115 VC firms investing in biotech & life sciences and robotics & automation at the Pre-Seed stage.
F4 Fund tracks 115 VC firms that actively invest in biotech & life sciences + robotics & automation at the Pre-Seed stage, with check sizes ranging from $5K – $500M (median: $1.6M – $1.6M). As of June 2026, and 92% lead or co-lead rounds. Rankings are based on F4's proprietary analysis of 1,358+ researched VC firms, scored by data completeness, portfolio depth, investment recency, and stage alignment.
| # | Firm | Check Size | Portfolio | Leads? | Activity | Decision | Intro |
|---|---|---|---|---|---|---|---|
| 1 | ▶ Undeterred Capital The breakthrough is the beginning. Partner with founders commercializing scientific and technological breakthroughs in biological platforms and applied robotics, helping them solve operational challenges to build durable, generational companies. Los Angeles | $500K – $1M | 23 | Leads | Active | — | Open |
| 2 | ▶ Pebblebed We back the foundational layers of progress. Developer platforms that accelerate creation. Robot operating systems that make autonomy real. Simulation engines training the next generation of AI. Formal verification securing billions in value. Foundational systems that quietly compound—built by founders who see elegance in complexity and possibility in constraints. San Francisco | $250K – $2M | 31 | Leads | Active | ~2 wks | Open |
| 3 | ▶ Initialized Capital Passion and vision matter more than pedigree. We seek founders with grit, audacity, and a spark of rebellion—regardless of background. We invest early, before success is inevitable, and support founders from 0-to-1 through Series A. San Francisco | $250K – $2M | 185 | Leads | Active | ~2 wks | Open |
| 4 | ▶ Hartmann Capital The future belongs to those who invest in it. Hartmann Capital is the institutional gateway to early-stage frontier tech — backing founders at the intersection of Generative AI, Brain-Computer Interfaces, XR & Spatial Computing, Programmable Biology, and Robotics. We identify innovations as they prepare to cross the chasm into mainstream adoption. Miami | $300K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 5 | ▶ Acre Venture Partners Driving positive, lasting change in food and agriculture creates exceptional financial outcomes. Impact and return aren't trade-offs—they're intertwined. Both are essential. We invest in technologies and companies addressing human health, planetary well-being, responsible production, and climate solutions. Santa Monica | $500K – $5M | 29 | Leads | Active | ~1 mo | Req'd |
| 6 | ▶ 2048 Ventures Thesis-driven early-stage venture capital firm investing in visionary founders building transformative technologies in Vertical AI, Deep Tech, Healthcare, and Biotech. Focus on companies built on defensible data moats and novel technological breakthroughs solving fundamental problems. Emphasis on long-term value creation and partnership from day zero. Rapid decision-making (10-15 business days) combined with hands-on operational support. NPS score of 100 from portfolio founders. New York | $500K – $3M | 28 | Leads | Active | ~2 wks | Open |
| 7 | ▶ Virta Ventures We back bold, growth-oriented founders transforming how the world is moved, powered, and built through AI and physical infrastructure innovation. We invest in early-stage companies making physical industries more profitable, efficient, and resilient through capital-efficient business models combining software, hardware, and structured finance. | $100K – $750K | 28 | Both | Active | ~1 mo | Open |
| 8 | ▶ ZAKA VC Founders backed by entrepreneurs. ZAKA bridges North American and CEE startup ecosystems, investing pre-seed to seed in Health & Biotech and Industrial Tech. The firm deploys institutional capital while leveraging operator networks to help European founders scale globally. Prague | $100K – $500K | 67 | Follows | Active | ~1 mo | Open |
| 9 | ▶ Carbon Silicon Ventures Backing founders transforming biology into an engineering discipline. We invest in the infrastructure stack of biology—synthetic DNA, cloud labs, automated experiments, computational drug design, and AI-for-biology—enabling science as a software problem at scale. We partner with technical founders who apply engineering rigor to biological challenges. San Francisco | $100K – $500K | 10 | Both | Active | ~2 wks | Open |
| 10 | ▶ Breakout Ventures The era of transformational science is here. Life sciences and industrial markets are being reshaped by founders who move fast and build at the intersection of biology, chemistry, computation, and AI. This is a step-change in how science becomes solutions. We back bold founders who go beyond solving technical problems to redefine entire markets. San Francisco | $250K – $15M | 24 | Leads | Active | ~2 wks | Req'd |
| 11 | ▶ First Star Ventures Invest with conviction in visionary, technical founders inventing the future with frontier computing technology. Focus on computing×real-world startups (techbio, climate, robotics, industrial infrastructure). Enforce strict rebuildability bar—won't invest if 3-5 Google engineers could recreate product in 3-12 months. Position against SaaS/consumer playbook; future venture outliers will be very different. Boston | $100K – $1M | 42 | Follows | Active | ~2 wks | Req'd |
| 12 | ▶ Bee Partners We identify and partner with exceptional technical founders building at the Frontier Curve of Innovation across four futures: Agentic Enterprise (AI agents transforming workflows), Unified AI Integration (AI woven into operations), Accelerated Hardware Development (AI-native hardware design), and Advanced Materials Innovation (AI and synthetic biology convergence). We provide first institutional checks at pre-seed stage with deep operational support. San Francisco | $500K – $1.5M | 22 | Leads | Active | ~1 mo | Req'd |
| 13 | ▶ Humba Ventures We invest in hard tech and hard sectors—companies building solutions to difficult, underexplored problems that others won't. Unlocking society's potential depends on founders willing to build what others won't. We're hyper curious, drawn to difficult and underexplored areas. San Francisco | $250K – $1M | 38 | Leads | Active | ~2 wks | Open |
