127 VC firms investing in healthcare & digital health and robotics & automation at the Series A stage.
F4 Fund tracks 127 VC firms that actively invest in healthcare & digital health + robotics & automation at the Series A stage, with check sizes ranging from $25K – $100000M (median: $2.8M – $2.8M). As of June 2026, and 94% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Compound Contrarian venture firm investing in scientific and technical breakthroughs. We identify white-space opportunities where technical founders are solving previously unsolvable problems. We combine capital with deep domain expertise, research capabilities, and operational support to help founders scale from idea to commercialization. New York | $400K – $1.5M | 38 | Both | Active | ~1 mo | Open |
| 2 | ▶ Type One Ventures We invest in startups building the technologies, infrastructure, and services that will be integral as we progress towards a Type I Civilization on the Kardashev Scale. Humanity is at ~Type 0.73 civilization and estimated to reach Type I in ~100 years. We fund moonshot technologies solving fundamental problems in space, robotics, AI, and human longevity. San Francisco | $500K – $20M | 38 | Leads | Active | ~1 mo | Open |
| 3 | ▶ Bethnal Green Ventures Tech for good - using technology to tackle big social and environmental problems while building commercially successful, scalable businesses. Purpose-driven value is not a trend but a paradigm shift. | $60K – $2M | 36 | Leads | Active | ~1 mo | Open |
| 4 | ▶ Point72 Ventures Point72 Ventures backs ambitious founders building for big outcomes across critical domains. Going deep, not wide—the firm focuses on specialized investment theses in AI, Consumer, and Defense Tech, bringing deep sector insights, partnership, and hands-on support from seed to pre-IPO. New York | $250K – $50M | 203 | Both | Active | ~2 wks | Req'd |
| 5 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 6 | ▶ Partners Resolute Invest in people and products that leverage technological breakthroughs or superior user experience to radically change the status quo. Focus on structurally sound, strategically defensible business models that create and capture new markets. True partnership approach: value-add extends beyond capital to include strategic guidance, operational expertise, and network introductions. | $250K – $8M | 54 | Leads | Active | ~2 wks | Open |
| 7 | ▶ Breakout Ventures The era of transformational science is here. Life sciences and industrial markets are being reshaped by founders who move fast and build at the intersection of biology, chemistry, computation, and AI. This is a step-change in how science becomes solutions. We back bold founders who go beyond solving technical problems to redefine entire markets. San Francisco | $250K – $15M | 24 | Leads | Active | ~2 wks | Req'd |
| 8 | ▶ Fusion Fund Technical founders with data and technology advantages can build transformational businesses that redefine industries. We partner with experienced founders who combine technical depth with operational excellence and benefit from access to an elite network of Fortune 1000 executives and technical experts. Palo Alto | $500K – $5M | 22 | Leads | Active | ~2 mo | Req'd |
| 9 | ▶ Gradient Ventures Artificial intelligence will reshape every industry. We partner with technical founders building the next generation of AI applications, infrastructure, and tools across every layer of the AI stack. San Francisco | $750K – $25M | 54 | Leads | Active | ~1 mo | Open |
| 10 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 11 | ▶ Delphi Ventures Delphi backs extraordinary founders at the bleeding edge of technology, operating at the intersection of crypto/blockchain and deep tech. Crypto is freedom technology enabling human coordination at scale without intermediaries. With AI and atomic breakthroughs, these forces will disintermediate legacy models and form foundations of civilizational change over the next decade. San Mateo, California | $50K – $25M | 33 | Leads | Active | ~1 wk | Open |
| 12 | ▶ Privilège Ventures We back bold, ambitious, and resilient founders driving breakthrough innovations in HealthTech, CleanTech, and AgriFoodTech. Female-led and gender-mixed teams deliver superior returns and drive meaningful impact. Over five decades of combined experience navigating financial cycles enables us to partner authentically with founders, providing not just capital but strategic guidance and operational support. Switzerland | $100K – $1M | 25 | Both | Active | — | — |
| 13 | ▶ Mundi Ventures Mundi backs bold, purpose-driven founders building technology companies at the intersection of deep tech and critical global challenges. Core thesis: Europe has world-class talent and ecosystem but suffers from a scale-up funding gap at growth stages. Kembara fund (€750M) bridges this by providing Series B/C growth capital to European deep tech and climate champions. Madrid | $1M – $40M | 53 | Leads | Active | ~2 mo | Open |
| 14 | ▶ Hyperplane Venture Capital Seed capital is the foundational layer in building enduring companies. We back bold, gritty founders applying AI and machine intelligence to solve the world's toughest challenges in enterprise and industrial sectors. By end of decade, software + hardware + AI will drive ubiquitous automation in every industry. We partner with visionary founders tackling hard technical problems in regulated, complex domains. Boston | $250K – $3M | 67 | Leads | Active | ~2 wks | Req'd |
| 15 | ▶ The E14 Fund We back MIT founders building deep-tech companies with defensible science or engineering advantages. We support the transition from researcher to founder, providing both capital ($500K-$5M) and operational support through the MIT ecosystem. Cambridge | $500K – $5M | 51 | Leads | Active | ~1 mo | Open |
