York | $250K – $750K | 16 | Leads | Active | ~2 wks | Open |
| 107 | ▶ Zigg Capital Real estate has been stagnant for 50 years despite massive innovation in other industries. Shifting demographics, transportation changes, and evolving preferences are forcing modernization. We back visionary entrepreneurs building solutions across construction, property management, residential finance, and retail that will improve quality of life, work, and community. New York | $500K – $10M | 26 | Both | Active | ~2 wks | Open |
| 108 | ▶ Argonautic Ventures AI is a milestone in data maturity progression, not a product category. Argonautic invests in founders building data-centric solutions across infrastructure (horizontal) and vertical markets. Multi-fund structure allows pre-seed to Series B deployment with unified thesis: recognizing verticals at different data adoption stages and deploying capital to those crossing inflection points into AI operationalization. | $250K – $1M | 7 | Both | Active | ~2 wks | Open |
| 109 | ▶ White Star Capital Technology companies are becoming intertwined with the global economy more so than ever before. The most compelling founders build businesses through a broader world view. White Star Capital backs globally ambitious entrepreneurs at Series A, B, and Seed stages across North America, Europe, and Asia, helping them scale internationally through deep local presence on three continents. London | $1M – $25M | 41 | Leads | Active | ~1 mo | Open |
| 110 | ▶ Coatue The best investment opportunities emerge at the intersection of innovation and scale. We invest across the full lifecycle from seed to public markets, focusing on technology companies that will transform sectors globally with particular conviction in AI-enabled platforms and infrastructure. New York | $1M – $100M | 30 | Both | Active | ~2 wks | Open |
| 111 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 112 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 113 | ▶ Sigma Prime Ventures Early-stage technology companies solving hard business problems with SaaS, cloud, mobile, and disruptive technologies. We back technical founders with domain expertise and market understanding across diverse sectors. Boston | $500K – $10M | 10 | Both | Active | ~2 wks | Req'd |
| 114 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 115 | ▶ Tribeca Venture Partners We partner with gritty and determined entrepreneurs leveraging emerging technologies to create or disrupt huge markets. We invest in people first, second, and third—founders with passion, obsession, and vision. Only partners with founders when we believe their company alone can return our entire fund or more. New York | $1M – $10M | 16 | Leads | Active | ~2 mo | Req'd |
| 116 | ▶ Tiger Global Management Leading global companies that leverage technological innovation across public and private markets. Proven founders (especially ex-Googlers, AWS, Stripe) with large TAMs (billions+), product-led growth, and global ambitions. Conviction-based investing post-2022 correction emphasizing quality over quantity. New York | $1M – $100M | 21 | Leads | Active | ~1 wk | Req'd |
| 117 | ▶ Insight Partners Software founders need more than capital to scale successfully. Insight Partners combines investment capital with hands-on operational expertise, embedded teams, and network access to accelerate company growth across all stages. New York | $10M – $350M | 28 | Leads | Active | ~1 mo | Open |
| 118 | ▶ Peak XV Partners Outlier founders and ideas shape the future of humanity. We back ambitious founders building category-defining companies that create significant impact while generating returns that support non-profit and educational causes. Bangalore | $500K – $100M | 18 | Leads | Active | ~2 wks | Open |
| 119 | ▶ Bessemer Venture Partners We partner with entrepreneurs from their early days through every stage of growth, focusing on innovative solutions in technology, healthcare, and financial services. Redwood City, California | $5.8M – $34.3M | 6 | — | 1mo | — | — |
| 120 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 121 | ▶ Cathay Innovation Startups positioned as transformation partners with Fortune 500 corporates create the most impactful solutions. We believe the next generation of market leaders will emerge through collaborative innovation between startups and incumbent enterprises, supported by global expertise and capital. Paris | $5M – $100M | 16 | Both | Active | ~1 mo | Req'd |
| 122 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 123 | ▶ Flucas Ventures Democratize access to venture capital by building large syndicates of non-traditional LPs. Invest across all stages, sectors, and geographies based on founder quality and market conviction, not category restrictions. Enable 2,000+ diverse co-investors to participate alongside marquee firms like Sequoia and Andreessen Horowitz while maintaining founder-friendly economics. Miami | $250K – $5M | 17 | Follows | Active | ~1 wk | Req'd |
| 124 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 124 VC firms that actively invest in enterprise software + healthcare & digital health at the Series B stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series b enterprise software + healthcare & digital health investors is $8.5M – $8.5M, with a full range from $10K – $100000M. The distribution breaks down as: 3 firms in the <$500K range, 9 firms in the $500K-$1M range, 6 firms in the $1M-$2M range, 14 firms in the $2M-$5M range, 32 firms in the $5M-$10M range, 60 firms in the $10M+ range.
Among the 124 firms tracked, 94% lead or co-lead rounds, and 4% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series b enterprise software + healthcare & digital health investors combine domain expertise with an active portfolio in the space. Among these firms, 29% prefer warm introductions, and the average firm has 40 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.