| 14 | ▶ Gradient Ventures Artificial intelligence will reshape every industry. We partner with technical founders building the next generation of AI applications, infrastructure, and tools across every layer of the AI stack. San Francisco | $750K – $25M | 54 | Leads | Active | ~1 mo | Open |
| 15 | ▶ Giant Ventures The biggest companies of the century will be built solving the world's most pressing problems. We champion ambitious founders using technology to reshape civilization around climate, health, and inclusive capitalism. London | $500K – $15M | 35 | Both | Active | ~2 mo | Open |
| 16 | ▶ AgFunder Progress in food, agriculture, and human health lags other sectors due to structural constraints. We invest in deep technologies that remove these bottlenecks at scale—whether AI, biology, robotics, or materials science. We're not intimidated by threats to the status quo. Silicon Valley | $500K – $5M | 34 | Both | Active | ~1 mo | Open |
| 17 | ▶ earthling.vc We're entering the augmentative era—a paradigm shift where digital technology feels more human by dissolving barriers between real and digital worlds. AI and AR/VR hit critical inflection points in 2023. We back extraordinary technical teams building market-viable solutions in gaming, consumer, and infrastructure. | $100K – $1M | 34 | Leads | Active | ~2 wks | Open |
| 18 | ▶ Material Impact Fund Material science and deep tech innovations drive outsized returns while solving urgent human problems. We back inception-stage founders turning lab breakthroughs into commercial products that make the world cleaner, more productive, and healthier. Boston | $100K – $10M | 34 | Leads | Active | ~1 mo | Open |
| 19 | ▶ Aera VC Investing in breakthrough deep technologies that address humanity's greatest challenges. We allocate ~80% to climate solutions (carbon-negative materials, renewable energy, climate adaptation) and ~20% to frontier tech (aerospace, robotics, advanced materials, biotech). We operate as a venture-and-philanthropy platform backed by the Fukutake family, blending profit-seeking with impact objectives. Singapore | $500K – $20M | 33 | Leads | Active | ~1 mo | Open |
| 20 | ▶ Playground Global Where breakthrough science turns into world-changing companies. We back scientists and engineers at the earliest stages—pre-formation and pre-product—at the intersection of AI, engineered biology, next-gen compute, and hard science. If it's too early for everyone else, it's probably right for us. Palo Alto | $1M – $20M | 31 | Both | Active | 3+ mo | Req'd |
| 21 | ▶ E2MC Ventures The space economy represents the next frontier for transformative economic opportunity and meaningful impact. We back pioneering founders building the technologies and services that enable humanity's expansion into space while creating value on Earth. We apply financial discipline (Wall Street cash-flow and intrinsic-value approach) to identify sustainable, scalable space businesses. Miami | $1M – $5M | 30 | Leads | Active | ~1 mo | Req'd |
| 22 | ▶ MFV Partners Early-stage deep tech entrepreneurs developing novel, patented solutions to the world's biggest problems in robotics, quantum computing, energy, climate, and healthcare. We back visionary founders with deep domain expertise and engage as thought partners through technology validation and commercialization. Palo Alto | $1M – $5M | 16 | Leads | Active | ~2 wks | Open |
| 23 | ▶ Divergent Capital We back deeply technical founders solving hard problems with innovative technologies. Combining capital with go-to-market expertise and structured fellowships, we partner with founders who have authentic personal connections to their problems and bring novel technological approaches to market. New York | $250K – $1M | 44 | Leads | Active | ~2 wks | Req'd |
| 24 | ▶ At One Ventures Invest in early-stage companies using disruptive deep tech to upend unit economics of established industries while delivering climate-positive outcomes. Focus on undercapitalized climate verticals (water, agriculture, robotics, materials, energy) where deep tech can achieve 2.5-3x unit economics improvement paired with environmental benefits. Menlo Park | $500K – $5M | 15 | Leads | Active | ~2 wks | Open |
| 25 | ▶ Silicon Roundabout We back 'sub-0.1% of the population' type exceptional founders building fundamental, infrastructure-level technologies in critical sectors (computing, defence, energy) reshaping our world. Community-driven approach provides proprietary deal flow and deep technical credibility. Focus on first cheques in pre-seed/seed with hands-on mentorship and network access. | $150K – $8.7M | 27 | Leads | Active | ~2 wks | Open |
| 26 | ▶ Air Street Capital We invest exclusively in AI-first companies where advances in artificial intelligence are the primary driver of product capability, competitive advantage, and long-term value creation. We are deeply coupled to the frontier of AI research and industry, enabling us to identify emerging technical inflection points and structural shifts early. London | $1M – $300M | 26 | Leads | Active | ~1 mo | Open |
| 27 | ▶ Privilège Ventures We back bold, ambitious, and resilient founders driving breakthrough innovations in HealthTech, CleanTech, and AgriFoodTech. Female-led and gender-mixed teams deliver superior returns and drive meaningful impact. Over five decades of combined experience navigating financial cycles enables us to partner authentically with founders, providing not just capital but strategic guidance and operational support. Switzerland | $100K – $1M | 25 | Both | Active | — | — |
| 28 | ▶ The E14 Fund We back MIT founders building deep-tech companies with defensible science or engineering advantages. We support the transition from researcher to founder, providing both capital ($500K-$5M) and operational support through the MIT ecosystem. Cambridge | $500K – $5M | 51 | Leads | Active | ~1 mo | Open |