| 16 | ▶ Spacecadet Ventures Founders building the possibly impossible deserve capital plus marketing support. Great technology combined with exceptional storytelling and narrative development creates world-changing moonshots. We provide both the capital and the story-telling expertise to help founders achieve escape velocity. New York | $250K – $1M | 99 | Leads | Active | ~2 wks | Open |
| 17 | ▶ Radical Ventures AI Eats Software. Over the next decade, virtually every bit of software will be replaced by artificial intelligence. We invest in founders and entrepreneurs who understand the transformational power of AI and are building solutions that reshape how we live, work, and play. Toronto | $1M – $25M | 50 | Leads | Active | ~2 mo | Req'd |
| 18 | ▶ Yu Galaxy Impact and profit are inseparable. We back visionary founders solving humanity's toughest problems in healthcare, AI, robotics, defense, and automation. We measure success in lives saved as well as returns. | $500K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 19 | ▶ SOSV Deep tech startups at the edge of what is possible solve critical human and planetary health problems. SOSV backs founders combining scientific rigor with entrepreneurial grit, providing not just capital but access to specialized labs, manufacturing, and global expertise networks. San Francisco | $250K – $5M | 22 | Leads | Active | ~1 wk | Open |
| 20 | ▶ TELUS Pollinator Fund for Good We refuse to compromise between doing good and delivering strong financial and commercial returns. Portfolio companies gain access to TELUS's commercial networks, data-rich platforms, and deep expertise across agriculture, health, and connectivity giving them a unique edge as they scale. Vancouver | $1M – $20M | 12 | Both | Active | ~1 mo | Open |
| 21 | ▶ NVIDIA Expand the AI ecosystem by backing technology visionaries solving complex problems to reshape our world. Focus on game changers and market makers in AI, robotics, biotech, autonomous vehicles, and applied AI. Leverage NVIDIA's unique position as GPU infrastructure leader to identify and support companies that will drive adoption of NVIDIA technology. | $20M – $100000M | 31 | Both | Active | ~2 wks | Open |
| 22 | ▶ Conviction We are extremely early in translating powerful AI models into products that transform industries. Startups have the speed and unruliness to build transformative AI-native companies; big companies are too slow. There has never been a better time to start a startup. United States | $1M – $25M | 20 | Leads | Active | ~2 wks | Open |
| 23 | ▶ Obvious Ventures The most valuable companies of our time will be the ones solving humanity's biggest problems across planetary health, human health, and economic health. We back exceptional founders building breakthrough solutions that create both financial returns and positive impact. San Francisco | $5M – $12M | 20 | Leads | Active | ~2 wks | Open |
| 24 | ▶ Emergence Capital Emergence invests in early-stage B2B software companies that will define the next era of enterprise technology. Founded in 2003 as the original cloud/SaaS-focused VC firm, they have pioneered investing through technology transitions: horizontal SaaS (Salesforce, Zoom), vertical SaaS (Veeva, Doximity), and now AI-native services — companies that sell outcomes rather than software, powered by AI that compounds competitive advantage over time. San Francisco | $5M – $50M | 55 | Leads | Active | ~1 mo | Open |
| 25 | ▶ True Ventures We invest in brilliant people who bring ideas that matter to life. We focus on AI-native founders building companies with strong founder-product fit, aligned on mission and meaning, seeking creative freedom and psychological safety. Great companies are built by diverse teams supported and empowered to be maximally creative. Palo Alto | $500K – $3M | 41 | Leads | Active | ~1 wk | Req'd |
| 26 | ▶ The Venture Collective (TVC) Permanent balance-sheet investor backing highly defensible, category-defining, mission-driven companies solving the world's biggest problems. Focus on founders transforming legacy industries with emphasis on diversity, equity, and inclusion. New York | $100K – $2M | 53 | Leads | Active | ~2 wks | Open |
| 27 | ▶ Headline We invest in top founders everywhere building the next generation of technology companies. We provide capital, operational expertise, and a truly global platform to scale with hands-on support through specialized teams. | $2M – $50M | 51 | Leads | Active | ~2 wks | Open |
| 28 | ▶ Future Ventures Support passionate founders forging the future. Invest in seed and early-stage companies with unique ideas that have potential to reinvent entire industries. Focus on frontier technologies that make the world better and don't prey on human frailty. San Francisco | $500K – $10M | 28 | Leads | Active | ~1 mo | Open |
| 29 | ▶ Launch NY Upstate New York can be the region for high-growth startup success. We provide mentorship, capital, and connections to fuel innovation, job creation, and regional economic growth. Founders aligned with community impact, job creation, and solving regional challenges are ideal. Buffalo, New York | $200K – $1M | 28 | Both | Active | ~1 mo | Req'd |
| 30 | ▶ Basis Set Ventures The best way to find and support AI companies is to be one ourselves. We back independent thinkers building real systems before consensus forms, partnering as radical learning partners from day one. Menlo Park | $250K – $3M | 27 | Leads | Active | ~2 wks | Open |