| 29 | ▶ Spacecadet Ventures Founders building the possibly impossible deserve capital plus marketing support. Great technology combined with exceptional storytelling and narrative development creates world-changing moonshots. We provide both the capital and the story-telling expertise to help founders achieve escape velocity. New York | $250K – $1M | 99 | Leads | Active | ~2 wks | Open |
| 30 | ▶ Radical Ventures AI Eats Software. Over the next decade, virtually every bit of software will be replaced by artificial intelligence. We invest in founders and entrepreneurs who understand the transformational power of AI and are building solutions that reshape how we live, work, and play. Toronto | $1M – $25M | 50 | Leads | Active | ~2 mo | Req'd |
| 31 | ▶ Supply Change Capital Supply Change Capital invests at the intersection of food, climate, and culture. We back early-stage technology transforming the food supply chain's foundational infrastructure - from supply chain resilience and logistics to health/nutrition innovation and labor automation. We believe the global food system ($10T industry) is least modernized sector globally, requiring urgent technological transformation to address climate impact (1/3 of GHG emissions), health crises (50%+ with diet-related chronic disease), and labor equity. We invest with dual lenses: climate impact (emissions reduction, soil health, biodiversity) and culture (supporting diverse founders who deliver 30% higher returns despite underinvestment). As former operators, we partner with founders not just with capital but operational expertise, impact metrics frameworks, and access to extensive advisor network of industry veterans. Chicago | $250K – $1M | 23 | Leads | Active | ~1 mo | Req'd |
| 32 | ▶ Yu Galaxy Impact and profit are inseparable. We back visionary founders solving humanity's toughest problems in healthcare, AI, robotics, defense, and automation. We measure success in lives saved as well as returns. | $500K – $5M | 23 | Leads | Active | ~1 wk | Open |
| 33 | ▶ R7 Partners Intelligence is coming into the physical world through AI and robotics applied to atoms rather than bits. We back capex-heavy, long-horizon bets in hard-to-abate decarbonization sectors and hardware-heavy industrial systems that many traditional early-stage funds avoid. Chicago | $100K – $5M | 35 | Leads | Active | ~2 mo | Req'd |
| 34 | ▶ SOSV Deep tech startups at the edge of what is possible solve critical human and planetary health problems. SOSV backs founders combining scientific rigor with entrepreneurial grit, providing not just capital but access to specialized labs, manufacturing, and global expertise networks. San Francisco | $250K – $5M | 22 | Leads | Active | ~1 wk | Open |
| 35 | ▶ Wireframe Ventures Extraordinary companies are built by driven founders whose mission to improve the health of people and planet is inseparable from their product. We partner with technical founders building technology solutions to the world's most important challenges across climate, health, biotech, and enabling technologies. San Francisco | $500K – $2M | 33 | Leads | Active | ~2 wks | Open |
| 36 | ▶ 11.2 Capital We invest in technically sophisticated founding teams solving breakthrough problems in deep-tech. We believe the next generation of transformational companies will be built by scientists and engineers with deep domain expertise tackling problems at the frontier of AI, cybersecurity, quantum, robotics, space, synthetic biology, and bioengineering. We provide patient capital and technical partnership to help these teams achieve escape velocity. San Francisco | $500K – $3M | 21 | Leads | Active | ~2 wks | Open |
| 37 | ▶ BlueYard Capital Invest in only two kinds of technologies: those that move humanity toward utopia, and those that hold the line against oblivion. Back n-of-1 visions for an era of Black Swans—unconventional companies solving civilization-scale problems that others dismiss as too early, too risky, or too misunderstood. Berlin | $500K – $5M | 58 | Leads | Active | ~2 mo | Open |
| 38 | ▶ Blue Bear Ventures We invest in co-founding teams from research labs solving the most pressing challenges in science and technology. The most important aspect of deep tech companies is the founding team—we invest in technical founders with entrepreneurial spirit, not just ideas. We provide patient capital, deep technical mentorship, and access to UC Berkeley's innovation ecosystem and corporate networks. San Francisco | $100K – $400K | 20 | Leads | Active | ~2 mo | Open |
| 39 | ▶ Empirical Ventures Backing 'Venture Scientists' — PhD-trained technical founders applying rigorous scientific methodology to build transformative companies from fundamental research. Focus on deep tech and life sciences areas that address climate change, resource scarcity, and healthcare accessibility. Targets university spinouts and science-led startups in areas that are difficult to diligence for generalist investors. Bristol, United Kingdom | $100K – $750K | 20 | Leads | Active | ~2 mo | Open |
| 40 | ▶ HCVC We back founders on a mission to industrialize scientific and technological progress. Hardtech startups solve difficult technological problems using interdisciplinary mixes of technology and engineering. We provide patient, supportive capital and community to help founders navigate R&D cycles and build technically defensible products. Paris | $100K – $2.5M | 30 | Leads | Active | ~2 mo | Open |
| 41 | ▶ The Venture Collective (TVC) Permanent balance-sheet investor backing highly defensible, category-defining, mission-driven companies solving the world's biggest problems. Focus on founders transforming legacy industries with emphasis on diversity, equity, and inclusion. New York | $100K – $2M | 53 | Leads | Active | ~2 wks | Open |
| 42 | ▶ Pale Blue Dot Early-stage climate tech companies building the sustainable future. We invest in both software and hardware solutions addressing climate change through optimization, adaptation, and pioneering innovations. The next billion-dollar companies will be built with climate in mind. Sweden | $500K – $2M | 40 | Leads | Active | ~2 mo | Req'd |