| 31 | ▶ Shine Capital Shine partners with creative, convincing, relentless entrepreneurs to build iconic businesses. They are lateralists - using non-linear logic to identify innovation at the intersections of technology, markets, and culture. The firm invests thematically in areas shaped by four trends: Great Expectations (demand for quality), Merging Digital/Physical (computing power), Reimagining Security (infrastructure/identity), and Reestablishing Meaning (community/belonging). New York | $1M – $10M | 49 | Leads | Active | ~2 wks | Req'd |
| 32 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 33 | ▶ Necessary Ventures Invest in companies addressing fundamental societal needs. Provide Talent/Capital/Attention platform via in-house content and advisory network. Mission-driven investments with specialized expertise in healthcare, climate, robotics, and deep tech. San Francisco | $1M – $2M | 37 | Leads | Active | ~2 wks | Open |
| 34 | ▶ Coefficient Capital Consumer investing requires a fundamentally new playbook built for an omni-channel world where technology, data, and brand storytelling are deeply intertwined. Coefficient identifies growth-stage consumer businesses in established categories undergoing structural change, using proprietary data and an annual Consumer Trends Report to find category-defining brands early. Strategy centers on backing brands positioned for strategic exits to major CPG acquirers. New York | $2M – $40M | 17 | Leads | Active | ~1 mo | Open |
| 35 | ▶ VSC Ventures VSC Ventures backs founders using AI to fix data, labor, and safety challenges in Dirty, Dusty, Dangerous industries. They combine capital with integrated PR/media infrastructure to help portfolio companies build narrative and distribution as a competitive moat. San Francisco | $250K – $750K | 17 | Follows | Active | ~1 mo | Req'd |
| 36 | ▶ BASS Ventures Back 'crazy dreamers' — founders with exceptional tenacity, ambition, and vision who are building transformative companies. BASS serves as the 'bassist' providing foundational support: capital, operational resources, global cloud credits, and talent. Focus on AI software, physical AI, and fashion & beauty in 2025. Seoul | $250K – $6M | 26 | Leads | Active | — | — |
| 37 | ▶ Mark VC Mark VC takes a deeply founder-centric approach, building '360-degree behavioral maps' of founders through extensive personal reference calls. They invest across industries but focus on security & defense, healthcare, consumer, and enterprise software. They strive to be the most valuable investor on the cap table through hands-on coaching and operational support. Austin | $500K – $5M | 25 | Both | Active | ~2 mo | Req'd |
| 38 | ▶ Plum Alley Investments Frontier technologies and medical breakthroughs offer the best opportunities to address fundamental human and environmental challenges. Diversity of founder backgrounds drives innovation and superior returns. Founders with domain expertise, technical credentials, and distinctive visions solve the world's biggest problems. New York | $750K – $3M | 25 | Both | Active | ~1 mo | Req'd |
| 39 | ▶ Menlo Ventures Menlo invests in transformative technology companies at multiple stages of early growth. We provide capital, operational expertise, and hands-on support to help founders build scalable businesses that change how we live and work. San Francisco | $500K – $20M | 16 | Leads | Active | ~2 wks | Open |
| 40 | ▶ 7percent Ventures Back determined founders with uncommon insights solving the world's biggest problems through transformative deeptech. Focus on moonshots: multi-billion-dollar, step-change opportunities across Future Compute (quantum, alternative architectures), Defense & Dual-Use (aerospace, strategic tech), Smart Planet (robotics, climate, materials), and Humantech (AR/VR, interfaces). Frame investments through free-world resilience lens, prioritizing Western technological independence. Support founders through capital, operational guidance, technical expertise, and extensive networks. London | $250K – $2M | 24 | Leads | Active | ~2 wks | Open |
| 41 | ▶ Exceptional Capital We back the most ambitious founders building for enterprise, providing them with capital, confidence, and credibility. We believe exceptional founders with unrivaled tenacity and imagination can engineer exceptional futures in enterprise software, AI, and infrastructure. Miami | $100K – $2M | 24 | Leads | Active | ~2 wks | Open |
| 42 | ▶ Costanoa Ventures Building transformational companies requires more than capital—it demands deep operational expertise, consistent partnership, and genuine commitment to founders' success. Costanoa backs visionaries solving big, hard problems across data infrastructure, applied AI, cybersecurity, fintech, and national security. The firm centers on the 'missing middle' of early-stage investing: providing unusually intensive, hands-on support to founder teams during their most critical growth phases. Palo Alto | $2M – $10M | 33 | Leads | Active | ~1 wk | Open |
| 43 | ▶ Bolt Bolt invests at the intersection of digital and physical. They believe the best hardware companies combine deep manufacturing expertise with software innovation. They operate a million-dollar prototyping shop and employ hardware engineers on staff to be true product partners with founders. Boston | $100K – $5M | 15 | Leads | Active | ~2 wks | Open |
| 44 | ▶ Robo Global The next generation of market-transforming companies will emerge from those applying advanced robotics and AI technologies to traditionally labor-intensive, capital-intensive, or dangerous industries. Dallas | $500K – $2M | 3 | Both | Active | ~1 mo | Req'd |
| 45 | ▶ Alleycorp We are tech pioneers, investors, and entrepreneurs. We build and invest in transformative companies for the present and future. Active early-stage investor providing capital combined with operational expertise and hands-on partnership. | $500K – $5M | 45 | Leads | Active | — | — |