| 43 | ▶ Prelude Ventures Climate is the biggest challenge of our lifetime and the greatest business opportunity of the coming decades. We back visionaries accelerating climate innovation that will reshape our global economy for the betterment of people and planet. The most successful companies are born from a vision for a better future and the ability of that vision to create large, lasting positive impact. We invest in frontier technologies addressing climate across seven sectors: Built Environment, Carbon Management, Compute, Energy, Food & Agriculture, Manufacturing & Industrials, and Mobility. The best ideas come from everywhere—we operate where many venture firms can't or won't. San Francisco | $100K – $5M | 51 | Both | Active | ~2 mo | Open |
| 44 | ▶ Future Ventures Support passionate founders forging the future. Invest in seed and early-stage companies with unique ideas that have potential to reinvent entire industries. Focus on frontier technologies that make the world better and don't prey on human frailty. San Francisco | $500K – $10M | 28 | Leads | Active | ~1 mo | Open |
| 45 | ▶ Xfund Back entrepreneurs who think laterally and experiment across disciplines. We seek founders with multidisciplinary abilities who will become more insightful innovators. We value creative problem-solving, intellectual curiosity, and the ability to synthesize insights across fields. Cambridge | $500K – $5M | 28 | Both | Active | ~1 mo | Req'd |
| 46 | ▶ Basis Set Ventures The best way to find and support AI companies is to be one ourselves. We back independent thinkers building real systems before consensus forms, partnering as radical learning partners from day one. Menlo Park | $250K – $3M | 27 | Leads | Active | ~2 wks | Open |
| 47 | ▶ Lerer Hippeau As founder-operators, we see returns in relationships. We back ambitious founders with exceptional vision at the earliest stages with capital, mentorship, and network access. | $100K – $1M | 73 | Leads | Active | ~1 mo | Open |
| 48 | ▶ Necessary Ventures Invest in companies addressing fundamental societal needs. Provide Talent/Capital/Attention platform via in-house content and advisory network. Mission-driven investments with specialized expertise in healthcare, climate, robotics, and deep tech. San Francisco | $1M – $2M | 37 | Leads | Active | ~2 wks | Open |
| 49 | ▶ Elementum Ventures Seed-stage deep technology with IP defensibility, deployed by multi-exit founder-operators willing to be hands-on operational partners. Focus on frontier sectors—defense, climate, space, biotech, fusion—where bold technical founders are building mission-critical capabilities. Menlo Park | $250K – $1.5M | 26 | Leads | Active | ~1 mo | Req'd |
| 50 | ▶ Fifty Years We back founders using technology to solve the world's biggest problems. We believe capitalism can be a force for good when companies are built to be both massively profitable AND create positive impact. The best entrepreneurs are determined, passionate, smart, creative, and can inspire thousands of talented people. San Francisco | $250K – $2M | 25 | Leads | Active | ~2 wks | Open |
| 51 | ▶ Plum Alley Investments Frontier technologies and medical breakthroughs offer the best opportunities to address fundamental human and environmental challenges. Diversity of founder backgrounds drives innovation and superior returns. Founders with domain expertise, technical credentials, and distinctive visions solve the world's biggest problems. New York | $750K – $3M | 25 | Both | Active | ~1 mo | Req'd |
| 52 | ▶ Binance Labs Support visionary founders building transformative technologies across blockchain, AI, and biotechnology. Provide capital, technical resources, and access to Binance's 300M+ user base and infrastructure. Partner for long-term value creation with founder-centric approach. Cayman Islands | $100K – $5M | 24 | Both | Active | ~2 wks | Open |
| 53 | ▶ FTW Ventures The $12 trillion food and agriculture industries still rely on centuries-old methods. We back disruptive science and technology to modernize the food system—from biotech and sensors to automation and software—to feed 10 billion people by 2050 while preserving nature and nurturing humankind. San Francisco | $500K – $5M | 24 | Leads | Active | ~2 mo | Req'd |
| 54 | ▶ Cantos We invest in people who will transform the physical world. Near frontier technology solving climate change, disease, armed conflict, poverty, and existential risks. Technical founders building capital-intensive, long-horizon companies. San Francisco | $400K – $1.5M | 42 | Leads | Active | ~1 mo | Req'd |
| 55 | ▶ Vanedge Capital Deep technology and hard tech company investing at inflection points. Partner with technical founders building infrastructure-level solutions for global scale. Founded 2010 on belief that next generation of transformative companies require deep technical expertise, not just capital. Vancouver | $1M – $15M | 42 | Both | Active | ~2 wks | Open |
| 56 | ▶ Story Ventures Story invests in the building blocks of automated systems across three interconnected layers: sensory systems (data capture), data processing (organization and structure), and machine intelligence (applications and decision-making). We believe the most impactful problems require the most innovative solutions, and we partner with founders pursuing audacious, challenging businesses because that's what it takes to create lasting impact. New York | $500K – $5M | 41 | Both | Active | ~1 mo | Req'd |
| 57 | ▶ AV8 Ventures Partner with visionary founders to build category-defining companies in healthcare, enterprise software, fintech/insurtech, and deep technology. Provide deep operational support, board participation, and access to domain expert network. Focus on companies solving problems in regulated or data-rich industries. Leverage Allianz's unique vantage point on risk, data, and regulation to identify opportunities at intersection of innovation and regulatory necessity. Palo Alto | $500K – $10M | 22 | Leads | Active | ~2 wks | Open |
| 58 | ▶ Cartography Capital Breakthrough technologies and materials that power every AI chip, quantum computer, robot, battery, solar panel, biotech solution, and space exploration tool. Back founders who move beyond conventional industry boundaries to build bedrock economic infrastructure. Oakland | $250K – $3M | 14 | Both | Active | ~1 mo | Open |
| 59 | ▶ Alumni Ventures We democratize venture capital by providing individual accredited investors with professional-grade access to elite venture opportunities. We leverage our massive 850,000+ community network and 11,000+ investors to create unique value for founders, sourcing and diligencing deals alongside top-tier VCs (a16z, Sequoia, Khosla) without leading rounds. Our network is our competitive advantage—it compounds value for all stakeholders. Manchester, NH | $250K – $5M | 58 | Follows | Active | ~2 wks | Open |
| 60 | ▶ Angular Ventures Backs inception-stage technical founders across Europe and Israel building solutions for hard markets including AI infrastructure, space/aerospace, advanced manufacturing, energy, biology, and other deep-tech verticals. London | $500K – $5M | 46 | Leads | Active | ~2 wks | Open |
| 61 | ▶ TSVC The most defensible companies are built on hard technology solving real problems at scale. We partner with technical founders leveraging deep domain expertise and the Tsinghua network to identify and nurture transformative innovations in deeptech, healthtech, and the data economy. Los Altos, California | $250K – $3M | 13 | Both | Active | ~2 wks | Req'd |
| 62 | ▶ Creative Ventures Humanizing deep tech by bringing advanced breakthrough technologies to where the people are and maximizing the value they generate for solving humanity's most critical crises. We invest in companies addressing climate, manufacturing labor shortages, healthcare costs, sustainable food production, and computing infrastructure. Oakland | $1M – $3M | 28 | Both | Active | ~1 mo | Req'd |
| 63 | ▶ Neotribe Ventures Breakthrough technologies that stretch the imagination — deep tech with the potential to create new product categories. We bring company-building skills and operating expertise to help founders find product-market fit. Menlo Park | $1M – $80M | 28 | Leads | Active | ~1 mo | Req'd |
| 64 | ▶ Cathexis Ventures Invest in talented people solving challenging problems. We back extraordinary founders building products that people want with speed, efficiency, and operational excellence. Houston | $250K – $1M | 20 | Leads | Active | ~2 wks | Req'd |
| 65 | ▶ Scribble Ventures AI companies are built differently. We back the world's best AI native founders and help them reshape our world for the better. We go wide on product and deep on GTM. San Francisco | $300K – $1.5M | 18 | Leads | Active | ~1 wk | Open |
| 66 | ▶ Foothill Ventures Back technical teams working on breakthrough products. We invest in seed stage companies that demonstrate technical differentiation - meaning technical or product-level superiority is a major reason for future success. We pursue investments from application layer (AI/ML) through software infrastructure to hardware layers (semiconductors, photonics). Los Altos, California | $250K – $10M | 25 | Leads | Active | ~1 wk | Open |
| 67 | ▶ Innovation Endeavors We invest in the Super Evolution—the convergence of ubiquitous sensors, advanced machine learning, cloud systems, robotics, 3D printing, and CRISPR. We partner with technical founders solving hard engineering and science problems to rethink large industries and tackle humanity's most pressing challenges. Palo Alto | $1M – $15M | 25 | Leads | Active | ~2 mo | Open |
| 68 | ▶ Better Capital Day 0 venture capital applied by a deep operator. Better Capital invests at the earliest stage where ambiguity is highest and operator judgment adds the most value. Solo GP model keeps conviction high and enables deep engagement with 20-25 companies at critical inflection points. Pune | $300K – $1M | 47 | Leads | Active | ~1 wk | Req'd |
| 69 | ▶ Julian Capital First check for deeptech founders building across all deeptech sectors (chips, energy, robotics, medtech, materials science, aerospace). We provide more than capital—we become your growth team, design your website, and offer hands-on go-to-market support backed by deep expertise in startup scaling and commercialization. San Francisco | $750K – $1M | 17 | Leads | Active | ~2 wks | Open |
| 70 | ▶ DCVC We back entrepreneurs using computational approaches (AI, simulation) to solve trillion-dollar problems in climate, health, industrial transformation, and national security. Deep tech requires patient capital and scientific rigor. San Francisco | $5M – $25M | 31 | Leads | Active | ~2 mo | Req'd |
| 71 | ▶ Batshit Crazy Ventures Support unconventional, bold founder-led companies solving real problems at the earliest stages. We provide capital, operational mentorship, and resources to pre-revenue and pre-seed startups that traditional investors overlook. Boulder, Colorado | $100K – $1M | 23 | Both | Between | ~2 wks | Req'd |
| 72 | ▶ In-Q-Tel (IQT) Transformative national security solutions emerge from early-stage private-sector startups developing frontier technologies. IQT identifies, evaluates, and leverages innovations to accelerate government adoption while enhancing commercial success. As of May 2026, IQT is emphasizing mission investing through fewer larger bets in autonomy, contested logistics, critical infrastructure, and technologies that can move to mission use quickly. Washington | $250K – $3M | 30 | Leads | Active | ~1 mo | Open |
| 73 | ▶ Valia Ventures We back technically ambitious founders building tomorrow's most iconic companies in frontier sectors like AI, hardtech, robotics, healthcare, and fintech. We believe great companies come from founders willing to tackle complex problems that generalist funds avoid. New York | $250K – $1.5M | 16 | Leads | Active | ~2 wks | Req'd |