| 46 | ▶ Eclipse Ventures Digital transformation is everywhere except where it matters. The world's essential physical industries—manufacturing, supply chain, transportation, healthcare infrastructure, and energy—have failed to keep pace with technological innovation. These industries are ripe for transformation through digitization, automation, and physical AI. We partner with experienced operators and technical founders to rebuild critical infrastructure. Palo Alto | $250K – $25M | 23 | Leads | Active | ~1 mo | Open |
| 47 | ▶ Story Ventures Story invests in the building blocks of automated systems across three interconnected layers: sensory systems (data capture), data processing (organization and structure), and machine intelligence (applications and decision-making). We believe the most impactful problems require the most innovative solutions, and we partner with founders pursuing audacious, challenging businesses because that's what it takes to create lasting impact. New York | $500K – $5M | 41 | Both | Active | ~1 mo | Req'd |
| 48 | ▶ AV8 Ventures Partner with visionary founders to build category-defining companies in healthcare, enterprise software, fintech/insurtech, and deep technology. Provide deep operational support, board participation, and access to domain expert network. Focus on companies solving problems in regulated or data-rich industries. Leverage Allianz's unique vantage point on risk, data, and regulation to identify opportunities at intersection of innovation and regulatory necessity. Palo Alto | $500K – $10M | 22 | Leads | Active | ~2 wks | Open |
| 49 | ▶ Pathlight Ventures Low volume, high conviction early-stage investing in 10 thematic areas where vertical AI is reshaping regulated, complex industries: healthcare, fintech, capital markets, industrial operations, security, and government. Back strongly opinionated founders building category-defining companies with direct operator support from a team with deep fintech and growth scaling experience. New York City | $250K – $3M | 39 | Leads | Active | ~1 mo | Open |
| 50 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 51 | ▶ Cybernetix Ventures Robotics represents a distinct, nuanced asset class requiring specialized operational insight. Physical AI breakthroughs are making once-theoretical use cases commercially viable. Investors need deep sector expertise to manage associated risks and unlock real value. Robotics is fundamentally different from software venture investing. Boston | $500K – $18M | 13 | Leads | Active | ~2 wks | Req'd |
| 52 | ▶ TSVC The most defensible companies are built on hard technology solving real problems at scale. We partner with technical founders leveraging deep domain expertise and the Tsinghua network to identify and nurture transformative innovations in deeptech, healthtech, and the data economy. Los Altos, California | $250K – $3M | 13 | Both | Active | ~2 wks | Req'd |
| 53 | ▶ Creative Ventures Humanizing deep tech by bringing advanced breakthrough technologies to where the people are and maximizing the value they generate for solving humanity's most critical crises. We invest in companies addressing climate, manufacturing labor shortages, healthcare costs, sustainable food production, and computing infrastructure. Oakland | $1M – $3M | 28 | Both | Active | ~1 mo | Req'd |
| 54 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 55 | ▶ Cathexis Ventures Invest in talented people solving challenging problems. We back extraordinary founders building products that people want with speed, efficiency, and operational excellence. Houston | $250K – $1M | 20 | Leads | Active | ~2 wks | Req'd |
| 56 | ▶ Kleiner Perkins Partner with exceptional founders building transformative technology companies from inception to IPO and beyond. Our moral compass is serving humanity with technology and capital. We provide not just capital but operational support, network access, and board participation to maximize the potential of founders' ideas and make history. Menlo Park | $100K – $150M | 27 | Leads | Active | ~2 wks | Open |
| 57 | ▶ REMUS Capital Building, not betting, with rebels transforming massive traditional industries through applied AI. Hands-on operational partnership combining capital with customer acquisition, team building, and strategic guidance. Boston | $1M – $20M | 27 | Leads | Active | ~2 wks | Req'd |
| 58 | ▶ Inspired Capital Partners Venture capital is the most powerful economic engine the world has ever seen. We back audacious founders solving humanity's hardest challenges through category-creating innovations. We embrace big risks and reject short-termism, committing to 15+ year partnerships with founders who have long-term vision and relentless determination. New York | $500K – $20M | 62 | Leads | Active | ~2 mo | Req'd |
| 59 | ▶ Dreamers VC Where capital becomes culture. Dreamers VC bridges established Japanese corporate investors with early-stage US companies by combining entertainment, sports, and technology expertise. The fund leverages celebrity networks, entertainment channels, and Japanese corporate partnerships to amplify storytelling and enable cross-cultural market expansion. Los Angeles | $250K – $5M | 43 | Both | Active | ~1 mo | Req'd |
| 60 | ▶ Boom Capital Boom Capital invests early in founders building at the frontiers of science. We position founders as scientist-protagonists and back highly technical teams tackling ambitious, non-obvious problems in genomics, machine intelligence, aerospace, new chemistries, and related deep science sectors. San Francisco | $50K – $300K | 12 | Leads | Active | ~2 wks | Open |