| 74 | ▶ Blackbird Back wild hearts with the wildest ideas from the very beginning. Invest in companies, not rounds — following exceptional founders from pre-seed through all subsequent stages. Focused on ANZ founders building globally ambitious companies across any sector. Sydney | $150K – $60M | 43 | Leads | Active | ~2 wks | Open |
| 75 | ▶ SpeedInvest Backs globally ambitious technology companies from pre-seed and seed through selected growth rounds using specialist EMEA sector teams and a platform model for capital, customers, talent, follow-on investors, and operational support. Vienna | $250K – $30M | 49 | Leads | Active | — | Open |
| 76 | ▶ Baobab Ventures Operator-led capital for global pre-seed and seed technical founders building AI, robotics, defense, developer tools, AI-native applications, and adjacent deep-tech companies where rapid execution and distribution matter. London | $300K – $350K | 15 | Both | Active | — | Open |
| 77 | ▶ Black Flag Be the first check in for founders building America's next era of critical technologies. Invest in audacious founders across Defense, Aerospace, Energy, AI, Manufacturing, Cybersecurity, and Health+Bio solving problems critical to national security and American technological leadership. Provide capital ($250K-$1M), unmatched government access, mentor network, and go-to-market acceleration. San Diego | $250K – $1M | 21 | Leads | Active | ~1 mo | Open |
| 78 | ▶ Andreessen Horowitz Backing the builders of the next layer of computing across AI infrastructure, defense, biotech, and American dynamism. Former 'Software is Eating the World' thesis evolved to 'AI is Eating Software'. Partners with technical founders building foundation models, cloud systems, and infrastructure for the AI era. Menlo Park | $1M – $200M | 48 | Both | Active | ~2 wks | Open |
| 79 | ▶ Valhalla Ventures We partner with visionaries building enduring moats in deeptech and gaming. We invest up to $12M from inception to Seed. We restore the original essence of venture capital - working directly with bold entrepreneurs to tackle the world's toughest challenges through breakthrough physical technologies and novel gaming experiences. | $500K – $12M | 14 | Leads | Active | ~2 wks | Req'd |
| 80 | ▶ AIX Ventures AI-native companies where artificial intelligence is the core product and competitive moat, not just a feature. Three investment baskets: (1) AI infrastructure (vector databases, model serving, optimization), (2) vertical applications with 20%+ performance advantages, and (3) frontier research with clear commercialization paths. Palo Alto | $750K – $3M | 25 | Leads | Active | ~1 wk | Open |
| 81 | ▶ Celesta (fka WRVI) Celesta invests in brilliance at the forefront of science and engineering, targeting companies that enable mass adoption of emerging tech, radically improve health outcomes, and transform large industries. Focus on platforms enabling emerging tech adoption, bioconvergence innovations (high-tech + biotech), and technologies disrupting legacy industries with deep tech. San Francisco | $250K – $20M | 19 | Leads | Active | ~2 mo | Open |
| 82 | ▶ Pear VC Exceptional founders backed at pre-seed and seed with both capital and hands-on operational support—talent, GTM, fundraising—build the most enduring companies. Pear is founder-first: founders-and-operators turned investors who have been in founders' shoes. Menlo Park | $250K – $6M | 43 | Leads | Active | ~1 mo | Open |
| 83 | ▶ Boost VC Back the quirky underdog pursuing seemingly impossible ideas. Frontier tech (aerospace, biotech, climate, robotics, crypto, AI, VR/AR) will create the next generation of legendary companies. Technical founders with deep domain expertise can solve the hardest problems in physics, chemistry, and computing. San Mateo, California | $500K – $3M | 30 | Leads | Active | ~1 wk | Open |
| 84 | ▶ 1517 Fund We back dropouts, renegade students, and deep-tech scientists working on ideas that would appear in science fiction. We exist to prove that great founders don't need university degrees and are found in the oddest places. We invest at inception stage (R&D through Seed), providing capital, mentorship, community access, and operational support. People-first approach: it's more about the who than the what. Telluride, Colorado | $50K – $1M | 18 | Leads | Active | ~1 wk | Open |
| 85 | ▶ Lux Capital Turn sci-fi into sci-fact by backing founders solving the most vexing puzzles facing humanity. We believe in counter-conventional solutions and contrarian positions in deep technology. We champion companies working at the intersection of breakthrough science and transformational technology, led by visionary founders who are equal parts mad scientist and business mastermind. New York | $100K – $100M | 18 | Leads | Active | ~2 wks | Req'd |
| 86 | ▶ Brickyard Extraordinary founders execute faster when isolated from distractions and provided intensive on-site support. We seek junkyard dogs with high agency, non-obvious vision, delusional optimism, and execution discipline. Category matters far less than founder quality. Chattanooga, TN | $100K – $500K | 52 | Both | Active | ~2 wks | Open |
| 87 | ▶ Antler Backing exceptional people at the very start of their journey. We support founders from inception to scale through our global residency programs, providing capital, mentorship, and access to a network of 1,500+ companies across six continents. | $125K – $500K | 28 | Leads | Active | ~2 wks | Open |
| 88 | ▶ Deep Checks Deep Checks matches deeptech founders worldwide with venture capital investors who specialize in their specific technology niches. We operate as a specialized deal-flow curation platform connecting founders with 50+ deeptech VCs, angels, and founder-investors. Our mission is to democratize access to expert capital for scientific and hardware founders who are otherwise hard to reach. San Francisco | $500K – $5M | 12 | — | 1mo | ~2 wks | Open |
| 89 | ▶ Impact Venture Capital Corporate-advantage seed investing. We identify promising AI and deep tech startups early, then leverage our hundreds of relationships with corporate venture capital arms to de-risk investments, accelerate time to exit, and create curated dealflow where both founders and corporates benefit from strategic alignment. El Dorado Hills, CA | $250K – $1M | 22 | Leads | Active | ~2 wks | Req'd |