| 61 | ▶ Drive Capital World-class technology companies can be built anywhere. Greatness is in our backyard. We invest in market-defining companies across the Driveway region (Hudson River to Rocky Mountains), partnering with founders from idea to IPO. Build where your talent is. Build where your customers are. Build where you're strongest. Columbus | $500K – $150M | 33 | Leads | Active | ~2 mo | Open |
| 62 | ▶ Scribble Ventures AI companies are built differently. We back the world's best AI native founders and help them reshape our world for the better. We go wide on product and deep on GTM. San Francisco | $300K – $1.5M | 18 | Leads | Active | ~1 wk | Open |
| 63 | ▶ Foothill Ventures Back technical teams working on breakthrough products. We invest in seed stage companies that demonstrate technical differentiation - meaning technical or product-level superiority is a major reason for future success. We pursue investments from application layer (AI/ML) through software infrastructure to hardware layers (semiconductors, photonics). Los Altos, California | $250K – $10M | 25 | Leads | Active | ~1 wk | Open |
| 64 | ▶ Innovation Endeavors We invest in the Super Evolution—the convergence of ubiquitous sensors, advanced machine learning, cloud systems, robotics, 3D printing, and CRISPR. We partner with technical founders solving hard engineering and science problems to rethink large industries and tackle humanity's most pressing challenges. Palo Alto | $1M – $15M | 25 | Leads | Active | ~2 mo | Open |
| 65 | ▶ Inertia Ventures Inertia invests in AI-native companies built to become core infrastructure for legacy industries, especially platforms operating in regulated, context-heavy, and physical-world workflows where durable data, compliance, audit trails, or embodied operations create compounding advantages. New York | $2M – $15M | 66 | Leads | Active | ~2 wks | Req'd |
| 66 | ▶ 1955 Capital Invest in advanced technologies solving the world's greatest challenges in energy, environment, food safety, sustainable manufacturing, healthcare, and education. Back contrarian founders building capital-intensive, deep-tech ventures that address survival-driven global needs. Bridge breakthrough technologies from developed markets into emerging economies and vice versa. Create high-return, high-impact outcomes through hard technology. Los Altos, California | $5M – $10M | 11 | Leads | Active | ~2 mo | Req'd |
| 67 | ▶ Better Capital Day 0 venture capital applied by a deep operator. Better Capital invests at the earliest stage where ambiguity is highest and operator judgment adds the most value. Solo GP model keeps conviction high and enables deep engagement with 20-25 companies at critical inflection points. Pune | $300K – $1M | 47 | Leads | Active | ~1 wk | Req'd |
| 68 | ▶ DCVC We back entrepreneurs using computational approaches (AI, simulation) to solve trillion-dollar problems in climate, health, industrial transformation, and national security. Deep tech requires patient capital and scientific rigor. San Francisco | $5M – $25M | 31 | Leads | Active | ~2 mo | Req'd |
| 69 | ▶ Defy VC Back exceptional entrepreneurs building enduring companies that defy expectations. Value authenticity and tenacity to turn daring ideas into lasting impact. One life-altering investment can lead to industry-wide transformation. San Mateo, California | $100K – $10M | 38 | Leads | Active | ~1 wk | Req'd |
| 70 | ▶ Two Sigma Ventures As the world becomes more information-rich, most transformative new companies will leverage data science, machine learning, and advanced computing power. We back founders building breakthrough solutions at this intersection. New York | $2M – $25M | 30 | Leads | Active | ~1 mo | Req'd |
| 71 | ▶ Valia Ventures We back technically ambitious founders building tomorrow's most iconic companies in frontier sectors like AI, hardtech, robotics, healthcare, and fintech. We believe great companies come from founders willing to tackle complex problems that generalist funds avoid. New York | $250K – $1.5M | 16 | Leads | Active | ~2 wks | Req'd |
| 72 | ▶ FoundersX Ventures AI-first venture capital firm investing in AI transformation and digital infrastructure across GenAI Infrastructure (AI chips, quantum, autonomous robotics), Deep Domains (fintech, healthcare, enterprise), and GenAI Agents (autonomous AI for real-world consumer and enterprise use). Menlo Park | $500K – $3M | 36 | Leads | Active | ~1 mo | Req'd |
| 73 | ▶ Greater Colorado Venture Fund Place matters. Exceptional founders who deliberately build in rural communities create stronger, more resilient companies. We provide first-check capital to founders with vision, grit, and roots—because we believe culture-aligned companies outperform. Durango, CO | $250K – $500K | 10 | Leads | Active | ~2 wks | Open |
| 74 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 75 | ▶ Swift Ventures Founders backing founders. Swift invests in B2B AI and automation companies led by bold operators with a high Do:Say ratio, offering garage-to-IPO operating expertise from former company-builders. San Francisco | $2M – $8M | 35 | Both | Active | — | Open |
| 76 | ▶ First Round Capital Beginnings matter. We work with founders exclusively at the earliest stages of company building, often when all they have is an 'imagine if.' We look for compelling and contrarian insights into how the world works—what do you understand about a market that others miss? Our role is to accelerate the path from idea to product-market fit through embedded partnership. San Francisco | $750K – $4M | 28 | Leads | Active | ~2 wks | Req'd |
| 77 | ▶ OpenAI Startup Fund New and powerful AI systems will give rise to transformative startups. We back exceptional engineers, designers, researchers, and product builders using AI to solve critical problems in healthcare, law, education, energy, sciences, and enterprise. We provide capital, operational support, talent expertise, and conviction follow-on investing. San Francisco | $1M – $5M | 15 | Both | Active | ~2 wks | Open |
| 78 | ▶ Mubadala Mubadala partners with world-class companies and institutions to drive transformational growth across strategic sectors and geographies. We believe in long-term value creation through patient capital, operational expertise, and global partnerships aligned with Abu Dhabi's economic diversification. Abu Dhabi | $5M – $5000M | 41 | Both | Active | ~2 mo | Req'd |
| 79 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 80 | ▶ Wonder Ventures Invest in Southern California's best founders earlier than anyone else. No idea is too early. We fund companies earlier than most VCs, providing not just capital but hands-on support and operational expertise. Our founder-first philosophy and No Ghosting Rule ensure responsive, engaged partnerships. Santa Monica | $250K – $2M | 47 | Leads | Active | ~1 wk | Req'd |
| 81 | ▶ Foundry Group We invest in startups and venture funds, creating a symbiotic network that propels innovation. Our approach is characterized by long-term thinking and a 'give first' philosophy. Boulder, Colorado | $500K – $10M | 26 | Leads | Active | ~1 mo | Req'd |
| 82 | ▶ Morpheus Ventures We are professional fixers for complex situations. An extension of your team. Fierce defenders when you need us most. Partners who roll up their sleeves. We invest in early-stage companies helping them avoid traditional roadblocks on their path to hypergrowth. We specialize in navigating hostile situations, IP protection, and crisis management. Los Angeles | $1M – $10M | 32 | Leads | Active | ~2 mo | Open |
| 83 | ▶ Khosla Ventures Technology-based economic disruption of large markets through black swan investments. We seek founders with domain expertise and unreasonable conviction to build billion-dollar companies solving the world's largest problems. Menlo Park | $500K – $50M | 38 | Both | Active | ~2 wks | Open |
| 84 | ▶ AIX Ventures AI-native companies where artificial intelligence is the core product and competitive moat, not just a feature. Three investment baskets: (1) AI infrastructure (vector databases, model serving, optimization), (2) vertical applications with 20%+ performance advantages, and (3) frontier research with clear commercialization paths. Palo Alto | $750K – $3M | 25 | Leads | Active | ~1 wk | Open |
| 85 | ▶ Incubate Fund Incubate Fund provides unwavering hands-on support to visionary entrepreneurs from the earliest stages. As Japan's leading seed-stage VC, they go beyond capital to provide operational support, founder counseling, talent recruitment, and business introductions. Core question: 'Does this action lead to impact?' Tokyo | $200K – $2M | 25 | Leads | Active | ~1 mo | — |
| 86 | ▶ Snatched Ventures Backs DeepTech startups at the intersection of AI/ML, materials science, advanced manufacturing, biotechnology, optics, electronics, robotics, and blockchain — driving sustainable operational transformation across six thematics: transportation & logistics, energy & water, food & agriculture, fashion & beauty, precision medicine & aging, and retail & e-commerce. Requires commercial traction (min $1M revenue, 50%+ gross margins) and a minimum 10% ownership stake. San Francisco | $500K – $5M | 25 | Leads | Active | — | — |
| 87 | ▶ Soma Capital Soma invests in technical founders building innovative companies across all sectors. We believe in building deep friendships day 1 with brilliant superhumans pushing humanity forward. Our founder-first approach emphasizes non-dilutive capital, founder autonomy, and access to Fortune 500 networks for customer development. San Francisco | $100K – $2M | 31 | Leads | Active | ~1 wk | Open |
| 88 | ▶ Creandum We back the companies of tomorrow before it's obvious. We combine early-stage European investing with a permanent San Francisco presence to help founders build category-defining global companies. We invest in ambitious technical founders who deeply understand industry transformation. Stockholm | $200K – $10M | 36 | Leads | Active | ~2 wks | Open |
| 89 | ▶ 1517 Fund We back dropouts, renegade students, and deep-tech scientists working on ideas that would appear in science fiction. We exist to prove that great founders don't need university degrees and are found in the oddest places. We invest at inception stage (R&D through Seed), providing capital, mentorship, community access, and operational support. People-first approach: it's more about the who than the what. Telluride, Colorado | $50K – $1M | 18 | Leads | Active | ~1 wk | Open |
| 90 | ▶ Outsiders Fund Technological innovation is unevenly distributed. The hottest, most visible sectors attract talent and capital, while overlooked industries hide massive value creation opportunities. We back unconventional founders disrupting unglamorous, technology-inefficient, long-standing industries. New York | $500K – $8M | 34 | Both | Active | ~2 wks | Open |
| 91 | ▶ Female Founders Fund Female founders build exceptional companies that outperform their male peers. We invest in category-defining female leaders with strong points of view who are reshaping their markets, backed by community and supported by a visible ecosystem. New York | $250K – $2M | 28 | Both | Active | ~2 wks | Req'd |
| 92 | ▶ Sierra Ventures Sierra believes enterprise software is being fundamentally transformed by cloud computing and AI. They invest in technical founders building the next generation of enterprise solutions that deliver superior ROI through better efficiency, automation, and capability. The firm particularly focuses on infrastructure, security, healthcare innovation, and emerging deep tech. San Mateo, California | $500K – $15M | 28 | Both | Active | ~2 wks | Req'd |