| 90 | ▶ Day One Ventures We help mission-driven pioneers win by harnessing the power of storytelling, art and culture. We back early-stage companies with customer obsession in their DNA and accelerate the mass adoption of technologies they create. Founders need more than capital—they need strategic support in building their narrative and leveraging media to accelerate adoption. San Francisco | $300K – $5M | 27 | Leads | Active | ~1 wk | Open |
| 91 | ▶ SVG Ventures We back bold founders and AI-enabled, game-changing innovations that improve planetary and population health. We target capital-efficient, highly scalable startups reimagining sectors like agri-food, climate, fintech, life sciences and nutrition through deep tech and proprietary IP. We engineer outcomes through operational support, strategic partnerships, and sector expertise. Los Gatos, California | $500K – $100M | 16 | Both | Active | ~2 mo | Req'd |
| 92 | ▶ FAST — by GETTYLAB Breakthrough innovations emerge from engineers tackling frontier problems. We provide fast capital, domain expertise across AI/robotics/space/biotech, and deeptech credibility to pre-seed teams. San Francisco | $5K – $100K | 11 | Follows | Active | ~1 wk | Open |
| 93 | ▶ Transpose Platform First-check investors to exceptional founders building category-defining companies and to emerging venture funds reshaping the industry. Formation-stage specialists operating as partners from inception, not simply deploying capital. Houston | $500K – $15M | 20 | Leads | Active | ~2 wks | Req'd |
| 94 | ▶ ZhenFund Believe in innovation, risk-taking, and young talent. Best entrepreneurs are rare and precious. Provide quick capital, friendly terms, genuine commitment. Help but don't complicate. Monthly founder support. Beijing | $250K – $3M | 25 | Leads | Active | ~2 wks | Open |
| 95 | ▶ Trousdale Ventures We invest in mission-driven companies that dare to tackle impossible challenges, striving to transform industries and create lasting societal impact. We seek founders with audacity to dream big, resilience to persevere, and potential to build forever companies that shape human history. Los Angeles | $5M – $25M | 30 | Leads | Active | ~1 mo | Open |
| 96 | ▶ HOF Capital HOF Capital invests in relentlessly ambitious founders building world-changing technologies that accelerate abundance: sustained technological progress that expands access to opportunity, health, and economic prosperity. Its current public thesis emphasizes AI and agentic systems as amplifiers of discovery, engineering, and knowledge creation, alongside frontier infrastructure and applications that can shorten scientific and technological invention timelines. New York | $500K – $10M | 29 | Both | Active | ~2 wks | Req'd |
| 97 | ▶ Bitspiration The only early-stage deep tech VC in CEE focusing on resilient technologies. We invest in founders building breakthrough technologies with proprietary IP in deep tech, MedTech, cleantech, autonomous vehicles/robotics, industrial, and resilient-tech. Technology must be genuinely unique and address real problems. Kraków, Poland | $50K – $1M | 10 | Both | Active | — | — |
| 98 | ▶ KittyHawk Ventures Backing exceptional, mission-driven entrepreneurs creating companies with Massively Transformative Purpose (MTP) that impact billions of people. We invest across the full innovation lifecycle, from early-stage frontier technology through scale to liquidity. We love companies and individuals that are different, fishing where others aren't, seeking opportunities where exceptional visionary entrepreneurs see novel paths to greatness. Los Angeles | $500K – $5M | 10 | Leads | Active | ~2 mo | Req'd |
| 99 | ▶ Draper Associates Invest in bold, visionary founders building transformational businesses long before the world believes in them. We back founders solving impossible-seeming problems across frontier sectors: AI/robotics, crypto, biotech, aerospace, and unconventional ideas. San Mateo, CA | $500K – $30M | 23 | Leads | Active | ~1 wk | Open |
| 100 | ▶ Pillar VC We invest in technical breakthroughs that overcome the world's greatest challenges. We partner at inception with technically brilliant dreamers who see past impossible to inevitable. We evaluate scientific opportunities through both commercial potential and human impact lenses. Boston | $100K – $10M | 22 | Leads | Active | ~2 mo | Open |
| 101 | ▶ Sand Hill Angels Sand Hill Angels backs seed-stage, high-tech companies with large and growing markets, well-defined problems, disruptive solutions, defensible technology, and strong teams with demonstrated ability to execute. The group leverages 145+ experienced angels to provide capital, mentorship, and network access across the Silicon Valley ecosystem. Mountain View | $50K – $2M | 30 | Follows | Active | — | Open |
| 102 | ▶ Ada Ventures Backing the best founders, not just the best-connected. We assess founders on their qualities, not CV or past experience. We focus on founders building solutions for climate equity, economic empowerment, and healthy ageing. London | $250K – $1M | 28 | Leads | Active | — | — |
| 103 | ▶ LDV Capital A majority of the data our brains analyze is visual. Therefore, the majority of the data AI will analyze will also be visual, spanning the light and electromagnetic spectrums across all sectors. We thrive on collaborating with deep technical teams who leverage computer vision, machine learning and artificial intelligence to analyze visual data. New York | $500K – $1.5M | 28 | Leads | Active | ~2 wks | Req'd |
| 104 | ▶ Vibe Capital Investing in the picks and shovels of volatility caused by convergent forces (AI, Web3, Deep Science) intersecting with demographic shifts and climate change. We seek to create venture-scale returns by backing bold founders building more equitable, beneficial, transparent, and accessible structures. New York | $250K – $500K | 22 | Both | Active | ~2 mo | Open |