| 93 | ▶ Impact Venture Capital Corporate-advantage seed investing. We identify promising AI and deep tech startups early, then leverage our hundreds of relationships with corporate venture capital arms to de-risk investments, accelerate time to exit, and create curated dealflow where both founders and corporates benefit from strategic alignment. El Dorado Hills, CA | $250K – $1M | 22 | Leads | Active | ~2 wks | Req'd |
| 94 | ▶ Day One Ventures We help mission-driven pioneers win by harnessing the power of storytelling, art and culture. We back early-stage companies with customer obsession in their DNA and accelerate the mass adoption of technologies they create. Founders need more than capital—they need strategic support in building their narrative and leveraging media to accelerate adoption. San Francisco | $300K – $5M | 27 | Leads | Active | ~1 wk | Open |
| 95 | ▶ Third Kind Venture Capital We seek extraordinary founders building transformational products. Product-obsessed founders with deep market understanding, exceptional execution ability, and the drive to build lasting companies create the most value. New York | $500K – $5M | 16 | Leads | Active | ~1 wk | Req'd |
| 96 | ▶ Origins Fund Origins backs legendary consumer founders with an unfair advantage from pre-seed to series A. We combine venture capital with the power of celebrity and athlete influence, providing not just capital but access to 160M+ social media followers through our limited partners for user acquisition and brand amplification. New York | $100K – $500K | 21 | Leads | Active | ~2 wks | Req'd |
| 97 | ▶ RRE Ventures RRE backs visionary early-stage founders leveraging technological breakthroughs to reshape industries. Systematic focus on Physical AI (AI that touches atoms) and Decentralized AI (bridging web3 and AI infrastructure). Boutique model enables direct partnerships with founders vs. large portfolio strategies. 30+ years of multi-cycle experience. New York | $1M – $15M | 26 | Leads | Active | ~2 wks | Open |
| 98 | ▶ Canaan Partners Canaan invests in visionaries with transformative ideas across a 60/40 technology-to-healthcare split. The firm seeks early-stage companies with authentic founder passion, clear problem-solving value, and the potential to improve lives. Canaan runs a transparent, debate-driven partnership with deep operational expertise in healthcare regulation, biotech fundraising, and enterprise scaling. Menlo Park | $1M – $20M | 20 | Both | Active | ~2 mo | Req'd |
| 99 | ▶ Offline Ventures The best ideas don't come from a screen—they're born offline in the real world. We invest in founders who build differently, prioritizing how they build as much as what they build. We believe original thinking, human-centric innovation, and founder wellness are prerequisites for building great companies. New York | $250K – $5M | 20 | Both | Active | ~2 wks | Open |
| 100 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 20 | Leads | Active | ~2 wks | Req'd |
| 101 | ▶ Force Ventures At the earliest stages, team > market > product > idea. Great founders find their way into large markets. Focus on unit economics and value capture alongside value creation. Strong emphasis on B2B managed marketplaces and India-first consumer/enterprise plays. Bengaluru, India | $50K – $2M | 25 | Follows | Active | ~1 mo | Open |
| 102 | ▶ 645 Ventures We partner with relentless founders who defy convention to change the future. Our four founder paradigms—purity of motivation, earned secret, obsessed problem solving, and non-consensus thinking—guide our investment decisions. We believe the best founders are intrinsically motivated to solve real problems, have deep domain expertise, relentlessly iterate to find better solutions, and have the courage to diverge from established paths. New York | $1M – $10M | 30 | Leads | Active | ~2 mo | Open |
| 103 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 104 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 105 | ▶ Upslope Ventures Exceptional teams can originate from any location. We provide more than capital and introductions. By leveraging our network we aim to empower entrepreneurs with the resources they need to have their best chance at success—even if we don't invest. Denver | $100K – $500K | 29 | Both | Active | ~2 wks | Req'd |
| 106 | ▶ KittyHawk Ventures Backing exceptional, mission-driven entrepreneurs creating companies with Massively Transformative Purpose (MTP) that impact billions of people. We invest across the full innovation lifecycle, from early-stage frontier technology through scale to liquidity. We love companies and individuals that are different, fishing where others aren't, seeking opportunities where exceptional visionary entrepreneurs see novel paths to greatness. Los Angeles | $500K – $5M | 10 | Leads | Active | ~2 mo | Req'd |
| 107 | ▶ Nava Ventures Early-stage technology and innovation companies with emphasis on vertical AI, health tech, developer infrastructure, fintech, and legacy industry modernization. Backs 'problem-obsessed' founders creating new markets. San Francisco | $250K – $5M | 14 | Leads | Active | ~1 mo | Open |
| 108 | ▶ New Stack Ventures Invest in outsiders—mission-driven, non-traditional founders in off-coast locations building hardware, deep tech, logistics, or legacy-industry companies. Reject the Stanford/Google/Bay Area formula in favor of exceptional founders who don't fit traditional VC molds. Chicago | $500K – $1.5M | 14 | Leads | Active | ~2 wks | Open |
| 109 | ▶ Draper Associates Invest in bold, visionary founders building transformational businesses long before the world believes in them. We back founders solving impossible-seeming problems across frontier sectors: AI/robotics, crypto, biotech, aerospace, and unconventional ideas. San Mateo, CA | $500K – $30M | 23 | Leads | Active | ~1 wk | Open |
| 110 | ▶ L'ATTITUDE Ventures Latino founders represent an underserved but exceptionally talented segment of the entrepreneurial ecosystem. We invest in visionary founders who combine bold ideas with execution excellence to build scalable, high-impact businesses that create both economic and social value. We believe institutional capital paired with strategic partnership from Fortune 100 executives and operating experts can unlock the full potential of Latino-led innovation. San Diego | $500K – $3M | 37 | Leads | Active | ~2 mo | Req'd |
| 111 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 112 | ▶ Expansion Venture Capital Entrepreneurs, not VCs, build great companies. We invest early in great & passionate entrepreneurs and serve as long-term partners. Available 24/7 to help founders with mentorship, product-market fit, fundraising, business development, customer acquisition, talent sourcing, and strategic partnerships. New York | $250K – $1M | 30 | Leads | Active | ~1 wk | Open |
| 113 | ▶ Sand Hill Angels Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem. Mountain View | $50K – $2M | 30 | Follows | Active | — | Open |
| 114 | ▶ Atomic By combining ideas, capital, and talent, we can scale entrepreneurship and build transformational companies. We source 800+ ideas internally, recruit co-founders, and provide day-one operational support in design, engineering, finance, and recruiting. Miami | $300K – $10M | 19 | Leads | Active | ~1 wk | Open |
| 115 | ▶ Vibe Capital Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures. New York | $250K – $500K | 22 | Both | Active | ~2 mo | Open |
| 116 | ▶ Halogen Ventures The smartest place you can invest your capital is in women. We bet on early-stage female-founded and female-led companies creating groundbreaking consumer and B2B software technologies that solve meaningful problems in families, healthcare, childcare, education, climate, and sustainability. Santa Monica | $100K – $1M | 29 | Follows | Active | ~1 mo | Req'd |
| 117 | ▶ TenOneTen Ventures Technical founders backing technical founders. We invest early in technical teams transforming major industries facing existential threats and tremendous opportunities. We target essential sectors—healthcare, logistics, real estate, manufacturing—where technical innovation solves critical problems. Los Angeles | $250K – $5M | 24 | Leads | Active | ~2 wks | Open |
| 118 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | — | 1mo | ~2 wks | Open |
| 119 | ▶ Crossbeam Venture Partners We are a stage-agnostic venture capital firm investing in exceptional founders building the companies that shape our world. New York | $500K – $3M | 20 | Both | Active | ~2 wks | Open |
| 120 | ▶ Bessemer Venture Partners We partner with entrepreneurs from their early days through every stage of growth, focusing on innovative solutions in technology, healthcare, and financial services. Redwood City, California | $5.8M – $34.3M | 6 | — | 1mo | — | — |
| 121 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 122 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 123 | ▶ MaC Venture Capital MaC backs visionary founders building category-defining companies with deep understanding of cultural shifts, technological advancements, and emerging market trends. Founders must demonstrate authentic insight into why their problem needs solving now, combined with ability to see how the world is changing. Particular focus on founders paying attention to shifts others might miss. | $500K – $2M | 19 | Leads | Active | ~2 wks | Req'd |
| 124 | ▶ Evolution Venture Capital Partners Culture-Tech companies that disrupt and define how we live, work, play, and interact with the world every day. We invest in passionate founders building transformative products that change cultural behaviors. New York | $500K – $6M | 28 | Leads | Active | ~1 wk | Open |
| 125 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 126 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
| 127 | ▶ IGC - Innovative Growth Capital IGC pioneered the Reverse VC™ model — starting with corporate demand rather than capital deployment. Their ReverseVision platform identifies what Global 5000 companies want to buy, then matches emerging tech founders to those demand signals. Investment flow: Demand → Commercialization → Valuation → Capital → Exit. This approach claims higher success rates, better deal terms, and reduced downside risk by replacing intuition with engineered outcomes. San Francisco | $25K – $500K | 1 | Leads | Active | ~1 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 127 VC firms that actively invest in healthcare & digital health + robotics & automation at the Series A stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for series a healthcare & digital health + robotics & automation investors is $2.8M – $2.8M, with a full range from $25K – $100000M. The distribution breaks down as: 9 firms in the <$500K range, 15 firms in the $500K-$1M range, 25 firms in the $1M-$2M range, 24 firms in the $2M-$5M range, 24 firms in the $5M-$10M range, 30 firms in the $10M+ range.
Among the 127 firms tracked, 94% lead or co-lead rounds, and 5% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best series a healthcare & digital health + robotics & automation investors combine domain expertise with an active portfolio in the space. Among these firms, 38% prefer warm introductions, and the average firm has 32 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.