| 105 | ▶ Rockies Venture Fund High-growth early-stage companies with disruptive innovation across diversified sectors. Particular focus on underserved communities and Rocky Mountain region. Platform approach with multiple themed funds for specialized strategies. Denver | $100K – $500K | 18 | Both | Active | ~2 mo | Req'd |
| 106 | ▶ Creative Destruction Lab The primary constraint for seed-stage, science-based entrepreneurs is access to experienced business judgment. CDL provides objective-based mentoring from accomplished entrepreneurs, angels, and scientists to help founders prioritize tasks and de-risk their businesses. Toronto | $50K – $250K | 20 | — | 1mo | ~2 wks | Open |
| 107 | ▶ Rule30 Rule30 uses a fully algorithmic decision engine to identify outlier founders at pre-seed and seed stages across Europe and North America. The fund removes human bias by analyzing founder experience, educational background, network evolution, and career trajectory — excluding names and photos. The algorithm ranks founders into top 10%, 3%, and 0.1% tiers. An index-style strategy of 75-85 bets targets ≥3x minimum returns with 97.5% confidence. London | $100K – $300K | 21 | Follows | Active | ~1 wk | Open |
| 108 | ▶ Stout Street Capital Great startups can be built anywhere. We believe in founder-centric investing with operational support from a team of successful founders. We serve undernetworked geographic regions. Denver | $100K – $500K | 26 | Both | Active | ~2 wks | Open |
| 109 | ▶ Montis VC Backs European pre-seed and seed founders building technologies for Energy, Industry, and Resilience, especially energy transition, industrial automation, practical AI for infrastructure, manufacturing, logistics, energy grids, and critical systems. Warsaw | $500K – $2M | 11 | Both | Active | — | Open |
| 110 | ▶ Gaingels Equity of access and representation in venture capital delivers positive returns. Diverse and underrepresented (including LGBTQ+) leaders of high-growth companies deserve capital access. When these founders succeed, they influence ecosystems and open doors for historically excluded groups. New York | $200K – $500K | 29 | Follows | Active | ~2 wks | Open |
| 111 | ▶ MaC Venture Capital MaC backs visionary founders building category-defining companies with deep understanding of cultural shifts, technological advancements, and emerging market trends. Founders must demonstrate authentic insight into why their problem needs solving now, combined with ability to see how the world is changing. Particular focus on founders paying attention to shifts others might miss. | $500K – $2M | 19 | Leads | Active | ~2 wks | Req'd |
| 112 | ▶ Gigafund Back the world's most ambitious and transformative entrepreneurs capable of building world-defining companies over 20+ years. Invest in founders with independent thought and first-principles vision to solve humanity's biggest problems across all sectors and geographies. Austin | $1M – $500M | 18 | Leads | Active | 3+ mo | Open |
| 113 | ▶ VU Venture Partners Invest in early-stage tech companies addressing world's largest market opportunities and solving humanity's biggest challenges. Leverage global distributed team to source, evaluate, and support transformational founders. San Francisco | $100K – $1M | 16 | Both | Active | ~2 mo | Open |
| 114 | ▶ TheoryForge Operator-led fund investing in ambitious founders building transformative AI applications. We partner with technical founders who understand AI/ML deeply and are solving real customer problems with capital efficiency. Great product is always the best marketing. | $200K – $500K | 38 | Both | Active | ~2 wks | Req'd |
| 115 | ▶ IGC - Innovative Growth Capital IGC pioneered the Reverse VC™ model — starting with corporate demand rather than capital deployment. Their ReverseVision platform identifies what Global 5000 companies want to buy, then matches emerging tech founders to those demand signals. Investment flow: Demand → Commercialization → Valuation → Capital → Exit. This approach claims higher success rates, better deal terms, and reduced downside risk by replacing intuition with engineered outcomes. San Francisco | $25K – $500K | 1 | Leads | Active | ~1 mo | Open |
Investors on this page also frequently invest in these sectors
What other stages do these firms also invest in?
What other sectors do these firms also invest in?
Firms that frequently co-invest with investors on this page
F4 Fund tracks 115 VC firms that actively invest in biotech & life sciences + robotics & automation at the Pre-Seed stage. These firms are ranked using a composite score that weighs data completeness (30%), portfolio depth (30%), investment recency (25%), and stage alignment (15%).
Based on F4's analysis, the median check size for pre-seed biotech & life sciences + robotics & automation investors is $1.6M – $1.6M, with a full range from $5K – $500M. The distribution breaks down as: 17 firms in the <$500K range, 23 firms in the $500K-$1M range, 24 firms in the $1M-$2M range, 23 firms in the $2M-$5M range, 12 firms in the $5M-$10M range, 16 firms in the $10M+ range.
Among the 115 firms tracked, 92% lead or co-lead rounds, and 6% typically follow. Founders seeking a lead investor should filter for firms marked "Leads" or "Both" in the rankings table above. Lead investors typically set deal terms and anchor the round.
The best pre-seed biotech & life sciences + robotics & automation investors combine domain expertise with an active portfolio in the space. Among these firms, 32% prefer warm introductions, and the average firm has 31 portfolio companies. Look for firms whose check size matches your raise, whose stage preference aligns with yours, and who have a track record of supporting companies in your sector through multiple growth phases.
Firm profiles are continuously updated through F4's research pipeline, which combines LLM-powered web research, portfolio analysis, and transcript extraction. The ranking data refreshes every 12 hours. Editorial analysis is reviewed weekly. Individual firm profiles are re-researched on a 30-day cycle or when new information surfaces.